Dhwani Patel - Academia.edu (original) (raw)
Papers by Dhwani Patel
Blood, 2021
Background and Scientific Rationale: Multiple myeloma (MM) is often preceded by the premalignant ... more Background and Scientific Rationale: Multiple myeloma (MM) is often preceded by the premalignant conditions monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). Obesity, low adiponectin levels, and diets high in inflammatory, insulinemic foods or lacking plant-based foods are known risk factors for the development of MGUS/SMM, as well as for progression to MM. Therefore, there is an opportunity to study a dietary intervention in cancer progression among patients with MGUS/SMM, for which the standard of care is observation even though some patients will eventually progress to MM. This is a pilot nutrition-based intervention study of a whole food, plant-based diet (WFPBD) in overweight and obese MGUS and SMM patients to enable weight loss, assess associated changes in disease biomarkers, epigenetics, and the gut microbiome. We expect that the findings will enable larger lifestyle-based studies of prevention and survivorship in plasma cell di...
International Journal of Health Research and Medico-Legal Practice, 2021
Medico-Legal Update, 2021
The growing number of legal issues in various fields and specialties in the current era has been ... more The growing number of legal issues in various fields and specialties in the current era has been no different in the healthcare sector. The complexity associated with such issues has been the major concern of practicing doctors/healthcare professionals. In this article, an attempt has been made to focus the legalities in the field of medicine with an emphasis on the Indian set up and existing Laws governing such actions. The article comprises of medico-legal case management, awareness and prevalent practices among the health care professionals especially among those who are directly or indirectly involved with the treatment of patients. As far the awareness is concerned regarding a procedure, the documentation and various other medico-legal issues were studied in detail. Also, various aspects of medico-legal cases admitted in the hospital.
Several risk stratification tools are available to predict short term mortality in patients with ... more Several risk stratification tools are available to predict short term mortality in patients with acute pulmonary embolism (PE). Right ventricular (RV) dysfunction, which is common to intermediate and high risk PE, is an independent predictor of mortality and may be a faster and simpler way to assess patient risk in acute care settings. We evaluated 571 patients presenting with acute PE as the primary diagnosis, stratifying them by the Pulmonary Embolism Severity Index (PESI), by the BOVA score, or categorically as low risk (no RV dysfunction by imaging), intermediate risk (RV dysfunction by imaging), or high risk PE (RV dysfunction by imaging with sustained hypotension). Using imaging data to firstly define the presence of RV dysfunction, and plasma cardiac troponin T (cTnT) and NTproBNP as additional evidence for myocardial strain, we evaluated the PESI and BOVA scoring systems compared to categorical assignment of PE as low risk, submassive, and massive PE. Cardiac biomarkers poor...
Canola (Brassica napus) is an important agricultural crop in Australia. Its value as an agricultu... more Canola (Brassica napus) is an important agricultural crop in Australia. Its value as an agricultural commodity has dramatically increased over the past few years to >$2000 million (AUD) in 2015. However, the production of this prosperous crop is threatened by up to 34 different pests, including fungal, bacterial and viral pathogens. Diseases caused by these pathogens lead to substantial crop losses that collectively amount to 130million(AUD)eachyear.Leptosphaeriamaculans(blackleg)isaubiquitousascomycetefungusthatisthemajorcausalagentofdiseaseoncanolaplants.Itiscalledblacklegduetoitsnecrotrophiceffectsthatcausestemcankeratthebaseofthestemduringthelaststagesofinfection.WhencanolawasfirstintroducedtoAustraliaasanagriculturalcropinthe1970s,blacklegdiseaseledtoalmost90130 million (AUD) each year. Leptosphaeria maculans (blackleg) is a ubiquitous ascomycete fungus that is the major causal agent of disease on canola plants. It is called blackleg due to its necrotrophic effects that cause stem canker at the base of the stem during the last stages of infection. When canola was first introduced to Australia as an agricultural crop in the 1970s, blackleg disease led to almost 90% crop