Divya Yada - Academia.edu (original) (raw)
Papers by Divya Yada
ChemInform, Sep 29, 2011
CuFe 2 O 4 Nanoparticles: A Magnetically Recoverable and Reusable Catalyst for the Synthesis of 5... more CuFe 2 O 4 Nanoparticles: A Magnetically Recoverable and Reusable Catalyst for the Synthesis of 5-Substituted 1H-Tetrazoles.-The catalyst can be reused five times without significant loss of activity.-(SREEDHAR*, B.
International Journal of Pharmacy, Apr 2, 2015
An efficient and economical protocol for the synthesis of 5-substituted 1H-tetrazoles from variou... more An efficient and economical protocol for the synthesis of 5-substituted 1H-tetrazoles from various nitriles and sodium azide is described using ZnO as catalyst. A wide variety of aryl nitriles underwent [2+3] cycloaddition under mild reaction conditions to afford tetrazoles in moderate to excellent yields. All the synthesized compounds were screened for their antibacterial activities were tested against Bacillus subtilis (Gram-positive), Pseudomonas aeruginosa (Gramnegative) and Streptomyces species (Actinomycetes).
ChemInform, Aug 25, 2011
Magnetically Recoverable Iron Nanoparticle Catalyzed Cross-Dehydrogenative Coupling (CDC) Between... more Magnetically Recoverable Iron Nanoparticle Catalyzed Cross-Dehydrogenative Coupling (CDC) Between Two Csp 3-H Bonds Using Molecular Oxygen.-Optimized conditions are developed for the oxidative coupling of tetrahydroisoquinolines with nitroalkanes or acetone. The catalyst can be magnetically removed from the mixture and reused at least 9 times.-(ZENG, T.;
International Journal of Pharmacy, 2016
The present work describes a validated reverse phase high performance liquid chromatographic meth... more The present work describes a validated reverse phase high performance liquid chromatographic method for simultaneous estimation of Ramipril and and Olmesartan medoxomil in tablet formulation. Chromatography was performed on a Hypersil C18 (4.6mmx250mm, 5m) column from inisocratic mode with mobile phase containing acetonitrile: 0.05 M KH2PO4 pH 3.0 (60:40). The flow rate was 1.0 ml/min and the eluent was monitored at 228 nm. The selected chromatographic conditions were found to effectively separate Ramipril (RT-2.836 min) and Olmesartan (RT-4.055 min). Linearity for Ramipril and Olmesartan medoxomil were found in the range of 5ppm-25ppm and 20ppm-100ppm respectively. The proposed method was found to be accurate, precise, reproducible and specific. The mean recovery was 99.84 ± 0.20% and 101.7 ± 0.20% for ramipril and olmesartan medoxomil respectively. The methods were validated according to the ICH guidelines.
Advanced Synthesis & Catalysis, Oct 1, 2011
The Suzuki cross‐coupling reaction of various aryl and heteroaryl halides with arylboronic and he... more The Suzuki cross‐coupling reaction of various aryl and heteroaryl halides with arylboronic and heteroarylboronic acids was studied using a titania‐supported palladium(0) catalyst at room temperature under air. The conversion and selectivity results obtained for many substrates were excellent and similar to those provided by more active or even homogeneous catalysts. The methodology is similarly effective using 2‐bromo‐3,4,5‐trimethoxybenzaldehyde as the coupling partner and gave products in good yield. Furthermore, it has been shown that it is useful for the synthesis of terphenyl and tetraphenyls. The catalyst is quantitatively recovered from the reaction by simple filtration and reused for a number of cycles without significant loss of activity. Inductively coupled plasma (ICP) mass‐spectrometric analysis of the filtrate from the reaction mixture demonstrated that the palladium metal hardly leached into the solution within the limits of the detector (1 ppm), thus suggesting that the present Suzuki–Miyaura reaction proceeded by heterogeneous catalysis.
Tetrahedron Letters, Jul 1, 2011
... CuFe 2 O 4 nanoparticles: A magnetically recoverable and reusable catalyst for the synthesis ... more ... CuFe 2 O 4 nanoparticles: A magnetically recoverable and reusable catalyst for the synthesis of 5-substituted 1H-tetrazoles B. Sreedhar*, A. Suresh Kumar, Divya Yada Inorganic and Physical Chemistry Division, Indian Institute of Chemical ... 14. (a). Kantam, ML; Shiva Kumar KB ...
