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Papers by Devolina Bhowmik

The Journal of Shaheed Suhrawardy Medical College/Journal of Shaheed Suhrawardy Medical College, May 14, 2024

Background: Psoriasis is an autoimmune chronic inflammatory disease where serum cytokines are mar... more Background: Psoriasis is an autoimmune chronic inflammatory disease where serum cytokines are marked as prime drivers of disease progression and severity. Objectives: To investigate serum TNF-α, IL-17 and IL-23 level according to disease severity of psoriasis. Methods: A total of 35 psoriasis patients and 35 healthy controls were enrolled. Disease severity of psoriatic patients was assessed by Psoriasis Area and Severity Index (PASI) scoring. Serum TNF-α, IL-17 and IL-23 of study subjects were measured by ELISA. Results: Serum level of is significantly increased in psoriasis patients than healthy controls. Among 35 patient 56.7% were suffering from moderate to severe psoriasis. Serum TNF-α level was more in mild group (P =0.70) and serum IL-23 level increased in moderate to severe psoriasis (P=0.42). Whereas serum IL-17 level significantly increased along with disease severity (P=0.03). Conclusion: Our study underscores the role of TNF-α, IL-17 and IL-23 in disease severity of psoriasis.

$Research paper thumbnail of Complications of Ilizarov method treatment for infected nonunion femoral shaft fracture$

International journal of research in orthopaedics, Apr 29, 2024

Infected nonunion of the femur is not uncommon in clinical practice, but the treatment of this di... more Infected nonunion of the femur is not uncommon in clinical practice, but the treatment of this disease has been a challenge for orthopedic surgeons. 1,2 Some related factors usually complicate the infected non-union including bone loss, deformities, limb-length inequalities, and polybacterial infection. 3 Ilizarov's methods can eliminate infection, recompense for bone defects, and ABSTRACT Background: Infected non-union of the femur is complicated by the involvement of soft tissue and bone, long-term resistant multi-bacterial infection, limb length discrepancy, deformities, joint stiffness, and multiple draining sinuses, and poses a challenge for orthopedic surgeons. This study aimed to analyze the complications of Ilizarov method treatment for infected non-union femoral shaft fracture. Methods: This prospective observational study was conducted at the national institute of traumatology and orthopedic rehabilitation (NITOR), Dhaka, Bangladesh, from May 2018 to August 2020. A total of 20 patients were selected as study subjects by purposive sampling technique. All data were collected using a pre-formed questionnaire. Data were processed and analyzed using computer software program SPSS version 22.0. Result: The mean bone gap created during the operation was 2.7±1.7 cm of them, in 12 (60%) patients, it was 0 to 2 cm, and in 8 (40%) patients it was more than 2 cm. The mean time needed for radiological union was 7.85±2.1 months ranging from 5 months to 11 months. In 10 (50%) patients, union was achieved within 4 to 7 months, and in 10 (50%) patients it was 8 to 11 months. Regarding limb length discrepancy, in 5 (25%) cases there was no limb length discrepancy (LLD). Twelve patients had 1 cm to 2.4 cm LLD and 3 (15%) patients had ≥2.5 cm LLD. The mean LLD was 1.2±0.9 cm. Regarding complications, in 10 (50%) cases, there was no complication and 10 (50%) patients had complications. The complications were pin tract infection in 7 (35%) patients and wire loosening in 3 (15%) patients. Conclusions: The study concludes that while the Ilizarov ring fixator proves to be a dependable and successful method for stabilizing, correcting length discrepancies, and eliminating infections, it is not without its share of complications. The findings of this research indicate a 50% complication rate among the patients undergoing this treatment.

