Deepali Raina - Academia.edu (original) (raw)

Papers by Deepali Raina

Research paper thumbnail of Post-Molar Gestational Trophoblastic Neoplasia After Ectopic Molar Pregnancy in Broad Ligament: A Rare Case Report

Indian Journal of Gynecologic Oncology, Jul 15, 2023

Research paper thumbnail of 304 Does nact reduce the extent of surgery and perioperative morbidity in surgical cytoreduction of advanced epithelial ovarian cancer? A single institute experience at fmri, gurugram

advanced stage(III/IV) and exhibit chemotherapy resistance. To find new biomarkers for early diag... more advanced stage(III/IV) and exhibit chemotherapy resistance. To find new biomarkers for early diagnosis, therapeutic monitoring and prognostic estimation of ovarian cancer is of great importance. The occurring of liquid biopsy provides a new direction for clinical research of this neoplasm. Methods Literatures had been searched through datebases using the certain theme of '''''ovarian cancer ''''' and '''''liquid biopsy'''''. Results Liquid biopsy offers a minimally invasive repeatable sample collection of blood. Recent studies attempted to shed light upon their values on early diagnosis, prognosis and prediction of ovarian cancer. Up to now, circulating tumor cells (CTCs), circulating tumor DNA (ctDNA) and tumor cellderived exosomes (TEXs) represent the main liquid biopsy approaches. Conclusions The occurring of liquid biopsy provides a new direction for clinical research of ovarian cancer. Liquid biopsy acts as an effective early detection approach to find new biomarkers for early diagnosis, therapeutic monitoring and prognostic estimation of ovarian cancer.

Research paper thumbnail of Secondary recurrent miscarriage and sex of previous child

International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2016

Background: Secondary Recurrent Miscarriage (SRM) is defined as occurrence of three or more spont... more Background: Secondary Recurrent Miscarriage (SRM) is defined as occurrence of three or more spontaneous consecutive abortions following the birth of one child. Mothers of boys often get immunized against male-specific minor histocompatibility (H-Y) antigens due to transfer of fetal cells into the maternal circulation. The birth of a boy is significantly more common than a girl prior to secondary recurrent miscarriage (SRM) and is known to be associated with a poorer chance of a subsequent live birth. Children born after Secondary Recurrent Miscarriage are more likely to be girls. Aberrant H-Y immunity may be a causal factor for SRM. Methods: The study was conducted over a period of one year from January 2012 to December 2012. All the women presenting with full term pregnancy and previous history of unexplained, three or more spontaneous consecutive abortions at 8 to 20 weeks gestation were taken as cases. Sex of the previous child was sought. The patients were followed till delivery and sex of the child born subsequently was also noted. Association of history of SRM to sex of the previous and present child was calculated by appropriates statistical methods. Results: A total of 34 patients with history of SRM were studied. 23 out of them had a previous male child and 11 had given birth to a female (p=0.004). The male: female sex ratio of children born prior and subsequent to SRM was 2.09 and 0.79 respectively. Conclusions: Study supports the hypothesis that aberrant maternal H-Y immune response may have a pathogenic role in SRM.

Research paper thumbnail of Pattern of Congenital Anomalies of Urinary System in Newborn- A Hospital Based Study

International Journal of Health Sciences and Research, 2016

BACKGROUND: The present study aims to study the incidence and pattern of urinary system anomalies... more BACKGROUND: The present study aims to study the incidence and pattern of urinary system anomalies in our region. MATERIAL AND METHOD: It is a cross-sectional study conducted in the Department of Obstetrics and Gynaecology, SMGS hospital, GMC Jammu over a period of one year from October 2012 to September 2013. All women diagnosed antenatally with urinary system anomalies and delivered during study period were included. Maternal and neonatal characteristics were recorded. RESULTS: 52 cases of kidney and urinary tract anomalies were antenatally diagnosed with incidence of 3.36 per 1000 births. The most common anomalies of this system were hydronephrosis (57.69%), followed by multicystic kidneys, polycystic kidneys, renal dysplasias, and renal agenesis in decreasing order of their frequency. These anomalies were more in male babies as compared to female babies ( p value= 0.035). CONCLUSION: Study of urinary tract anomalies is very important as their timely diagnosis can help in planning...

Research paper thumbnail of Does Nact Reduce the Extent of Surgery and Perioperative Morbidity in Surgical Cytoreduction of Advanced Epithelial Ovarian Cancer? A Single Institute Experience at Fmri, Gurugram

Research paper thumbnail of Detection of Regional Lymph Node Metastasis by 18-FDG PET/CT in Patients with Endometrial Cancer

Indian Journal of Gynecologic Oncology

Research paper thumbnail of Mermaid syndrome

International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2017

Sirenomelia, alternatively known as Mermaid Syndrome, is a very rare congenital deformity in whic... more Sirenomelia, alternatively known as Mermaid Syndrome, is a very rare congenital deformity in which the legs are fused together, giving them the appearance of a mermaid's tail. This syndrome was originally stated by Rocheas and Palfya in 16th century. It occurs in about 1 in 100,000 live births. It is also associated with multiple anomalies like renal agenesis, ambiguous external genitalia, imperforate anus, blind intestinal loop and single umbilical artery. Occasionally double inferior Venacava, dextrocardia and angiomatous lumbosacral myelocystocele are reported as well. Most of the Sirenomelia come to an end as stillbirth. Only a few are born alive and survival beyond few hours after delivery is extremely rare. About 300 cases have been reported in the world literature so far.