The simple, reliable and reproducible HPLC methods were developed for analysis of cefixime trihyd... more The simple, reliable and reproducible HPLC methods were developed for analysis of cefixime trihydrate and cefuroxime axetil. The column used was Merck C-18 analytical column(100 x 4.6 mm,5µm packing). The mobile phase used was a mixture of methanol:water (90 : 10 v/v) and run at the flow rate of 1ml/min with UV detector at 254 nm at ambient temperature. Evaluation of cefixime and cefuroxime from tablet were carried out using methanol. Assay of cefixime and cefuroxime were carried out and potency was found to be 99 and 99 respectively. The method is suitable for routine analysis of the drug. KEY WORDS: Cefixime trihydrate, Cefuroxime axetil, HPLC analytical method. INTRODUCTION The chemical name of cefixime trihydrate [9] is 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl) [(caroxymethoxy) imino] acetyl]amino]-3-ethenyl-8-oxo-trihydrate. [3][5] The chemical name of cefuroxime axetil [9] is 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[ (am...
The present work describes a validated reverse phase high performance liquid chromatographic meth... more The present work describes a validated reverse phase high performance liquid chromatographic method for simultaneous estimation of Ramipril and and Olmesartan medoxomil in tablet formulation. Chromatography was performed on a Hypersil C18 (4.6mmx250mm, 5m) column from inisocratic mode with mobile phase containing acetonitrile: 0.05 M KH2PO4 pH 3.0 (60:40). The flow rate was 1.0 ml/min and the eluent was monitored at 228 nm. The selected chromatographic conditions were found to effectively separate Ramipril (RT- 2.836 min) and Olmesartan (RT- 4.055 min). Linearity for Ramipril and Olmesartan medoxomil were found in the range of 5ppm- 25ppm and 20ppm -100ppm respectively. The proposed method was found to be accurate, precise, reproducible and specific. The mean recovery was 99.84 ± 0.20% and 101.7 ± 0.20% for ramipril and olmesartan medoxomil respectively. The methods were validated according to the ICH guidelines.
An efficient and economical protocol for the synthesis of 5-substituted 1H-tetrazoles from variou... more An efficient and economical protocol for the synthesis of 5-substituted 1H-tetrazoles from various nitriles and sodium azide is described using ZnO as catalyst. A wide variety of aryl nitriles underwent [2+3] cycloaddition under mild reaction conditions to afford tetrazoles in moderate to excellent yields. All the synthesized compounds were screened for their antibacterial activities were tested against Bacillus subtilis (Gram-positive), Pseudomonas aeruginosa (Gramnegative) and Streptomyces species (Actinomycetes).
Advanced Synthesis & Catalysis, 2011
The Suzuki cross‐coupling reaction of various aryl and heteroaryl halides with arylboronic and he... more The Suzuki cross‐coupling reaction of various aryl and heteroaryl halides with arylboronic and heteroarylboronic acids was studied using a titania‐supported palladium(0) catalyst at room temperature under air. The conversion and selectivity results obtained for many substrates were excellent and similar to those provided by more active or even homogeneous catalysts. The methodology is similarly effective using 2‐bromo‐3,4,5‐trimethoxybenzaldehyde as the coupling partner and gave products in good yield. Furthermore, it has been shown that it is useful for the synthesis of terphenyl and tetraphenyls. The catalyst is quantitatively recovered from the reaction by simple filtration and reused for a number of cycles without significant loss of activity. Inductively coupled plasma (ICP) mass‐spectrometric analysis of the filtrate from the reaction mixture demonstrated that the palladium metal hardly leached into the solution within the limits of the detector (1 ppm), thus suggesting that t...
