Dilek Aydın - Academia.edu (original) (raw)

Papers by Dilek Aydın

Research paper thumbnail of Gender differences in polysomnographic findings in Turkish patients with obstructive sleep apnea syndrome

European Archives of Oto-Rhino-Laryngology, 2008

Research paper thumbnail of Association of sleep apnea with coronary slow-flow phenomenon

Journal of Cardiovascular Medicine, 2012

Both obstructive sleep apnea (OSA) and coronary slow-flow phenomenon (CSFP) are known to share si... more Both obstructive sleep apnea (OSA) and coronary slow-flow phenomenon (CSFP) are known to share similar etiopathogenic mechanisms, such as chronic sympathetic activation, upregulation of inflammatory pathways, oxidative stress and, finally, endothelial dysfunction. We evaluated whether there is an association between OSA and coronary flow rates. We retrospectively reviewed medical records of all patients who underwent diagnostic nocturnal polysomnography for suspected OSA. Those who had coronary angiography performed within the same year of polysomnography were divided into two main groups: those with (group 1) and without (group 2) OSA; also, angiographic coronary TIMI (thrombolysis in myocardial infarction) frame counts (TFC) were compared between the groups. Patients with coronary arterial stenosis and angiograms with inadequate filling of the coronary arteries or visualization of the distal landmarks for frame counting were excluded from the study. There was a statistically significant difference between the groups regarding TFCs. We found a significant positive correlation between mean TFC and apnea-hypopnea index (r=0.611, P<0.001). The current study demonstrated that sleep apnea impairs coronary flow rates and is associated with CSFP.

Research paper thumbnail of Influence of the right- versus left-sided sleeping position on the apnea-hypopnea index in patients with sleep apnea

Sleep and Breathing, 2012

Purpose Sleep and sleep position have a significant impact on physical, cardiac and mental health... more Purpose Sleep and sleep position have a significant impact on physical, cardiac and mental health, and have been evaluated in numerous studies particularly in terms of lateral sleeping positions and their association with diseases. We retrospectively examined the relationship between the sleeping position and position-specific apneahypopnea index (AHI) in obstructive sleep apnea-hypopnea (OSA) patients. Methods We assessed the sleeping body position and the body position-specific AHI score in patients who were referred for suspected OSA and underwent diagnostic nocturnal polysomnography. In order to eliminate interindividual differences, only those who had a similar percentage of time spent in the LSSP and RSSP for each patient were enrolled. To provide this validity, only subjects that had a similar percentage of left and right lateral sleep time (±10%) were included in the analysis. Results A total of 864 patients had nocturnal diagnostic PSG. Of them, 131 patients met the inclusion criteria. The percent rate spent in the supine sleeping position (SSP) was 31.3±18.7%, in the LSSP was 31.8±10% and in the RSSP was 32.6±10.8%. Whereas the SSP-specific AHI score was the highest with 60.4±36.2/h among all the sleeping position-specific AHI scores (p<0.001), the LSSP-specific AHI score was statistically higher than that for RSSP (30.2 ±32.6/h vs. 23.6±30.1/h; p<0.001). When comparing individuals sub-grouped based on OSA severity, there was a statistically significant difference between the LSSPspecific AHI score and RSSP-specific AHI score in patients with severe (p=0.002) and moderate (p=0.026), but not mild (p=0.130) OSA. Conclusion We found that the sleeping position had a significant influence on apneic events and RSSP decreased the frequency of obstructive respiratory events in patients with moderate and severe disease.

