Dominic Yu - Academia.edu (original) (raw)

Papers by Dominic Yu

Research paper thumbnail of Outcomes of a therapeutic stepwise approach involving low-dose systemic thrombolysis for managing acute portomesenteric thrombosis

Journal of Hepatology, Jun 1, 2023

Research paper thumbnail of Myeloproliferative neoplasms and splanchnic vein thrombosis: results of a long-term UK prospective cohort study

Journal of Hepatology, Jun 1, 2023

Research paper thumbnail of Transjugular Intrahepatic Portosystemic Shunt (TIPS) – Common complications and how to manage them

Research paper thumbnail of Vascular Access: Haemodialysis Catheters

Research paper thumbnail of Seeding following percutaneous diagnostic and therapeutic approaches for hepatocellular carcinoma. What is the risk and the outcome?

Cancer Treatment Reviews, Aug 1, 2007

Background: Tumour biopsy is usually considered mandatory for patient management by oncologists. ... more Background: Tumour biopsy is usually considered mandatory for patient management by oncologists. Currently percutaneous ablation is used therapeutically for cirrhotic patients with small hepatocellular carcinoma (HCC), not suitable for resection or waiting for liver transplantation. However malignant seeding is a recognized complication of both diagnostic and therapeutic procedures in patients with HCC. Although percutaneous therapy whether with or without biopsy of a suspected HCC nodule may minimize the risk of seeding, this has not been confirmed. Aim: To evaluate the risk of seeding, defined as new neoplastic disease occurring outside the liver capsule, either in the subcutaneous tissue or peritoneal cavity following needle biopsy and/or local ablation therapy (LAT). Methods: A literature search resulted in 179 events in 99 articles between January 1983 and February 2007: 66 seedings followed liver biopsy, 26 percutaneous ethanol injection (PEI), 1 microwave, 22 radiofrequency ablation (RFA), and 64 after combined biopsy and percutaneous treatment (5 microwave; 33 PEI; 26 RFA). Results: In 41 papers specifying the total number of patients biopsied and/or treated, the median risk of seeding was 2.29% (range 0-11%) for biopsy group; 1.4% (1.

Research paper thumbnail of Data from Circulating Tumor Cells and EpCAM Expression in Neuroendocrine Tumors

Purpose: Neuroendocrine tumors (NET) are heterogeneous tumors with widely variable survival. It i... more Purpose: Neuroendocrine tumors (NET) are heterogeneous tumors with widely variable survival. It is unknown whether they express EpCAM (epithelial cell adhesion molecule) and thus whether NET circulating tumor cells (CTC) are detectable. We systematically investigated EpCAM expression and CTC detection in patients with metastatic NETs and evaluated the potential of CTCs to predict radiological progression.Experimental Design: EpCAM protein expression was evaluated in 74 samples of formalin-fixed, paraffin-embedded NET tissue by immunohistochemistry. Seventy-nine patients with metastatic NETs (42 midgut, 5 unknown primary, 19 pancreatic, 13 bronchopulmonary) had blood samples drawn for CTC isolation and enumeration utilizing the CellSearch platform. Patients were classified as having progressive or nonprogressive disease on the basis of serial imaging.Results: Strong homogeneous, membranous EpCAM expression was observed in all ileal (n = 26) and pancreatic NETs (n = 16), whereas varia...

Research paper thumbnail of OP18 The story of transjugular intrahepatic portosystemic shunt (TIPSS) at the Royal Free Hospital, 2021–2022: indications and outcomes of 84 procedures

Research paper thumbnail of Radiology of pediatric liver tumours: A pictorial review

European Congress of Radiology - ECR 2004, Mar 5, 2004

Research paper thumbnail of Review of Radiofrequency Ablation of Neuroendocrine Liver Metastases -A Single Centre Experience

Research paper thumbnail of Splanchnic Vein Thrombosis in Myeloproloferative Neoplasms; a Prospective Analysis of Thrombosis Outcome

Research paper thumbnail of Outcomes of a therapeutic stepwise approach involving low-dose systemic thrombolysis for managing acute portomesenteric thrombosis

