Derya Akdeniz - Academia.edu (original) (raw)
Papers by Derya Akdeniz
Eurasian journal of medicine and oncology, 2017
A ccording to records of Turkey Renal Diseases Study Group, the prevalence and incidence of chron... more A ccording to records of Turkey Renal Diseases Study Group, the prevalence and incidence of chronic kidney disease (CKD) is 17.6% in Turkey, [1] and the morbidity associated with the CRD has become an important public health issue. On the same study it is reported that CKD is more common in women, elder people and patients living in the rural areas. Also the prevalanace of disease is higher in Southeastern and Marmara regions. The causes of CKD among Turkish population are diverse, the most common being diabetes mellitus, hypertension, smoking, hypertension and metabolic syndrome. [2] It is worth noting that 17.8% of late-stage CKD patients, the etiology of the disease is not eluciated. [1] Although chronic renal diseases have an important morbidity, fifth of patients were not known about etiology of disease The HLA system belongs to the major histocompatibility complex (MHC) family in humans. Which is located on chromosome 6p. [3] HLA genes encode cell surface moleculeswhich is essential to present molecules T cell receptors. [4] Specific HLA types have been known to be associat-Objectives: Chronic renal disease is a common clinical problem, the etiology of which has not yet been fully elucidated. Human leukocyte antigen profiling has recently gained popularity as an important new tool for precision medicine approaches. In the present study, directed approaches were applied to understand the distribution of HLA antigens and how different HLA expressions affect the frequency of patients with chronic kidney disease in the Black Sea region. Methods: A total of 156 patients with end-stage renal disease and 216 healthy participants who were not related to the patients were enrolled in the study. Results: The frequency of the HLA B*52 and HLA B*58 alleles was significantly lower and the frequency of the HLA B*40, HLA CW*04, HLA CW*05, HLA DRB1*12, and HLA DQB1*03 alleles was significantly higher in end-stage renal disease patients. Conclusion: The study results indicated that the HLA distribution in end-stage renal disease is different from that of healthy individuals. A significantly larger number of HLA B*40, HLA CW*04 , HLA DRBB1*12 and HLA DQB1*03 and fewer HLA B*52 and HLA B*58 haplotypes were observed in patients with chronic renal disease. More studies on this subject are required.
Archives of Gynecology and Obstetrics, Jul 24, 2013
Our study was undertaken to evaluate the levels of asymmetric dimethyl-arginine (ADMA) in a group... more Our study was undertaken to evaluate the levels of asymmetric dimethyl-arginine (ADMA) in a group of patients affected with polycystic ovary syndrome (PCOS)--under ethinyl estradiol-cyproterone acetate treatment or not--as compared with a group of healthy controls. Fifty-eight women with PCOS and 45 patients as control group were included in the study. The 58 women with PCOS were separated into two groups: Group A (n = 29) were treated with an oral contraceptive pill containing 0.035 mg of ethinyl estradiol (EE) and 2 mg of cyproterone acetate (CA) (Diane-35) for 6 months. Group B (n = 29) did not take any drug. Group C (n = 45) was healthy women as control group. Serum levels of ADMA, lipid and glucose metabolism parameters, hormone profile were measured on the sixth month of treatment. ADMA levels were similar in women with PCOS and controls, whereas ADMA levels significantly decreased after a period of 6 months treatment with EE + CA in women with PCOS. ADMA levels and insulin resistance were decreased with treatment. However, patients with PCOS had significantly higher total cholesterol and Low-density lipoprotein cholesterol (LDL-C) compared to controls, treatment with EE + CA did not provide any improvement on lipid parameters. Serum ADMA levels and insulin resistance were lower in PCOS group treated with EE + CA than control group.
