Deepak Burad - Academia.edu (original) (raw)

Papers by Deepak Burad

International Journal of Research in Medical Sciences

Mucoepidermoid carcinoma, a malignant tumour of the salivary gland is histologically characterize... more Mucoepidermoid carcinoma, a malignant tumour of the salivary gland is histologically characterized by the presence of mucoid cells, epidermoid cells and intermediate cells. There are many variants of this tumour. A particular variant, sclerosing variant of mucoepidermoid carcinoma is presented due to its rarity and chances of misdiagnosis as benign lesions due to the presence of extensive sclerosing stroma.

Tropical Gastroenterology, Jun 1, 2015

BMJ Case Reports, Sep 21, 2015

We present a thalassaemic patient with extramedullary haematopoiesis in the adrenal gland, which ... more We present a thalassaemic patient with extramedullary haematopoiesis in the adrenal gland, which is one of the rare sites of involvement. A 29-year-old man presented with a history of anaemia since childhood which required blood transfusion recently. On examination, he had pallor, icterus and splenomegaly with no other palpable abdominal mass. He was diagnosed to have β-thalassaemia. Ultrasonography of the abdomen showed an incidental right adrenal mass with splenomegaly; CT revealed a large right adrenal mass with heterogeneous density. Adrenal adenoma, carcinoma and extramedullary haematopoiesis were considered in the differential diagnosis. After excluding a functioning tumour, the diagnosis was confirmed by ultrasound-guided biopsy. Since the patient was asymptomatic, the adrenal lesion was managed conservatively.

Jornal Brasileiro de Pneumologia, Oct 1, 2015

australasian medical journal, Aug 31, 2014

Paraneoplastic polyarthritis is an uncommon cause of polyarthritis, described in association with... more Paraneoplastic polyarthritis is an uncommon cause of polyarthritis, described in association with various solid tumours. 2. What new information is offered in this case study? In this case report, we describe paraneoplastic polyarthritis

Annals of Diagnostic Pathology

Pediatric Blood & Cancer

Criteria for the pathological classification of adult adrenocortical tumours (ACTs) have been fou... more Criteria for the pathological classification of adult adrenocortical tumours (ACTs) have been found to overestimate the malignant potential of childhood ACTs. We sought to evaluate the accuracy and utility of criteria developed for paediatric ACT compared to current criteria for adults.

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, Jan 4, 2017

The aim of the study was to analyze the prevalence of risk factors for non-alcoholic fatty liver ... more The aim of the study was to analyze the prevalence of risk factors for non-alcoholic fatty liver disease (NAFLD) in patients with non-B non-C hepatocellular carcinoma (HCC). Between June 2012 and November 2014, patients with HCC, negative for hepatitis B surface antigen and hepatitis C virus antibody, were included in this study. All patients were assessed for risk factors for NAFLD such as diabetes mellitus (DM), hypertension, dyslipidemia, metabolic syndrome, and obesity. Forty-seven patients with non-B non-C HCC (males, 37; age, 60±10 years; mean±SD) were studied. Model for end-stage liver disease score was 11±4. Twenty-five patients were in Child's class A. History of significant alcohol intake was noted in 11 (23%) patients. Prevalence of risk factors for NAFLD were obesity 24 (51%), DM 22 (47%), metabolic syndrome 21 (45%), hypertension 16 (34%), and dyslipidemia 13 (28%). Forty (85%) patients had at least one risk factor for NAFLD. The mean duration of at least one NAFLD ...

World journal of gastroenterology, Jan 28, 2016

To study the clinicopathological characteristics of neuroendocrine neoplasms (NEN) on liver sampl... more To study the clinicopathological characteristics of neuroendocrine neoplasms (NEN) on liver samples and apply World Health Organization (WHO) 2010 grading of gastroenteropancreatic (GEP) NEN. Clinicopathological features of 79 cases of NEN of the liver diagnosed between January 2011 to December 2015 were analyzed. WHO 2010 classification of GEP NEN was applied and the tumors were graded as G1, G2 or G3. Two more categories, D1/2 (discordant 1/2) and D2/3 (discordant 2/3) were also applied. The D1/2 grade tumors had a mitotic count of G1 and Ki-67 index of G2. The D2/3 tumors had a mitotic count of G2 and Ki-67 index of G3. The follow up details which were available till the end of the study period (December 2015) were collected. Of the 79 tumors, 16 each were G1 and G2, and 18 were G3 tumors. Of the remaining 29 tumors, 13 were assigned to D1/2 and 16 were D2/3 grade. Male preponderance was noted in all tumors except for G2 neoplasms, which showed a slight female predilection. The m...

Introduction: Kasabach Merritt (KM) phenomenon is consumption coagulopathy in a vascular neoplasm... more Introduction: Kasabach Merritt (KM) phenomenon is consumption coagulopathy in a vascular neoplasm. The combination of haemangioma, thrombocytopenia, and coagulopathy is termed Kasabach-Merritt phenomenon. Vascular neoplasms are more common in children wherein they may resolve spontaneously. Kaposi form hemangioendothelioma and tufted angioma are most common vascular neoplasms in children associated with Kassabah-Merritt phenomenon but are found with other vascular neoplasms too. These lesions are rare in adults. Radiotherapy was the treatment of choice in the past in children but not considered in the absence of life threatening complication presently due to its late effects. The other modalities that are tried are surgery, embolization, laser surgery, and pharmacologic agents such as steroids, interferons, and cyclophosphamide. We report a persistent 10 years' long response of a benign vascular neoplasm with Kasabach-Merritt phenomenon and life threatening bleeding to radiotherapy in an adult with asymptomatic late side effects. Case report: A 35-year-old lady from south India presented with a 15x15 cm left lower back swelling and hemorrhagic pleural effusion and thrombocytopenia. She received radiotherapy of 40 Gy in 20 fractions to the swelling. Swelling, effusion and thrombocytopenia resolved and remain resolved for 10 long years. She did have asymptomatic late side effects of radiotherapy. Conclusion: Though radiation therapy is not considered in children with KM phenomenon, it could be considered as an option of treatment in adults with KM phenomenon.

