Dennis Watson - Academia.edu (original) (raw)
Papers by Dennis Watson
American Journal of Medical Genetics, 2005
The human ETSZ and ERG genes are members of the ETS gene family, with sequence homology to the vi... more The human ETSZ and ERG genes are members of the ETS gene family, with sequence homology to the viral ets gene of the avian erythroblastosis retrovirus, E26. These genes are located on chromosome 21 and molecular genetic analysis of Down syndrome (DS) patients with partial trisomy 21 suggested that ETSZ may be a gene within the minimal DS genetic region. We have, in fact, been able to confirm the presence of the ETSZgene dosage in triplicate occurring in occult human 21 chromosome abnormalities. It is known that ERG and ETSZ gene translocations occur in certain specific leukemias associated with defined chromosome rearrangements [e.g., t(8;2l)l. Moreover, it is known that DS individuals are at greater risk for leukemic disease than their normal familial cohorts, implying that trisomy of that region of human chromosome 21 may play a role in the development of this type of neoplasia. The human ETS genes, first identified in our laboratory, are highly conserved, being found from lower organisms, like Drosophila and sea urchin, to humans. In mammals, the ETS genes are structurally distinct, located on separate chromosomes; they are transcriptionally active and differentially regulated. The ETSZ protein is phosphorylated and turns over with a half-life of -20 min. After activation with the tumor promoter, TPA, the level of ETSZ elevates 5-to 20-fold. The properties of the ETS2 protein, such as nuclear localization, phosphorylation, rapid turnover, and response to protein kinase C, indicate that this protein belongs to a group of oncogene proteins thought to have regulatory functions in the nucleus. In the mouse thymus ets-1 and ets-2 are 8-10-fold higher, respectively, in the CD4' subset than in other subsets examined,
The Journal of Immunology, Aug 1, 1968
Journal of Experimental Medicine, Apr 30, 1965
The mechanism of tolerance to the pyrogenic activity of Gram-negative bacterial endotoxins is mos... more The mechanism of tolerance to the pyrogenic activity of Gram-negative bacterial endotoxins is most often attributed to a non-specific increase in the activity of the reticuloendothelial system (RES) (1). Recently, it was shown that Group A streptococcal exotoxins produced biphasic fever responses in rabbits (2). In contrast to the non-specific tolerance induced by endotoxins, three distinct toxins were identified based on their ability to induce specific pyrogenic tolerance; in addition, the pyrogenic activity was neutralized specifically with antiserum.
This is a report of a 2-year collaborative study of homeless people aged 50 to 64 in Chicago betw... more This is a report of a 2-year collaborative study of homeless people aged 50 to 64 in Chicago between Loyola University Center for Urban Research and Learning and the Chicago Alliance to End Homelessness. This study had three goals: To obtain a demographic profile of people who are homeless in Chicago and are between the ages of 50 and 64; to understand how the various systems designed to serve this population do and do not meet their needs; and to begin to suggest a range of policy and programmatic responses to meet the needs of this population.
American Journal of Medical Genetics, 2005
The human ETSZ and ERG genes are members of the ETS gene family, with sequence homology to the vi... more The human ETSZ and ERG genes are members of the ETS gene family, with sequence homology to the viral ets gene of the avian erythroblastosis retrovirus, E26. These genes are located on chromosome 21 and molecular genetic analysis of Down syndrome (DS) patients with partial trisomy 21 suggested that ETSZ may be a gene within the minimal DS genetic region. We have, in fact, been able to confirm the presence of the ETSZgene dosage in triplicate occurring in occult human 21 chromosome abnormalities. It is known that ERG and ETSZ gene translocations occur in certain specific leukemias associated with defined chromosome rearrangements [e.g., t(8;2l)l. Moreover, it is known that DS individuals are at greater risk for leukemic disease than their normal familial cohorts, implying that trisomy of that region of human chromosome 21 may play a role in the development of this type of neoplasia. The human ETS genes, first identified in our laboratory, are highly conserved, being found from lower organisms, like Drosophila and sea urchin, to humans. In mammals, the ETS genes are structurally distinct, located on separate chromosomes; they are transcriptionally active and differentially regulated. The ETSZ protein is phosphorylated and turns over with a half-life of -20 min. After activation with the tumor promoter, TPA, the level of ETSZ elevates 5-to 20-fold. The properties of the ETS2 protein, such as nuclear localization, phosphorylation, rapid turnover, and response to protein kinase C, indicate that this protein belongs to a group of oncogene proteins thought to have regulatory functions in the nucleus. In the mouse thymus ets-1 and ets-2 are 8-10-fold higher, respectively, in the CD4' subset than in other subsets examined,
The Journal of Immunology, Aug 1, 1968
Journal of Experimental Medicine, Apr 30, 1965
The mechanism of tolerance to the pyrogenic activity of Gram-negative bacterial endotoxins is mos... more The mechanism of tolerance to the pyrogenic activity of Gram-negative bacterial endotoxins is most often attributed to a non-specific increase in the activity of the reticuloendothelial system (RES) (1). Recently, it was shown that Group A streptococcal exotoxins produced biphasic fever responses in rabbits (2). In contrast to the non-specific tolerance induced by endotoxins, three distinct toxins were identified based on their ability to induce specific pyrogenic tolerance; in addition, the pyrogenic activity was neutralized specifically with antiserum.
This is a report of a 2-year collaborative study of homeless people aged 50 to 64 in Chicago betw... more This is a report of a 2-year collaborative study of homeless people aged 50 to 64 in Chicago between Loyola University Center for Urban Research and Learning and the Chicago Alliance to End Homelessness. This study had three goals: To obtain a demographic profile of people who are homeless in Chicago and are between the ages of 50 and 64; to understand how the various systems designed to serve this population do and do not meet their needs; and to begin to suggest a range of policy and programmatic responses to meet the needs of this population.