Human Reproduction, 2012
Introduction: Weight loss amongst women with polycystic ovary syndrome (PCOS) is crucial to reduc... more Introduction: Weight loss amongst women with polycystic ovary syndrome (PCOS) is crucial to reduce the risk of endocrine, reproductive and metabolic complications including hirsutism, menstrual disturbances and cardiovascular disease. With approximately 50% of women with PCOS being overweight or obese, effective dietary management of weight in PCOS is essential. However, there is inconsistent evidence as to whether specifically modified diets (e.g. reduced carbohydrate diets) are more effective at achieving weight loss amongst women with PCOS than are conventional healthy hypocaloric diets. Material and Methods: A systematic review and meta-analysis of randomized controlled trials that had compared weight and BMI between women with PCOS who had undergone either a specifically modified diet or a conventional healthy hypocaloric diet were performed. Six electronic databases were searched, a manual search of the reference lists of the included studies was carried out and authors were contacted for additional information. Nine studies with a total of 395 participants (all with a body mass index [BMI] ≥30) were included in the meta-analysis. The effect size used was the mean difference in post-intervention weight and BMI between participants who had undergone a specifically modified diet and participants who had undergone a conventional healthy hypocaloric diet. Results: There were no differences between groups in post-intervention weight (mean difference 1.26, 95% confidence interval (CI) -0.92 to 3.43, p = .26; heterogeneity I2 = 50%, p = .04) or BMI (mean difference 0.15, 95% CI -0.93 to 1.23, p = 0.79; heterogeneity I2 = 44%, p = 0.10). Subgroup analyses according to the presence of a dietary run-in period (a period at the start of the study during which all participants are placed on an identical diet in order to equalize them on variables influenced by diet), intervention duration and type of diet and a sensitivity analysis according to study quality were not significant. Conclusions: Whilst the results should be interpreted in light of the moderate heterogeneity observed, they suggest that specifically modified diets offer no added benefit for weight loss in women with PCOS over conventional healthy hypocaloric diets. The findings of this meta-analysis may promote the unification of guidelines for the dietary management of PCOS and allow clinicians to be confident in prescribing conventional healthy hypocaloric diets for weight loss amongst their PCOS patients.
ORTADOĞU TIP DERGİSİ, 2012
Objective: The aim of this study was to evaluate mean platelet volume (MPV), thrombopoietin (TPO)... more Objective: The aim of this study was to evaluate mean platelet volume (MPV), thrombopoietin (TPO), and platelet levels in patients with ischemic stroke and compare this with healthy controls. Methods: We prospectively studied 50 patients with ischemic stroke and compared them with 37 control participants who have evaluated in internal medicine polyclinic and had no history of cerebrovascular events. All patients were within 24 hours after stroke; MPV and TPO were measured on admission. Results: Both TPO and MPV values were significantly higher in patients with stroke (P .00; P .001). Conclusion: Increased TPO levels may increase both platelet count and platelet size, resulting in more hemostatic tendency, which may contribute to the progression of ischemic stroke.
Background: It is known that bone mineral density changes with sexual hormone levels and age in p... more Background: It is known that bone mineral density changes with sexual hormone levels and age in postmenopausal women
American Journal of Clinical Pathology, 2009
Fraser et al / TRANSDIFFERENTIATION OF CLL/SLL TO IDCS * The genes mentioned in the text are bold... more Fraser et al / TRANSDIFFERENTIATION OF CLL/SLL TO IDCS * The genes mentioned in the text are boldface. The numbers indicate the base positions of the genes in chromosome 16
A ccording to records of Turkey Renal Diseases Study Group, the prevalence and incidence of chron... more A ccording to records of Turkey Renal Diseases Study Group, the prevalence and incidence of chronic kidney disease (CKD) is 17.6% in Turkey, [1] and the morbidity associated with the CRD has become an important public health issue. On the same study it is reported that CKD is more common in women, elder people and patients living in the rural areas. Also the prevalanace of disease is higher in Southeastern and Marmara regions. The causes of CKD among Turkish population are diverse, the most common being diabetes mellitus, hypertension, smoking, hypertension and metabolic syndrome. [2] It is worth noting that 17.8% of late-stage CKD patients, the etiology of the disease is not eluciated. [1] Although chronic renal diseases have an important morbidity, fifth of patients were not known about etiology of disease The HLA system belongs to the major histocompatibility complex (MHC) family in humans. Which is located on chromosome 6p. [3] HLA genes encode cell surface moleculeswhich is essential to present molecules T cell receptors. [4] Specific HLA types have been known to be associat-Objectives: Chronic renal disease is a common clinical problem, the etiology of which has not yet been fully elucidated. Human leukocyte antigen profiling has recently gained popularity as an important new tool for precision medicine approaches. In the present study, directed approaches were applied to understand the distribution of HLA antigens and how different HLA expressions affect the frequency of patients with chronic kidney disease in the Black Sea region. Methods: A total of 156 patients with end-stage renal disease and 216 healthy participants who were not related to the patients were enrolled in the study. Results: The frequency of the HLA B*52 and HLA B*58 alleles was significantly lower and the frequency of the HLA B*40, HLA CW*04, HLA CW*05, HLA DRB1*12, and HLA DQB1*03 alleles was significantly higher in end-stage renal disease patients. Conclusion: The study results indicated that the HLA distribution in end-stage renal disease is different from that of healthy individuals. A significantly larger number of HLA B*40, HLA CW*04 , HLA DRBB1*12 and HLA DQB1*03 and fewer HLA B*52 and HLA B*58 haplotypes were observed in patients with chronic renal disease. More studies on this subject are required.
