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Papers by Donna Gift Cabalo

Research paper thumbnail of HippoMaps: Multiscale Cartography of Human Hippocampal Organization

Research Square (Research Square), Mar 25, 2024

Research paper thumbnail of HippoMaps: Multiscale cartography of the human hippocampal formation

bioRxiv (Cold Spring Harbor Laboratory), Feb 23, 2024

Research paper thumbnail of Differential Reorganization of Episodic and Semantic Memory Systems in Epilepsy-Related Mesiotemporal Pathology

bioRxiv (Cold Spring Harbor Laboratory), Sep 28, 2023

Research paper thumbnail of Multimodal Gradients Unify Local and Global Cortical Organization

bioRxiv (Cold Spring Harbor Laboratory), Mar 12, 2024

Research paper thumbnail of Multimodal Precision Neuroimaging of the Individual Human Brain at Ultra-high fields

bioRxiv (Cold Spring Harbor Laboratory), Jun 19, 2024

Multimodal neuroimaging allows for non-invasive examination of human brain structure and function... more Multimodal neuroimaging allows for non-invasive examination of human brain structure and function across multiple scales. Precision neuroimaging builds upon this foundation, enabling the mapping of brain structure, function, and connectivity patterns with high fidelity in single individuals. Ultra-high field (UHF) neuroimaging, operating at magnetic field strengths of 7 Tesla or higher, increases signal-to-noise ratio and offers even higher spatial resolution. Here, we provide a multimodal Precision Neuroimaging and Connectomics (PNI) dataset, utilizing UHF 7T magnetic resonance imaging (MRI). Ten healthy individuals underwent a comprehensive MRI protocol, including T1 relaxometry, magnetization transfer imaging, T2*-weighted imaging, diffusion MRI, and multi-state functional MRI paradigms, aggregated across three imaging sessions. Alongside anonymized raw imaging data, we release cortex-wide connectomes from different modalities across multiple parcellation scales, and supply "gradients" that compactly characterize spatial patterning of cortical organization. Our precision imaging dataset will advance our understanding of structure-function relationships in the individual human brain and is publicly available via the Open Science Framework (https://osf.io/mhq3f/) and the Canadian Open Neuroscience Platform data portal (https://portal.conp.ca).

Research paper thumbnail of Low-grade glioma resting-state fMRI pre-operative maps: a comparison with functional atlas from direct electrode stimulation

A cortical-subcortical functional atlas has been recently proposed from direct-electrode stimulat... more A cortical-subcortical functional atlas has been recently proposed from direct-electrode stimulation on low grade glioma patients. The agreement between that atlas and non-invasive pre-operative resting-state functional MRI (rs-fMRI) data has not yet been investigated. In this study, we use pre-operative rs-fMRI data and the RestNeuMap tool to investigate the agreement between language and sensory networks in a group of low grade glioma patients. We find that rs-fMRI networks of language and speech arrest show greater overlap with DES-derived functional atlas than the sensorimotor network.

Research paper thumbnail of Static and dynamic connectivity are differentially affected by head motion: a healthy control and Parkinson’s disease study

An open discussion in functional connectivity (FC) studies is the mitigation of motion-related ar... more An open discussion in functional connectivity (FC) studies is the mitigation of motion-related artifacts. Data-driven denoising such as Independent Component Analysis (ICA) could help in improving the reproducibility of results, however, the definition of pipelines to deal with mild to high motion cases is still controversial. We estimate the effect of different workflows optimized for best-controlling head motion both in healthy and Parkinson’s Disease cohorts. Regardless of baseline head motion level, ICA-based control of motion confounds affects functional connectivity metrics, with non-negligible impact on static connectivity and most severe effects on temporal and spatial features of dynamic functional connectivity measures.

Research paper thumbnail of Head motion correction shapes functional network estimates: evidence from healthy and Parkinson’s disease cohorts

bioRxiv (Cold Spring Harbor Laboratory), Dec 27, 2022

Research paper thumbnail of Atypical connectome topography and signal flow in temporal lobe epilepsy

Temporal lobe epilepsy (TLE) is one of the most common pharmaco-resistant epilepsies in adults. W... more Temporal lobe epilepsy (TLE) is one of the most common pharmaco-resistant epilepsies in adults. While hippocampal pathology is the hallmark of this condition, emerging evidence indicates that brain alterations extend beyond the mesiotemporal epicenter and affect macroscale brain function and cognition. We studied macroscale functional reorganization in TLE, explored structural substrates, and examined cognitive associations. We investigated a multisite cohort of 95 patients with pharmaco-resistant TLE and 95 healthy controls using state-of-the-art multimodal 3T magnetic resonance imaging (MRI). We quantified macroscale functional topographic organization using connectome dimensionality reduction techniques and estimated directional functional flow using generative models of effective connectivity. We observed atypical functional topographies in patients with TLE relative to controls, manifesting as reduced functional differentiation between sensory/motor networks and transmodal syst...

