Domagoj Marjan - Academia.edu (original) (raw)

Papers by Domagoj Marjan

Research paper thumbnail of Nonenhancing spinal subdural metastatic tumor

AJNR. American journal of neuroradiology, 2005

We describe a case of a spinal subdural metastatic tumor that became rapidly symptomatic after a ... more We describe a case of a spinal subdural metastatic tumor that became rapidly symptomatic after a minor trauma, as a result of severe cord compression and cord hemorrhage. On MR imaging, the lesion was oval, hyperintense with a dark rim on T2-weighted fast spin-echo images, isointense to the cord on T1-weighted images, and had dark and bright areas on gradient-echo T2*-weighted images, consistent with a hyperacute-to-acute hematoma. The hemorrhagic tumor showed no evidence of contrast enhancement.

Research paper thumbnail of MR assessment of bile duct size in healthy individuals: comparison with US measurements

Collegium antropologicum, 2007

The purpose of the study was to determine the difference in extrahepatic bile duct (EBD) size mea... more The purpose of the study was to determine the difference in extrahepatic bile duct (EBD) size measured by magnetic resonance (MR) compared with those measured by ultrasound (US). Changes of EBD size related to aging were analyzed too. Size of EBD was measured in 76 randomly selected healthy individuals. Three radiologists blinded to the result of other study preformed measurements by US and three different T2 weighted MR sequences. Correlation and linear regression analysis of obtained data were performed. The mean diameter of EBD measured by US was 3.17 mm and by MR was 3.14 mm on thick slab rapid acquisition with relaxation enhancement (TSE), 3.26 mm on thin section single-shot TSE (HASTE) and 3.30 mm on coronal fully rewound gradient echo (True FISP). There was no statistical difference between US and different MR sequences (p < 0.05). A trend of increase of EBD with age (0.0155 mm per year, p = 0.0954) was observed. Size of EBD highly correlated for each MR sequence with US m...

Research paper thumbnail of Fat Stranding as a Useful CT Sign in Patient with Acute Abdominal Pain Authors

Poster: "ECR 2016 / C-0884 / Fat Stranding as a Useful CT Sign in Patient with Acute Abdomin... more Poster: "ECR 2016 / C-0884 / Fat Stranding as a Useful CT Sign in Patient with Acute Abdominal Pain Authors" by: "J. Nincevic, D. Marjan; zagreb/HR"

Research paper thumbnail of Septic sacroiliitis-clinical and MR findings

Poster: "ECR 2016 / C-0435 / Septic sacroiliitis-clinical and MR findings" by: "R.... more Poster: "ECR 2016 / C-0435 / Septic sacroiliitis-clinical and MR findings" by: "R. Vukojevic, M. Mustapic, D. Marjan, D. Tomasovic, Z. Brnic; Zagreb/HR"

Research paper thumbnail of Hemophilic arthropathy of the knee- magnetic resonance imaging-what radiology resident should know?

Poster: "ECR 2017 / C-0515 / Hemophilic arthropathy of the knee- magnetic resonance imaging-... more Poster: "ECR 2017 / C-0515 / Hemophilic arthropathy of the knee- magnetic resonance imaging-what radiology resident should know? " by: " R. Vukojevic , M. Mustapic, D. Marjan, D. Tomasovic, I. Ravlic, A. Filipovic-Grcic; Zagreb/HR"

Research paper thumbnail of Impact of Comorbidities on MRI Findings in Patients with Vertebral Osteomyelitis

Poster: "ECR 2014 / C-0062 / Impact of Comorbidities on MRI Findings in Patients with Verteb... more Poster: "ECR 2014 / C-0062 / Impact of Comorbidities on MRI Findings in Patients with Vertebral Osteomyelitis" by: "M. Mustapic1, K. viskovic1, D. Miklic1, D. Marjan1, L. Luetic Cavor1, I. Boric2; 1Zagreb/HR, 2Zabok/HR"

Research paper thumbnail of Lumbosacral Transitional Vertebrae

Poster: "ECR 2016 / C-0173 / Lumbosacral Transitional Vertebrae " by: " M. Mustapi... more Poster: "ECR 2016 / C-0173 / Lumbosacral Transitional Vertebrae " by: " M. Mustapic 1, R. Vukojevic1, M. Gulin1, D. Marjan1, I. Boric2; 1Zagreb/HR, 2Zabok/HR"

Research paper thumbnail of Duodenal neuroendocrine tumors (d-NETs): challenges in diagnosis and treatment