losses, threatening to drive the nascent canola industry in Australia to the ground. In recent years, crop losses still amount to 130million(AUD)eachyear.Leptosphaeriamaculans(blackleg)isaubiquitousascomycetefungusthatisthemajorcausalagentofdiseaseoncanolaplants.Itiscalledblacklegduetoitsnecrotrophiceffectsthatcausestemcankeratthebaseofthestemduringthelaststagesofinfection.WhencanolawasfirstintroducedtoAustraliaasanagriculturalcropinthe1970s,blacklegdiseaseledtoalmost9076.6 million (AUD) per annum. Therefore, it is imperative to devise methods to control the devastating effects of this pathogen to protect this economically significant crop. In order to do so, we must decipher the genomic content that drives this pathogen to cause large-scale infections in the field. Blackleg disease is a major concern not only in Australia, but also in other parts of the world such as Europe and Canada. Over the past few years, scientists have made significant advances in decoding the genome of this pathogen. It has been established that L. maculans interacts in a genefor-gene manner with its host. It is composed of disease-causing avirulence (Avr) genes that are specifically recognised by the corresponding resistance (R) gene in the host plant. The specific location and characterisation of the Avr genes AvrLm1,
Forensic Science International: Reports, 2019
Abstract The non-metric characteristics like the tooth shape, number of cusps and other structura... more Abstract The non-metric characteristics like the tooth shape, number of cusps and other structural features contribute for the forensic and anthropological investigations and in establishing the population inter-relationships. The mandibular 2nd premolar and the maxillary 2nd molars often show variations in their occlusal morphology. The Hardy-Weinberg equilibrium is applied in a novel way to determine the cusp phenotype in these two teeth in a representative sample from Gujarati population. The dental stone models of 295 students of dental college in the age range of 19–23 years were used for this study. The two-cusped second premolar was present in around 60% the subjects on both the right and left side. There is no significant difference in the distribution of the number of cusps in both the right and left second premolars between male and female subjects. There was a significant difference in the distribution of the number of cusps in left second molar between male and female (χ2 = 4.073, df = 2, p
Blood, 2021
Background and Scientific Rationale: Multiple myeloma (MM) is often preceded by the premalignant ... more Background and Scientific Rationale: Multiple myeloma (MM) is often preceded by the premalignant conditions monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). Obesity, low adiponectin levels, and diets high in inflammatory, insulinemic foods or lacking plant-based foods are known risk factors for the development of MGUS/SMM, as well as for progression to MM. Therefore, there is an opportunity to study a dietary intervention in cancer progression among patients with MGUS/SMM, for which the standard of care is observation even though some patients will eventually progress to MM. This is a pilot nutrition-based intervention study of a whole food, plant-based diet (WFPBD) in overweight and obese MGUS and SMM patients to enable weight loss, assess associated changes in disease biomarkers, epigenetics, and the gut microbiome. We expect that the findings will enable larger lifestyle-based studies of prevention and survivorship in plasma cell di...
International Journal of Health Research and Medico-Legal Practice, 2021
Medico-Legal Update, 2021
The growing number of legal issues in various fields and specialties in the current era has been ... more The growing number of legal issues in various fields and specialties in the current era has been no different in the healthcare sector. The complexity associated with such issues has been the major concern of practicing doctors/healthcare professionals. In this article, an attempt has been made to focus the legalities in the field of medicine with an emphasis on the Indian set up and existing Laws governing such actions. The article comprises of medico-legal case management, awareness and prevalent practices among the health care professionals especially among those who are directly or indirectly involved with the treatment of patients. As far the awareness is concerned regarding a procedure, the documentation and various other medico-legal issues were studied in detail. Also, various aspects of medico-legal cases admitted in the hospital.