Saudi medical journal, 2012
OBJECTIVE To observe thrombopoietin (TPO) levels in patients with non-alcoholic fatty liver disea... more OBJECTIVE To observe thrombopoietin (TPO) levels in patients with non-alcoholic fatty liver disease (NAFLD). METHODS The study was performed between November 2010 and March 2011 at the Department of Internal Medicine, Faculty of Medicine, Fatih University, Ankara, Turkey. A total of 60 consecutive patients with ultrasound proven NAFLD (study group), and 28 healthy volunteers (control study) were included in the study. The patient group was divided into 3 subgroups according to the ultrasonographic images as follows: minimal, intermediate, and marked hepatosteatosis. The TPO levels of the patient subgroups were compared with the healthy controls. All the data were collected prospectively, and recorded in FUHIS data collecting system, which is produced by our data-knowledge team. Quantitative measurements of thrombopoietin level were carried out by using the Human Thrombopoietin Quantikine ELISA Kit (R&D Systems, Minneapolis, Minnesota, USA). RESULTS Thrombopoietin levels were signifi...
Chronic lymphocytic leukemia (CLL) is a clonal lymphoproliferative disease characterized by clona... more Chronic lymphocytic leukemia (CLL) is a clonal lymphoproliferative disease characterized by clonal expansion of B lymphocytes. Richter Transformation (RT) must be considered if CLL patient had fever, weight loss, cytopenia and resistance to standard therapy. Despite CLL usually transforms to diffuse large cell lymphoma, some rare lymphomas may occur as RT such as Hodgkin variants, lymphoblastic lymphoma nad mantle cell lymphoma. Here, we report a case of Mantle cell lymphoma has become secondary to chronic lymphocytic leukemia due to its being a rare entity. J Clin Exp Invest 2011; 2 (4): 443-445 OZET Kronik lenfositik losemi (KLL) morfolojik olarak B tip lenfo
Antiphospholipid syndrome is a disease presenting with arterial/ venous thrombosis and obstetrica... more Antiphospholipid syndrome is a disease presenting with arterial/ venous thrombosis and obstetrical complications. Pulmonary embolism is an important pulmonary complication of antiphospholipid syndrome, whereas, intra-alveolar hemorrhage is a rarely encountered manifestation. Hemophilia B is caused by factor IX deficiency that results in prolonged oozing after injuries and/or surgery, and delayed or recurrent bleeding prior to complete wound healing. Antithrombotic therapy may be used for recurrent hemostatic attacks in APS; but if there is a hemostatic defect, it may lead to serious bleeding complications. Here, we present a case of antiphospholipid syndrome accompanied by heterozygote methylene tetrahydrofolate reductase gene mutation (MTHFR) mutation and hemophilia B.
Turkiye Klinikleri Journal of Rheumatology Special Topics, 2012
Amac: Polikistik over sendromu, uretken cagdaki kadinlarda sik gorulen bir klinik durumdur. Hiper... more Amac: Polikistik over sendromu, uretken cagdaki kadinlarda sik gorulen bir klinik durumdur. Hiperinsulinemi ve insulin direnci, hastaligin patofizyolojisinde onemli bir antite olarak karsimiza cikar. Calismamizin amaci; antimullerian hormon (AMH) duzeylerinin metformin tedavisi sonrasi degisimini incelemekti. Yontem: Rotterdam kriterlerine gore Polikistik over tanisi alan 84 hasta ve 28 saglikli gonullu calismaya alindi. Hastalarin yarisi (n=42) 1,7 gr/gun metformin tedavisi alirken diger 42 hasta tedavisiz izlendi. 6 aylik perioddan sonra hastalarin laboratuar testleri karsilastirildi. Bulgular: AMH duzeyleri tedavi oncesi benzerdi. Metformin tedavisi sonrasi tedavi alan PCOS hastalari ve kontrol grubu AMH duzeyleri 6 aylik period sonrasinda benzer duzeylerde bulundu. Tedavi edilmeyenlere gore 1.7 gr/gun metformin alan hastalarda AMH duzeyleri belirgin dusuk olarak izlendi (p<0.001). Sonuc: AMH duzeyleri antral follikul volumu ve serum testosteron duzeyleri ile korelasyon goster...
