Djumadi Achmad - Academia.edu (original) (raw)

Papers by Djumadi Achmad

Open Access Macedonian Journal of Medical Sciences

Prostate cancer is one of the most common cancer worldwide, where South Sulawesi is included in f... more Prostate cancer is one of the most common cancer worldwide, where South Sulawesi is included in four provinces with the highest prevalence of prostate cancer in Indonesia. Laboratorium Sentra Patologia Makassar (SDPM) stated that prostate cancer cases continue to rise each year. Androgen receptor (AR) plays a role in the growth and differentiation of male urogenital structures, both under normal and neoplastic conditions, the neoplastic condition is caused by the mechanism of the AR pathway which undergoes changes that continue in the development and progression of prostate lesions, both benign and malignant. Androgen receptors are generally found evenly distributed in the nuclei of glandular and stromal cells in prostate hyperplasia and vary widely in prostate cancer. These inventions show that AR inhibitors are used to treat prostate adenocarcinoma by inhibiting androgen synthesis. Assessment of AR expression can be used in determining therapy and predicting the success of hormona...

Colorectal cancer is one of the most common cancers and the fourth leading cause of cancer-relate... more Colorectal cancer is one of the most common cancers and the fourth leading cause of cancer-related death in the world. According to the type of histopathology, more than 90% of colorectal carcinomas are adenocarcinomas which are grouped into low grade and high grade based on their grading. Identification of characteristic groupings based on grading is still rarely done in Indonesia, especially in Makassar. This study aims to determine the clinical and pathological characteristics of high grade colorectal adenocarcinoma at Hasanuddin University Hospital, Makassar from January 2015 to December 2020. This study used a descriptive method. The sample used was a sample that was diagnosed histopathologically as high grade colorectal adenocarcinoma and met the inclusion criteria then selected by total sampling and also used data from medical records. The distribution of data in this study is classified based on age, gender, tumor location, clinical symptoms, and tumor stage. Descriptive sta...

International Journal of Sciences: Basic and Applied Research, Aug 13, 2021

BACKGROUND: Neuroendocrine neoplasm (NEN) is an epithelial cell neoplasm that can give a histopat... more BACKGROUND: Neuroendocrine neoplasm (NEN) is an epithelial cell neoplasm that can give a histopathological appearance resembling high-grade colorectal adenocarcinoma. Immunohistochemical assays with specific neuroendocrine markers of chromogranin A and synaptophysin are required to establish a definite diagnosis of NEN. AIM: This study aimed to determine whether there was an expression of chromogranin A, synaptophysin and Ki67 which indicated the presence of neuroendocrine neoplasms in samples that have been diagnosed as high-grade colorectal adenocarcinoma. MATERIALS AND METHODS: A study of the expression of chromogranin A, synaptophysin and Ki67 in paraffin blocks was carried out as a result of biopsy and tissue surgery of 70 samples of colorectal tumor specimens diagnosed with colorectal adenocarcinoma. Descriptive analyses were used to assess the study results of the amount of chromogranin A, synaptophysin, and sample characteristics. RESULTS: We discovered that eight (8) samples (11.4%) were NEN from 70 previously diagnosed samples as high-grade colorectal adenocarcinoma using immunohistochemical assay with neuroendocrine markers, namely chromogranin A and synaptophysin. CONCLUSION: The final diagnosis obtained from 8 samples diagnosed as NEN were Neuroendocrine tumor (NET) G1, G2, and G3, respectively 1.4% and LCNEC 7.1% based on the specific neuroendocrine markers of chromogranin A, synaptophysin and Ki67.

Lesi kelenjar tiroid merupakan kelainan yang sering ditemukan, namun penegakan diagnosis berdasar... more Lesi kelenjar tiroid merupakan kelainan yang sering ditemukan, namun penegakan diagnosis berdasarkan gambaran histopatologik sesuai kriteria morfologi WHO, seringkali sulit dilakukan terutama pada tumor folikuler berdiferensiasi baik. Antibodi HBME-1 adalah antibodi yang diproduksi dari suspensi sel mesotelioma yang bereaksi dengan…

