Dineli Bras - Academia.edu (original) (raw)

Papers by Dineli Bras

Veterinary Ophthalmology, Nov 1, 2010

Veterinary Ophthalmology, 2006

Objective To describe the clinical presentation and surgical outcome of diabetic canine patients... more Objective To describe the clinical presentation and surgical outcome of diabetic canine patients with cataracts and preoperative spontaneous lens capsule rupture.Animals studied A total of 20 dogs and 40 eyes were included in the retrospective evaluation. The patients’ ages ranged from 5 to 14 years (mean 8.5 years).Results All dogs had clinical diabetes mellitus, with the duration since diagnosis ranging from 30 to 240 days (mean 123 days). Cataracts were bilateral and noted to have been present for 14–112 days (mean 39 days). Of the 40 eyes affected with cataracts, 30 had a spontaneous rupture of the lens capsule prior to surgery. The capsular rupture was diagnosed on clinical examination in 28/30 eyes and was noted intraoperatively in 2/30. The location of the capsular rupture was equatorial in 29/30 and posterior in 1/30 eyes. Surgery was performed in 38/40 eyes, with one case lost to follow‐up without surgical intervention. Prior to surgery, routine diagnostic ophthalmic exa...

Investigative Ophthalmology & Visual Science, 2009

Acta Ophthalmologica, 2009

ABSTRACT Diabetic dogs rapidly form bilateral sugar cataracts within one year of diagnosis. Simil... more ABSTRACT Diabetic dogs rapidly form bilateral sugar cataracts within one year of diagnosis. Similar sugar cataracts also form in galactose-fed dogs. Since topical KinostatTM has been shown to reverse initial cataract formation in young galactose-fed dogs, we have conducted a proof of concept masked pilot study with 41 newly diagnosed dogs with diabetes mellitus (DM) to investigate whether KinostatTM can inhibit the progression of cataracts in a clinical setting. After obtaining owner consent to participate in the study, all dogs were randomly assigned a coded vial containing either KinostatTM or vehicle for 1 year with the contents of the vial (drug or placebo) masked from the examiners. Thirty dogs received the active agent while the remainder received the placebo vehicle. Owners were instructed to administer the agent 3 times daily to both eyes and compliance was monitored by recording each time of administration. Ocular examinations on dilated eyes conducted at the initial examination and at 1, 2, 3, 6, and 9 month intervals with slit lamp and indirect ophthalmoscopy indicated that KinostatTM is beneficial in arresting the onset and/or progression of cataracts in dogs with DM. The implications of this study for human sugar cataracts will also be discussed. Supported by NIH SBIR 1R43EY018013-01A1Commercial interest

Veterinary Ophthalmology

OBJECTIVE To present a novel case of perinatal bilateral exophthalmos and corneal ulcers in a neo... more OBJECTIVE To present a novel case of perinatal bilateral exophthalmos and corneal ulcers in a neonate Antillean manatee and describe the medical treatment that led to the resolution of the observed clinical signs and vision restoration. ANIMAL STUDIED A manatee stranded alone in Puerto Rico on July 5, 2020. RESULTS The manatee was found in critical condition with pronounced exophthalmos, lagophthalmos, and corneal opacification of both eyes (OU). Vision impairment was evident due to the lack of ocular menace reflex and bumping into the tank's walls. Biomicroscopy revealed conjunctival hyperemia and chemosis, limited third eyelid movement, but had viscous tears present OU. Dense, full-thickness, white to cream-colored cellular infiltrates affected 70% of the cornea with peripheral active vascularization OU. Rubeosis iridis was also present OU. Treatment consisted of supportive medical management, including nutritional support and topical treatment for ulcerative keratitis. Resolution of the corneal ulcers and functional vision were achieved after 6 weeks of therapy. Currently, bilateral, mild, intermittent exophthalmos is observed with no adverse clinical signs, and the calf is in good health. CONCLUSIONS The extent of bilateral corneal disease on a neonatal calf may be a result of an intrauterine infection or possible trauma at or right after birth. While the latter may have led to exophthalmia and consequent corneal disease, the exact cause could not be determined. Supportive therapy and medical management of infectious keratitis were successful and led to vision recovery. This is the first report of ocular pathology in a neonatal manatee.

Veterinary ophthalmology, 2020

AIM To examine the use of prophylactic anti-glaucoma medications in the normotensive fellow eye i... more AIM To examine the use of prophylactic anti-glaucoma medications in the normotensive fellow eye in dogs with unilateral overt primary glaucoma by veterinary ophthalmology clinicians. METHODS A survey of veterinary ophthalmology clinicians was distributed over two international list serves servicing veterinary ophthalmologists, trainees, and individuals whose practice consisted primarily of ophthalmic patients. The survey was developed following analysis of historical and currently available medical options for control of intraocular pressure and for neuroprotection. RESULTS Responses from 199 veterinary ophthalmology clinicians were evaluated. While a large variety of topical anti-hypertensive drugs and protocols were used, the most commonly used medications were aqueous humor production suppressors such as dorzolamide 2.0% ophthalmic solution, timolol 0.5% ophthalmic solution, and a combination product containing both drugs. Latanoprost 0.005% ophthalmic solution was used infrequen...

Veterinary Clinics of North America: Small Animal Practice, 2015

Medical and surgical management of canine glaucoma can be challenging. The goal of surgical treat... more Medical and surgical management of canine glaucoma can be challenging. The goal of surgical treatment is to manipulate the inflow and/or outflow of aqueous humor. This article describes the inflow-reducing, cyclodestructive techniques. Diode cyclophotocoagulation is the most common cyclodestructive procedure performed in humans and animals. Diode laser energy can be applied via a transscleral (transscleral cyclophotocoagulation [TSCP]) or an endoscopic (endoscopic cyclophotocoagulation [ECP]) approach. ECP provides direct visualization of the targeted ciliary body, allowing safer and more titratable treatment than TSCP techniques, offering a better long-term prognosis for vision and intraocular pressure control. Advancements in diode laser therapy seem promising.