Research paper thumbnail of Existence of anti-tobacco news in selected newspapers: Example from Turkey Hacettepe University non-smokers' group

ABSTRACT Aim: In this study, we aimed to evaluate the existence of tobacco news, anti tobacco con... more ABSTRACT Aim: In this study, we aimed to evaluate the existence of tobacco news, anti tobacco concern in selected Turkish daily newspapers between 1-15 April, 2008. Materials and methods: The most frequently circulated six newspapers between 1-15 April, 2008 were assessed during the study. The total number of the newspapers was 90. We used a questionnaire to gather the information about the news’ content, etc. Findings: Ninety newspapers had 24 news (daily) concerning tobacco related issues (%24.6). Two news per day at weekends and 1.5 news per days during the week were published. News existed in the supplements more than the main body of the newspapers. The news were published in the 3rd and 4th pages. Only one of news was presented as first page news in the supplement. The frequency of photograph in the news was 58,3%. Only four (16,7%) news had information about the health hazards of smoking. Majority of the news did not include smoking rates in the community (83,3%), campaign to support quitting (87,5%). Seven news had a promoting image in terms of smoking (29,2%). News about anti-tobacco law was announced in only five (20,8%) news. Conclusion: Although Turkey one of the fifteen countries with “smoke-free” legislation in the world, the most popular newspapers were not found to be satisfactory in terms of anti-tobacco campaign support during the study period. Anti tobacco campaigns via media and press should be improved for the most important cause of death in the world and in Turkey. Key words: Anti-tobacco activity, newspaper, news

Research paper thumbnail of Association of sleep apnea with coronary slow-flow phenomenon

Journal of Cardiovascular Medicine, 2012

Both obstructive sleep apnea (OSA) and coronary slow-flow phenomenon (CSFP) are known to share si... more Both obstructive sleep apnea (OSA) and coronary slow-flow phenomenon (CSFP) are known to share similar etiopathogenic mechanisms, such as chronic sympathetic activation, upregulation of inflammatory pathways, oxidative stress and, finally, endothelial dysfunction. We evaluated whether there is an association between OSA and coronary flow rates. We retrospectively reviewed medical records of all patients who underwent diagnostic nocturnal polysomnography for suspected OSA. Those who had coronary angiography performed within the same year of polysomnography were divided into two main groups: those with (group 1) and without (group 2) OSA; also, angiographic coronary TIMI (thrombolysis in myocardial infarction) frame counts (TFC) were compared between the groups. Patients with coronary arterial stenosis and angiograms with inadequate filling of the coronary arteries or visualization of the distal landmarks for frame counting were excluded from the study. There was a statistically significant difference between the groups regarding TFCs. We found a significant positive correlation between mean TFC and apnea-hypopnea index (r=0.611, P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001). The current study demonstrated that sleep apnea impairs coronary flow rates and is associated with CSFP.

Research paper thumbnail of Influence of the right- versus left-sided sleeping position on the apnea-hypopnea index in patients with sleep apnea

Sleep and Breathing, 2012

Purpose Sleep and sleep position have a significant impact on physical, cardiac and mental health... more Purpose Sleep and sleep position have a significant impact on physical, cardiac and mental health, and have been evaluated in numerous studies particularly in terms of lateral sleeping positions and their association with diseases. We retrospectively examined the relationship between the sleeping position and position-specific apneahypopnea index (AHI) in obstructive sleep apnea-hypopnea (OSA) patients. Methods We assessed the sleeping body position and the body position-specific AHI score in patients who were referred for suspected OSA and underwent diagnostic nocturnal polysomnography. In order to eliminate interindividual differences, only those who had a similar percentage of time spent in the LSSP and RSSP for each patient were enrolled. To provide this validity, only subjects that had a similar percentage of left and right lateral sleep time (±10%) were included in the analysis. Results A total of 864 patients had nocturnal diagnostic PSG. Of them, 131 patients met the inclusion criteria. The percent rate spent in the supine sleeping position (SSP) was 31.3±18.7%, in the LSSP was 31.8±10% and in the RSSP was 32.6±10.8%. Whereas the SSP-specific AHI score was the highest with 60.4±36.2/h among all the sleeping position-specific AHI scores (p<0.001), the LSSP-specific AHI score was statistically higher than that for RSSP (30.2 ±32.6/h vs. 23.6±30.1/h; p<0.001). When comparing individuals sub-grouped based on OSA severity, there was a statistically significant difference between the LSSPspecific AHI score and RSSP-specific AHI score in patients with severe (p=0.002) and moderate (p=0.026), but not mild (p=0.130) OSA. Conclusion We found that the sleeping position had a significant influence on apneic events and RSSP decreased the frequency of obstructive respiratory events in patients with moderate and severe disease.