Journal of Hepatology, Jun 1, 2023

Research paper thumbnail of Myeloproliferative neoplasms and splanchnic vein thrombosis: results of a long-term UK prospective cohort study

Journal of Hepatology, Jun 1, 2023

Research paper thumbnail of PWE-092 Systemic tpa for acute splanchnic vein thrombosis: Abstract PWE-092 Table 1

Gut, 2015

Conclusion This early experience suggests that systemic tPA in patients with acute PMVT and sympt... more Conclusion This early experience suggests that systemic tPA in patients with acute PMVT and symptoms/signs of gut ischaemia Abstracts A252 Gut 2015;64(Suppl 1):A1-A584 can be used to achieve resolution of thrombus and symptoms and avoid catastrophic complications of gut infarction. We propose that tPA is of value in a multi-modality approach to the management of acute splanchnic vein thrombosis. Disclosure of interest None Declared.

Research paper thumbnail of Transjugular Intrahepatic Portosystemic Shunt (TIPS) – Common complications and how to manage them

Research paper thumbnail of Vascular Access: Haemodialysis Catheters

Research paper thumbnail of When banding fails; investigation hails

Research paper thumbnail of Seeding following percutaneous diagnostic and therapeutic approaches for hepatocellular carcinoma. What is the risk and the outcome?

Cancer Treatment Reviews, Aug 1, 2007

Background: Tumour biopsy is usually considered mandatory for patient management by oncologists. ... more Background: Tumour biopsy is usually considered mandatory for patient management by oncologists. Currently percutaneous ablation is used therapeutically for cirrhotic patients with small hepatocellular carcinoma (HCC), not suitable for resection or waiting for liver transplantation. However malignant seeding is a recognized complication of both diagnostic and therapeutic procedures in patients with HCC. Although percutaneous therapy whether with or without biopsy of a suspected HCC nodule may minimize the risk of seeding, this has not been confirmed. Aim: To evaluate the risk of seeding, defined as new neoplastic disease occurring outside the liver capsule, either in the subcutaneous tissue or peritoneal cavity following needle biopsy and/or local ablation therapy (LAT). Methods: A literature search resulted in 179 events in 99 articles between January 1983 and February 2007: 66 seedings followed liver biopsy, 26 percutaneous ethanol injection (PEI), 1 microwave, 22 radiofrequency ablation (RFA), and 64 after combined biopsy and percutaneous treatment (5 microwave; 33 PEI; 26 RFA). Results: In 41 papers specifying the total number of patients biopsied and/or treated, the median risk of seeding was 2.29% (range 0-11%) for biopsy group; 1.4% (1.

Research paper thumbnail of Data from Circulating Tumor Cells and EpCAM Expression in Neuroendocrine Tumors

Purpose: Neuroendocrine tumors (NET) are heterogeneous tumors with widely variable survival. It i... more Purpose: Neuroendocrine tumors (NET) are heterogeneous tumors with widely variable survival. It is unknown whether they express EpCAM (epithelial cell adhesion molecule) and thus whether NET circulating tumor cells (CTC) are detectable. We systematically investigated EpCAM expression and CTC detection in patients with metastatic NETs and evaluated the potential of CTCs to predict radiological progression.Experimental Design: EpCAM protein expression was evaluated in 74 samples of formalin-fixed, paraffin-embedded NET tissue by immunohistochemistry. Seventy-nine patients with metastatic NETs (42 midgut, 5 unknown primary, 19 pancreatic, 13 bronchopulmonary) had blood samples drawn for CTC isolation and enumeration utilizing the CellSearch platform. Patients were classified as having progressive or nonprogressive disease on the basis of serial imaging.Results: Strong homogeneous, membranous EpCAM expression was observed in all ileal (n = 26) and pancreatic NETs (n = 16), whereas varia...