Research paper thumbnail of Cortical microstructural gradients capture memory network reorganization in temporal lobe epilepsy

Temporal lobe epilepsy (TLE), one of the most common pharmaco-resistant epilepsies, is associated... more Temporal lobe epilepsy (TLE), one of the most common pharmaco-resistant epilepsies, is associated with pathology of paralimbic brain regions, particularly in the mesiotemporal lobe. Cognitive dysfunction in TLE is frequent, and particularly affects episodic memory. Crucially, these difficulties challenge the quality of life of patients, sometimes more than seizures, underscoring the need to assess neural processes of cognitive dysfunction in TLE to improve patient management. Our work harnessed a novel conceptual and analytical approach to assess spatial gradients of microstructural differentiation between cortical areas based on high-resolution MRI analysis. Gradients track region-to-region variations in intracortical lamination and myeloarchitecture, serving as a system-level measure of structural and functional reorganization. Comparing cortex-wide microstructural gradients between 21 patients and 35 healthy controls, we observed a contracted gradient in TLE driven by reduced mic...

Research paper thumbnail of Memory distortions: When suggestions cannot be easily ignored

Applied Cognitive Psychology, 2019

In the present study, the persistence of personal false memories (FM) after social feedback that ... more In the present study, the persistence of personal false memories (FM) after social feedback that denies their truth was assessed with a procedure similar to Nash, Wade and Lindsay (2009b). Participants imitated actions performed by the experimenter (Session 1) and watched a doctored video with performed and critical "fake" actions (Session 2), followed by a memory rating and a recognition task. A few days later (Session 3) participants were clearly told that some memories were false and received daily reminders of the correct list of objects/actions before testing their memory again in Session 4. Results of both memory ratings and recognition indicated effective FM implantation. Interestingly, response times for correct rejections were longer for fake than true objects, suggesting participants struggled to ignore false suggestions. Crucial for our aim, Session 4 showed that FM persisted also after the debriefing and repeated presentations of correct list of objects/actions, suggesting that FM for actions are rather difficult to discard.

Research paper thumbnail of HippoMaps: Multiscale Cartography of Human Hippocampal Organization

Research Square (Research Square), Mar 25, 2024

Research paper thumbnail of HippoMaps: Multiscale cartography of the human hippocampal formation

bioRxiv (Cold Spring Harbor Laboratory), Feb 23, 2024

Research paper thumbnail of Differential Reorganization of Episodic and Semantic Memory Systems in Epilepsy-Related Mesiotemporal Pathology

bioRxiv (Cold Spring Harbor Laboratory), Sep 28, 2023

Research paper thumbnail of Multimodal Gradients Unify Local and Global Cortical Organization

bioRxiv (Cold Spring Harbor Laboratory), Mar 12, 2024

Research paper thumbnail of Multimodal Precision Neuroimaging of the Individual Human Brain at Ultra-high fields

bioRxiv (Cold Spring Harbor Laboratory), Jun 19, 2024

Multimodal neuroimaging allows for non-invasive examination of human brain structure and function... more Multimodal neuroimaging allows for non-invasive examination of human brain structure and function across multiple scales. Precision neuroimaging builds upon this foundation, enabling the mapping of brain structure, function, and connectivity patterns with high fidelity in single individuals. Ultra-high field (UHF) neuroimaging, operating at magnetic field strengths of 7 Tesla or higher, increases signal-to-noise ratio and offers even higher spatial resolution. Here, we provide a multimodal Precision Neuroimaging and Connectomics (PNI) dataset, utilizing UHF 7T magnetic resonance imaging (MRI). Ten healthy individuals underwent a comprehensive MRI protocol, including T1 relaxometry, magnetization transfer imaging, T2*-weighted imaging, diffusion MRI, and multi-state functional MRI paradigms, aggregated across three imaging sessions. Alongside anonymized raw imaging data, we release cortex-wide connectomes from different modalities across multiple parcellation scales, and supply "gradients" that compactly characterize spatial patterning of cortical organization. Our precision imaging dataset will advance our understanding of structure-function relationships in the individual human brain and is publicly available via the Open Science Framework (https://osf.io/mhq3f/) and the Canadian Open Neuroscience Platform data portal (https://portal.conp.ca).