Research paper thumbnail of Influence of the severity of obstructive sleep apnea on nocturnal heart rate indices and its association with hypertension

Anadolu Kardiyoloji Dergisi/The Anatolian Journal of Cardiology, 2011

Both heart rate (HR) and blood pressure parameters provide important information on the pathophys... more Both heart rate (HR) and blood pressure parameters provide important information on the pathophysiology of the cardiovascular regulatory mechanisms, and are mainly affected by the autonomic nervous system. We sought to clarify whether the severity of obstructive sleep apnea (OSA) affects nocturnal HRs and whether there is a relationship between nocturnal HRs and the presence of hypertension. We retrospectively reviewed medical records of all patients who performed nocturnal polysomnography with monitoring of HRs, and examined whether there is a relationship among the nocturnal HRs, the severity of OSA and the presence of hypertension. A total of 540 patients were included in the study. Nocturnal mean and maximal HRs were significantly higher in severe OSA group than in moderate (p=0.002 and p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;0.05 in females; p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.049 and p=0.044, in males, respectively) and mild OSA groups (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001 and p=0.003, respectively in females, p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001 and p=0.004, respectively in males); and there was a positive correlation between the nocturnal mean HR and apnea-hypopnea index (Pearson&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s p=0.504, p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001 in female group; Pearson&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s p=0.254, p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001 in male group) and again the nocturnal mean HR and the presence of HT (Spearman&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s p=0.090, p=0.394 in female group; Spearman&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s p=0.272, p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001 in male group) in both gender groups. We found that nocturnal mean and maximal HRs to be associated with severity of OSA and the presence of hypertension. We speculated that increased nocturnal mean and maximal HRs caused by sympathetic nervous system activation in OSA might be one of the mechanisms in explaining the hypertension and OSA association.

Research paper thumbnail of Gender differences in polysomnographic findings in Turkish patients with obstructive sleep apnea syndrome

European Archives of Oto-Rhino-Laryngology, 2008

In this study, we evaluated the gender diVerences in body mass index (BMI), age and their eVects ... more In this study, we evaluated the gender diVerences in body mass index (BMI), age and their eVects on apnea-hypopnea index during total sleep time (AHI TST ) in the Turkish population who were diagnosed with obstructive sleep apnea syndrome (OSAS) and compared them with data from the literature. A computerized database of 244 Turkish patients (194 males, 50 females) who had undergone overnight polysomnography (PSG) and diagnosed with OSAS at BayÂndÂr Hospital sleep laboratory between October 2004 and January 2007 was reviewed. The male:female ratio of the patients was 3.88:1. Male patients were signiWcantly younger compared to females (48.87 § 10.82 vs 52.94 § 12.14 years, respectively, P = 0.003). The BMI and AHI TST were similar in male and female patients (BMI = 29.52 § 4.63 vs 31.17 § 6.08 kg/ m 2 , respectively, P = 0.083) (AHI TST = 27.45 § 22.97 vs 24.77 § 23.83, respectively, P = 0.149). For the male and female groups, AHI TST increased as BMI increased (P = 0.03, 0.04). The median values of AHI TST in male group, for the normal, overweight and obese + pathological obese groups were 12.45, 20.20 and 23.50, respectively, whereas the median values of AHI TST in female group were 11.10, 10.95 and 26.20, respectively. In the normal and obese + pathological obese groups, there was no statistically signiWcant diVerence according to gender, whereas in the overweight group, male patients had signiWcantly higher AHI TST (P = 0.02). There was no statistically signiWcant diVerence between the male and female patients regarding the severity of OSAS (P = 0.358). However, there was a male tendency to moderate and severe OSAS in the normal and overweight BMI groups. In Turkish patients with OSAS, there was no gender diVerence in BMI and AHI TST and female patients were signiWcantly older than the males. The OSAS was diagnosed in men nearly four times more often than in women.