Research Journal of Pharmacy and Technology, 2021
The current line of investigation was focused at perusing the presence of phytochemical constitue... more The current line of investigation was focused at perusing the presence of phytochemical constituents, investigation of total phenol and flavonoid content, the antioxidant potential of various extracts of Caralluma adscendens whole plant using various in-vitro assays. The dried plant powder was extracted with various solvents based on polarity (Pet ether, Chloroform, Ethyl acetate, Ethanol and Aqueous) by hot continuous extraction in Soxhlet's apparatus and Extracts were dried. Phytoconstituents present in each extract was examined by performing preliminary phytochemical screening. Total Phenolic Content (TPC), Total Flavonoid Content (TFC) and Antioxidant potential for crude extracts were studied by DPPH, nitric oxide scavenging and FRAP methods. The total phenolic content and flavonoid content of Ethanolic extract of plant was found to be 80.08±0.629mg and 70.88±1.170mg of GAE and Quercetin equivalents respectively. The Ethanolic extract exhibited potent antioxidant activity as...
There is an ever increasing interest in impurities present in APIs. Now days, not only purity pro... more There is an ever increasing interest in impurities present in APIs. Now days, not only purity profile but also impurity profile has become mandatory according to various regulatory authorities. In the pharmaceutical world, an impurity is considered as any other inorganic or organic material, or residual solvents other than the drug substances, or ingredients, arise out of synthesis or unwanted chemicals that remains with APIs. Impurity profiling includes identification, structure elucidation and quantitative determination of impurities and degradation products in bulk drug materials and pharmaceutical formulations. Impurity profiling has gained importance in modern pharmaceutical analysis due to the fact that unidentified, potentially toxic impurities are hazardous to health and in order to increase the safety of drug therapy, impurities should be identified and determined by selective methods. Terms such as residual solvents, byproduct, transformation products, degradation products, interaction products and related products are frequently used to define impurities. The control of impurities in Formulated products and Active Pharmaceutical ingredient's were regulated by various regulatory authorities like ICH, USFDA, Canadian Drug and Health Agency are emphasizing on the purity requirements and the identification of impurities in Active Pharmaceutical Ingredient's (API's). Identification of impurities is done by variety of Chromatographic and Spectroscopic techniques, either alone or in combination with other techniques. There are different methods for detecting and characterizing impurities with TLC, HPLC, HPTLC, AAS etc. Impurity profiling study has been in the limelight in the recent pharmaceutical scenario and its importance is increasing day-by-day. The present review covers various aspects related to the analytical method development for impurity profiling of Active Pharmaceutical ingredient and pharmaceutical products.
ChemInform, Sep 29, 2011
CuFe 2 O 4 Nanoparticles: A Magnetically Recoverable and Reusable Catalyst for the Synthesis of 5... more CuFe 2 O 4 Nanoparticles: A Magnetically Recoverable and Reusable Catalyst for the Synthesis of 5-Substituted 1H-Tetrazoles.-The catalyst can be reused five times without significant loss of activity.-(SREEDHAR*, B.
International Journal of Pharmacy, Apr 2, 2015
An efficient and economical protocol for the synthesis of 5-substituted 1H-tetrazoles from variou... more An efficient and economical protocol for the synthesis of 5-substituted 1H-tetrazoles from various nitriles and sodium azide is described using ZnO as catalyst. A wide variety of aryl nitriles underwent [2+3] cycloaddition under mild reaction conditions to afford tetrazoles in moderate to excellent yields. All the synthesized compounds were screened for their antibacterial activities were tested against Bacillus subtilis (Gram-positive), Pseudomonas aeruginosa (Gramnegative) and Streptomyces species (Actinomycetes).
ChemInform, Aug 25, 2011
Magnetically Recoverable Iron Nanoparticle Catalyzed Cross-Dehydrogenative Coupling (CDC) Between... more Magnetically Recoverable Iron Nanoparticle Catalyzed Cross-Dehydrogenative Coupling (CDC) Between Two Csp 3-H Bonds Using Molecular Oxygen.-Optimized conditions are developed for the oxidative coupling of tetrahydroisoquinolines with nitroalkanes or acetone. The catalyst can be magnetically removed from the mixture and reused at least 9 times.-(ZENG, T.;
International Journal of Pharmacy, 2016
The present work describes a validated reverse phase high performance liquid chromatographic meth... more The present work describes a validated reverse phase high performance liquid chromatographic method for simultaneous estimation of Ramipril and and Olmesartan medoxomil in tablet formulation. Chromatography was performed on a Hypersil C18 (4.6mmx250mm, 5m) column from inisocratic mode with mobile phase containing acetonitrile: 0.05 M KH2PO4 pH 3.0 (60:40). The flow rate was 1.0 ml/min and the eluent was monitored at 228 nm. The selected chromatographic conditions were found to effectively separate Ramipril (RT-2.836 min) and Olmesartan (RT-4.055 min). Linearity for Ramipril and Olmesartan medoxomil were found in the range of 5ppm-25ppm and 20ppm-100ppm respectively. The proposed method was found to be accurate, precise, reproducible and specific. The mean recovery was 99.84 ± 0.20% and 101.7 ± 0.20% for ramipril and olmesartan medoxomil respectively. The methods were validated according to the ICH guidelines.