Endocrine Oncology and Metabolism

Duodenal neuroendocrine tumors (d-NETs) represent 2% of all gastroenteropancreatic neuroendocrine... more Duodenal neuroendocrine tumors (d-NETs) represent 2% of all gastroenteropancreatic neuroendocrine neoplasms. Approximately 40 to 60% of patients at the time of diagnosis have metastases to regional lymph nodes and 10% have liver metastases. D-NETs are mostly incidentally discovered during upper gastrointestinal endoscopy as solitary lesions confined to the mucosa and submucosa. The majority of d-NETs are non-functional, but 10% are gastrinomas and less than 4% present with typical carcinoid syndrome. Measurement of serum gastrin and chromogranin A and screening for the MEN-1 syndrome is mandatory in all patients, while 5-HIAA should be measured only in case of typical symptoms. Magnetic resonance imaging (MRI) may be used to assess tumor spread and to detect primary tumor. Endoscopic ultrasound should be routinely used only for patients who are candidates for endoscopic treatment. Approximately 50% of patients have positive findings on somatostatin receptor scintigraphy (SRS), which should be used only in patients with metastatic disease. Treatment of d-NETs is controversial. Further studies are mandatory in order to detect patients who would benefit from radical surgery, which is associated with high mortality and morbidity rates. Current knowledge suggests that all tumors larger than 20 mm in diameter, sporadic gastrinomas and all periampulary dNETs must undergo radical surgery. Endoscopic mucosal resection is treatment of choice for G1 d-NETs smaller than 20 mm confined to submucosa. Transduodenal surgical resection may be used for patients with d-NETs invading muscularis propria. Additional surgical interventions are recommended after endoscopic treatment in case of G1 or G2 d-NETs with positive margins, G2 or G3 histological grading, invasion into muscular layer or in case of lymphovascular invasion. In case of metastatic disease, cytoreductive surgery should be considered as it improves overall 5-year survival rates. Somatostatin analogs may be used for G1 and G2 tumors, while cisplatin and etopozide should be used for G3 d-NETs. Everolimus may be effective for patients with G2 d-NETs. Peptide receptor radionuclide therapy may be used for patients with positive SRS and progressive disease.

Research paper thumbnail of Vertebral Osteomyelitis in Adult Patients--Characteristics and Outcome

Acta clinica Croatica, 2016

The aim of the study was to assess disease characteristics and outcome in patients with vertebral... more The aim of the study was to assess disease characteristics and outcome in patients with vertebral osteomyelitis (VO). A two medical centre retrospective cohort study was performed by chart review after discharge of 110 patients with confirmed VO treated during a 5-year period. Patients were divided in two groups: patients with uncomplicated VO and patients with complicated VO. All patients underwent clinical and biological examinations and magnetic resonance imaging (MRI) according to the same protocol. Patients with complicated VO were significantly older (p = 0.038). They were longer treated with antibiotics parenterally (p = 0.047) and more often surgically (p < 0.001). In these patients, high Charlson comorbidity index (CCI) score was more often observed (p = 0.024), as well as liver cirrhosis (p = 0.013) and degenerative spine disease (p = 0.007) as comorbidities. Patients with advanced MRI changes of VO had a modified CCI score of 2 or more (p = 0.006). They more often expe...

Research paper thumbnail of Ileal Herniation Through the Foramen of Winslow: Overeating as a Risk Factor for Internal Herniation

Acta clinica Croatica, 2016

Internal hernias have an overall incidence of less than 1% and are difficult to diagnose clinical... more Internal hernias have an overall incidence of less than 1% and are difficult to diagnose clinically due to their nonspecific presentation. Most internal hernias present as strangulating closed-loop obstruction and delay in surgical intervention is responsible for a high mortality rate (49%). We present a case of ileal herniation through the foramen of Winslow. A 29-year-old previously healthy female presented with acute onset right upper quadrant pain, abdominal fullness, and nausea. The pain was sudden in onset and began shortly after a dinner party where she consumed larger portions of food. Laboratory investigations revealed mild leukocytosis with left shift. Dual-phase multi-detector computed tomography disclosed herniation of the small bowel into the lesser sac. The patient underwent an emergency median laparotomy that revealed ileal herniation through the foramen of Winslow. Adhesiolysis and manual reduction of the bowel was performed, and the reduced bowel showed only congest...

Research paper thumbnail of Nonenhancing spinal subdural metastatic tumor

AJNR. American journal of neuroradiology, 2005

We describe a case of a spinal subdural metastatic tumor that became rapidly symptomatic after a ... more We describe a case of a spinal subdural metastatic tumor that became rapidly symptomatic after a minor trauma, as a result of severe cord compression and cord hemorrhage. On MR imaging, the lesion was oval, hyperintense with a dark rim on T2-weighted fast spin-echo images, isointense to the cord on T1-weighted images, and had dark and bright areas on gradient-echo T2*-weighted images, consistent with a hyperacute-to-acute hematoma. The hemorrhagic tumor showed no evidence of contrast enhancement.

