Deborah Zibrik - Academia.edu (original) (raw)

Papers by Deborah Zibrik

Research paper thumbnail of P18-023-23 High Prevalence of Iron Deficiency in Canadian Toddlers With Adequate Dietary Iron Intakes and Weak Association With Maternal Dietary Iron Intake at 18 Months Postpartum

Current Developments in Nutrition

Research paper thumbnail of PTFS01-04-23 The Relative Validity of a Food Frequency Questionnaire for Toddlers Aged 18 and 24 Months

Current Developments in Nutrition

Research paper thumbnail of Decreasing Linoleic Acid with Constant α-Linolenic Acid in Dietary Fats Increases (n-3) Eicosapentaenoic Acid in Plasma Phospholipids in Healthy Men

The Journal of Nutrition, 2007

High linoleic acid (LA) intakes have been suggested to reduce a-linolenic acid [ALA, 18:3(n-3)] m... more High linoleic acid (LA) intakes have been suggested to reduce a-linolenic acid [ALA, 18:3(n-3)] metabolism to eicosapentaenoic acid [EPA, 20:5(n-3)] and docosahexaenoic acid [DHA, 22:6(n-3)], and favor high arachidonic acid [ARA, 20:4(n-6)]. We used a randomized cross-over study with men (n ¼ 22) to compare the effect of replacing vegetable oils high in LA with oils low in LA in foods, while maintaining constant ALA, for 4 wk each, on plasma (n-3) fatty acids. Nonvegetable sources of fat, except fish and seafoods, were unrestricted. We determined plasma phospholipid fatty acids at wk 0, 2, 4, 6, and 8, and triglycerides, cholesterol, serum CRP, and IL-6, and platelet aggregation at wk 0, 4, and 8. LA and ALA intakes were 3.8 6 0.12% and 1.0 6 0.05%, and 10.5 6 0.53% and 1.1 6 0.06% energy with LA:ALA ratios of 4:0 and 10:1 during the low and high LA diets, respectively. The plasma phospholipid LA was higher and EPA was lower during the high than during the low LA diet period (P , 0.001), but DHA declined over the 8-wk period (r ¼ 20.425, P , 0.001). The plasma phospholipid ARA:EPA ratios were (mean 6 SEM) 20.7 6 1.52 and 12.9 6 1.01 after 4 wk consuming the high or low LA diets, respectively (P , 0.001); LA was inversely associated with EPA (r ¼ 20.729, P , 0.001) but positively associated with ARA:EPA (r ¼ 0.432, P , 0.001). LA intake did not influence ALA, ARA, DPA, DHA, or total, LDL or HDL cholesterol, CRP or IL-6, or platelet aggregation. In conclusion, high LA intakes decrease plasma phospholipid EPA and increase the ARA:EPA ratio, but do not favor higher ARA.

Research paper thumbnail of A Survey of the Use of Low Microbial Diets in Pediatric Bone Marrow Transplant Programs

Journal of the American Dietetic Association, 2001

A survey was used to determine the use of low microbial diets for pediatric bone marrow transplan... more A survey was used to determine the use of low microbial diets for pediatric bone marrow transplantation patients at hospitals in Canada and the northwestern United States. Five out of 7 hospitals responding to the survey provided a low microbial diet to this population to reduce the potential risk posed by food pathogens. Two hospitals prepared their low microbial diet in a separate kitchen using aseptic techniques. One hospital provided a diet consisting of well-cooked foods or foods containing a minimum number of pathogen-forming units. Another hospital focused on safe food-handling guidelines, avoiding foods associated with foodborne illness. A final hospital reported using a modified house diet that excluded fresh fruits and vegetables. Various guidelines were used to determine when to initiate and discontinue the low microbial diet. These guidelines included criteria such as a specific day relative to transplantation and a patient's absolute neutrophil count. Results indicate that most hospitals acknowledge the potential for food to cause infection in patients with compromised immune systems by imposing dietary restrictions to limit pathogen exposure.