Research paper thumbnail of Gender differences in polysomnographic findings in Turkish patients with obstructive sleep apnea syndrome

European Archives of Oto-Rhino-Laryngology, 2008

Research paper thumbnail of Association of sleep apnea with coronary slow-flow phenomenon

Journal of Cardiovascular Medicine, 2012

Both obstructive sleep apnea (OSA) and coronary slow-flow phenomenon (CSFP) are known to share si... more Both obstructive sleep apnea (OSA) and coronary slow-flow phenomenon (CSFP) are known to share similar etiopathogenic mechanisms, such as chronic sympathetic activation, upregulation of inflammatory pathways, oxidative stress and, finally, endothelial dysfunction. We evaluated whether there is an association between OSA and coronary flow rates. We retrospectively reviewed medical records of all patients who underwent diagnostic nocturnal polysomnography for suspected OSA. Those who had coronary angiography performed within the same year of polysomnography were divided into two main groups: those with (group 1) and without (group 2) OSA; also, angiographic coronary TIMI (thrombolysis in myocardial infarction) frame counts (TFC) were compared between the groups. Patients with coronary arterial stenosis and angiograms with inadequate filling of the coronary arteries or visualization of the distal landmarks for frame counting were excluded from the study. There was a statistically significant difference between the groups regarding TFCs. We found a significant positive correlation between mean TFC and apnea-hypopnea index (r=0.611, P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001). The current study demonstrated that sleep apnea impairs coronary flow rates and is associated with CSFP.

Research paper thumbnail of Influence of the right- versus left-sided sleeping position on the apnea-hypopnea index in patients with sleep apnea

Sleep and Breathing, 2012

Purpose Sleep and sleep position have a significant impact on physical, cardiac and mental health... more Purpose Sleep and sleep position have a significant impact on physical, cardiac and mental health, and have been evaluated in numerous studies particularly in terms of lateral sleeping positions and their association with diseases. We retrospectively examined the relationship between the sleeping position and position-specific apneahypopnea index (AHI) in obstructive sleep apnea-hypopnea (OSA) patients. Methods We assessed the sleeping body position and the body position-specific AHI score in patients who were referred for suspected OSA and underwent diagnostic nocturnal polysomnography. In order to eliminate interindividual differences, only those who had a similar percentage of time spent in the LSSP and RSSP for each patient were enrolled. To provide this validity, only subjects that had a similar percentage of left and right lateral sleep time (±10%) were included in the analysis. Results A total of 864 patients had nocturnal diagnostic PSG. Of them, 131 patients met the inclusion criteria. The percent rate spent in the supine sleeping position (SSP) was 31.3±18.7%, in the LSSP was 31.8±10% and in the RSSP was 32.6±10.8%. Whereas the SSP-specific AHI score was the highest with 60.4±36.2/h among all the sleeping position-specific AHI scores (p<0.001), the LSSP-specific AHI score was statistically higher than that for RSSP (30.2 ±32.6/h vs. 23.6±30.1/h; p<0.001). When comparing individuals sub-grouped based on OSA severity, there was a statistically significant difference between the LSSPspecific AHI score and RSSP-specific AHI score in patients with severe (p=0.002) and moderate (p=0.026), but not mild (p=0.130) OSA. Conclusion We found that the sleeping position had a significant influence on apneic events and RSSP decreased the frequency of obstructive respiratory events in patients with moderate and severe disease.

