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Research paper thumbnail of Identification of Potential COX-2 Inhibitors from Phytochemical Constituents of Indian “Garam Masala” Using in Silico Analysis

Innovare journal of medical sciences, Mar 1, 2022

Objective: The objective of the study was to analyze the active principles of "Garam Masala" (rou... more Objective: The objective of the study was to analyze the active principles of "Garam Masala" (routinely used spice-mix in Indian cuisine) for their antiinflammatory potential against Cyclooxygenase-2 (COX-2), a crucial player in inflammatory response in humans, using molecular docking simulation. Methods: After obtaining three-dimensional structures of spice phytochemicals and COX-2 protein from PUBCHEM and PDB databases, phytochemicals with suitable absorption, distribution, metabolism, and excretion (ADME) properties were docked against COX-2 protein using PyRx and AutoDock tools 1.5.6 and their binding properties were compared with "Coxibs" drugs (NSAIDs, known COX-2 inhibitors) to establish their anti-COX-2 potential. Results: Farnesiferol A showed better binding affinity to COX-2 whereas three other phytochemicals Piperine, Cedrelanol, and Usnic acid demonstrated comparable binding affinity like those of "coxibs." Conclusion: Molecular docking simulation and ADME analysis reveal that Farnesiferol A, Piperine, Cedrelanol, and Usnic acid could be considered for potential drug candidates for COX-2 inhibition due to their promising binding affinities with COX-2.

Research paper thumbnail of Identification of Potential COX-2 Inhibitors from Phytochemical Constituents of Indian “Garam Masala” Using in Silico Analysis

Innovare journal of medical sciences, Mar 1, 2022

Objective: The objective of the study was to analyze the active principles of "Garam Masala" (rou... more Objective: The objective of the study was to analyze the active principles of "Garam Masala" (routinely used spice-mix in Indian cuisine) for their antiinflammatory potential against Cyclooxygenase-2 (COX-2), a crucial player in inflammatory response in humans, using molecular docking simulation. Methods: After obtaining three-dimensional structures of spice phytochemicals and COX-2 protein from PUBCHEM and PDB databases, phytochemicals with suitable absorption, distribution, metabolism, and excretion (ADME) properties were docked against COX-2 protein using PyRx and AutoDock tools 1.5.6 and their binding properties were compared with "Coxibs" drugs (NSAIDs, known COX-2 inhibitors) to establish their anti-COX-2 potential. Results: Farnesiferol A showed better binding affinity to COX-2 whereas three other phytochemicals Piperine, Cedrelanol, and Usnic acid demonstrated comparable binding affinity like those of "coxibs." Conclusion: Molecular docking simulation and ADME analysis reveal that Farnesiferol A, Piperine, Cedrelanol, and Usnic acid could be considered for potential drug candidates for COX-2 inhibition due to their promising binding affinities with COX-2.

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