Doğukan Yılmaz - Academia.edu (original) (raw)
Papers by Doğukan Yılmaz
Background and Aim: Allografts and alloplasts are graft materials with satisfactory clinical outc... more Background and Aim: Allografts and alloplasts are graft materials with satisfactory clinical outcomes that can be obtained in sufficient quantities. This report aims to determine and compare the contribution of alloplast and allograft materials applied to the atrophic mandibular crest with the tunnel technique. Materials and Methods: 14 patients with unilateral mandibular posterior atrophic crests were included, randomly divided into two groups. Computed tomographic images were taken preoperatively from patients with stents. Horizontal and vertical bone were determined preoperatively. During surgeries, the mucoperiosteal flap was elevated using the “tunnel technique,” then both graft materials were placed into the flaps. Follow-up programs were scheduled at each month after surgeries. Computed tomographic images were taken for postoperative measurements with acrylic stents at the end of the fourth month. Results: Postsurgical healing was uneventful for each group. There was a statis...
Background and Aim: Allografts and alloplasts are graft materials with satisfactory clinical outc... more Background and Aim: Allografts and alloplasts are graft materials with satisfactory clinical outcomes that can be obtained in sufficient quantities. This report aims to determine and compare the contribution of alloplast and allograft materials applied to the atrophic mandibular crest with the tunnel technique. Materials and Methods: 14 patients with unilateral mandibular posterior atrophic crests were included, randomly divided into two groups. Computed tomographic images were taken preoperatively from patients with stents. Horizontal and vertical bone were determined preoperatively. During surgeries, the mucoperiosteal flap was elevated using the “tunnel technique,” then both graft materials were placed into the flaps. Follow-up programs were scheduled at each month after surgeries. Computed tomographic images were taken for postoperative measurements with acrylic stents at the end of the fourth month. Results: Postsurgical healing was uneventful for each group. There was a statis...
Yeditepe Dental Journal, 2019
Frontiers in Cellular and Infection Microbiology, 2015
In the pathogenesis of periodontitis, an infection-induced inflammatory disease of the tooth-supp... more In the pathogenesis of periodontitis, an infection-induced inflammatory disease of the tooth-supporting tissues, there is a complex interaction between the subgingival microbiota and host tissues. A periodontal diagnostic tool for detecting the initiation and progression of the disease, monitoring the response to therapy, or measuring the degree of susceptibility to future disease progression has been of interest for a long time. The value of various enzymes, proteins, and immunoglobulins, which are abundant constituents of saliva, as potential biomarkers has been recognized and extensively investigated for periodontal diseases. Gingival defensins and cathelicidins are small cationic antimicrobial peptides that play an important role in innate immune response. However, their applicability as salivary biomarkers is still under debate. The present review focuses on proteomic biomarkers and antimicrobial peptides, in particular, to be used at early phases of periodontitis.
Journal of Medical Economics, 2005
The effectiveness data were derived from a retrospective analysis, expert opinion and published s... more The effectiveness data were derived from a retrospective analysis, expert opinion and published studies. Link between effectiveness and cost data The cost analysis was carried out retrospectively on the same sample as that used for the effectiveness analysis. Study sample The study sample comprised 105 bleeding episodes in 24 patients. Bleedings were treated with rFVIIa in 28 events, with PCC in 25, with aPCC in 9, and with high-dose Factor VIII in 43. Sixteen of the 24 patients were adults aged over 17 years. The mean weight was 49 kg. No further information was given.
Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih... more Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih Bölümü, 2017.This work is a student project of the The Department of History, Faculty of Economics, Administrative and Social Sciences, İhsan Doğramacı Bilkent University.by Öztürk, İbrahim Mert
Insan oral kavitesi; disler, disetleri, dil, yumusak ve sert damak gibi farkli anatomik ozellikle... more Insan oral kavitesi; disler, disetleri, dil, yumusak ve sert damak gibi farkli anatomik ozelliklere sahip zengin bir habitat icerir. Oral mikrobiyota; bakteri, fungus, virus ve ark’lardan olusan bu habitatlarda yerlesim gosteren mikroorganizma toplulugudur. Bu mikroorganizmalarin her birinin tek baslarina onemli rolleri vardir ancak birbirleriyle ve konakla da ciddi etkilesime girmektedirler. Bu derlemede, oral mikrobiyota elemanlarinin oral kaviteye nasil yerlestikleri ve konakla yasam boyunca girdikleri dinamik etkilesimin yani sira, Oral kavitenin baslica hastaliklarindan, dis curugu, periodontal hastaliklar gibi durumlarda mikrobiyotanin etkisi ve degisiminden bahsedilmistir. Oral mikrobiyotanin zengin yapisi sadece agiz hastaliklari ile sinirli kalmaz ayni zamanda diabet, kardiyovaskuler hastaliklar ve kanser gibi populasyonun cok buyuk bir bolumunu etkileyen sistemik ve metabolik hastaliklarin etyolojik ve patofizyolojik mekanizmalarinda onemli etkileri mevcuttur. Oral mikrobi...
Surekli olarak bakteriler ile yakin temasta olan oral kavitede antimikrobiyal peptidler dogal imm... more Surekli olarak bakteriler ile yakin temasta olan oral kavitede antimikrobiyal peptidler dogal immun cevapta onemli bir rol oynamaktadirlar. Diabetes Mellitus (DM) periodontal hastaliklara sebep olabilen oldukca yaygin bir metabolik hastaliktir. Gunumuzde DM hastalarinda defensin ve kathelisidin salinimi ile ilgili sinirli miktarda bilgi bulunmaktadir. Bu nedenle, calismamizin amaci DM'li hastalarda defensin salinim ve fonksiyonlarindaki farkliliklari tanimlamaktir. Gingival doku ornekleri, periodontal tedavi gereksinimi olan DM teshisi konulmus 14 bireyden (T2DM+GP), sistemik olarak saglikli ancak periodontitis teshisi konulmus 11 bireyden (GP) ve sistemik ve periodontal olarak saglikli 13 bireyden (Kontrol) alinmistir. Doku ornekleri % 4 paraformaldehit icinde fikse edildikten sonra parafin bloklara gomulmustur. Beta-defensin 2, 3 (hBD-2, -3) kathelisidin (LL-37) ve sitokeratin-19 (CK-19) icin immunhistokimyasal boyamalar yapilmistir. Ornekler isik mikroskobu altinda ×40 buyutm...
Yeditepe Dental Journal, 2020
İnsan beta-defensinler (hBD) ve kathelisin (LL-37) homeostazın sağlanmasında önemli ve çoklu göre... more İnsan beta-defensinler (hBD) ve kathelisin (LL-37) homeostazın sağlanmasında önemli ve çoklu görevler alırlar. Oral ve periodontal doku ve sıvılarda, Tip 2 Diabetes Mellitus (T2DM) ile bu peptidler arasındaki ilişki net değildir. Çalışmamızın amacı, T2DM'li bireylerde glisemik kontrol seviyesinin, salya hBD ve LL-37 konsantrasyonu üzerine olan etkisinin incelenmesidir. Gereç ve Yöntem: Çalışmaya 178 birey dahil edilmiştir. Demografik veriler, dental ve medikal geçmişler sözlü olarak elde edilmiştir. Glisemik kontrol seviyeleri için açlık kan şekeri ve glikolize hemoglobin (HbA1c) değerleri ölçülmüştür. Tüm ağız periodontal indeks değerleri ölçülerek panaromik filmler yardımıyla periodontal teşhisler yapılmıştır. Bireylerden stimüle olmayan yöntemle salya örnekleri toplanmış ve ELISA tekniği ile salya hBD-1,-2,-3, LL-37 ve ileri glikolizasyon son ürünü (AGE) değerleri ölçülmüştür. Bulgular: Dişeti sağlıklı bireylerden oluşan gruplar arasında ve kontrollü T2DM bireylerin salya hBD seviyelerinin diğer gruplara oranla anlamlı derecede yüksek olduğu tespit edilmiştir. (p<0.001) Periodontitisli ve kontrollü T2DM'li bireylerin salya hBD seviyelerinin ise; diğer periodontitisli gruplara göre anlamlı derecede