Advanced Synthesis & Catalysis, Oct 1, 2011
The Suzuki cross‐coupling reaction of various aryl and heteroaryl halides with arylboronic and he... more The Suzuki cross‐coupling reaction of various aryl and heteroaryl halides with arylboronic and heteroarylboronic acids was studied using a titania‐supported palladium(0) catalyst at room temperature under air. The conversion and selectivity results obtained for many substrates were excellent and similar to those provided by more active or even homogeneous catalysts. The methodology is similarly effective using 2‐bromo‐3,4,5‐trimethoxybenzaldehyde as the coupling partner and gave products in good yield. Furthermore, it has been shown that it is useful for the synthesis of terphenyl and tetraphenyls. The catalyst is quantitatively recovered from the reaction by simple filtration and reused for a number of cycles without significant loss of activity. Inductively coupled plasma (ICP) mass‐spectrometric analysis of the filtrate from the reaction mixture demonstrated that the palladium metal hardly leached into the solution within the limits of the detector (1 ppm), thus suggesting that the present Suzuki–Miyaura reaction proceeded by heterogeneous catalysis.
Tetrahedron Letters, Jul 1, 2011
... CuFe 2 O 4 nanoparticles: A magnetically recoverable and reusable catalyst for the synthesis ... more ... CuFe 2 O 4 nanoparticles: A magnetically recoverable and reusable catalyst for the synthesis of 5-substituted 1H-tetrazoles B. Sreedhar*, A. Suresh Kumar, Divya Yada Inorganic and Physical Chemistry Division, Indian Institute of Chemical ... 14. (a). Kantam, ML; Shiva Kumar KB ...
The simple, reliable and reproducible HPLC methods were developed for analysis of cefixime trihyd... more The simple, reliable and reproducible HPLC methods were developed for analysis of cefixime trihydrate and cefuroxime axetil. The column used was Merck C-18 analytical column(100 x 4.6 mm,5µm packing). The mobile phase used was a mixture of methanol:water (90 : 10 v/v) and run at the flow rate of 1ml/min with UV detector at 254 nm at ambient temperature. Evaluation of cefixime and cefuroxime from tablet were carried out using methanol. Assay of cefixime and cefuroxime were carried out and potency was found to be 99 and 99 respectively. The method is suitable for routine analysis of the drug. KEY WORDS: Cefixime trihydrate, Cefuroxime axetil, HPLC analytical method. INTRODUCTION The chemical name of cefixime trihydrate [9] is 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl) [(caroxymethoxy) imino] acetyl]amino]-3-ethenyl-8-oxo-trihydrate. [3][5] The chemical name of cefuroxime axetil [9] is 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[ (am...
The present work describes a validated reverse phase high performance liquid chromatographic meth... more The present work describes a validated reverse phase high performance liquid chromatographic method for simultaneous estimation of Ramipril and and Olmesartan medoxomil in tablet formulation. Chromatography was performed on a Hypersil C18 (4.6mmx250mm, 5m) column from inisocratic mode with mobile phase containing acetonitrile: 0.05 M KH2PO4 pH 3.0 (60:40). The flow rate was 1.0 ml/min and the eluent was monitored at 228 nm. The selected chromatographic conditions were found to effectively separate Ramipril (RT- 2.836 min) and Olmesartan (RT- 4.055 min). Linearity for Ramipril and Olmesartan medoxomil were found in the range of 5ppm- 25ppm and 20ppm -100ppm respectively. The proposed method was found to be accurate, precise, reproducible and specific. The mean recovery was 99.84 ± 0.20% and 101.7 ± 0.20% for ramipril and olmesartan medoxomil respectively. The methods were validated according to the ICH guidelines.
