Deon Green - Academia.edu (original) (raw)

Papers by Deon Green

Nature, 2007

Insulin resistance (IR) is a key determinant of type 2 diabetes (T2D) and other metabolic disorde... more Insulin resistance (IR) is a key determinant of type 2 diabetes (T2D) and other metabolic disorders. This genome-wide association study (GWAS) was designed to shed light on the genetic basis of fasting insulin (FI) and IR in 927 non-diabetic African Americans. 5 396 838 single-nucleotide polymorphisms (SNPs) were tested for associations with FI or IR with adjustments for age, sex, body mass index, hypertension status and first two principal components. Genotyped SNPs (n 5 12) with P < 5 3 10 26 in African Americans were carried forward for de novo genotyping in 570 non-diabetic West Africans. We replicated SNPs in or near SC4MOL and TCERG1L in West Africans. The meta-analysis of 1497 African Americans and West Africans yielded genome-wide significant associations for SNPs in the SC4MOL gene: rs17046216 (P 5 1.7 3 10 28 and 2.9 3 10 28 for FI and IR, respectively); and near the TCERG1L gene with rs7077836 as the top scoring (P 5 7.5 3 10 29 and 4.9 3 10 210 for FI and IR, respectively). In silico replication in the MAGIC study (n 5 37 037) showed weak but significant association (adjusted P-value of 0.0097) for rs34602777 in the MYO5A gene. In addition, we replicated previous GWAS findings for IR and FI in Europeans for GCKR, and for variants in four T2D loci (FTO, IRS1, KLF14 and PPARG) which exert their action via IR. In summary, variants in/near SC4MOL, and TCERG1L were associated with FI and IR in this cohort of African Americans and were replicated in West Africans. SC4MOL is under-expressed in an animal model of T2D and plays a key role in lipid biosynthesis, with implications for the regulation of energy metabolism, obesity and dyslipidemia. TCERG1L is associated with plasma adiponectin, a key modulator of obesity, inflammation, IR and diabetes.

Planta, 1979

The lysine analogs S-2-aminoethyl-L-cysteine (AEC) and DL-Δ-hydroxylysine (DHL) caused severe gro... more The lysine analogs S-2-aminoethyl-L-cysteine (AEC) and DL-Δ-hydroxylysine (DHL) caused severe growth inhibition in dark-grown oat seedlings (Avena sativa L. and A. nuda L.) at similar concentrations while L-lysine methyl ester (LME) had little effect. Lysine, arginine, and ornithine reversed the inhibition caused by AEC and DHL, the order of effectiveness being lysine>arginine>ornithine. Of aspartate-pathway amino acids, tested individually and in combinations for inhibitory effects on seedling growth, lysine and combinations containing lysine were the most inhibitory, but the inhibition was much less than that produced by AEC. Only slight synergistic effects occurred when oat seedlings were grown in the presence of paired combinations of aspartatepathway endproduct amino acids. Ca. 54,000 seeds obtained from 3,463 plants grown from ethyl-methanesulfonate (EMS) treated seed were screened for resistance to AEC. Three resistant variants were identified but the resistance was not recovered among their self-pollinated progeny.

Mineralogy and Petrology, 1993

Olivine-plagioclase and phlogopite-plagioclase coronas have been identified from olivine melanori... more Olivine-plagioclase and phlogopite-plagioclase coronas have been identified from olivine melanorites of the Mid-to Late Proterozoic Equeefa Suite in southern Natal, South Africa. Olivine, in contact with plagioclase, is mantled by a shell of clear orthopyroxene, in turn rimmed by pale green (pargasitic) clinoamphibole. Locally a third rim, composed of a fine pargasite-spinel symplectite is developed adjacent to the plagioclase. The second corona reaction has produced greenish-brown pargasite at phlogopite-plagioclase interfaces. A third, less obvious reaction, between olivine and phlogopite is also noted. Analytical data of all the mineral phases present, along with the coronas, are given. Two-pyroxene thermometry yields magmatic core temperatures (~ 1120°C), with rim compositions indicating equilibration at ~ 850°C. Consistent with this, the modelled olivine-plagioclase reaction occurs between 830-1050°C with awate r between 0.1 and 1.0 at 7 kbar. The three reactions took place during a prolonged history of cooling and partial hydration of the magmatic olivine melanorites from over 1000°C down to 600°C. The P-T conditions indicated by the reactions suggest this cooling process was essentially isobaric, indicating that the area was not subjected to rapid uplift or burial throughout this entire period.

