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Papers by Donald Coleman

Research paper thumbnail of Ultrasound Determination of Anterior and Posterior Corneal Curvature

Investigative Ophthalmology & Visual Science, 2005

Research paper thumbnail of Pars plana vitrectomy. The role of vitrectomy in traumatic vitreopathy

Transactions. Section on Ophthalmology. American Academy of Ophthalmology and Otolaryngology

Debridement of the vitreous from perforating injuries can be more effectively and expeditiously a... more Debridement of the vitreous from perforating injuries can be more effectively and expeditiously accomplished with the aid of vitreous suction and cutting instruments than with conventional sponge-forceps technique. This technique is of great value as part of primary closure of perforating ocular injuries. In addition, trauma which results in (1) lens rupture with expulsion of the lens material into the vitreous; (2) massive vitreous hemorrhage with ciliary body laceration or posterior globe laceration; (3) retinal detachment with vitreous hemorrhage; or (4) retained reactive intraocular foreign body, requires vitrectomy. Because of inflammatory and fibroplastic changes, the earliest possible surgical intervention is recommended in these situations. Removal of lens material, reactive foreign body, or traction membranes, and early repair of retinal detachment may all be facilitated by new vitrectomy instrumentation.

Research paper thumbnail of A model for acoustic characterization of intraocular tumors

Investigative ophthalmology & visual science, 1985

Human intraocular tumors and tumors derived from human tumor cell lines grown subcutaneously in t... more Human intraocular tumors and tumors derived from human tumor cell lines grown subcutaneously in the athymic nude mouse were scanned by diagnostic ultrasound. Radiofrequency scan data were converted to digital form and analyzed in the frequency domain. Characteristics of normalized power spectra were found to be significantly different among human spindle cell malignant melanomas, mixed/epithelioid malignant melanomas, metastatic carcinomas, and hemangiomas. Significant differences, as well, were found between implanted primary skin malignant melanomas and adenocarcinomas of the lung, colon, and stomach. Comparison of spectral properties of human intraocular and implanted tumors revealed that human spindle cell malignant melanomas and implanted melanomas exhibit similar characteristics. Human intraocular metastatic tumors from the lung were found to exhibit characteristics similar to those of implanted lung tumors. These results indicate that the implantation of human tumor cell line...

Research paper thumbnail of Unified Model for Accommodative Mechanism

American Journal of Ophthalmology, 1970

Research paper thumbnail of Measurement of Choroidal Pulsation with M-Scan Ultrasound

American Journal of Ophthalmology, 1971

Research paper thumbnail of A Suction Tip for Controlled Removal of Nonmagnetic Intraocular Foreign Bodies

American Journal of Ophthalmology, 1978

Research paper thumbnail of Ultrasonography in Ocular Trauma

American Journal of Ophthalmology, 1973

ABSTRACT

Research paper thumbnail of Diagnostic spectrum analysis in ophthalmology: A physical perspective

Ultrasound in Medicine & Biology, 1986

Research paper thumbnail of The Effect of Transducer Bandwidth on Ultrasonic Image Characteristics

Research paper thumbnail of Evaluation of Ciliary Body Detachment in Hypotony

Research paper thumbnail of Ultrasonography of the Eye

International Ophthalmology Clinics, 1986

Research paper thumbnail of Production of Corneal Lesions Using High-Intensity Focused Ultrasound

Cornea, 1990

In order to study the potential use of ultrasound as a noninvasive system for altering corneal cu... more In order to study the potential use of ultrasound as a noninvasive system for altering corneal curvature, we used high-density focused ultrasound at a frequency of 4.8 MHz and 7.9 MHz to produce corneal lesions in the rabbit eye. Intensity and duration threshold exposure conditions were determined for the production of minimally visible lesions. Threshold lesions were initially apparent as discrete white opacities resulting from stromal edema and disruption. Light and scanning electron microscopy of higher-energy, suprathreshold lesions revealed more extensive disruption, including the formation of a superficial stromal depression and a larger zone of edema and disorganization surrounding each lesion. Posterior stromal lamellae, endothelium, and Descemet's membrane were intact. Healing and reepithelialization resulted in a smooth corneal surface with no residual opacification. Threshold determinations predict safe exposure levels to the cornea during insonification of other ocular structures. Selective heating of the peripheral cornea using focused ultrasound may be a useful technique for correcting astigmatism.