An efficient and economical protocol for the synthesis of 5-substituted 1H-tetrazoles from variou... more An efficient and economical protocol for the synthesis of 5-substituted 1H-tetrazoles from various nitriles and sodium azide is described using ZnO as catalyst. A wide variety of aryl nitriles underwent [2+3] cycloaddition under mild reaction conditions to afford tetrazoles in moderate to excellent yields. All the synthesized compounds were screened for their antibacterial activities were tested against Bacillus subtilis (Gram-positive), Pseudomonas aeruginosa (Gramnegative) and Streptomyces species (Actinomycetes).
Advanced Synthesis & Catalysis, 2011
The Suzuki cross‐coupling reaction of various aryl and heteroaryl halides with arylboronic and he... more The Suzuki cross‐coupling reaction of various aryl and heteroaryl halides with arylboronic and heteroarylboronic acids was studied using a titania‐supported palladium(0) catalyst at room temperature under air. The conversion and selectivity results obtained for many substrates were excellent and similar to those provided by more active or even homogeneous catalysts. The methodology is similarly effective using 2‐bromo‐3,4,5‐trimethoxybenzaldehyde as the coupling partner and gave products in good yield. Furthermore, it has been shown that it is useful for the synthesis of terphenyl and tetraphenyls. The catalyst is quantitatively recovered from the reaction by simple filtration and reused for a number of cycles without significant loss of activity. Inductively coupled plasma (ICP) mass‐spectrometric analysis of the filtrate from the reaction mixture demonstrated that the palladium metal hardly leached into the solution within the limits of the detector (1 ppm), thus suggesting that t...
Research Journal of Pharmacy and Technology, 2021
The current line of investigation was focused at perusing the presence of phytochemical constitue... more The current line of investigation was focused at perusing the presence of phytochemical constituents, investigation of total phenol and flavonoid content, the antioxidant potential of various extracts of Caralluma adscendens whole plant using various in-vitro assays. The dried plant powder was extracted with various solvents based on polarity (Pet ether, Chloroform, Ethyl acetate, Ethanol and Aqueous) by hot continuous extraction in Soxhlet's apparatus and Extracts were dried. Phytoconstituents present in each extract was examined by performing preliminary phytochemical screening. Total Phenolic Content (TPC), Total Flavonoid Content (TFC) and Antioxidant potential for crude extracts were studied by DPPH, nitric oxide scavenging and FRAP methods. The total phenolic content and flavonoid content of Ethanolic extract of plant was found to be 80.08±0.629mg and 70.88±1.170mg of GAE and Quercetin equivalents respectively. The Ethanolic extract exhibited potent antioxidant activity as...
There is an ever increasing interest in impurities present in APIs. Now days, not only purity pro... more There is an ever increasing interest in impurities present in APIs. Now days, not only purity profile but also impurity profile has become mandatory according to various regulatory authorities. In the pharmaceutical world, an impurity is considered as any other inorganic or organic material, or residual solvents other than the drug substances, or ingredients, arise out of synthesis or unwanted chemicals that remains with APIs. Impurity profiling includes identification, structure elucidation and quantitative determination of impurities and degradation products in bulk drug materials and pharmaceutical formulations. Impurity profiling has gained importance in modern pharmaceutical analysis due to the fact that unidentified, potentially toxic impurities are hazardous to health and in order to increase the safety of drug therapy, impurities should be identified and determined by selective methods. Terms such as residual solvents, byproduct, transformation products, degradation products, interaction products and related products are frequently used to define impurities. The control of impurities in Formulated products and Active Pharmaceutical ingredient's were regulated by various regulatory authorities like ICH, USFDA, Canadian Drug and Health Agency are emphasizing on the purity requirements and the identification of impurities in Active Pharmaceutical Ingredient's (API's). Identification of impurities is done by variety of Chromatographic and Spectroscopic techniques, either alone or in combination with other techniques. There are different methods for detecting and characterizing impurities with TLC, HPLC, HPTLC, AAS etc. Impurity profiling study has been in the limelight in the recent pharmaceutical scenario and its importance is increasing day-by-day. The present review covers various aspects related to the analytical method development for impurity profiling of Active Pharmaceutical ingredient and pharmaceutical products.