Indian Journal of Gastroenterology, 2015

Background Xpert™ MTB/Rif is a multiplex hemi-nested real-time PCR-based assay to detect presence... more Background Xpert™ MTB/Rif is a multiplex hemi-nested real-time PCR-based assay to detect presence of M. tuberculosis within 2 hours of sample collection. The present study aimed at assessing efficacy of Xpert™ MTB/Rif assay for diagnosing peritoneal tuberculosis. Methods Patients with exudative ascites, fluid negative for acid-fast bacilli on auramine O fluorescence staining and unyielding fluid cytology for malignant cells, were included. Ultrasound-guided omental biopsy samples were obtained in all. Xpert™ MTB/Rif assay on tissue samples was assessed against a composite Breference^standard for diagnosis of peritoneal tuberculosis, defined as presence of any of the threeculture showing M tuberculosis, granulomatous inflammation on histology or resolution of ascites with 2 months of antitubercular therapy. Results During January 2012-July 2013, 28 patients (age:43 ±15 years; mean±SD; male:20) were recruited. Serum ascitic albumin gradient was <1.1 in all except in four patients with underlying cirrhosis. Twenty-one of the 28 patients had peritoneal TB as diagnosed by composite reference standard (histology:18; culture:4; treatment response:3). Seven patients (25 %) had an alternative diagnosis (metastatic carcinoma 2, adenocarcinoma 2, mesothelioma 2, and systemic lupus erythematous 1). Xpert™ MTB/Rif assay was positive in 4/21 patients with peritoneal tuberculosis and in none of the 7 patients with alternative diagnosis. Thus, sensitivity, specificity, positive, and negative predictive values for tissue Xpert™ MTB/Rif assay in diagnosing peritoneal tuberculosis were 19 % (95 % C.I: 6 % to 42 %), 100 % (95 % C.I: 59 % to 100 %), 100 % (40 % to 100 %), and 29 % (95 % C.I: 13 % to 51 %), respectively. Interpretation and conclusion Tissue Xpert™ MTB/Rif assay was of limited use in diagnosing peritoneal tuberculosis.

Respiratory Medicine Case Reports, 2016

Idiopathic pleuroparenchymal fibroelastosis is a rare idiopathic interstitial pneumonia. It was f... more Idiopathic pleuroparenchymal fibroelastosis is a rare idiopathic interstitial pneumonia. It was first described in 2004 and subsequently included in the ATS/ERS classification of idiopathic interstitial pneumonia in 2013. There have been few cases reported so far. The diagnostic criteria is still emerging and its etiology is being questioned. We report a case of pleuroparenchymal fibroelastosis probably idiopathic, the first of its kind to be reported from India, and a brief review of the literature.

Indian Journal of Pathology and Microbiology, Jan 10, 2012

Peripheral T/NK-cell lymphomas are uncommon types of non-Hodgkin&amp;amp;amp;amp;amp;amp;... more Peripheral T/NK-cell lymphomas are uncommon types of non-Hodgkin&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s lymphoma (NHL) with a higher frequency in Far East countries as compared to the West. This study was undertaken to ascertain the frequency and distribution pattern of peripheral T-cell lymphomas (PTCLs) diagnosed in a tertiary care center in South India. This retrospective study was carried out in Department of General Pathology, Christian Medical College, Vellore. The time period was for 2 years from 1 st January 2008 till 31st December 2009. All PTCLs were reviewed and classified according to the World Health Organization (WHO) 2008 classification. Of a total of 1032 cases of NHL, 180 cases were PTCL, which accounted for 17.4% cases of all the NHLs. Of these, PTCL, not otherwise specified (PTCL, NOS) was the most common subtype (48 cases, 26.1%), followed by anaplastic large cell lymphoma (41 cases, 22.8%), mycosis fungoides (21 cases, 11.7%), angioimmunoblastic T-cell lymphoma (16 cases, 8.9%), subcutaneous panniculitis like T-cell lymphoma (15 cases, 8.4%), extranodal NK/T-cell lymphoma, nasal type (12 cases, 6.7%), and hepatosplenic T-cell lymphoma (10 cases, 5.6%). The most common primary site of presentation was nodal accounting for 42% followed by cutaneous (34%), upper aerodigestive sites (8.9%), spleen (6.7%), and gastrointestinal tract (GIT; 3.3%). This is the largest single study on PTCLs in India and we document that its frequency is higher than that reported in Western literature and previous Indian studies and almost similar to that reported in some Far East studies. The frequency of mycosis fungoides, subcutaneous panniculitis like T-cell lymphoma, and hepatosplenic T-cell lymphoma was higher than that reported in the World literature and previous Indian studies. The frequency of extranodal NK/T-cell lymphoma and angioimmunoblastic T-cell lymphoma was much lower than that reported in the Far East literature.

Endocrine Abstracts, 2015