Research paper thumbnail of Low-grade glioma resting-state fMRI pre-operative maps: a comparison with functional atlas from direct electrode stimulation

A cortical-subcortical functional atlas has been recently proposed from direct-electrode stimulat... more A cortical-subcortical functional atlas has been recently proposed from direct-electrode stimulation on low grade glioma patients. The agreement between that atlas and non-invasive pre-operative resting-state functional MRI (rs-fMRI) data has not yet been investigated. In this study, we use pre-operative rs-fMRI data and the RestNeuMap tool to investigate the agreement between language and sensory networks in a group of low grade glioma patients. We find that rs-fMRI networks of language and speech arrest show greater overlap with DES-derived functional atlas than the sensorimotor network.

Research paper thumbnail of Static and dynamic connectivity are differentially affected by head motion: a healthy control and Parkinson’s disease study

An open discussion in functional connectivity (FC) studies is the mitigation of motion-related ar... more An open discussion in functional connectivity (FC) studies is the mitigation of motion-related artifacts. Data-driven denoising such as Independent Component Analysis (ICA) could help in improving the reproducibility of results, however, the definition of pipelines to deal with mild to high motion cases is still controversial. We estimate the effect of different workflows optimized for best-controlling head motion both in healthy and Parkinson’s Disease cohorts. Regardless of baseline head motion level, ICA-based control of motion confounds affects functional connectivity metrics, with non-negligible impact on static connectivity and most severe effects on temporal and spatial features of dynamic functional connectivity measures.

Research paper thumbnail of Head motion correction shapes functional network estimates: evidence from healthy and Parkinson’s disease cohorts

bioRxiv (Cold Spring Harbor Laboratory), Dec 27, 2022

Research paper thumbnail of Atypical connectome topography and signal flow in temporal lobe epilepsy

Temporal lobe epilepsy (TLE) is one of the most common pharmaco-resistant epilepsies in adults. W... more Temporal lobe epilepsy (TLE) is one of the most common pharmaco-resistant epilepsies in adults. While hippocampal pathology is the hallmark of this condition, emerging evidence indicates that brain alterations extend beyond the mesiotemporal epicenter and affect macroscale brain function and cognition. We studied macroscale functional reorganization in TLE, explored structural substrates, and examined cognitive associations. We investigated a multisite cohort of 95 patients with pharmaco-resistant TLE and 95 healthy controls using state-of-the-art multimodal 3T magnetic resonance imaging (MRI). We quantified macroscale functional topographic organization using connectome dimensionality reduction techniques and estimated directional functional flow using generative models of effective connectivity. We observed atypical functional topographies in patients with TLE relative to controls, manifesting as reduced functional differentiation between sensory/motor networks and transmodal syst...

Research paper thumbnail of Cortical microstructural gradients capture memory network reorganization in temporal lobe epilepsy

Temporal lobe epilepsy (TLE), one of the most common pharmaco-resistant epilepsies, is associated... more Temporal lobe epilepsy (TLE), one of the most common pharmaco-resistant epilepsies, is associated with pathology of paralimbic brain regions, particularly in the mesiotemporal lobe. Cognitive dysfunction in TLE is frequent, and particularly affects episodic memory. Crucially, these difficulties challenge the quality of life of patients, sometimes more than seizures, underscoring the need to assess neural processes of cognitive dysfunction in TLE to improve patient management. Our work harnessed a novel conceptual and analytical approach to assess spatial gradients of microstructural differentiation between cortical areas based on high-resolution MRI analysis. Gradients track region-to-region variations in intracortical lamination and myeloarchitecture, serving as a system-level measure of structural and functional reorganization. Comparing cortex-wide microstructural gradients between 21 patients and 35 healthy controls, we observed a contracted gradient in TLE driven by reduced mic...

Research paper thumbnail of Memory distortions: When suggestions cannot be easily ignored

Applied Cognitive Psychology, 2019

In the present study, the persistence of personal false memories (FM) after social feedback that ... more In the present study, the persistence of personal false memories (FM) after social feedback that denies their truth was assessed with a procedure similar to Nash, Wade and Lindsay (2009b). Participants imitated actions performed by the experimenter (Session 1) and watched a doctored video with performed and critical "fake" actions (Session 2), followed by a memory rating and a recognition task. A few days later (Session 3) participants were clearly told that some memories were false and received daily reminders of the correct list of objects/actions before testing their memory again in Session 4. Results of both memory ratings and recognition indicated effective FM implantation. Interestingly, response times for correct rejections were longer for fake than true objects, suggesting participants struggled to ignore false suggestions. Crucial for our aim, Session 4 showed that FM persisted also after the debriefing and repeated presentations of correct list of objects/actions, suggesting that FM for actions are rather difficult to discard.