Research paper thumbnail of Nonenhancing spinal subdural metastatic tumor

AJNR. American journal of neuroradiology, 2005

We describe a case of a spinal subdural metastatic tumor that became rapidly symptomatic after a ... more We describe a case of a spinal subdural metastatic tumor that became rapidly symptomatic after a minor trauma, as a result of severe cord compression and cord hemorrhage. On MR imaging, the lesion was oval, hyperintense with a dark rim on T2-weighted fast spin-echo images, isointense to the cord on T1-weighted images, and had dark and bright areas on gradient-echo T2*-weighted images, consistent with a hyperacute-to-acute hematoma. The hemorrhagic tumor showed no evidence of contrast enhancement.

Research paper thumbnail of MR assessment of bile duct size in healthy individuals: comparison with US measurements

Collegium antropologicum, 2007

The purpose of the study was to determine the difference in extrahepatic bile duct (EBD) size mea... more The purpose of the study was to determine the difference in extrahepatic bile duct (EBD) size measured by magnetic resonance (MR) compared with those measured by ultrasound (US). Changes of EBD size related to aging were analyzed too. Size of EBD was measured in 76 randomly selected healthy individuals. Three radiologists blinded to the result of other study preformed measurements by US and three different T2 weighted MR sequences. Correlation and linear regression analysis of obtained data were performed. The mean diameter of EBD measured by US was 3.17 mm and by MR was 3.14 mm on thick slab rapid acquisition with relaxation enhancement (TSE), 3.26 mm on thin section single-shot TSE (HASTE) and 3.30 mm on coronal fully rewound gradient echo (True FISP). There was no statistical difference between US and different MR sequences (p < 0.05). A trend of increase of EBD with age (0.0155 mm per year, p = 0.0954) was observed. Size of EBD highly correlated for each MR sequence with US m...

Research paper thumbnail of Fat Stranding as a Useful CT Sign in Patient with Acute Abdominal Pain Authors

Poster: "ECR 2016 / C-0884 / Fat Stranding as a Useful CT Sign in Patient with Acute Abdomin... more Poster: "ECR 2016 / C-0884 / Fat Stranding as a Useful CT Sign in Patient with Acute Abdominal Pain Authors" by: "J. Nincevic, D. Marjan; zagreb/HR"

Research paper thumbnail of Septic sacroiliitis-clinical and MR findings

Poster: "ECR 2016 / C-0435 / Septic sacroiliitis-clinical and MR findings" by: "R.... more Poster: "ECR 2016 / C-0435 / Septic sacroiliitis-clinical and MR findings" by: "R. Vukojevic, M. Mustapic, D. Marjan, D. Tomasovic, Z. Brnic; Zagreb/HR"

Research paper thumbnail of Hemophilic arthropathy of the knee- magnetic resonance imaging-what radiology resident should know?

Poster: "ECR 2017 / C-0515 / Hemophilic arthropathy of the knee- magnetic resonance imaging-... more Poster: "ECR 2017 / C-0515 / Hemophilic arthropathy of the knee- magnetic resonance imaging-what radiology resident should know? " by: " R. Vukojevic , M. Mustapic, D. Marjan, D. Tomasovic, I. Ravlic, A. Filipovic-Grcic; Zagreb/HR"

Research paper thumbnail of Impact of Comorbidities on MRI Findings in Patients with Vertebral Osteomyelitis

Poster: "ECR 2014 / C-0062 / Impact of Comorbidities on MRI Findings in Patients with Verteb... more Poster: "ECR 2014 / C-0062 / Impact of Comorbidities on MRI Findings in Patients with Vertebral Osteomyelitis" by: "M. Mustapic1, K. viskovic1, D. Miklic1, D. Marjan1, L. Luetic Cavor1, I. Boric2; 1Zagreb/HR, 2Zabok/HR"

Research paper thumbnail of Lumbosacral Transitional Vertebrae

Poster: "ECR 2016 / C-0173 / Lumbosacral Transitional Vertebrae " by: " M. Mustapi... more Poster: "ECR 2016 / C-0173 / Lumbosacral Transitional Vertebrae " by: " M. Mustapic 1, R. Vukojevic1, M. Gulin1, D. Marjan1, I. Boric2; 1Zagreb/HR, 2Zabok/HR"

Research paper thumbnail of Duodenal neuroendocrine tumors (d-NETs): challenges in diagnosis and treatment