Research paper thumbnail of Nutritional Status in Breastfed 18-Month Old Toddlers: Cross-Sectional Findings

Current Developments in Nutrition, 2020

Objectives Adequate nutrition is critical for infant and toddler growth and development. Breastfe... more Objectives Adequate nutrition is critical for infant and toddler growth and development. Breastfeeding is recommended until 2 years of age or beyond, and breastmilk is an important source of energy and nutrients for many toddlers beyond 12 mo of age. The composition of breastmilk changes over time during the lactation period. It is not yet known how prolonged breastfeeding influences nutritional status in toddlers aged 12–24 mo. The objective of this research was to explore biomarker differences between breastfed and non-breastfed toddlers residing in Metro Vancouver, Canada. Methods We studied cross-sectional baseline data from 18 mo old toddlers enrolled in a partially randomized controlled trial. Toddlers were categorized as breastfed (currently receiving breastmilk as the primary milk source, i.e., ≥2 times/day) and non-/occasionally-breastfed. Results Sixty-five toddlers, with preliminary data available at the time of analysis, had an equal distribution of males and females, 68...

Research paper thumbnail of Blood DHA, Choline, and Lutein Concentrations and Their Correlation with Cognitive and Behavioral Outcomes in 18-Month Old Toddlers: Preliminary Findings

Current Developments in Nutrition, 2020

Objectives The objective of this study was to investigate associations between key nutrients iden... more Objectives The objective of this study was to investigate associations between key nutrients identified as critical for central nervous system development and function, but which are limited in the diet of toddlers, and neurodevelopmental outcomes in toddler-aged children. We hypothesize that higher concentrations of key nutrients are associated with higher neurocognitive development scores. Methods Cross-sectional baseline data were drawn from 18-month old toddlers residing in Vancouver, Canada, who participated in a partially randomized controlled trial investigating associations between feeding patterns, nutrient biomarker status, and neurodevelopmental outcomes. Cognitive and behavioural outcomes considered for this analysis included: The Bayley Scale of Infant Development (3rd Ed; BSID-III); Child Behavior Checklist (CBCL); Early Childhood Behavior Questionnaire Very Short Form (ECBQ); and the MacArthur-Bates Communicative Development Inventories (Words & Gestures and Words & S...

Research paper thumbnail of Liou YA, King DJ, Zibrik D, Innis SM. Decreasing linoleic acid with constant -linolenic acid in dietary fats increases (n-3) eicosapentaenoic acid in plasma phospholipids in healthy men. J Nutr 137, 945-952

Journal of Nutrition

High linoleic acid (LA) intakes have been suggested to reduce alpha-linolenic acid [ALA, 18:3(n-3... more High linoleic acid (LA) intakes have been suggested to reduce alpha-linolenic acid [ALA, 18:3(n-3)] metabolism to eicosapentaenoic acid [EPA, 20:5(n-3)] and docosahexaenoic acid [DHA, 22:6(n-3)], and favor high arachidonic acid [ARA, 20:4(n-6)]. We used a randomized cross-over study with men (n = 22) to compare the effect of replacing vegetable oils high in LA with oils low in LA in foods, while maintaining constant ALA, for 4 wk each, on plasma (n-3) fatty acids. Nonvegetable sources of fat, except fish and seafoods, were unrestricted. We determined plasma phospholipid fatty acids at wk 0, 2, 4, 6, and 8, and triglycerides, cholesterol, serum CRP, and IL-6, and platelet aggregation at wk 0, 4, and 8. LA and ALA intakes were 3.8 +/- 0.12% and 1.0 +/- 0.05%, and 10.5 +/- 0.53% and 1.1 +/- 0.06% energy with LA:ALA ratios of 4:0 and 10:1 during the low and high LA diets, respectively. The plasma phospholipid LA was higher and EPA was lower during the high than during the low LA diet pe...