Congenital adrenal hyperplasia is a group of autosomal recessive disorders characterized by impai... more Congenital adrenal hyperplasia is a group of autosomal recessive disorders characterized by impaired cortisol synthesis. Dysregulation of corticotropin synthesis often leads to increased synthesis of adrenal androgens. Low fertility is often and troublesome condition in patients with congenital adrenal hyperplasia . In this report, we presented a case report which is a woman with non- classical hyperplasia who were pregnant and followed until delivery in our clinic.
Background We aimed to estimate the glomerular filtration rate (GFR) in women with polycystic ova... more Background We aimed to estimate the glomerular filtration rate (GFR) in women with polycystic ovary syndrome (PCOS) and to determine the relationship between GFR with C-reactive protein (CRP) and uric acid. Materials and Methods In this cross-sectional study, one-hundred and forty PCOS women and 60 healthy subjects were evaluated. The study was carried out at Endocrinol- ogy Outpatient Clinic, Erzurum Training and Research Hospital, Erzurum, Turkey, from December 2010 to January 2011. GFRs were estimated by Modification of Diet in Renal Disease (MDRD) formula. CRP, urinary albumin excretion (UAE) and uric acid levels were also measured. Results GFRs were significantly higher in PCOS group than control (135.24 ± 25.62 vs. 114.92 ± 24.07 ml/min per 1.73 m2). CRP levels were significantly higher in PCOS patients (4.4 ± 3.4 vs. 2.12 ± 1.5 mg/l). The PCOS group had significantly higher serum uric acid levels (4.36 ± 1.3 mg/dl vs. 3.2 ± 0.73 mg/dl). There was also significantly higher pro...
International Journal of Hematology and Oncology, 2013
Although regimens of harvesting peripheric stem cell vary from one center to another, the most co... more Although regimens of harvesting peripheric stem cell vary from one center to another, the most common ones are chemotherapy plus growth factor or growth factor alone. We aimed to determine which variables of harvesting peripheral stem cells are effective on the number of harvested CD34+ cells and successfull mobilisation defined as "the collection of >2.0 x 106 CD34+ cells/kg b.w. with a maximum of three leukaphereres". From August 2008 to January 2011, the documents of 56 patients included in the autologous peripheral stem cell harvesting program were retrieved retrospectively. Regarding harvesting regimens, 28 patients (50.0%) were administered filgrastim 10 µg/kg/day (filgrastim group), 18 patients (32.1%) were administered a standard regime with ifosphamide + etoposide + epirubicin + filgrastim 5 µg/kg/day or cyclophosphamide + etoposide + filgrastim 5 µg/kg/day (standard group), and 10 patients (17.9%) were administered a salvage regime + filgrastim 5 µg/kg/day (salvage group). Rituximab was added if the disease was CD20 positive. The median number of CD34+ cells and the number of inadequate collection did not differ between these 3 groups. Transplantation before mobilization was found to have a negative effect on the harvesting success. The transplantated patients had a lower number of harvested CD34+ cells than the patients without transplantation history. But no clear relationship was seen between harvest success and the diagnosis of the patients, pretransplant response, radiotherapy history before mobilization, or mobilization with a standard regimen. Finally, the number of standard CT cycles before mobilization were found to have a borderline negative effect on the harvested CD34+ cells.
Turkiye Klinikleri Journal of Rheumatology Special Topics, 2012
Journal of Investigative Medicine, 2015
Background / Purpose: The aim of this study was to determine the protective effect of erdosteine ... more Background / Purpose: The aim of this study was to determine the protective effect of erdosteine on Cyclosporine (CsA) induced chronic nephrotoxicity.We assessed oxidative stress enzymes (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx), malondialdehyde (MDA) and nitric oxide (NO) levels) and light microscopic changes before and after erdosteine treatment in damaged kidneys. The rats were assigned randomly to one of four groups, these were: control group (n=8), CsA group (15 mg/kg day, n=8), erdosteine treated group (10 mg/kg day orally, n=8) and CsA+ erdosteine group (n=8). CsA nephrotoxicity was induced by administrating oral dose of 15 mg/kg CsA daily for 21 days. Main conclusion: For the first time, we have demonstrated in vivo that erdosteine causes improvement in CsA related nephrotoxicity by increasing GSHPx, CAT, MDA and NO levels. Histological clues of renal damage can be diminished by erdostein treatment. As an exogenous antioxidant agent, erdoste...