Endocrine Oncology and Metabolism

Duodenal neuroendocrine tumors (d-NETs) represent 2% of all gastroenteropancreatic neuroendocrine... more Duodenal neuroendocrine tumors (d-NETs) represent 2% of all gastroenteropancreatic neuroendocrine neoplasms. Approximately 40 to 60% of patients at the time of diagnosis have metastases to regional lymph nodes and 10% have liver metastases. D-NETs are mostly incidentally discovered during upper gastrointestinal endoscopy as solitary lesions confined to the mucosa and submucosa. The majority of d-NETs are non-functional, but 10% are gastrinomas and less than 4% present with typical carcinoid syndrome. Measurement of serum gastrin and chromogranin A and screening for the MEN-1 syndrome is mandatory in all patients, while 5-HIAA should be measured only in case of typical symptoms. Magnetic resonance imaging (MRI) may be used to assess tumor spread and to detect primary tumor. Endoscopic ultrasound should be routinely used only for patients who are candidates for endoscopic treatment. Approximately 50% of patients have positive findings on somatostatin receptor scintigraphy (SRS), which should be used only in patients with metastatic disease. Treatment of d-NETs is controversial. Further studies are mandatory in order to detect patients who would benefit from radical surgery, which is associated with high mortality and morbidity rates. Current knowledge suggests that all tumors larger than 20 mm in diameter, sporadic gastrinomas and all periampulary dNETs must undergo radical surgery. Endoscopic mucosal resection is treatment of choice for G1 d-NETs smaller than 20 mm confined to submucosa. Transduodenal surgical resection may be used for patients with d-NETs invading muscularis propria. Additional surgical interventions are recommended after endoscopic treatment in case of G1 or G2 d-NETs with positive margins, G2 or G3 histological grading, invasion into muscular layer or in case of lymphovascular invasion. In case of metastatic disease, cytoreductive surgery should be considered as it improves overall 5-year survival rates. Somatostatin analogs may be used for G1 and G2 tumors, while cisplatin and etopozide should be used for G3 d-NETs. Everolimus may be effective for patients with G2 d-NETs. Peptide receptor radionuclide therapy may be used for patients with positive SRS and progressive disease.

Research paper thumbnail of Vertebral Osteomyelitis in Adult Patients--Characteristics and Outcome

Acta clinica Croatica, 2016

The aim of the study was to assess disease characteristics and outcome in patients with vertebral... more The aim of the study was to assess disease characteristics and outcome in patients with vertebral osteomyelitis (VO). A two medical centre retrospective cohort study was performed by chart review after discharge of 110 patients with confirmed VO treated during a 5-year period. Patients were divided in two groups: patients with uncomplicated VO and patients with complicated VO. All patients underwent clinical and biological examinations and magnetic resonance imaging (MRI) according to the same protocol. Patients with complicated VO were significantly older (p = 0.038). They were longer treated with antibiotics parenterally (p = 0.047) and more often surgically (p < 0.001). In these patients, high Charlson comorbidity index (CCI) score was more often observed (p = 0.024), as well as liver cirrhosis (p = 0.013) and degenerative spine disease (p = 0.007) as comorbidities. Patients with advanced MRI changes of VO had a modified CCI score of 2 or more (p = 0.006). They more often expe...

Research paper thumbnail of Ileal Herniation Through the Foramen of Winslow: Overeating as a Risk Factor for Internal Herniation

Acta clinica Croatica, 2016

Internal hernias have an overall incidence of less than 1% and are difficult to diagnose clinical... more Internal hernias have an overall incidence of less than 1% and are difficult to diagnose clinically due to their nonspecific presentation. Most internal hernias present as strangulating closed-loop obstruction and delay in surgical intervention is responsible for a high mortality rate (49%). We present a case of ileal herniation through the foramen of Winslow. A 29-year-old previously healthy female presented with acute onset right upper quadrant pain, abdominal fullness, and nausea. The pain was sudden in onset and began shortly after a dinner party where she consumed larger portions of food. Laboratory investigations revealed mild leukocytosis with left shift. Dual-phase multi-detector computed tomography disclosed herniation of the small bowel into the lesser sac. The patient underwent an emergency median laparotomy that revealed ileal herniation through the foramen of Winslow. Adhesiolysis and manual reduction of the bowel was performed, and the reduced bowel showed only congest...

Research paper thumbnail of Nonenhancing spinal subdural metastatic tumor

AJNR. American journal of neuroradiology, 2005

We describe a case of a spinal subdural metastatic tumor that became rapidly symptomatic after a ... more We describe a case of a spinal subdural metastatic tumor that became rapidly symptomatic after a minor trauma, as a result of severe cord compression and cord hemorrhage. On MR imaging, the lesion was oval, hyperintense with a dark rim on T2-weighted fast spin-echo images, isointense to the cord on T1-weighted images, and had dark and bright areas on gradient-echo T2*-weighted images, consistent with a hyperacute-to-acute hematoma. The hemorrhagic tumor showed no evidence of contrast enhancement.