Research paper thumbnail of A survey of the relationship of dietitians’ future intentions to participate and their past continuing education activity

Research paper thumbnail of High Prevalence of Vitamin D Inadequacy During Late Postpartum in Canadian Mothers

Research paper thumbnail of Plasma Choline Concentration Is Positively Correlated with Visual Acuity in 18-Month Old Toddlers: Preliminary Findings

Current Developments in Nutrition

Objectives Adequate dietary intake of key nutrients is critical for brain and eye development in ... more Objectives Adequate dietary intake of key nutrients is critical for brain and eye development in the first 1000 days of life. In particular, docosahexaenoic acid (DHA) and lutein are known for their roles in the development of visual acuity during infancy and early childhood. Preliminary data suggest that choline may also play a role in visual acuity; however, little is known about choline's role in visual acuity during toddlerhood. We hypothesize thatbiomarkers for DHA, choline, and lutein status are positively correlated with visual acuity in toddler-aged children. Methods We studied cross-sectional baseline data from participants aged 18 months ± 2 weeks enrolled in a partially randomized controlled trial investigating associations between feeding patterns, nutrient biomarker status, and neurodevelopmental outcomes. Participants were recruited in Metro Vancouver, Canada. Visual acuity was measured using the Cardiff Acuity test with the logarithm of the minimum angle of resolu...

Research paper thumbnail of Plasma Choline Concentration Is Positively Correlated with Visual Acuity in 18-Month Old Toddlers: Preliminary Findings

Current Developments in Nutrition

Objectives Adequate dietary intake of key nutrients is critical for brain and eye development in ... more Objectives Adequate dietary intake of key nutrients is critical for brain and eye development in the first 1000 days of life. In particular, docosahexaenoic acid (DHA) and lutein are known for their roles in the development of visual acuity during infancy and early childhood. Preliminary data suggest that choline may also play a role in visual acuity; however, little is known about choline's role in visual acuity during toddlerhood. We hypothesize thatbiomarkers for DHA, choline, and lutein status are positively correlated with visual acuity in toddler-aged children. Methods We studied cross-sectional baseline data from participants aged 18 months ± 2 weeks enrolled in a partially randomized controlled trial investigating associations between feeding patterns, nutrient biomarker status, and neurodevelopmental outcomes. Participants were recruited in Metro Vancouver, Canada. Visual acuity was measured using the Cardiff Acuity test with the logarithm of the minimum angle of resolu...

Research paper thumbnail of Knowledge and attitudes of Vancouver residents toward food additives

Canadian journal of public health = Revue canadienne de santé publique

Research paper thumbnail of A Survey of the Use of Low Microbial Diets in Pediatric Bone Marrow Transplant Programs

Journal of The American Dietetic Association, 2001

A survey was used to determine the use of low microbial diets for pediatric bone marrow transplan... more A survey was used to determine the use of low microbial diets for pediatric bone marrow transplantation patients at hospitals in Canada and the northwestern United States. Five out of 7 hospitals responding to the survey provided a low microbial diet to this population to reduce the potential risk posed by food pathogens. Two hospitals prepared their low microbial diet in a separate kitchen using aseptic techniques. One hospital provided a diet consisting of well-cooked foods or foods containing a minimum number of pathogen-forming units. Another hospital focused on safe food-handling guidelines, avoiding foods associated with foodborne illness. A final hospital reported using a modified house diet that excluded fresh fruits and vegetables. Various guidelines were used to determine when to initiate and discontinue the low microbial diet. These guidelines included criteria such as a specific day relative to transplantation and a patient's absolute neutrophil count. Results indicate that most hospitals acknowledge the potential for food to cause infection in patients with compromised immune systems by imposing dietary restrictions to limit pathogen exposure.

Research paper thumbnail of Decreasing Linoleic Acid with Constant a-Linolenic Acid in Dietary Fats Increases (n-3) Eicosapentaenoic Acid in Plasma Phospholipids in Healthy Men1

High linoleic acid (LA) intakes have been suggested to reduce a-linolenic acid [ALA, 18:3(n-3)] m... more High linoleic acid (LA) intakes have been suggested to reduce a-linolenic acid [ALA, 18:3(n-3)] metabolism to eicosapentaenoic acid [EPA,] and docosahexaenoic acid [DHA, 22:6(n-3)], and favor high arachidonic acid [ARA,]. We used a randomized cross-over study with men (n ¼ 22) to compare the effect of replacing vegetable oils high in LA with oils low in LA in foods, while maintaining constant ALA, for 4 wk each, on plasma (n-3) fatty acids.