Eurasian journal of medicine and oncology, 2017
A ccording to records of Turkey Renal Diseases Study Group, the prevalence and incidence of chron... more A ccording to records of Turkey Renal Diseases Study Group, the prevalence and incidence of chronic kidney disease (CKD) is 17.6% in Turkey, [1] and the morbidity associated with the CRD has become an important public health issue. On the same study it is reported that CKD is more common in women, elder people and patients living in the rural areas. Also the prevalanace of disease is higher in Southeastern and Marmara regions. The causes of CKD among Turkish population are diverse, the most common being diabetes mellitus, hypertension, smoking, hypertension and metabolic syndrome. [2] It is worth noting that 17.8% of late-stage CKD patients, the etiology of the disease is not eluciated. [1] Although chronic renal diseases have an important morbidity, fifth of patients were not known about etiology of disease The HLA system belongs to the major histocompatibility complex (MHC) family in humans. Which is located on chromosome 6p. [3] HLA genes encode cell surface moleculeswhich is essential to present molecules T cell receptors. [4] Specific HLA types have been known to be associat-Objectives: Chronic renal disease is a common clinical problem, the etiology of which has not yet been fully elucidated. Human leukocyte antigen profiling has recently gained popularity as an important new tool for precision medicine approaches. In the present study, directed approaches were applied to understand the distribution of HLA antigens and how different HLA expressions affect the frequency of patients with chronic kidney disease in the Black Sea region. Methods: A total of 156 patients with end-stage renal disease and 216 healthy participants who were not related to the patients were enrolled in the study. Results: The frequency of the HLA B*52 and HLA B*58 alleles was significantly lower and the frequency of the HLA B*40, HLA CW*04, HLA CW*05, HLA DRB1*12, and HLA DQB1*03 alleles was significantly higher in end-stage renal disease patients. Conclusion: The study results indicated that the HLA distribution in end-stage renal disease is different from that of healthy individuals. A significantly larger number of HLA B*40, HLA CW*04 , HLA DRBB1*12 and HLA DQB1*03 and fewer HLA B*52 and HLA B*58 haplotypes were observed in patients with chronic renal disease. More studies on this subject are required.
Archives of Gynecology and Obstetrics, Jul 24, 2013
Our study was undertaken to evaluate the levels of asymmetric dimethyl-arginine (ADMA) in a group... more Our study was undertaken to evaluate the levels of asymmetric dimethyl-arginine (ADMA) in a group of patients affected with polycystic ovary syndrome (PCOS)--under ethinyl estradiol-cyproterone acetate treatment or not--as compared with a group of healthy controls. Fifty-eight women with PCOS and 45 patients as control group were included in the study. The 58 women with PCOS were separated into two groups: Group A (n = 29) were treated with an oral contraceptive pill containing 0.035 mg of ethinyl estradiol (EE) and 2 mg of cyproterone acetate (CA) (Diane-35) for 6 months. Group B (n = 29) did not take any drug. Group C (n = 45) was healthy women as control group. Serum levels of ADMA, lipid and glucose metabolism parameters, hormone profile were measured on the sixth month of treatment. ADMA levels were similar in women with PCOS and controls, whereas ADMA levels significantly decreased after a period of 6 months treatment with EE + CA in women with PCOS. ADMA levels and insulin resistance were decreased with treatment. However, patients with PCOS had significantly higher total cholesterol and Low-density lipoprotein cholesterol (LDL-C) compared to controls, treatment with EE + CA did not provide any improvement on lipid parameters. Serum ADMA levels and insulin resistance were lower in PCOS group treated with EE + CA than control group.