Research paper thumbnail of Existence of anti-tobacco news in selected newspapers: Example from Turkey Hacettepe University non-smokers' group

ABSTRACT Aim: In this study, we aimed to evaluate the existence of tobacco news, anti tobacco con... more ABSTRACT Aim: In this study, we aimed to evaluate the existence of tobacco news, anti tobacco concern in selected Turkish daily newspapers between 1-15 April, 2008. Materials and methods: The most frequently circulated six newspapers between 1-15 April, 2008 were assessed during the study. The total number of the newspapers was 90. We used a questionnaire to gather the information about the news’ content, etc. Findings: Ninety newspapers had 24 news (daily) concerning tobacco related issues (%24.6). Two news per day at weekends and 1.5 news per days during the week were published. News existed in the supplements more than the main body of the newspapers. The news were published in the 3rd and 4th pages. Only one of news was presented as first page news in the supplement. The frequency of photograph in the news was 58,3%. Only four (16,7%) news had information about the health hazards of smoking. Majority of the news did not include smoking rates in the community (83,3%), campaign to support quitting (87,5%). Seven news had a promoting image in terms of smoking (29,2%). News about anti-tobacco law was announced in only five (20,8%) news. Conclusion: Although Turkey one of the fifteen countries with “smoke-free” legislation in the world, the most popular newspapers were not found to be satisfactory in terms of anti-tobacco campaign support during the study period. Anti tobacco campaigns via media and press should be improved for the most important cause of death in the world and in Turkey. Key words: Anti-tobacco activity, newspaper, news

Research paper thumbnail of Association of sleep apnea with coronary slow-flow phenomenon

Journal of Cardiovascular Medicine, 2012

Both obstructive sleep apnea (OSA) and coronary slow-flow phenomenon (CSFP) are known to share si... more Both obstructive sleep apnea (OSA) and coronary slow-flow phenomenon (CSFP) are known to share similar etiopathogenic mechanisms, such as chronic sympathetic activation, upregulation of inflammatory pathways, oxidative stress and, finally, endothelial dysfunction. We evaluated whether there is an association between OSA and coronary flow rates. We retrospectively reviewed medical records of all patients who underwent diagnostic nocturnal polysomnography for suspected OSA. Those who had coronary angiography performed within the same year of polysomnography were divided into two main groups: those with (group 1) and without (group 2) OSA; also, angiographic coronary TIMI (thrombolysis in myocardial infarction) frame counts (TFC) were compared between the groups. Patients with coronary arterial stenosis and angiograms with inadequate filling of the coronary arteries or visualization of the distal landmarks for frame counting were excluded from the study. There was a statistically significant difference between the groups regarding TFCs. We found a significant positive correlation between mean TFC and apnea-hypopnea index (r=0.611, P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001). The current study demonstrated that sleep apnea impairs coronary flow rates and is associated with CSFP.

Research paper thumbnail of Influence of the right- versus left-sided sleeping position on the apnea-hypopnea index in patients with sleep apnea

Sleep and Breathing, 2012

Purpose Sleep and sleep position have a significant impact on physical, cardiac and mental health... more Purpose Sleep and sleep position have a significant impact on physical, cardiac and mental health, and have been evaluated in numerous studies particularly in terms of lateral sleeping positions and their association with diseases. We retrospectively examined the relationship between the sleeping position and position-specific apneahypopnea index (AHI) in obstructive sleep apnea-hypopnea (OSA) patients. Methods We assessed the sleeping body position and the body position-specific AHI score in patients who were referred for suspected OSA and underwent diagnostic nocturnal polysomnography. In order to eliminate interindividual differences, only those who had a similar percentage of time spent in the LSSP and RSSP for each patient were enrolled. To provide this validity, only subjects that had a similar percentage of left and right lateral sleep time (±10%) were included in the analysis. Results A total of 864 patients had nocturnal diagnostic PSG. Of them, 131 patients met the inclusion criteria. The percent rate spent in the supine sleeping position (SSP) was 31.3±18.7%, in the LSSP was 31.8±10% and in the RSSP was 32.6±10.8%. Whereas the SSP-specific AHI score was the highest with 60.4±36.2/h among all the sleeping position-specific AHI scores (p<0.001), the LSSP-specific AHI score was statistically higher than that for RSSP (30.2 ±32.6/h vs. 23.6±30.1/h; p<0.001). When comparing individuals sub-grouped based on OSA severity, there was a statistically significant difference between the LSSPspecific AHI score and RSSP-specific AHI score in patients with severe (p=0.002) and moderate (p=0.026), but not mild (p=0.130) OSA. Conclusion We found that the sleeping position had a significant influence on apneic events and RSSP decreased the frequency of obstructive respiratory events in patients with moderate and severe disease.