Research paper thumbnail of P18-023-23 High Prevalence of Iron Deficiency in Canadian Toddlers With Adequate Dietary Iron Intakes and Weak Association With Maternal Dietary Iron Intake at 18 Months Postpartum

Current Developments in Nutrition

Research paper thumbnail of PTFS01-04-23 The Relative Validity of a Food Frequency Questionnaire for Toddlers Aged 18 and 24 Months

Current Developments in Nutrition

Research paper thumbnail of Decreasing Linoleic Acid with Constant α-Linolenic Acid in Dietary Fats Increases (n-3) Eicosapentaenoic Acid in Plasma Phospholipids in Healthy Men

The Journal of Nutrition, 2007

High linoleic acid (LA) intakes have been suggested to reduce a-linolenic acid [ALA, 18:3(n-3)] m... more High linoleic acid (LA) intakes have been suggested to reduce a-linolenic acid [ALA, 18:3(n-3)] metabolism to eicosapentaenoic acid [EPA, 20:5(n-3)] and docosahexaenoic acid [DHA, 22:6(n-3)], and favor high arachidonic acid [ARA, 20:4(n-6)]. We used a randomized cross-over study with men (n ¼ 22) to compare the effect of replacing vegetable oils high in LA with oils low in LA in foods, while maintaining constant ALA, for 4 wk each, on plasma (n-3) fatty acids. Nonvegetable sources of fat, except fish and seafoods, were unrestricted. We determined plasma phospholipid fatty acids at wk 0, 2, 4, 6, and 8, and triglycerides, cholesterol, serum CRP, and IL-6, and platelet aggregation at wk 0, 4, and 8. LA and ALA intakes were 3.8 6 0.12% and 1.0 6 0.05%, and 10.5 6 0.53% and 1.1 6 0.06% energy with LA:ALA ratios of 4:0 and 10:1 during the low and high LA diets, respectively. The plasma phospholipid LA was higher and EPA was lower during the high than during the low LA diet period (P , 0.001), but DHA declined over the 8-wk period (r ¼ 20.425, P , 0.001). The plasma phospholipid ARA:EPA ratios were (mean 6 SEM) 20.7 6 1.52 and 12.9 6 1.01 after 4 wk consuming the high or low LA diets, respectively (P , 0.001); LA was inversely associated with EPA (r ¼ 20.729, P , 0.001) but positively associated with ARA:EPA (r ¼ 0.432, P , 0.001). LA intake did not influence ALA, ARA, DPA, DHA, or total, LDL or HDL cholesterol, CRP or IL-6, or platelet aggregation. In conclusion, high LA intakes decrease plasma phospholipid EPA and increase the ARA:EPA ratio, but do not favor higher ARA.

Research paper thumbnail of A Survey of the Use of Low Microbial Diets in Pediatric Bone Marrow Transplant Programs

Journal of the American Dietetic Association, 2001

A survey was used to determine the use of low microbial diets for pediatric bone marrow transplan... more A survey was used to determine the use of low microbial diets for pediatric bone marrow transplantation patients at hospitals in Canada and the northwestern United States. Five out of 7 hospitals responding to the survey provided a low microbial diet to this population to reduce the potential risk posed by food pathogens. Two hospitals prepared their low microbial diet in a separate kitchen using aseptic techniques. One hospital provided a diet consisting of well-cooked foods or foods containing a minimum number of pathogen-forming units. Another hospital focused on safe food-handling guidelines, avoiding foods associated with foodborne illness. A final hospital reported using a modified house diet that excluded fresh fruits and vegetables. Various guidelines were used to determine when to initiate and discontinue the low microbial diet. These guidelines included criteria such as a specific day relative to transplantation and a patient's absolute neutrophil count. Results indicate that most hospitals acknowledge the potential for food to cause infection in patients with compromised immune systems by imposing dietary restrictions to limit pathogen exposure.