Journal of The National Cancer Institute, 1998

We have previously demonstrated that breast cancers associated with inherited BRCA1 and BRCA2 gen... more We have previously demonstrated that breast cancers associated with inherited BRCA1 and BRCA2 gene mutations differ from each other in their histopathologic appearances and that each of these types differs from breast cancers in patients unselected for family history (i.e., sporadic cancers). We have now conducted a more detailed examination of cytologic and architectural features of these tumors. Methods: Specimens of tumor tissue (5-µm-thick sections) were examined independently by two pathologists, who were unaware of the case or control subject status, for the presence of cell mitosis, lymphocytic infiltration, continuous pushing margins, and solid sheets of cancer cells; cell nuclei, cell nucleoli, cell necrosis, and cell borders were also evaluated. The resulting data were combined with previously available information on tumor type and tumor grade and further evaluated by multifactorial analysis. All statistical tests are two-sided. Results: Cancers associated with BRCA1 mutations exhibited higher mitotic counts (P = .001), a greater proportion of the tumor with a continuous pushing margin (P<.0001), and more lymphocytic infiltration (P = .002) than sporadic (i.e., control) cancers. Cancers associated with BRCA2 mutations exhibited a higher score for tubule formation (fewer tubules) (P = .0002), a higher proportion of the tumor perimeter with a continuous pushing margin (P<.0001), and a lower mitotic count (P = .003) than control cancers.

Critical Care Medicine, 1974

Page 1. 1060 THE NEW ENGLAND JOURNAL OF MEDICINE Nov. 15. 1973 Wells H. Lloyd W: Hypercalcémie an... more Page 1. 1060 THE NEW ENGLAND JOURNAL OF MEDICINE Nov. 15. 1973 Wells H. Lloyd W: Hypercalcémie and hypophosphatemic effects of di-butvrvl cyclic ЛМР in rats after parathyroidectomy. Endocrinolosy 84:861-867. ...

The Journal of Applied Behavioral Science, 2003

Organizational Dynamics, 2011

PLOS One, 2009

Although humpback whales are among the best-studied of the large whales, population boundaries in... more Although humpback whales are among the best-studied of the large whales, population boundaries in the Southern Hemisphere (SH) have remained largely untested. We assess population structure of SH humpback whales using 1,527 samples collected from whales at fourteen sampling sites within the Southwestern and Southeastern Atlantic, the Southwestern Indian Ocean, and Northern Indian Ocean (Breeding Stocks A, B, C and X, respectively). Evaluation of mtDNA population structure and migration rates was carried out under different statistical frameworks. Using all genetic evidence, the results suggest significant degrees of population structure between all ocean basins, with the Southwestern and Northern Indian Ocean most differentiated from each other. Effective migration rates were highest between the Southeastern Atlantic and the Southwestern Indian Ocean, followed by rates within the Southeastern Atlantic, and the lowest between the Southwestern and Northern Indian Ocean. At finer scales, very low gene flow was detected between the two neighbouring sub-regions in the Southeastern Atlantic, compared to high gene flow for whales within the Southwestern Indian Ocean. Our genetic results support the current management designations proposed by the International Whaling Commission of Breeding Stocks A, B, C, and X as four strongly structured populations. The population structure patterns found in this study are likely to have been influenced by a combination of long-term maternally directed fidelity of migratory destinations, along with other ecological and oceanographic features in the region.

ABSTRACT In 2000, a project was launched to produce an accumulated 24-hour rainfall map, at a spa... more ABSTRACT In 2000, a project was launched to produce an accumulated 24-hour rainfall map, at a spatial resolution of 1x1 km2, over South Africa and to post this map on the Internet on a daily basis. The project was dubbed SIMAR and the results can be viewed at http:// ...

Meteoritics & Planetary Science, 2004

The ICDP Yaxcopoil-1 (Yax-1) borehole located 60 km south-southwest of the center of the Chicxulu... more The ICDP Yaxcopoil-1 (Yax-1) borehole located 60 km south-southwest of the center of the Chicxulub impact structure intercepted an interval of allogenic impactites (depth of 795-895 m). Petrographic analysis of these impactites allows them to be differentiated into five units based on their textural and modal variations. Unit 1 (795-922 m) comprises an apparently reworked, poorly sorted and graded, fine-grained, clast-supported, melt fragment-bearing suevitic breccia. The interstitial material, similar to units 2 and 3, is permeated by numerous carbonate veinlets. Units 2 (823-846 m) and 3 (846-861 m) are groundmass-supported breccias that comprise green to variegated angular and fluidal melt particles. The groundmass of units 2 and 3 comprises predominantly fine-grained calcite, altered alkali element-, Ca-, and Si-rich cement, as well as occasional lithic fragments. Unit 4 (861- 885 m) represents a massive, variably devitrified, and brecciated impact melt rock. The lowermost unit, unit 5 (885-895 m), comprises highly variable proportions of melt rock particles (MRP) and lithic fragments in a fine-grained, carbonate-dominated groundmass. This groundmass could represent either a secondary hydrothermal phase or a carbonate melt phase, or both. Units 1 and 5 contain well-preserved foraminifera fossils and a significantly higher proportion of carbonate clasts than the other units. All units show diagnostic shock deformation features in quartz and feldspar clasts. Our observations reveal that most felsic and all mafic MRP are altered. They register extensive K-metasomatism. In terms of emplacement, we suggest that units 1 to 3 represent fallout suevite from a collapsing impact plume, whereby unit 1 was subsequently reworked by resurging water. Unit 4 represents a coherent impact melt body, the formation of which involved a significant proportion of crystalline basement. Unit 5 is believed to represent an initial ejecta/ground-surge deposit.