International Journal of Sciences: Basic and Applied Research, 2019

Several previous studies reported the fact that expression of Programmed Death – Ligan 1 (PD-L1) ... more Several previous studies reported the fact that expression of Programmed Death – Ligan 1 (PD-L1) in various types of histopathology of thyroid cancer showed varied results and had predictive value and prognosis that were expected to be targeted for anti PD-1/PD-L1 immunotherapy. The aim of this study was to evaluate comparison expression of PD-L1 one to each other group between papillary thyroid carcinoma (PTC), follicular thyroid carcinoma (FTC), poorly differentiated carcinoma (PDTC) and anaplastic thyroid carcinoma (ATC). This study was an observational analytic with a cross sectional design using paraffin block samples from three anatomic pathology laboratories in Makassar during the periode of July 2015 – February 2019. PD-L1 expression was evaluated using Rabbit Monoclonal Antibody (28-8) and data were analysed using The Mann – Whitney Test. There was a significant difference of PD-L1 expression score between PTC with PDTC (p = 0,045 ; p 0,05), between FTC with PDTC (p = 0,147...

ABSTRAK Latar belakang Tumor ganas tiroid merupakan salah satu dari beberapa jenis keganasan yang... more ABSTRAK Latar belakang Tumor ganas tiroid merupakan salah satu dari beberapa jenis keganasan yang masih menjadi dilema bagi para klinisi dalam mendiagnosa. Fine needle aspiration biopsy (FNAB) adalah salah satu metoda diagnostik yang penting dalam menilai nodul pada kelenjar tiroid. Namun pada sebagian besar kasus, diagnosa tumor ganas tiroid masih belum dapat ditegakkan secara pasti. Galectin-3 adalah molekul protein 31-kDa yang tergolong dalam -galactoside binding family of lectins. Galectin-3 terlibat dalam berbagai proses biologik. seperti adhesi antar sel, proliferasi, transformasi maligna, dan metastasis. Tujuan penelitian ini untuk menilai peranan ekspresi galectin-3 dalam membedakan lesi jinak dan ganas pada kelenjar tiroid. Metode Dilakukan pemeriksaan immunohistokimia untuk menilai ekspresi galectin-3 pada 80 sediaan lesi kelenjar tiroid (20 nodular goiter, 20 adenoma folikuler, 20 karsinoma folikuler, dan 20 karsinoma papiler). Hasil Seluruh sediaan karsinoma folikuler d...

American Journal of Clinical and Experimental Medicine, 2016

Jintan hitam (Nigella sativa) has been widely used in traditional medicine to treat several disea... more Jintan hitam (Nigella sativa) has been widely used in traditional medicine to treat several diseases, including gastric ulcer. However, there are no scientific data demonstrating anti-ulcerogenic activity conferred by use of jintan hitam. The present study aimed to evaluate the antiulcer properties of oil extract from jintan hitam. In the gastric ulcer induced by administration of 80% ethanol model, observation made for ulcer score and index, level of ulcer erosion, total amount of polymorphonuclear cells and morphological change of 80% ethanol induced gastric ulcer of mice. Research was conducted on laboratory in Faculty of Medicine Universitas Hasanuddin from April to September 2015, with post test only experimental group design. There were 40 mice used in this research, divided into five groups, each group consisted of 8 mice: negative control group, positive control group, and three different doses of oil extract (0.1, 0.2 and 0.3 ml per 20g bw of mice). Observation made for 4 and 7 days. The oil extract of jintan hitam showed significant differences on doses of 0.1 ml per 20g bw of mice given in 4 days, with p = 0.034 (p<0.05) based on score and index of gastric ulcer.

International Journal of Sciences: Basic and Applied Research, Oct 27, 2021

International Journal of Research in Medical Sciences

Background: Breast cancer is the second most common cancer in the world and is the most epidemic ... more Background: Breast cancer is the second most common cancer in the world and is the most epidemic cancer in women, with approximately 1.67 million cases. Metastasis of tumor cells to other organs is a major cause of the increasing trend of mortality in breast cancer. This study aims to analyze the expression of c-Met associated with metastasis to axillary lymph nodes in invasive breast cancer.Method: The research was conducted at the Laboratory of Anatomical Pathology of Hasanuddin University Hospital. Stratified sampling was performed from January 2014 - January 2019. Immunohistochemical staining technique was applied upon 66 collected samples, followed by evaluating the c-Met expression score in invasive breast cancer group with positive and negative lymph node status.Result: c-Met overexpression was found among the invasive breast cancer incidence with lymph node metastasis. Among 50 cases with c-Met overexpression (c-Met positive), 40 cases (80%) of invasive breast cancer with ly...