Dilip Gude - Academia.edu (original) (raw)

Papers by Dilip Gude

There is a plethora of biomarkers proposed and being researched in the field of sepsis. The compl... more There is a plethora of biomarkers proposed and being researched in the field of sepsis. The complex pathophysiology of sepsis involves many mediators of inflammation pertaining to coagulation, complement, contact system activation, inflammation, apoptosis, etc. Markers related to those processes can gauge the degree of sepsis. Compared with localized pathology, the systemic nature and involvement of multiple organs in sepsis gives scope for numerous potential biomarkers. There is no ‘gold standard’ for the diagnosis of sepsis. Currently available/in'research biomarkers are compared for t heir efficacy with methods used to diagnose and monitor sepsis such as combination of clinical signs and available laboratory variables. An arbitrary classification of these biomarkers is made and the literature surrounding these markers and their efficacy in diagnosis of sepsis is reviewed.

Journal of the Scientific Society

Hyperkalemia with normal or minimal electrocardiogram (ECG) changes is not commonly encountered. ... more Hyperkalemia with normal or minimal electrocardiogram (ECG) changes is not commonly encountered. The ′milder′ presentation may mask and hence lead to an under-management of a severe hyperkalemia. We discuss a case of severe hyperkalemia secondary to tumor lysis syndrome and its ′innocuous′ ECG changes.

Indian Journal of Paediatric Dermatology

Despite decades of studies, vitiligo still evades us its exact pathophysiology and remains a chal... more Despite decades of studies, vitiligo still evades us its exact pathophysiology and remains a challenge for clinicians. With a devastating cosmetic impact, the implications on the patient are dispiriting. A combination of the different proposed hypotheses may be responsible for its pathophysiologic basis. A variety of hypotheses that included autoimmune, neural, self-destruct and biochemical means to explain the pathophysiologic basis of vitiligo were proposed. But they are increasingly giving way to newer theories that better delineate the basis of the disease and have paved way for different advancements in treatment accordingly. Our newer management modalities have bolstered our weaponry in fighting vitiligo. A review of the newer insights in to the pathophysiology and management of vitiligo is presented.

Journal of the Scientific Society, May 1, 2013

Pioglitazone is a thiazolidinedione that has significant extra-glycemic benefits most promising o... more Pioglitazone is a thiazolidinedione that has significant extra-glycemic benefits most promising of which is its anti-atherogenicity. Pioglitazone may be cardioprotective interfering with atherosclerosis at various points such as atherogenesis, plaque inflammation, plaque rupture and hemostatic disturbances (i.e., thrombus/embolism formation), and microangiopathy. The far reaching effects of pioglitazone and its extra-glycemic benefits warrant a better place for it in the plethora of drugs that a diabetic is treated with. A review of literature is presented.

Journal of Medical Nutrition and Nutraceuticals, Jul 1, 2013

Clinical Kidney Journal, 2012

Annals of cardiac anaesthesia

Journal of pediatric neurosciences, 2011

Journal of the Indian Medical Association, 2013

Acute transverse myelitis is a well known neurological complication occurring in systemic lupus e... more Acute transverse myelitis is a well known neurological complication occurring in systemic lupus erythematosus. Many prior studies have shown a link between transverse myelitis and the presence of antiphospholipid antibodies. Earlier theories have linked thrombotic tendency to be the culprit in such manifestations but currently there is evidence to support other causative mechanisms. A case of a young female diagnosed as systemic lupus erythematosus has been reported who presented with acute transverse myelitis and was found to be seronegative for antiphospholipid antibody. It is important to pay heed to and accordingly treat complications like acute transverse myelitis that occur regardless of antiphospholipid antibody positivity in a systemic lupus erythematosus setting.

International journal of applied & basic medical research, 2011

Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2012

Paraphenylenediamine is an important constituent of hair dye toxicity of which one could herald f... more Paraphenylenediamine is an important constituent of hair dye toxicity of which one could herald fatal complications such as rhabdomyolysis, renal failure, angioneurotic edema, and respiratory failure. We present a case of hair dye poisoning that presented with respiratory distress due to laryngeal edema and later developed trismus, subclinical tetany, apnea, and conduction abnormality on electrocardiogram. This case report highlights the need for a thorough toxicological review of the components of any ingested substance.