Research paper thumbnail of Nutritional Status in Breastfed 18-Month Old Toddlers: Cross-Sectional Findings

Current Developments in Nutrition, 2020

Objectives Adequate nutrition is critical for infant and toddler growth and development. Breastfe... more Objectives Adequate nutrition is critical for infant and toddler growth and development. Breastfeeding is recommended until 2 years of age or beyond, and breastmilk is an important source of energy and nutrients for many toddlers beyond 12 mo of age. The composition of breastmilk changes over time during the lactation period. It is not yet known how prolonged breastfeeding influences nutritional status in toddlers aged 12–24 mo. The objective of this research was to explore biomarker differences between breastfed and non-breastfed toddlers residing in Metro Vancouver, Canada. Methods We studied cross-sectional baseline data from 18 mo old toddlers enrolled in a partially randomized controlled trial. Toddlers were categorized as breastfed (currently receiving breastmilk as the primary milk source, i.e., ≥2 times/day) and non-/occasionally-breastfed. Results Sixty-five toddlers, with preliminary data available at the time of analysis, had an equal distribution of males and females, 68...

Research paper thumbnail of Blood DHA, Choline, and Lutein Concentrations and Their Correlation with Cognitive and Behavioral Outcomes in 18-Month Old Toddlers: Preliminary Findings

Current Developments in Nutrition, 2020

Objectives The objective of this study was to investigate associations between key nutrients iden... more Objectives The objective of this study was to investigate associations between key nutrients identified as critical for central nervous system development and function, but which are limited in the diet of toddlers, and neurodevelopmental outcomes in toddler-aged children. We hypothesize that higher concentrations of key nutrients are associated with higher neurocognitive development scores. Methods Cross-sectional baseline data were drawn from 18-month old toddlers residing in Vancouver, Canada, who participated in a partially randomized controlled trial investigating associations between feeding patterns, nutrient biomarker status, and neurodevelopmental outcomes. Cognitive and behavioural outcomes considered for this analysis included: The Bayley Scale of Infant Development (3rd Ed; BSID-III); Child Behavior Checklist (CBCL); Early Childhood Behavior Questionnaire Very Short Form (ECBQ); and the MacArthur-Bates Communicative Development Inventories (Words & Gestures and Words & S...

Research paper thumbnail of Liou YA, King DJ, Zibrik D, Innis SM. Decreasing linoleic acid with constant -linolenic acid in dietary fats increases (n-3) eicosapentaenoic acid in plasma phospholipids in healthy men. J Nutr 137, 945-952

Journal of Nutrition

High linoleic acid (LA) intakes have been suggested to reduce alpha-linolenic acid [ALA, 18:3(n-3... more High linoleic acid (LA) intakes have been suggested to reduce alpha-linolenic acid [ALA, 18:3(n-3)] metabolism to eicosapentaenoic acid [EPA, 20:5(n-3)] and docosahexaenoic acid [DHA, 22:6(n-3)], and favor high arachidonic acid [ARA, 20:4(n-6)]. We used a randomized cross-over study with men (n = 22) to compare the effect of replacing vegetable oils high in LA with oils low in LA in foods, while maintaining constant ALA, for 4 wk each, on plasma (n-3) fatty acids. Nonvegetable sources of fat, except fish and seafoods, were unrestricted. We determined plasma phospholipid fatty acids at wk 0, 2, 4, 6, and 8, and triglycerides, cholesterol, serum CRP, and IL-6, and platelet aggregation at wk 0, 4, and 8. LA and ALA intakes were 3.8 +/- 0.12% and 1.0 +/- 0.05%, and 10.5 +/- 0.53% and 1.1 +/- 0.06% energy with LA:ALA ratios of 4:0 and 10:1 during the low and high LA diets, respectively. The plasma phospholipid LA was higher and EPA was lower during the high than during the low LA diet pe...