Research paper thumbnail of Squamous cell carcinoma endometrium

International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2017

Primary pure squamous cell carcinoma (SCC) of endometrium is very rare. About 70 cases have been ... more Primary pure squamous cell carcinoma (SCC) of endometrium is very rare. About 70 cases have been reported, according to WHO blue book. It is defined as a primary carcinoma of the endometrium composed of squamous cells of varying degree of differentiation. The frequency of SCC of the endometrium is unknown.

Research paper thumbnail of Secondary recurrent miscarriage and sex of previous child

International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2016

Background: Secondary Recurrent Miscarriage (SRM) is defined as occurrence of three or more spont... more Background: Secondary Recurrent Miscarriage (SRM) is defined as occurrence of three or more spontaneous consecutive abortions following the birth of one child. Mothers of boys often get immunized against male-specific minor histocompatibility (H-Y) antigens due to transfer of fetal cells into the maternal circulation. The birth of a boy is significantly more common than a girl prior to secondary recurrent miscarriage (SRM) and is known to be associated with a poorer chance of a subsequent live birth. Children born after Secondary Recurrent Miscarriage are more likely to be girls. Aberrant H-Y immunity may be a causal factor for SRM. Methods: The study was conducted over a period of one year from January 2012 to December 2012. All the women presenting with full term pregnancy and previous history of unexplained, three or more spontaneous consecutive abortions at 8 to 20 weeks gestation were taken as cases. Sex of the previous child was sought. The patients were followed till delivery and sex of the child born subsequently was also noted. Association of history of SRM to sex of the previous and present child was calculated by appropriates statistical methods. Results: A total of 34 patients with history of SRM were studied. 23 out of them had a previous male child and 11 had given birth to a female (p=0.004). The male: female sex ratio of children born prior and subsequent to SRM was 2.09 and 0.79 respectively. Conclusions: Study supports the hypothesis that aberrant maternal H-Y immune response may have a pathogenic role in SRM.

Research paper thumbnail of Post-Molar Gestational Trophoblastic Neoplasia After Ectopic Molar Pregnancy in Broad Ligament: A Rare Case Report

Indian Journal of Gynecologic Oncology, Jul 15, 2023

Research paper thumbnail of 304 Does nact reduce the extent of surgery and perioperative morbidity in surgical cytoreduction of advanced epithelial ovarian cancer? A single institute experience at fmri, gurugram

advanced stage(III/IV) and exhibit chemotherapy resistance. To find new biomarkers for early diag... more advanced stage(III/IV) and exhibit chemotherapy resistance. To find new biomarkers for early diagnosis, therapeutic monitoring and prognostic estimation of ovarian cancer is of great importance. The occurring of liquid biopsy provides a new direction for clinical research of this neoplasm. Methods Literatures had been searched through datebases using the certain theme of '''''ovarian cancer ''''' and '''''liquid biopsy'''''. Results Liquid biopsy offers a minimally invasive repeatable sample collection of blood. Recent studies attempted to shed light upon their values on early diagnosis, prognosis and prediction of ovarian cancer. Up to now, circulating tumor cells (CTCs), circulating tumor DNA (ctDNA) and tumor cellderived exosomes (TEXs) represent the main liquid biopsy approaches. Conclusions The occurring of liquid biopsy provides a new direction for clinical research of ovarian cancer. Liquid biopsy acts as an effective early detection approach to find new biomarkers for early diagnosis, therapeutic monitoring and prognostic estimation of ovarian cancer.

Research paper thumbnail of Secondary recurrent miscarriage and sex of previous child

International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2016

Background: Secondary Recurrent Miscarriage (SRM) is defined as occurrence of three or more spont... more Background: Secondary Recurrent Miscarriage (SRM) is defined as occurrence of three or more spontaneous consecutive abortions following the birth of one child. Mothers of boys often get immunized against male-specific minor histocompatibility (H-Y) antigens due to transfer of fetal cells into the maternal circulation. The birth of a boy is significantly more common than a girl prior to secondary recurrent miscarriage (SRM) and is known to be associated with a poorer chance of a subsequent live birth. Children born after Secondary Recurrent Miscarriage are more likely to be girls. Aberrant H-Y immunity may be a causal factor for SRM. Methods: The study was conducted over a period of one year from January 2012 to December 2012. All the women presenting with full term pregnancy and previous history of unexplained, three or more spontaneous consecutive abortions at 8 to 20 weeks gestation were taken as cases. Sex of the previous child was sought. The patients were followed till delivery and sex of the child born subsequently was also noted. Association of history of SRM to sex of the previous and present child was calculated by appropriates statistical methods. Results: A total of 34 patients with history of SRM were studied. 23 out of them had a previous male child and 11 had given birth to a female (p=0.004). The male: female sex ratio of children born prior and subsequent to SRM was 2.09 and 0.79 respectively. Conclusions: Study supports the hypothesis that aberrant maternal H-Y immune response may have a pathogenic role in SRM.