Dental research journal, 2012

Periodontal disease is now increasingly believed to play a significant part in various systemic c... more Periodontal disease is now increasingly believed to play a significant part in various systemic conditions. Likewise these systemic diseases and their severity have been found to have an impact on the morbidity of periodontal disease. A number of mechanisms specific to such interlink have been proposed and later established in numerous studies. The disorders with such bidirectional link with periodontal disease include cardiovascular, respiratory, neurological, and connective tissue diseases. The periodontal - systemic interlink has a vibrant effect on the management aspects and is of paramount topical interest to clinicians. We review the pertaining literature (Google scholar and pubmed).

The Journal of the Association of Physicians of India, 2012

Poland syndrome is a rare congenital anomaly typically characterized by unilateral chest wall hyp... more Poland syndrome is a rare congenital anomaly typically characterized by unilateral chest wall hypoplasia and ipsilateral hand abnormalities. Occasionally functionally debilitating, the disorder is mostly benign in nature with the severe deformities requiring surgical correction. A need to watch for possible malignant associations is also warranted. We present a case of a young female with the quintessential features of Poland syndrome with a relatively rare association of ipsilateral renal hypoplasia. We review the literature and discuss the possible renal complications that may arise and their management.

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2012

Journal of pharmacology & pharmacotherapeutics, 2012

The rapidly increasing prevalence of diabetes on a global scale beseeches an urgent need for newe... more The rapidly increasing prevalence of diabetes on a global scale beseeches an urgent need for newer and better treatment options. Our better understanding of the pathophysiology of diabetes has enabled a continual churn out of newer antidiabetic agents with varying modes of action. Sodium-Glucose Transport Proteins-2 inhibitors, dipeptidyl peptidase IV inhibitors, glucagon-like peptide analogues, glucokinase activators, dual peroxisome proliferator-activated receptor agonists, monoclonal antibodies, and dopamine-2 receptor agonists either as monotherapy or combination therapy with the existing oral hypoglycemic agents compound our fight against diabetes. A review of the newer drugs targeting various aspects in the management of diabetes is presented.

Indian journal of occupational and environmental medicine, 2011

... Nampally, Hyderabad, Andhra Pradesh, India. For correspondence: Dr. Dilip Gude, AMC, 3 rd Flo... more ... Nampally, Hyderabad, Andhra Pradesh, India. For correspondence: Dr. Dilip Gude, AMC, 3 rd Floor, Medwin Hospital, Chirag Ali lane, Nampally ... Gujjar lung, a chronic lung disease caused by pinewood smoke inhalation in the Gujjar community is characterized by progressive ...

Pharmacotherapy

Angiotensin-converting enzyme (ACE) inhibitors have been used for more than a decade in the treat... more Angiotensin-converting enzyme (ACE) inhibitors have been used for more than a decade in the treatment of chronic congestive heart failure. In recent years these agents have been used in patients who survived a myocardial infarction. However, primary care providers are often confused as to which patients would benefit the most, and as a result, these life-prolonging drugs are underutilized. The results of randomized controlled trials evaluating ACE inhibitors' effect on morbidity and mortality in patients with chronic congestive heart failure or acute myocardial infarction were evaluated. Angiotensin-converting enzyme inhibitors clearly improve survival in patients with symptomatic congestive heart failure. This survival benefit is approximately 6 months. In patients with asymptomatic systolic dysfunction, these agents also decrease the number of hospital admissions due to heart failure. Angiotensin-converting enzyme inhibitors also improve survival in all patients who experience...

Journal of Family Medicine and Primary Care, 2012

Endosulfan toxicity could precipitate gargantuan jeopardy and may result in irreversible and fata... more Endosulfan toxicity could precipitate gargantuan jeopardy and may result in irreversible and fatal damage. The spectrum of involvement may range from mild nausea, vomiting, and anxiety to intractable seizures and multiorgan damage resulting in death. We report a case of endosulfan poisoning complicated by multi-organ dysfunction, cardiac arrest, and death.