Human Reproduction, 2012
Introduction: Weight loss amongst women with polycystic ovary syndrome (PCOS) is crucial to reduc... more Introduction: Weight loss amongst women with polycystic ovary syndrome (PCOS) is crucial to reduce the risk of endocrine, reproductive and metabolic complications including hirsutism, menstrual disturbances and cardiovascular disease. With approximately 50% of women with PCOS being overweight or obese, effective dietary management of weight in PCOS is essential. However, there is inconsistent evidence as to whether specifically modified diets (e.g. reduced carbohydrate diets) are more effective at achieving weight loss amongst women with PCOS than are conventional healthy hypocaloric diets. Material and Methods: A systematic review and meta-analysis of randomized controlled trials that had compared weight and BMI between women with PCOS who had undergone either a specifically modified diet or a conventional healthy hypocaloric diet were performed. Six electronic databases were searched, a manual search of the reference lists of the included studies was carried out and authors were contacted for additional information. Nine studies with a total of 395 participants (all with a body mass index [BMI] ≥30) were included in the meta-analysis. The effect size used was the mean difference in post-intervention weight and BMI between participants who had undergone a specifically modified diet and participants who had undergone a conventional healthy hypocaloric diet. Results: There were no differences between groups in post-intervention weight (mean difference 1.26, 95% confidence interval (CI) -0.92 to 3.43, p = .26; heterogeneity I2 = 50%, p = .04) or BMI (mean difference 0.15, 95% CI -0.93 to 1.23, p = 0.79; heterogeneity I2 = 44%, p = 0.10). Subgroup analyses according to the presence of a dietary run-in period (a period at the start of the study during which all participants are placed on an identical diet in order to equalize them on variables influenced by diet), intervention duration and type of diet and a sensitivity analysis according to study quality were not significant. Conclusions: Whilst the results should be interpreted in light of the moderate heterogeneity observed, they suggest that specifically modified diets offer no added benefit for weight loss in women with PCOS over conventional healthy hypocaloric diets. The findings of this meta-analysis may promote the unification of guidelines for the dietary management of PCOS and allow clinicians to be confident in prescribing conventional healthy hypocaloric diets for weight loss amongst their PCOS patients.
ORTADOĞU TIP DERGİSİ, 2012
Objective: The aim of this study was to evaluate mean platelet volume (MPV), thrombopoietin (TPO)... more Objective: The aim of this study was to evaluate mean platelet volume (MPV), thrombopoietin (TPO), and platelet levels in patients with ischemic stroke and compare this with healthy controls. Methods: We prospectively studied 50 patients with ischemic stroke and compared them with 37 control participants who have evaluated in internal medicine polyclinic and had no history of cerebrovascular events. All patients were within 24 hours after stroke; MPV and TPO were measured on admission. Results: Both TPO and MPV values were significantly higher in patients with stroke (P .00; P .001). Conclusion: Increased TPO levels may increase both platelet count and platelet size, resulting in more hemostatic tendency, which may contribute to the progression of ischemic stroke.
Background: It is known that bone mineral density changes with sexual hormone levels and age in p... more Background: It is known that bone mineral density changes with sexual hormone levels and age in postmenopausal women
American Journal of Clinical Pathology, 2009
Fraser et al / TRANSDIFFERENTIATION OF CLL/SLL TO IDCS * The genes mentioned in the text are bold... more Fraser et al / TRANSDIFFERENTIATION OF CLL/SLL TO IDCS * The genes mentioned in the text are boldface. The numbers indicate the base positions of the genes in chromosome 16
A ccording to records of Turkey Renal Diseases Study Group, the prevalence and incidence of chron... more A ccording to records of Turkey Renal Diseases Study Group, the prevalence and incidence of chronic kidney disease (CKD) is 17.6% in Turkey, [1] and the morbidity associated with the CRD has become an important public health issue. On the same study it is reported that CKD is more common in women, elder people and patients living in the rural areas. Also the prevalanace of disease is higher in Southeastern and Marmara regions. The causes of CKD among Turkish population are diverse, the most common being diabetes mellitus, hypertension, smoking, hypertension and metabolic syndrome. [2] It is worth noting that 17.8% of late-stage CKD patients, the etiology of the disease is not eluciated. [1] Although chronic renal diseases have an important morbidity, fifth of patients were not known about etiology of disease The HLA system belongs to the major histocompatibility complex (MHC) family in humans. Which is located on chromosome 6p. [3] HLA genes encode cell surface moleculeswhich is essential to present molecules T cell receptors. [4] Specific HLA types have been known to be associat-Objectives: Chronic renal disease is a common clinical problem, the etiology of which has not yet been fully elucidated. Human leukocyte antigen profiling has recently gained popularity as an important new tool for precision medicine approaches. In the present study, directed approaches were applied to understand the distribution of HLA antigens and how different HLA expressions affect the frequency of patients with chronic kidney disease in the Black Sea region. Methods: A total of 156 patients with end-stage renal disease and 216 healthy participants who were not related to the patients were enrolled in the study. Results: The frequency of the HLA B*52 and HLA B*58 alleles was significantly lower and the frequency of the HLA B*40, HLA CW*04, HLA CW*05, HLA DRB1*12, and HLA DQB1*03 alleles was significantly higher in end-stage renal disease patients. Conclusion: The study results indicated that the HLA distribution in end-stage renal disease is different from that of healthy individuals. A significantly larger number of HLA B*40, HLA CW*04 , HLA DRBB1*12 and HLA DQB1*03 and fewer HLA B*52 and HLA B*58 haplotypes were observed in patients with chronic renal disease. More studies on this subject are required.