düşük olduğu tespit edilmiştir. (p<0.001). Salya LL-37 değerleri incelendiğinde ise; hem dişeti sağlıklı hem de periodontitisli bireylerden oluşan gruplarda, kontrolsüz T2DM'li bireylerden oluşan gruplarda en yüksek olduğu tespit edilmiştir. (p<0.001, p<0.001, sırasıyla) Korelasyon analizlerine göre, periodontitisli ve kontrollü T2DM'li bireylerin salya hBD-1,-2,-3 değerleri salya AGE miktarı ile negatif korelasyon gösterirken (r=-0.411 p=0.020, r=-0.389 p=0.028, r=-0.344 p=0.044, sırasıyla) LL-37 miktarı pozitif korelasyon göstermektedir (r=0.601 p=<0.001). Sonuç: Glisemik kontrol salya hBD ve LL-37 konsantrasyonu üzerinde bağımsız bir belirteçtir. Anahtar kelimeler: Antimikrobiyal peptid, Tip 2 Diabetes Mellitus, Salya, Glisemik Kontrol. SUMMARY Aim: The purpose of this study was to evaluate the dentists' knowledge, attitude and behaviour regarding dental trauma in Rize Province. Materials and Methods: Total of 121 dentists, 73 females and 48 males, were included in this study. A questionnaire consisted of 34 questions and three sections was applied face to face. Personal and professional knowledge and attitudes about dental trauma were evaluated. The association between the dentists at different education level and trauma intervention were analyzed with chi-square test. Results: Most of general dentists (48.1%), postgraduate students (69.6%) and specialists (53.3%) preferred composite, fiber and ligature wire as splint materials, respectively (p<0.001). There was statistically significant association between dental education level with permanent extrusion (p = 0.004) and avulsion cases with closed apex in dry environ-ÖZGÜN ARAŞTIRMA
Background and Aim: Allografts and alloplasts are graft materials with satisfactory clinical outc... more Background and Aim: Allografts and alloplasts are graft materials with satisfactory clinical outcomes that can be obtained in sufficient quantities. This report aims to determine and compare the contribution of alloplast and allograft materials applied to the atrophic mandibular crest with the tunnel technique. Materials and Methods: 14 patients with unilateral mandibular posterior atrophic crests were included, randomly divided into two groups. Computed tomographic images were taken preoperatively from patients with stents. Horizontal and vertical bone were determined preoperatively. During surgeries, the mucoperiosteal flap was elevated using the “tunnel technique,” then both graft materials were placed into the flaps. Follow-up programs were scheduled at each month after surgeries. Computed tomographic images were taken for postoperative measurements with acrylic stents at the end of the fourth month. Results: Postsurgical healing was uneventful for each group. There was a statis...
Background and Aim: Allografts and alloplasts are graft materials with satisfactory clinical outc... more Background and Aim: Allografts and alloplasts are graft materials with satisfactory clinical outcomes that can be obtained in sufficient quantities. This report aims to determine and compare the contribution of alloplast and allograft materials applied to the atrophic mandibular crest with the tunnel technique. Materials and Methods: 14 patients with unilateral mandibular posterior atrophic crests were included, randomly divided into two groups. Computed tomographic images were taken preoperatively from patients with stents. Horizontal and vertical bone were determined preoperatively. During surgeries, the mucoperiosteal flap was elevated using the “tunnel technique,” then both graft materials were placed into the flaps. Follow-up programs were scheduled at each month after surgeries. Computed tomographic images were taken for postoperative measurements with acrylic stents at the end of the fourth month. Results: Postsurgical healing was uneventful for each group. There was a statis...