Journal of Managerial Psychology, 1996

Abstract: Little research has been done on the impact of social decision schemes on group process... more Abstract: Little research has been done on the impact of social decision schemes on group process variables. Green and Taber created a self-report scale to provide five measures of the group process. These measures deal with the descriptions of an individual&amp;amp;#x27;s behaviour as well as others&amp;amp;#x27; behaviour towards a specific person. The items within each measure also probe evaluative ratings of several specific group processes and outcomes. Evaluates the relationship between the process variables and a dependent performance variable-the ...

Drill core samples of an anomalous shale layer in the 2.8 Ga Witwatersrand Supergroup, known as t... more Drill core samples of an anomalous shale layer in the 2.8 Ga Witwatersrand Supergroup, known as the Green Bar, were analyzed for PGE abundances to determine whether the layer may represent an Archean impactite. The Green Bar occurs in the lower part of the fluvial quartzites and conglomerates of the Johannesburg Subgroup of the Central Rand, approximately 1 to 2 meters above the Au-bearing Carbon Leader. It is comprised of 1 m of chloritoid-rich, laminated to massive siltstone that disconformably overlies a cross-bedded quartz arenite and is disconformably overlain by a cross-bedded quartz wacke. The Green Bar can be correlated over a distance of ~10 km in the northern margin of the Witwatersrand basin. DeKock (1949) proposed that the Green Bar might be a volcanic tuff, perhaps not unlike the stratigraphically younger, chloritoid-rich, Bird Reef Marker, interpreted as a volcanic tuff associated with the Bird Amygdaloidal lava. PGE analyses of laminated and massive Green Bar samples yielded Ir concentrations ranging from 0.17 to 0.22 ppb. The concentrations of Ir, Ru, Rh, Pt, Pd and Au normalized to C1 chondrites are consistent with those of ultramafic rocks. The laminated facies exhibited some relative enrichment of Au that may be related to its mobilization during metamorphism. These data are more consistent with an ultramafic exhalative origin for the Green Bar. The presence of ultramafic eruptives during Witwatersrand deposition may also explain the origin of the detrital diamonds associated with some of the conglomerates. An impactite origin is not necessarily precluded by the PGE data if the impact occurred in ultramafic oceanic crust, but it does require some other evidence to support that case. DeKock, W.P. The Carbon Leader on the Far West Rand. Trans. Geol. Soc. S. Africa, 51, 1949.

Water Air and Soil Pollution, 2010

Environmental problems many times could evolve when manure-containing pathogens are distributed i... more Environmental problems many times could evolve when manure-containing pathogens are distributed into an open environment with no effort made to reduce the content of pathogens or limit their movement in the environment. Wind, surface flow, and subsurface flow can all carry enough pathogens to receiving waters to exceed water quality standards. This study was conducted to assess the microbiological quality of water associated with animal-based agriculture in the sub-basin of Pinhal River located in the rural area of Concordia, Santa Catarina, Brazil. Six sampling points representing different agricultural land uses (LU1—dairy cattle; LU2—without animals; LU3—dairy + pigs + poultry + crops; LU4—pigs + poultry + crops; LU5—dairy + pigs + poultry + crops + human; and LU6—dairy+pigs+crops) along the Pinhal River sub-basin (north to south) were sampled biweekly from August 2006 to December 2008. Concentrations of fecal coliforms and Escherichia coli varied significantly (p ≤ 0.05) with land use (LU), but there was no interaction effect of LU, season, and time. Water samples from the catchment area of LU1 had the highest concentration of fecal coliforms (4,479 ± 597 CFU ml−1) when compared with other catchment areas. Catchment area associated with LU2 (no animal) had the lowest concentrations of fecal coliforms (39.2 ± 5.2 CFU ml−1). With the exception of LU2 (control site), all the maximum concentrations of E. coli exceeded the single maximum allowable concentration for E. coli (100 CFU ml−1). When LU1 was compared with other catchment areas (LU3, 50%; LU4, 67%; LU5, 58%; and LU6, 44%), it had the lowest counts (39%) of Salmonella sp. Our results suggest that spatial pattern of bacterial water quality is evident, which can be linked to the different land uses and associated practices (present or absent of animal activities). Therefore, varying responses associated with the different land uses would be critical in identifying the importance of different sources of bacteria in the catchment area and the mechanisms transferring them.