Saudi medical journal, 2012
OBJECTIVE To observe thrombopoietin (TPO) levels in patients with non-alcoholic fatty liver disea... more OBJECTIVE To observe thrombopoietin (TPO) levels in patients with non-alcoholic fatty liver disease (NAFLD). METHODS The study was performed between November 2010 and March 2011 at the Department of Internal Medicine, Faculty of Medicine, Fatih University, Ankara, Turkey. A total of 60 consecutive patients with ultrasound proven NAFLD (study group), and 28 healthy volunteers (control study) were included in the study. The patient group was divided into 3 subgroups according to the ultrasonographic images as follows: minimal, intermediate, and marked hepatosteatosis. The TPO levels of the patient subgroups were compared with the healthy controls. All the data were collected prospectively, and recorded in FUHIS data collecting system, which is produced by our data-knowledge team. Quantitative measurements of thrombopoietin level were carried out by using the Human Thrombopoietin Quantikine ELISA Kit (R&D Systems, Minneapolis, Minnesota, USA). RESULTS Thrombopoietin levels were signifi...
Chronic lymphocytic leukemia (CLL) is a clonal lymphoproliferative disease characterized by clona... more Chronic lymphocytic leukemia (CLL) is a clonal lymphoproliferative disease characterized by clonal expansion of B lymphocytes. Richter Transformation (RT) must be considered if CLL patient had fever, weight loss, cytopenia and resistance to standard therapy. Despite CLL usually transforms to diffuse large cell lymphoma, some rare lymphomas may occur as RT such as Hodgkin variants, lymphoblastic lymphoma nad mantle cell lymphoma. Here, we report a case of Mantle cell lymphoma has become secondary to chronic lymphocytic leukemia due to its being a rare entity. J Clin Exp Invest 2011; 2 (4): 443-445 OZET Kronik lenfositik losemi (KLL) morfolojik olarak B tip lenfo
Antiphospholipid syndrome is a disease presenting with arterial/ venous thrombosis and obstetrica... more Antiphospholipid syndrome is a disease presenting with arterial/ venous thrombosis and obstetrical complications. Pulmonary embolism is an important pulmonary complication of antiphospholipid syndrome, whereas, intra-alveolar hemorrhage is a rarely encountered manifestation. Hemophilia B is caused by factor IX deficiency that results in prolonged oozing after injuries and/or surgery, and delayed or recurrent bleeding prior to complete wound healing. Antithrombotic therapy may be used for recurrent hemostatic attacks in APS; but if there is a hemostatic defect, it may lead to serious bleeding complications. Here, we present a case of antiphospholipid syndrome accompanied by heterozygote methylene tetrahydrofolate reductase gene mutation (MTHFR) mutation and hemophilia B.
Turkiye Klinikleri Journal of Rheumatology Special Topics, 2012
Amac: Polikistik over sendromu, uretken cagdaki kadinlarda sik gorulen bir klinik durumdur. Hiper... more Amac: Polikistik over sendromu, uretken cagdaki kadinlarda sik gorulen bir klinik durumdur. Hiperinsulinemi ve insulin direnci, hastaligin patofizyolojisinde onemli bir antite olarak karsimiza cikar. Calismamizin amaci; antimullerian hormon (AMH) duzeylerinin metformin tedavisi sonrasi degisimini incelemekti. Yontem: Rotterdam kriterlerine gore Polikistik over tanisi alan 84 hasta ve 28 saglikli gonullu calismaya alindi. Hastalarin yarisi (n=42) 1,7 gr/gun metformin tedavisi alirken diger 42 hasta tedavisiz izlendi. 6 aylik perioddan sonra hastalarin laboratuar testleri karsilastirildi. Bulgular: AMH duzeyleri tedavi oncesi benzerdi. Metformin tedavisi sonrasi tedavi alan PCOS hastalari ve kontrol grubu AMH duzeyleri 6 aylik period sonrasinda benzer duzeylerde bulundu. Tedavi edilmeyenlere gore 1.7 gr/gun metformin alan hastalarda AMH duzeyleri belirgin dusuk olarak izlendi (p<0.001). Sonuc: AMH duzeyleri antral follikul volumu ve serum testosteron duzeyleri ile korelasyon goster...