Graefe's Archives for Clinical and Experimental Ophthalmology, Aug 1, 2006

Veterinary ophthalmology, 2020

G3 (Bethesda, Md.), Jan 7, 2017

A unique eye color, called tiger-eye, segregates in the Puerto Rican Paso Fino (PRPF) horse breed... more A unique eye color, called tiger-eye, segregates in the Puerto Rican Paso Fino (PRPF) horse breed and is characterized by a bright yellow, amber, or orange iris. Pedigree analysis identified a simple autosomal recessive mode of inheritance for this trait. A genome-wide association study (GWAS) with 24 individuals identified a locus on ECA 1 reaching genome-wide significance (Pcorrected = 1.32 × 10(-5)). This ECA1 locus harbors the candidate gene, Solute Carrier Family 24 (Sodium/Potassium/Calcium Exchanger), Member 5 (SLC24A5), with known roles in pigmentation in humans, mice, and zebrafish. Humans with compound heterozygous mutations in SLC24A5 have oculocutaneous albinism (OCA) type 6 (OCA6), which is characterized by dilute skin, hair, and eye pigmentation, as well as ocular anomalies. Twenty tiger-eye horses were homozygous for a nonsynonymous mutation in exon 2 (p.Phe91Tyr) of SLC24A5 (called here Tiger-eye 1), which is predicted to be deleterious to protein function. Additiona...

$Research paper thumbnail of In vivo effects of adjunctive tetracycline treatment on refractory corneal ulcers in dogs$

Journal of the American Veterinary Medical Association, Aug 15, 2010

To evaluate effect of adjunctive treatment with tetracycline analogues on time to complete cornea... more To evaluate effect of adjunctive treatment with tetracycline analogues on time to complete corneal reepithelialization in dogs with nonhealing (ie, refractory) corneal ulcers. Randomized controlled clinical trial. 89 dogs with refractory corneal ulcers. Corneal ulcers were treated via debridement and grid keratotomy. Dogs were assigned to receive 1 of 3 treatment regimens for up to 6 weeks: doxycycline (5 mg/kg [2.27 mg/lb], PO, q 12 h) with topically applied ophthalmic ointment containing neomycin, polymyxin B, and bacitracin (ie, triple antibiotic ointment; q 8 h); cephalexin (22 mg/kg [10 mg/lb], PO, q 12 h) with topically applied oxytetracycline ophthalmic ointment (q 8 h); or a control treatment of cephalexin (22 mg/kg, PO, q 12 h) with topically applied triple antibiotic ointment (q 8 h). Healing was monitored via measurements of the wound with calipers and evaluation of photographs obtained every 2 weeks. Treatment effectiveness was evaluated by wound healing and decreased signs of pain. The Boxer breed was overrepresented in all groups. At the 2-week time point, wound healing was significantly more common in small-breed dogs, compared with large-breed dogs. Dogs treated with oxytetracycline ophthalmic ointment had a significantly shorter healing time than did dogs receiving the control treatment. Corneal ulcers in dogs that received doxycycline PO healed more rapidly than did ulcers in dogs in the control treatment group; however, this difference was not significant. Topical tetracycline ophthalmic ointment was a safe, inexpensive, and effective adjunctive treatment for refractory corneal ulcers in dogs.

Veterinary ophthalmology

To identify visual outcome and postoperative complications following phacoemulsification of equin... more To identify visual outcome and postoperative complications following phacoemulsification of equine cataracts. Records of 39 horses (55 eyes) with cataracts were reviewed. Eyes with cataracts removed by phacoemulsification were included in the study. Data collected included age, breed, sex, stage and etiology of cataract, unilateral vs. bilateral involvement, and ultrasound findings. Horses were grouped by etiology of the cataract. Visual outcome and complications were evaluated for each group and the overall population. Immediately postoperatively 46 out of 47 eyes (98%) were sighted. Four weeks postoperatively 23 of 29 operated eyes (79%) were sighted [13/18 (72%) eyes with congenital/juvenile onset, 6/6 (100%) eyes with traumatic and 4/5 (90%) eyes with uveitis-induced cataracts], with 18 eyes lost to follow-up. The most common postoperative complications included corneal edema (19 eyes/40%), fibrin in the anterior chamber (11 eyes/23%), postoperative ocular hypertension (9 eyes/1...

Veterinary ophthalmology

Posterior capsular opacification (PCO) is the most common postoperative complication of contempor... more Posterior capsular opacification (PCO) is the most common postoperative complication of contemporary cataract surgery. Limited information is available regarding PCO formation and factors that influence PCO development in the dog. Two hundred sixty-five eyes (144 from diabetic dogs and 121 from dogs with breed-related cataracts) were prospectively evaluated for PCO formation for up to 12 months postoperatively. The mean age of all dogs in the study was 7.77 years and diabetic dogs were significantly older than dogs with breed-related cataracts. There were 73 males (61 neutered, 12 intact) and 74 females (70 neutered, 4 intact) in the study. Statistical analysis was performed based on age, breed/size, gender, stage of cataract at the time of surgery, PCO score at each time point, breed-related vs. diabetic cataract, right eyes compared to left eyes, and presence/absence of uveitis. Age and gender did not significantly influence PCO formation. Small and medium-sized breeds developed s...