Research paper thumbnail of Presbyopia, accommodation, and mature catenary1 1The following six letters address on article that appeared in the September 2001 issue of the Journal: Coleman DJ, Fish SK. Presbyopia, accommodation, and the mature catenary. (Ophthalmology 2001;108:1544–51)

Research paper thumbnail of Ultrasonic Hyperthermia and Radiation in the Management of Intraocular Malignant Melanoma

American Journal of Ophthalmology, 1986

Hyperthermia and radiation were used in combination to treat four patients with choroidal maligna... more Hyperthermia and radiation were used in combination to treat four patients with choroidal malignant melanoma. This technique uses ultrasonically induced hyperthermia synergistically with radiation to destroy tumor cells. The lower levels of radiation used should avoid the late vascular and inflammatory complications seen in conventional radiation therapy. Tumors were scanned by a computerized diagnostic ultrasound system before treatment and assigned an acoustic tissue type on the basis of a statistical comparison of their ultrasound backscatter spectrum with spectra of tumors of known pathologic status. During the follow-up period, the longest of which was 15 months, alltumors demonstrated regression patterns consistent with choroidal tumors of the same acoustic tissue types treated with conventional radiation therapy. UNTIL RECENTLY, the standard method of managing ocular melanoma has been enucIea

Research paper thumbnail of Digital Processing and Imaging Modes for Clinical Ultrasound

Documenta Ophthalmologica Proceedings Series, 1981

A computer-based ultrasound system has been designed and constructed to provide new approaches to... more A computer-based ultrasound system has been designed and constructed to provide new approaches to processing, analyzing, and displaying clinical ultrasonograms, (c.f. Lizzi, et al. 1979, 1980). Over the past year, the system has been applied in ophthalmic examinations, and it has been continually refined and expanded as clinical trials proceed.

Research paper thumbnail of Ultrasonic Volume Determination in Ophthalmology

Ultrasound in Medicine, 1975

Estimation of ocular volumes by means of B-scan sections and planimeter measurements provides uni... more Estimation of ocular volumes by means of B-scan sections and planimeter measurements provides unique information for several areas of ophthalmic management.

Research paper thumbnail of High-resolution ultrasonic imaging of blood flow in the anterior segment of the eye

Investigative ophthalmology & visual science, 1999

To develop a noninvasive technique to visualize and measure blood flow in the iris and ciliary bo... more To develop a noninvasive technique to visualize and measure blood flow in the iris and ciliary body. Echo data from 50-MHz ultrasound scans of the iris and ciliary body of rabbits were digitized using a new "swept scan" modality. The method makes use of spatial oversampling to identify regions with scatterers whose range changes with time. The data allowed construction of high-resolution B-mode images with embedded flow information. Pulsatility over the cardiac cycle was evaluated by sending a series of pulses along a single line of sight containing a vessel of interest. Local blood flow and changes over the cardiac cycle before and after application of atropine were quantified. Flow was identified in the radial vessels and major arterial circle of the iris. Vessels with lumens as small as 40 microm in diameter and flow velocities as low as 0.6 mm/sec were measured. Change in blood velocity over the cardiac cycle was determined to be approximately 27%. Peak systolic veloci...

Research paper thumbnail of Ocular tumor patterns

Bibliotheca ophthalmologica : supplementa ad ophthalmologica, 1975

The use of choroidal excavation and vascular pulsations in the ultrasonic diagnosis of tumors has... more The use of choroidal excavation and vascular pulsations in the ultrasonic diagnosis of tumors has been a helpful diagnostic feature. Evaluation of choroidal tumors is presently performed with A-, B- and M-scan techniques. Solid tumors of high homogeneity produce characteristic hollows or acoustic quiet zones that replace the normal choroidal pattern. M-scan patterns of vascular pulsations are also useful in demonstrating vascularity or choroidal tumors. Color displays accentuate amplitude variations in ocular tumors.

Research paper thumbnail of Experimental Production of Chorioretinal Lesions: I. Continuous Wave Ultrasound

Ultrasound in Medicine, 1978

Lesions were created in the retina, choroid and sclera of the rabbit using continuous-wave, high-... more Lesions were created in the retina, choroid and sclera of the rabbit using continuous-wave, high-intensity ultrasound. In-vivo studies were performed on albino and pigmented rabbits using focussed ultrasound at 9.8 MHz. The quantitative evaluation of the effects of continuous-wave ultrasound is of interest because of the potential therapeutic applications to ocular tissues in those cases which cannot be purposely altered by optical energy.

Research paper thumbnail of Computer Assisted Acoustic Measurements of the Posterior Ocular Coats

Documenta Ophthalmologica Proceedings Series, 1981

The thickness of the posterior ocular coats of the eye (the retina, choroid, and sclera) has only... more The thickness of the posterior ocular coats of the eye (the retina, choroid, and sclera) has only been evaluable by indirect methods such as histologic examination, which allow extrapolation to the in vivo thickness. Many functional and aging processes are related to the integrity and thickness of these structures, thus the ability to provide an in vivo measurement would be valuable in studying both normal variations and disease states.