Congenital adrenal hyperplasia is a group of autosomal recessive disorders characterized by impai... more Congenital adrenal hyperplasia is a group of autosomal recessive disorders characterized by impaired cortisol synthesis. Dysregulation of corticotropin synthesis often leads to increased synthesis of adrenal androgens. Low fertility is often and troublesome condition in patients with congenital adrenal hyperplasia . In this report, we presented a case report which is a woman with non- classical hyperplasia who were pregnant and followed until delivery in our clinic.
Background We aimed to estimate the glomerular filtration rate (GFR) in women with polycystic ova... more Background We aimed to estimate the glomerular filtration rate (GFR) in women with polycystic ovary syndrome (PCOS) and to determine the relationship between GFR with C-reactive protein (CRP) and uric acid. Materials and Methods In this cross-sectional study, one-hundred and forty PCOS women and 60 healthy subjects were evaluated. The study was carried out at Endocrinol- ogy Outpatient Clinic, Erzurum Training and Research Hospital, Erzurum, Turkey, from December 2010 to January 2011. GFRs were estimated by Modification of Diet in Renal Disease (MDRD) formula. CRP, urinary albumin excretion (UAE) and uric acid levels were also measured. Results GFRs were significantly higher in PCOS group than control (135.24 ± 25.62 vs. 114.92 ± 24.07 ml/min per 1.73 m2). CRP levels were significantly higher in PCOS patients (4.4 ± 3.4 vs. 2.12 ± 1.5 mg/l). The PCOS group had significantly higher serum uric acid levels (4.36 ± 1.3 mg/dl vs. 3.2 ± 0.73 mg/dl). There was also significantly higher pro...
International Journal of Hematology and Oncology, 2013
Although regimens of harvesting peripheric stem cell vary from one center to another, the most co... more Although regimens of harvesting peripheric stem cell vary from one center to another, the most common ones are chemotherapy plus growth factor or growth factor alone. We aimed to determine which variables of harvesting peripheral stem cells are effective on the number of harvested CD34+ cells and successfull mobilisation defined as "the collection of >2.0 x 106 CD34+ cells/kg b.w. with a maximum of three leukaphereres". From August 2008 to January 2011, the documents of 56 patients included in the autologous peripheral stem cell harvesting program were retrieved retrospectively. Regarding harvesting regimens, 28 patients (50.0%) were administered filgrastim 10 µg/kg/day (filgrastim group), 18 patients (32.1%) were administered a standard regime with ifosphamide + etoposide + epirubicin + filgrastim 5 µg/kg/day or cyclophosphamide + etoposide + filgrastim 5 µg/kg/day (standard group), and 10 patients (17.9%) were administered a salvage regime + filgrastim 5 µg/kg/day (salvage group). Rituximab was added if the disease was CD20 positive. The median number of CD34+ cells and the number of inadequate collection did not differ between these 3 groups. Transplantation before mobilization was found to have a negative effect on the harvesting success. The transplantated patients had a lower number of harvested CD34+ cells than the patients without transplantation history. But no clear relationship was seen between harvest success and the diagnosis of the patients, pretransplant response, radiotherapy history before mobilization, or mobilization with a standard regimen. Finally, the number of standard CT cycles before mobilization were found to have a borderline negative effect on the harvested CD34+ cells.
Turkiye Klinikleri Journal of Rheumatology Special Topics, 2012
Journal of Investigative Medicine, 2015
Background / Purpose: The aim of this study was to determine the protective effect of erdosteine ... more Background / Purpose: The aim of this study was to determine the protective effect of erdosteine on Cyclosporine (CsA) induced chronic nephrotoxicity.We assessed oxidative stress enzymes (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx), malondialdehyde (MDA) and nitric oxide (NO) levels) and light microscopic changes before and after erdosteine treatment in damaged kidneys. The rats were assigned randomly to one of four groups, these were: control group (n=8), CsA group (15 mg/kg day, n=8), erdosteine treated group (10 mg/kg day orally, n=8) and CsA+ erdosteine group (n=8). CsA nephrotoxicity was induced by administrating oral dose of 15 mg/kg CsA daily for 21 days. Main conclusion: For the first time, we have demonstrated in vivo that erdosteine causes improvement in CsA related nephrotoxicity by increasing GSHPx, CAT, MDA and NO levels. Histological clues of renal damage can be diminished by erdostein treatment. As an exogenous antioxidant agent, erdoste...