Yeditepe Dental Journal, 2019
Frontiers in Cellular and Infection Microbiology, 2015
In the pathogenesis of periodontitis, an infection-induced inflammatory disease of the tooth-supp... more In the pathogenesis of periodontitis, an infection-induced inflammatory disease of the tooth-supporting tissues, there is a complex interaction between the subgingival microbiota and host tissues. A periodontal diagnostic tool for detecting the initiation and progression of the disease, monitoring the response to therapy, or measuring the degree of susceptibility to future disease progression has been of interest for a long time. The value of various enzymes, proteins, and immunoglobulins, which are abundant constituents of saliva, as potential biomarkers has been recognized and extensively investigated for periodontal diseases. Gingival defensins and cathelicidins are small cationic antimicrobial peptides that play an important role in innate immune response. However, their applicability as salivary biomarkers is still under debate. The present review focuses on proteomic biomarkers and antimicrobial peptides, in particular, to be used at early phases of periodontitis.
Journal of Medical Economics, 2005
The effectiveness data were derived from a retrospective analysis, expert opinion and published s... more The effectiveness data were derived from a retrospective analysis, expert opinion and published studies. Link between effectiveness and cost data The cost analysis was carried out retrospectively on the same sample as that used for the effectiveness analysis. Study sample The study sample comprised 105 bleeding episodes in 24 patients. Bleedings were treated with rFVIIa in 28 events, with PCC in 25, with aPCC in 9, and with high-dose Factor VIII in 43. Sixteen of the 24 patients were adults aged over 17 years. The mean weight was 49 kg. No further information was given.
Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih... more Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih Bölümü, 2017.This work is a student project of the The Department of History, Faculty of Economics, Administrative and Social Sciences, İhsan Doğramacı Bilkent University.by Öztürk, İbrahim Mert
Insan oral kavitesi; disler, disetleri, dil, yumusak ve sert damak gibi farkli anatomik ozellikle... more Insan oral kavitesi; disler, disetleri, dil, yumusak ve sert damak gibi farkli anatomik ozelliklere sahip zengin bir habitat icerir. Oral mikrobiyota; bakteri, fungus, virus ve ark’lardan olusan bu habitatlarda yerlesim gosteren mikroorganizma toplulugudur. Bu mikroorganizmalarin her birinin tek baslarina onemli rolleri vardir ancak birbirleriyle ve konakla da ciddi etkilesime girmektedirler. Bu derlemede, oral mikrobiyota elemanlarinin oral kaviteye nasil yerlestikleri ve konakla yasam boyunca girdikleri dinamik etkilesimin yani sira, Oral kavitenin baslica hastaliklarindan, dis curugu, periodontal hastaliklar gibi durumlarda mikrobiyotanin etkisi ve degisiminden bahsedilmistir. Oral mikrobiyotanin zengin yapisi sadece agiz hastaliklari ile sinirli kalmaz ayni zamanda diabet, kardiyovaskuler hastaliklar ve kanser gibi populasyonun cok buyuk bir bolumunu etkileyen sistemik ve metabolik hastaliklarin etyolojik ve patofizyolojik mekanizmalarinda onemli etkileri mevcuttur. Oral mikrobi...
Surekli olarak bakteriler ile yakin temasta olan oral kavitede antimikrobiyal peptidler dogal imm... more Surekli olarak bakteriler ile yakin temasta olan oral kavitede antimikrobiyal peptidler dogal immun cevapta onemli bir rol oynamaktadirlar. Diabetes Mellitus (DM) periodontal hastaliklara sebep olabilen oldukca yaygin bir metabolik hastaliktir. Gunumuzde DM hastalarinda defensin ve kathelisidin salinimi ile ilgili sinirli miktarda bilgi bulunmaktadir. Bu nedenle, calismamizin amaci DM'li hastalarda defensin salinim ve fonksiyonlarindaki farkliliklari tanimlamaktir. Gingival doku ornekleri, periodontal tedavi gereksinimi olan DM teshisi konulmus 14 bireyden (T2DM+GP), sistemik olarak saglikli ancak periodontitis teshisi konulmus 11 bireyden (GP) ve sistemik ve periodontal olarak saglikli 13 bireyden (Kontrol) alinmistir. Doku ornekleri % 4 paraformaldehit icinde fikse edildikten sonra parafin bloklara gomulmustur. Beta-defensin 2, 3 (hBD-2, -3) kathelisidin (LL-37) ve sitokeratin-19 (CK-19) icin immunhistokimyasal boyamalar yapilmistir. Ornekler isik mikroskobu altinda ×40 buyutm...