Research paper thumbnail of A survey of the relationship of dietitians’ future intentions to participate and their past continuing education activity

Research paper thumbnail of High Prevalence of Vitamin D Inadequacy During Late Postpartum in Canadian Mothers

Research paper thumbnail of Plasma Choline Concentration Is Positively Correlated with Visual Acuity in 18-Month Old Toddlers: Preliminary Findings

Current Developments in Nutrition

Objectives Adequate dietary intake of key nutrients is critical for brain and eye development in ... more Objectives Adequate dietary intake of key nutrients is critical for brain and eye development in the first 1000 days of life. In particular, docosahexaenoic acid (DHA) and lutein are known for their roles in the development of visual acuity during infancy and early childhood. Preliminary data suggest that choline may also play a role in visual acuity; however, little is known about choline's role in visual acuity during toddlerhood. We hypothesize thatbiomarkers for DHA, choline, and lutein status are positively correlated with visual acuity in toddler-aged children. Methods We studied cross-sectional baseline data from participants aged 18 months ± 2 weeks enrolled in a partially randomized controlled trial investigating associations between feeding patterns, nutrient biomarker status, and neurodevelopmental outcomes. Participants were recruited in Metro Vancouver, Canada. Visual acuity was measured using the Cardiff Acuity test with the logarithm of the minimum angle of resolu...

Research paper thumbnail of Plasma Choline Concentration Is Positively Correlated with Visual Acuity in 18-Month Old Toddlers: Preliminary Findings

Current Developments in Nutrition

Objectives Adequate dietary intake of key nutrients is critical for brain and eye development in ... more Objectives Adequate dietary intake of key nutrients is critical for brain and eye development in the first 1000 days of life. In particular, docosahexaenoic acid (DHA) and lutein are known for their roles in the development of visual acuity during infancy and early childhood. Preliminary data suggest that choline may also play a role in visual acuity; however, little is known about choline's role in visual acuity during toddlerhood. We hypothesize thatbiomarkers for DHA, choline, and lutein status are positively correlated with visual acuity in toddler-aged children. Methods We studied cross-sectional baseline data from participants aged 18 months ± 2 weeks enrolled in a partially randomized controlled trial investigating associations between feeding patterns, nutrient biomarker status, and neurodevelopmental outcomes. Participants were recruited in Metro Vancouver, Canada. Visual acuity was measured using the Cardiff Acuity test with the logarithm of the minimum angle of resolu...

Research paper thumbnail of Knowledge and attitudes of Vancouver residents toward food additives

Canadian journal of public health = Revue canadienne de santé publique

Research paper thumbnail of A Survey of the Use of Low Microbial Diets in Pediatric Bone Marrow Transplant Programs

Journal of The American Dietetic Association, 2001

A survey was used to determine the use of low microbial diets for pediatric bone marrow transplan... more A survey was used to determine the use of low microbial diets for pediatric bone marrow transplantation patients at hospitals in Canada and the northwestern United States. Five out of 7 hospitals responding to the survey provided a low microbial diet to this population to reduce the potential risk posed by food pathogens. Two hospitals prepared their low microbial diet in a separate kitchen using aseptic techniques. One hospital provided a diet consisting of well-cooked foods or foods containing a minimum number of pathogen-forming units. Another hospital focused on safe food-handling guidelines, avoiding foods associated with foodborne illness. A final hospital reported using a modified house diet that excluded fresh fruits and vegetables. Various guidelines were used to determine when to initiate and discontinue the low microbial diet. These guidelines included criteria such as a specific day relative to transplantation and a patient's absolute neutrophil count. Results indicate that most hospitals acknowledge the potential for food to cause infection in patients with compromised immune systems by imposing dietary restrictions to limit pathogen exposure.

Research paper thumbnail of Decreasing Linoleic Acid with Constant a-Linolenic Acid in Dietary Fats Increases (n-3) Eicosapentaenoic Acid in Plasma Phospholipids in Healthy Men1

High linoleic acid (LA) intakes have been suggested to reduce a-linolenic acid [ALA, 18:3(n-3)] m... more High linoleic acid (LA) intakes have been suggested to reduce a-linolenic acid [ALA, 18:3(n-3)] metabolism to eicosapentaenoic acid [EPA,] and docosahexaenoic acid [DHA, 22:6(n-3)], and favor high arachidonic acid [ARA,]. We used a randomized cross-over study with men (n ¼ 22) to compare the effect of replacing vegetable oils high in LA with oils low in LA in foods, while maintaining constant ALA, for 4 wk each, on plasma (n-3) fatty acids.