Research paper thumbnail of Ultrasound Determination of Anterior and Posterior Corneal Curvature

Investigative Ophthalmology & Visual Science, 2005

Research paper thumbnail of Pars plana vitrectomy. The role of vitrectomy in traumatic vitreopathy

Transactions. Section on Ophthalmology. American Academy of Ophthalmology and Otolaryngology

Debridement of the vitreous from perforating injuries can be more effectively and expeditiously a... more Debridement of the vitreous from perforating injuries can be more effectively and expeditiously accomplished with the aid of vitreous suction and cutting instruments than with conventional sponge-forceps technique. This technique is of great value as part of primary closure of perforating ocular injuries. In addition, trauma which results in (1) lens rupture with expulsion of the lens material into the vitreous; (2) massive vitreous hemorrhage with ciliary body laceration or posterior globe laceration; (3) retinal detachment with vitreous hemorrhage; or (4) retained reactive intraocular foreign body, requires vitrectomy. Because of inflammatory and fibroplastic changes, the earliest possible surgical intervention is recommended in these situations. Removal of lens material, reactive foreign body, or traction membranes, and early repair of retinal detachment may all be facilitated by new vitrectomy instrumentation.

Research paper thumbnail of A model for acoustic characterization of intraocular tumors

Investigative ophthalmology & visual science, 1985

Human intraocular tumors and tumors derived from human tumor cell lines grown subcutaneously in t... more Human intraocular tumors and tumors derived from human tumor cell lines grown subcutaneously in the athymic nude mouse were scanned by diagnostic ultrasound. Radiofrequency scan data were converted to digital form and analyzed in the frequency domain. Characteristics of normalized power spectra were found to be significantly different among human spindle cell malignant melanomas, mixed/epithelioid malignant melanomas, metastatic carcinomas, and hemangiomas. Significant differences, as well, were found between implanted primary skin malignant melanomas and adenocarcinomas of the lung, colon, and stomach. Comparison of spectral properties of human intraocular and implanted tumors revealed that human spindle cell malignant melanomas and implanted melanomas exhibit similar characteristics. Human intraocular metastatic tumors from the lung were found to exhibit characteristics similar to those of implanted lung tumors. These results indicate that the implantation of human tumor cell line...

Research paper thumbnail of Unified Model for Accommodative Mechanism

American Journal of Ophthalmology, 1970

Research paper thumbnail of Measurement of Choroidal Pulsation with M-Scan Ultrasound

American Journal of Ophthalmology, 1971

Research paper thumbnail of A Suction Tip for Controlled Removal of Nonmagnetic Intraocular Foreign Bodies

American Journal of Ophthalmology, 1978

Research paper thumbnail of Ultrasonography in Ocular Trauma

American Journal of Ophthalmology, 1973

ABSTRACT

Research paper thumbnail of Diagnostic spectrum analysis in ophthalmology: A physical perspective

Ultrasound in Medicine & Biology, 1986

Research paper thumbnail of The Effect of Transducer Bandwidth on Ultrasonic Image Characteristics

Research paper thumbnail of Evaluation of Ciliary Body Detachment in Hypotony

Research paper thumbnail of Ultrasonography of the Eye

International Ophthalmology Clinics, 1986

Research paper thumbnail of Production of Corneal Lesions Using High-Intensity Focused Ultrasound

Cornea, 1990

In order to study the potential use of ultrasound as a noninvasive system for altering corneal cu... more In order to study the potential use of ultrasound as a noninvasive system for altering corneal curvature, we used high-density focused ultrasound at a frequency of 4.8 MHz and 7.9 MHz to produce corneal lesions in the rabbit eye. Intensity and duration threshold exposure conditions were determined for the production of minimally visible lesions. Threshold lesions were initially apparent as discrete white opacities resulting from stromal edema and disruption. Light and scanning electron microscopy of higher-energy, suprathreshold lesions revealed more extensive disruption, including the formation of a superficial stromal depression and a larger zone of edema and disorganization surrounding each lesion. Posterior stromal lamellae, endothelium, and Descemet's membrane were intact. Healing and reepithelialization resulted in a smooth corneal surface with no residual opacification. Threshold determinations predict safe exposure levels to the cornea during insonification of other ocular structures. Selective heating of the peripheral cornea using focused ultrasound may be a useful technique for correcting astigmatism.