Research paper thumbnail of Influence of the severity of obstructive sleep apnea on nocturnal heart rate indices and its association with hypertension

Anadolu Kardiyoloji Dergisi/The Anatolian Journal of Cardiology, 2011

Both heart rate (HR) and blood pressure parameters provide important information on the pathophys... more Both heart rate (HR) and blood pressure parameters provide important information on the pathophysiology of the cardiovascular regulatory mechanisms, and are mainly affected by the autonomic nervous system. We sought to clarify whether the severity of obstructive sleep apnea (OSA) affects nocturnal HRs and whether there is a relationship between nocturnal HRs and the presence of hypertension. We retrospectively reviewed medical records of all patients who performed nocturnal polysomnography with monitoring of HRs, and examined whether there is a relationship among the nocturnal HRs, the severity of OSA and the presence of hypertension. A total of 540 patients were included in the study. Nocturnal mean and maximal HRs were significantly higher in severe OSA group than in moderate (p=0.002 and p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;0.05 in females; p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.049 and p=0.044, in males, respectively) and mild OSA groups (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001 and p=0.003, respectively in females, p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001 and p=0.004, respectively in males); and there was a positive correlation between the nocturnal mean HR and apnea-hypopnea index (Pearson&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s p=0.504, p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001 in female group; Pearson&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s p=0.254, p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001 in male group) and again the nocturnal mean HR and the presence of HT (Spearman&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s p=0.090, p=0.394 in female group; Spearman&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s p=0.272, p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001 in male group) in both gender groups. We found that nocturnal mean and maximal HRs to be associated with severity of OSA and the presence of hypertension. We speculated that increased nocturnal mean and maximal HRs caused by sympathetic nervous system activation in OSA might be one of the mechanisms in explaining the hypertension and OSA association.

Research paper thumbnail of Gender differences in polysomnographic findings in Turkish patients with obstructive sleep apnea syndrome

European Archives of Oto-Rhino-Laryngology, 2008

In this study, we evaluated the gender diVerences in body mass index (BMI), age and their eVects ... more In this study, we evaluated the gender diVerences in body mass index (BMI), age and their eVects on apnea-hypopnea index during total sleep time (AHI TST ) in the Turkish population who were diagnosed with obstructive sleep apnea syndrome (OSAS) and compared them with data from the literature. A computerized database of 244 Turkish patients (194 males, 50 females) who had undergone overnight polysomnography (PSG) and diagnosed with OSAS at BayÂndÂr Hospital sleep laboratory between October 2004 and January 2007 was reviewed. The male:female ratio of the patients was 3.88:1. Male patients were signiWcantly younger compared to females (48.87 § 10.82 vs 52.94 § 12.14 years, respectively, P = 0.003). The BMI and AHI TST were similar in male and female patients (BMI = 29.52 § 4.63 vs 31.17 § 6.08 kg/ m 2 , respectively, P = 0.083) (AHI TST = 27.45 § 22.97 vs 24.77 § 23.83, respectively, P = 0.149). For the male and female groups, AHI TST increased as BMI increased (P = 0.03, 0.04). The median values of AHI TST in male group, for the normal, overweight and obese + pathological obese groups were 12.45, 20.20 and 23.50, respectively, whereas the median values of AHI TST in female group were 11.10, 10.95 and 26.20, respectively. In the normal and obese + pathological obese groups, there was no statistically signiWcant diVerence according to gender, whereas in the overweight group, male patients had signiWcantly higher AHI TST (P = 0.02). There was no statistically signiWcant diVerence between the male and female patients regarding the severity of OSAS (P = 0.358). However, there was a male tendency to moderate and severe OSAS in the normal and overweight BMI groups. In Turkish patients with OSAS, there was no gender diVerence in BMI and AHI TST and female patients were signiWcantly older than the males. The OSAS was diagnosed in men nearly four times more often than in women.