Psoriatic arthritis is an inflammatory arthritis associated with psoriasis. Both rheumatoid facto... more Psoriatic arthritis is an inflammatory arthritis associated with psoriasis. Both rheumatoid factor and anti-cyclic citrullinated peptide antibodies positive psoriatic arthritis patients may be in risk for development of symmetrical polyarthritis pattern. Symmetrical polyarthritis pattern was predominant (42%) among clinical pattern of psoriatic arthritis. Among 10 rheumatoid factor positive patients, 8 (80%) patients had symmetrical polyarthritis pattern and out of 7 anti-cyclic citrullinated peptide antibody positive patients, 7 (100%) patients had symmetrical polyarthritis pattern. Association of anti-cyclic citrullinated peptide (P = 0.008) and rheumatoid factor (P = 0.006) showed statistical significance with symmetrical polyarthritis pattern. Human leukocyte antigen-B*07, *38 and human leukocyte antigen-C*07 were predominantly found in rheumatoid factor and anti-cyclic citrullinated peptide positive psoriatic arthritis patients.

Journal of Shaheed Suhrawardy Medical College, Sep 17, 2019

Background: Tuberculosis is a highly infectious disease and has the highest burden with it. Diagn... more Background: Tuberculosis is a highly infectious disease and has the highest burden with it. Diagnosis of tuberculosis in many countries is still dependent on microscopy. For developing countries with a large number of cases and financial constraints, evaluation of rapid and inexpensive diagnostic methods has great importance. Culture of Mycobacterium tuberculosis complex (MtbC) is the accepted reference standard for confirmation of TB infection and is necessary for drug susceptibility testing (DST). There are several methods for culturing MtbC using solid and liquid media. Although solid media has been used for over 100 years, liquid culture media is increasingly being introduced in low and middle income countries (LMIC). Objective: The purpose of the present study was to compare the efficacy of solid culture and liquid culture in the diagnosis of pulmonary tuberculosis.

Bangladesh Journal of Medical Microbiology, Aug 16, 2018

This study was designed to investigate the distribution of HLA-B locus antigens in patients with ... more This study was designed to investigate the distribution of HLA-B locus antigens in patients with psoriatic arthritis (PsA) in Bangladesh and identify HLA markers related to disease manifestation in PsA. HLA-B typing was carried out by polymerase chain reaction (PCR) with sequence specific primers in a group of 50 consecutive PsA patients. The reports of HLA-B locus antigens typing were collected from 50 ages and sex matched unrelated healthy donors as controls. A total of 17 HLA-B locus antigens were determined in both patients and controls. The most common antigen was B*15 (34%) followed by B*07 (26%), B*27 (24%), B*38 (20%). Human leukocyte antigens B*07, B*27 and B*38 alleles were found to be significantly prevalent in PsA patients compared with healthy controls. We found a statistically significant association between spondylitis pattern and the presence of HLA-B*27. PsA in Bangladeshi patients seems to be associated with the presence of B*07, B*27 and B*38 alleles.

Aging Communications

Journal of Shaheed Suhrawardy Medical College, 2022

Introduction: Psoriatic arthritis (PsA) is established as a multifactorial disease resulting from... more Introduction: Psoriatic arthritis (PsA) is established as a multifactorial disease resulting from a complex interplay between genetic, environmental and immunological factors. It is a seronegative arthritis but rheumatoid factor may be present in up to 15% of PsA patients Antibodies recognizing a cyclic citrullinated peptide are highly speciûc for rheumatoid arthritis (RA) but their role in PsA remains unclear. An increased prevalence of anti-CCP antibody in PsA is also reported. Study shows that HLA-DRB1 shared epitope is signiûcantly associated with the presence of anti-CCP antibody in PsA patients but this type of association is not found with other human leukocyte antigens. Objectives: The aim of this study was to investigate the frequency of anti-CCP and RF in PsA patients and their associations with HLA-B locus antigens. Methods: In this cross sectional study, we selected 50 unrelated consecutive patients with PsA according to CASPAR criteria for PsA. 6 ml of blood was collect...

Bangladesh Journal of Medical Microbiology

Journal of Shaheed Suhrawardy Medical College