Research paper thumbnail of Presbyopia, accommodation, and mature catenary1 1The following six letters address on article that appeared in the September 2001 issue of the Journal: Coleman DJ, Fish SK. Presbyopia, accommodation, and the mature catenary. (Ophthalmology 2001;108:1544–51)

Research paper thumbnail of Ultrasonic Hyperthermia and Radiation in the Management of Intraocular Malignant Melanoma

American Journal of Ophthalmology, 1986

Hyperthermia and radiation were used in combination to treat four patients with choroidal maligna... more Hyperthermia and radiation were used in combination to treat four patients with choroidal malignant melanoma. This technique uses ultrasonically induced hyperthermia synergistically with radiation to destroy tumor cells. The lower levels of radiation used should avoid the late vascular and inflammatory complications seen in conventional radiation therapy. Tumors were scanned by a computerized diagnostic ultrasound system before treatment and assigned an acoustic tissue type on the basis of a statistical comparison of their ultrasound backscatter spectrum with spectra of tumors of known pathologic status. During the follow-up period, the longest of which was 15 months, alltumors demonstrated regression patterns consistent with choroidal tumors of the same acoustic tissue types treated with conventional radiation therapy. UNTIL RECENTLY, the standard method of managing ocular melanoma has been enucIea

Research paper thumbnail of Digital Processing and Imaging Modes for Clinical Ultrasound

Documenta Ophthalmologica Proceedings Series, 1981

A computer-based ultrasound system has been designed and constructed to provide new approaches to... more A computer-based ultrasound system has been designed and constructed to provide new approaches to processing, analyzing, and displaying clinical ultrasonograms, (c.f. Lizzi, et al. 1979, 1980). Over the past year, the system has been applied in ophthalmic examinations, and it has been continually refined and expanded as clinical trials proceed.

Research paper thumbnail of Ultrasonic Volume Determination in Ophthalmology

Ultrasound in Medicine, 1975

Estimation of ocular volumes by means of B-scan sections and planimeter measurements provides uni... more Estimation of ocular volumes by means of B-scan sections and planimeter measurements provides unique information for several areas of ophthalmic management.

Research paper thumbnail of High-resolution ultrasonic imaging of blood flow in the anterior segment of the eye

Investigative ophthalmology & visual science, 1999

To develop a noninvasive technique to visualize and measure blood flow in the iris and ciliary bo... more To develop a noninvasive technique to visualize and measure blood flow in the iris and ciliary body. Echo data from 50-MHz ultrasound scans of the iris and ciliary body of rabbits were digitized using a new "swept scan" modality. The method makes use of spatial oversampling to identify regions with scatterers whose range changes with time. The data allowed construction of high-resolution B-mode images with embedded flow information. Pulsatility over the cardiac cycle was evaluated by sending a series of pulses along a single line of sight containing a vessel of interest. Local blood flow and changes over the cardiac cycle before and after application of atropine were quantified. Flow was identified in the radial vessels and major arterial circle of the iris. Vessels with lumens as small as 40 microm in diameter and flow velocities as low as 0.6 mm/sec were measured. Change in blood velocity over the cardiac cycle was determined to be approximately 27%. Peak systolic veloci...

Research paper thumbnail of Ocular tumor patterns

Bibliotheca ophthalmologica : supplementa ad ophthalmologica, 1975

The use of choroidal excavation and vascular pulsations in the ultrasonic diagnosis of tumors has... more The use of choroidal excavation and vascular pulsations in the ultrasonic diagnosis of tumors has been a helpful diagnostic feature. Evaluation of choroidal tumors is presently performed with A-, B- and M-scan techniques. Solid tumors of high homogeneity produce characteristic hollows or acoustic quiet zones that replace the normal choroidal pattern. M-scan patterns of vascular pulsations are also useful in demonstrating vascularity or choroidal tumors. Color displays accentuate amplitude variations in ocular tumors.

Research paper thumbnail of Experimental Production of Chorioretinal Lesions: I. Continuous Wave Ultrasound

Ultrasound in Medicine, 1978

Lesions were created in the retina, choroid and sclera of the rabbit using continuous-wave, high-... more Lesions were created in the retina, choroid and sclera of the rabbit using continuous-wave, high-intensity ultrasound. In-vivo studies were performed on albino and pigmented rabbits using focussed ultrasound at 9.8 MHz. The quantitative evaluation of the effects of continuous-wave ultrasound is of interest because of the potential therapeutic applications to ocular tissues in those cases which cannot be purposely altered by optical energy.

Research paper thumbnail of Computer Assisted Acoustic Measurements of the Posterior Ocular Coats

Documenta Ophthalmologica Proceedings Series, 1981

The thickness of the posterior ocular coats of the eye (the retina, choroid, and sclera) has only... more The thickness of the posterior ocular coats of the eye (the retina, choroid, and sclera) has only been evaluable by indirect methods such as histologic examination, which allow extrapolation to the in vivo thickness. Many functional and aging processes are related to the integrity and thickness of these structures, thus the ability to provide an in vivo measurement would be valuable in studying both normal variations and disease states.