Yeditepe Dental Journal, 2020
İnsan beta-defensinler (hBD) ve kathelisin (LL-37) homeostazın sağlanmasında önemli ve çoklu göre... more İnsan beta-defensinler (hBD) ve kathelisin (LL-37) homeostazın sağlanmasında önemli ve çoklu görevler alırlar. Oral ve periodontal doku ve sıvılarda, Tip 2 Diabetes Mellitus (T2DM) ile bu peptidler arasındaki ilişki net değildir. Çalışmamızın amacı, T2DM'li bireylerde glisemik kontrol seviyesinin, salya hBD ve LL-37 konsantrasyonu üzerine olan etkisinin incelenmesidir. Gereç ve Yöntem: Çalışmaya 178 birey dahil edilmiştir. Demografik veriler, dental ve medikal geçmişler sözlü olarak elde edilmiştir. Glisemik kontrol seviyeleri için açlık kan şekeri ve glikolize hemoglobin (HbA1c) değerleri ölçülmüştür. Tüm ağız periodontal indeks değerleri ölçülerek panaromik filmler yardımıyla periodontal teşhisler yapılmıştır. Bireylerden stimüle olmayan yöntemle salya örnekleri toplanmış ve ELISA tekniği ile salya hBD-1,-2,-3, LL-37 ve ileri glikolizasyon son ürünü (AGE) değerleri ölçülmüştür. Bulgular: Dişeti sağlıklı bireylerden oluşan gruplar arasında ve kontrollü T2DM bireylerin salya hBD seviyelerinin diğer gruplara oranla anlamlı derecede yüksek olduğu tespit edilmiştir. (p<0.001) Periodontitisli ve kontrollü T2DM'li bireylerin salya hBD seviyelerinin ise; diğer periodontitisli gruplara göre anlamlı derecede düşük olduğu tespit edilmiştir. (p<0.001). Salya LL-37 değerleri incelendiğinde ise; hem dişeti sağlıklı hem de periodontitisli bireylerden oluşan gruplarda, kontrolsüz T2DM'li bireylerden oluşan gruplarda en yüksek olduğu tespit edilmiştir. (p<0.001, p<0.001, sırasıyla) Korelasyon analizlerine göre, periodontitisli ve kontrollü T2DM'li bireylerin salya hBD-1,-2,-3 değerleri salya AGE miktarı ile negatif korelasyon gösterirken (r=-0.411 p=0.020, r=-0.389 p=0.028, r=-0.344 p=0.044, sırasıyla) LL-37 miktarı pozitif korelasyon göstermektedir (r=0.601 p=<0.001). Sonuç: Glisemik kontrol salya hBD ve LL-37 konsantrasyonu üzerinde bağımsız bir belirteçtir. Anahtar kelimeler: Antimikrobiyal peptid, Tip 2 Diabetes Mellitus, Salya, Glisemik Kontrol. SUMMARY Aim: The purpose of this study was to evaluate the dentists' knowledge, attitude and behaviour regarding dental trauma in Rize Province. Materials and Methods: Total of 121 dentists, 73 females and 48 males, were included in this study. A questionnaire consisted of 34 questions and three sections was applied face to face. Personal and professional knowledge and attitudes about dental trauma were evaluated. The association between the dentists at different education level and trauma intervention were analyzed with chi-square test. Results: Most of general dentists (48.1%), postgraduate students (69.6%) and specialists (53.3%) preferred composite, fiber and ligature wire as splint materials, respectively (p<0.001). There was statistically significant association between dental education level with permanent extrusion (p = 0.004) and avulsion cases with closed apex in dry environ-ÖZGÜN ARAŞTIRMA