Research paper thumbnail of OP18 The story of transjugular intrahepatic portosystemic shunt (TIPSS) at the Royal Free Hospital, 2021–2022: indications and outcomes of 84 procedures

Research paper thumbnail of Radiology of pediatric liver tumours: A pictorial review

European Congress of Radiology - ECR 2004, Mar 5, 2004

Research paper thumbnail of Outcomes of a therapeutic stepwise approach involving low-dose systemic thrombolysis for managing acute portomesenteric thrombosis

Journal of Hepatology, Jun 1, 2023

Research paper thumbnail of Myeloproliferative neoplasms and splanchnic vein thrombosis: results of a long-term UK prospective cohort study

Journal of Hepatology, Jun 1, 2023

Research paper thumbnail of Transjugular Intrahepatic Portosystemic Shunt (TIPS) – Common complications and how to manage them

Research paper thumbnail of Vascular Access: Haemodialysis Catheters

Research paper thumbnail of Seeding following percutaneous diagnostic and therapeutic approaches for hepatocellular carcinoma. What is the risk and the outcome?

Cancer Treatment Reviews, Aug 1, 2007

Background: Tumour biopsy is usually considered mandatory for patient management by oncologists. ... more Background: Tumour biopsy is usually considered mandatory for patient management by oncologists. Currently percutaneous ablation is used therapeutically for cirrhotic patients with small hepatocellular carcinoma (HCC), not suitable for resection or waiting for liver transplantation. However malignant seeding is a recognized complication of both diagnostic and therapeutic procedures in patients with HCC. Although percutaneous therapy whether with or without biopsy of a suspected HCC nodule may minimize the risk of seeding, this has not been confirmed. Aim: To evaluate the risk of seeding, defined as new neoplastic disease occurring outside the liver capsule, either in the subcutaneous tissue or peritoneal cavity following needle biopsy and/or local ablation therapy (LAT). Methods: A literature search resulted in 179 events in 99 articles between January 1983 and February 2007: 66 seedings followed liver biopsy, 26 percutaneous ethanol injection (PEI), 1 microwave, 22 radiofrequency ablation (RFA), and 64 after combined biopsy and percutaneous treatment (5 microwave; 33 PEI; 26 RFA). Results: In 41 papers specifying the total number of patients biopsied and/or treated, the median risk of seeding was 2.29% (range 0-11%) for biopsy group; 1.4% (1.

Research paper thumbnail of Data from Circulating Tumor Cells and EpCAM Expression in Neuroendocrine Tumors

Purpose: Neuroendocrine tumors (NET) are heterogeneous tumors with widely variable survival. It i... more Purpose: Neuroendocrine tumors (NET) are heterogeneous tumors with widely variable survival. It is unknown whether they express EpCAM (epithelial cell adhesion molecule) and thus whether NET circulating tumor cells (CTC) are detectable. We systematically investigated EpCAM expression and CTC detection in patients with metastatic NETs and evaluated the potential of CTCs to predict radiological progression.Experimental Design: EpCAM protein expression was evaluated in 74 samples of formalin-fixed, paraffin-embedded NET tissue by immunohistochemistry. Seventy-nine patients with metastatic NETs (42 midgut, 5 unknown primary, 19 pancreatic, 13 bronchopulmonary) had blood samples drawn for CTC isolation and enumeration utilizing the CellSearch platform. Patients were classified as having progressive or nonprogressive disease on the basis of serial imaging.Results: Strong homogeneous, membranous EpCAM expression was observed in all ileal (n = 26) and pancreatic NETs (n = 16), whereas varia...

Research paper thumbnail of OP18 The story of transjugular intrahepatic portosystemic shunt (TIPSS) at the Royal Free Hospital, 2021–2022: indications and outcomes of 84 procedures

Research paper thumbnail of Radiology of pediatric liver tumours: A pictorial review

European Congress of Radiology - ECR 2004, Mar 5, 2004

Research paper thumbnail of Review of Radiofrequency Ablation of Neuroendocrine Liver Metastases -A Single Centre Experience

Research paper thumbnail of Splanchnic Vein Thrombosis in Myeloproloferative Neoplasms; a Prospective Analysis of Thrombosis Outcome

Research paper thumbnail of Outcomes of a therapeutic stepwise approach involving low-dose systemic thrombolysis for managing acute portomesenteric thrombosis