Several risk stratification tools are available to predict short term mortality in patients with ... more Several risk stratification tools are available to predict short term mortality in patients with acute pulmonary embolism (PE). Right ventricular (RV) dysfunction, which is common to intermediate and high risk PE, is an independent predictor of mortality and may be a faster and simpler way to assess patient risk in acute care settings. We evaluated 571 patients presenting with acute PE as the primary diagnosis, stratifying them by the Pulmonary Embolism Severity Index (PESI), by the BOVA score, or categorically as low risk (no RV dysfunction by imaging), intermediate risk (RV dysfunction by imaging), or high risk PE (RV dysfunction by imaging with sustained hypotension). Using imaging data to firstly define the presence of RV dysfunction, and plasma cardiac troponin T (cTnT) and NTproBNP as additional evidence for myocardial strain, we evaluated the PESI and BOVA scoring systems compared to categorical assignment of PE as low risk, submassive, and massive PE. Cardiac biomarkers poor...
Canola (Brassica napus) is an important agricultural crop in Australia. Its value as an agricultu... more Canola (Brassica napus) is an important agricultural crop in Australia. Its value as an agricultural commodity has dramatically increased over the past few years to >$2000 million (AUD) in 2015. However, the production of this prosperous crop is threatened by up to 34 different pests, including fungal, bacterial and viral pathogens. Diseases caused by these pathogens lead to substantial crop losses that collectively amount to 130million(AUD)eachyear.Leptosphaeriamaculans(blackleg)isaubiquitousascomycetefungusthatisthemajorcausalagentofdiseaseoncanolaplants.Itiscalledblacklegduetoitsnecrotrophiceffectsthatcausestemcankeratthebaseofthestemduringthelaststagesofinfection.WhencanolawasfirstintroducedtoAustraliaasanagriculturalcropinthe1970s,blacklegdiseaseledtoalmost90130 million (AUD) each year. Leptosphaeria maculans (blackleg) is a ubiquitous ascomycete fungus that is the major causal agent of disease on canola plants. It is called blackleg due to its necrotrophic effects that cause stem canker at the base of the stem during the last stages of infection. When canola was first introduced to Australia as an agricultural crop in the 1970s, blackleg disease led to almost 90% crop losses, threatening to drive the nascent canola industry in Australia to the ground. In recent years, crop losses still amount to 130million(AUD)eachyear.Leptosphaeriamaculans(blackleg)isaubiquitousascomycetefungusthatisthemajorcausalagentofdiseaseoncanolaplants.Itiscalledblacklegduetoitsnecrotrophiceffectsthatcausestemcankeratthebaseofthestemduringthelaststagesofinfection.WhencanolawasfirstintroducedtoAustraliaasanagriculturalcropinthe1970s,blacklegdiseaseledtoalmost9076.6 million (AUD) per annum. Therefore, it is imperative to devise methods to control the devastating effects of this pathogen to protect this economically significant crop. In order to do so, we must decipher the genomic content that drives this pathogen to cause large-scale infections in the field. Blackleg disease is a major concern not only in Australia, but also in other parts of the world such as Europe and Canada. Over the past few years, scientists have made significant advances in decoding the genome of this pathogen. It has been established that L. maculans interacts in a genefor-gene manner with its host. It is composed of disease-causing avirulence (Avr) genes that are specifically recognised by the corresponding resistance (R) gene in the host plant. The specific location and characterisation of the Avr genes AvrLm1,
Forensic Science International: Reports, 2019
Abstract The non-metric characteristics like the tooth shape, number of cusps and other structura... more Abstract The non-metric characteristics like the tooth shape, number of cusps and other structural features contribute for the forensic and anthropological investigations and in establishing the population inter-relationships. The mandibular 2nd premolar and the maxillary 2nd molars often show variations in their occlusal morphology. The Hardy-Weinberg equilibrium is applied in a novel way to determine the cusp phenotype in these two teeth in a representative sample from Gujarati population. The dental stone models of 295 students of dental college in the age range of 19–23 years were used for this study. The two-cusped second premolar was present in around 60% the subjects on both the right and left side. There is no significant difference in the distribution of the number of cusps in both the right and left second premolars between male and female subjects. There was a significant difference in the distribution of the number of cusps in left second molar between male and female (χ2 = 4.073, df = 2, p