Research paper thumbnail of Pattern of Congenital Anomalies of Urinary System in Newborn- A Hospital Based Study

International Journal of Health Sciences and Research, 2016

BACKGROUND: The present study aims to study the incidence and pattern of urinary system anomalies... more BACKGROUND: The present study aims to study the incidence and pattern of urinary system anomalies in our region. MATERIAL AND METHOD: It is a cross-sectional study conducted in the Department of Obstetrics and Gynaecology, SMGS hospital, GMC Jammu over a period of one year from October 2012 to September 2013. All women diagnosed antenatally with urinary system anomalies and delivered during study period were included. Maternal and neonatal characteristics were recorded. RESULTS: 52 cases of kidney and urinary tract anomalies were antenatally diagnosed with incidence of 3.36 per 1000 births. The most common anomalies of this system were hydronephrosis (57.69%), followed by multicystic kidneys, polycystic kidneys, renal dysplasias, and renal agenesis in decreasing order of their frequency. These anomalies were more in male babies as compared to female babies ( p value= 0.035). CONCLUSION: Study of urinary tract anomalies is very important as their timely diagnosis can help in planning...

Research paper thumbnail of Does Nact Reduce the Extent of Surgery and Perioperative Morbidity in Surgical Cytoreduction of Advanced Epithelial Ovarian Cancer? A Single Institute Experience at Fmri, Gurugram

Research paper thumbnail of Detection of Regional Lymph Node Metastasis by 18-FDG PET/CT in Patients with Endometrial Cancer

Indian Journal of Gynecologic Oncology

Research paper thumbnail of Mermaid syndrome

International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2017

Sirenomelia, alternatively known as Mermaid Syndrome, is a very rare congenital deformity in whic... more Sirenomelia, alternatively known as Mermaid Syndrome, is a very rare congenital deformity in which the legs are fused together, giving them the appearance of a mermaid's tail. This syndrome was originally stated by Rocheas and Palfya in 16th century. It occurs in about 1 in 100,000 live births. It is also associated with multiple anomalies like renal agenesis, ambiguous external genitalia, imperforate anus, blind intestinal loop and single umbilical artery. Occasionally double inferior Venacava, dextrocardia and angiomatous lumbosacral myelocystocele are reported as well. Most of the Sirenomelia come to an end as stillbirth. Only a few are born alive and survival beyond few hours after delivery is extremely rare. About 300 cases have been reported in the world literature so far.

Research paper thumbnail of Squamous cell carcinoma endometrium

International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2017

Primary pure squamous cell carcinoma (SCC) of endometrium is very rare. About 70 cases have been ... more Primary pure squamous cell carcinoma (SCC) of endometrium is very rare. About 70 cases have been reported, according to WHO blue book. It is defined as a primary carcinoma of the endometrium composed of squamous cells of varying degree of differentiation. The frequency of SCC of the endometrium is unknown.

Research paper thumbnail of Secondary recurrent miscarriage and sex of previous child

International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2016

Background: Secondary Recurrent Miscarriage (SRM) is defined as occurrence of three or more spont... more Background: Secondary Recurrent Miscarriage (SRM) is defined as occurrence of three or more spontaneous consecutive abortions following the birth of one child. Mothers of boys often get immunized against male-specific minor histocompatibility (H-Y) antigens due to transfer of fetal cells into the maternal circulation. The birth of a boy is significantly more common than a girl prior to secondary recurrent miscarriage (SRM) and is known to be associated with a poorer chance of a subsequent live birth. Children born after Secondary Recurrent Miscarriage are more likely to be girls. Aberrant H-Y immunity may be a causal factor for SRM. Methods: The study was conducted over a period of one year from January 2012 to December 2012. All the women presenting with full term pregnancy and previous history of unexplained, three or more spontaneous consecutive abortions at 8 to 20 weeks gestation were taken as cases. Sex of the previous child was sought. The patients were followed till delivery and sex of the child born subsequently was also noted. Association of history of SRM to sex of the previous and present child was calculated by appropriates statistical methods. Results: A total of 34 patients with history of SRM were studied. 23 out of them had a previous male child and 11 had given birth to a female (p=0.004). The male: female sex ratio of children born prior and subsequent to SRM was 2.09 and 0.79 respectively. Conclusions: Study supports the hypothesis that aberrant maternal H-Y immune response may have a pathogenic role in SRM.