Journal of Hepatology, Jun 1, 2023

Research paper thumbnail of Myeloproliferative neoplasms and splanchnic vein thrombosis: results of a long-term UK prospective cohort study

Journal of Hepatology, Jun 1, 2023

Research paper thumbnail of PWE-092 Systemic tpa for acute splanchnic vein thrombosis: Abstract PWE-092 Table 1

Gut, 2015

Conclusion This early experience suggests that systemic tPA in patients with acute PMVT and sympt... more Conclusion This early experience suggests that systemic tPA in patients with acute PMVT and symptoms/signs of gut ischaemia Abstracts A252 Gut 2015;64(Suppl 1):A1-A584 can be used to achieve resolution of thrombus and symptoms and avoid catastrophic complications of gut infarction. We propose that tPA is of value in a multi-modality approach to the management of acute splanchnic vein thrombosis. Disclosure of interest None Declared.

Research paper thumbnail of Transjugular Intrahepatic Portosystemic Shunt (TIPS) – Common complications and how to manage them

Research paper thumbnail of Vascular Access: Haemodialysis Catheters

Research paper thumbnail of When banding fails; investigation hails

Research paper thumbnail of Seeding following percutaneous diagnostic and therapeutic approaches for hepatocellular carcinoma. What is the risk and the outcome?

Cancer Treatment Reviews, Aug 1, 2007

Background: Tumour biopsy is usually considered mandatory for patient management by oncologists. ... more Background: Tumour biopsy is usually considered mandatory for patient management by oncologists. Currently percutaneous ablation is used therapeutically for cirrhotic patients with small hepatocellular carcinoma (HCC), not suitable for resection or waiting for liver transplantation. However malignant seeding is a recognized complication of both diagnostic and therapeutic procedures in patients with HCC. Although percutaneous therapy whether with or without biopsy of a suspected HCC nodule may minimize the risk of seeding, this has not been confirmed. Aim: To evaluate the risk of seeding, defined as new neoplastic disease occurring outside the liver capsule, either in the subcutaneous tissue or peritoneal cavity following needle biopsy and/or local ablation therapy (LAT). Methods: A literature search resulted in 179 events in 99 articles between January 1983 and February 2007: 66 seedings followed liver biopsy, 26 percutaneous ethanol injection (PEI), 1 microwave, 22 radiofrequency ablation (RFA), and 64 after combined biopsy and percutaneous treatment (5 microwave; 33 PEI; 26 RFA). Results: In 41 papers specifying the total number of patients biopsied and/or treated, the median risk of seeding was 2.29% (range 0-11%) for biopsy group; 1.4% (1.

Research paper thumbnail of Data from Circulating Tumor Cells and EpCAM Expression in Neuroendocrine Tumors

Purpose: Neuroendocrine tumors (NET) are heterogeneous tumors with widely variable survival. It i... more Purpose: Neuroendocrine tumors (NET) are heterogeneous tumors with widely variable survival. It is unknown whether they express EpCAM (epithelial cell adhesion molecule) and thus whether NET circulating tumor cells (CTC) are detectable. We systematically investigated EpCAM expression and CTC detection in patients with metastatic NETs and evaluated the potential of CTCs to predict radiological progression.Experimental Design: EpCAM protein expression was evaluated in 74 samples of formalin-fixed, paraffin-embedded NET tissue by immunohistochemistry. Seventy-nine patients with metastatic NETs (42 midgut, 5 unknown primary, 19 pancreatic, 13 bronchopulmonary) had blood samples drawn for CTC isolation and enumeration utilizing the CellSearch platform. Patients were classified as having progressive or nonprogressive disease on the basis of serial imaging.Results: Strong homogeneous, membranous EpCAM expression was observed in all ileal (n = 26) and pancreatic NETs (n = 16), whereas varia...

Research paper thumbnail of OP18 The story of transjugular intrahepatic portosystemic shunt (TIPSS) at the Royal Free Hospital, 2021–2022: indications and outcomes of 84 procedures

Research paper thumbnail of Radiology of pediatric liver tumours: A pictorial review

European Congress of Radiology - ECR 2004, Mar 5, 2004