Doris Miller - Academia.edu (original) (raw)
Papers by Doris Miller
John Wiley & Sons, Inc. eBooks, Apr 5, 2013
John Wiley & Sons, Inc. eBooks, Apr 5, 2013
John Wiley & Sons, Inc. eBooks, Apr 5, 2013
John Wiley & Sons, Inc. eBooks, Apr 5, 2013
John Wiley & Sons, Inc. eBooks, Apr 5, 2013
Muscle & Nerve, Sep 1, 1988
Clinicopathologic findings from two golden retriever dogs with an inherited, progressive, degener... more Clinicopathologic findings from two golden retriever dogs with an inherited, progressive, degenerative muscle disease that were studied until 27 and 40 months of age are described. Initial clinical signs included stilted gait and simultaneous advancement of their pelvic limbs. Further gait restriction and muscle hypertrophy eventually occurred. Serum creatine kinase was dramatically elevated (>I 0,000 U/L). There were persistent "spontaneous" high-frequency discharges (pseudomyotonia) on electromyographic evaluation. Features of both muscle fiber degeneration (hyaline fibers, myophagocytosis) and regeneration (small basophilic fibers) were seen on light microscopy. Similar ultrastructural changes (fiber hypercontraction, increased myoblasts) were present. On morphometric histochemical evaluation, mean fiber diameter of both type 1 and 2 fibers was increased compared with controls in two of three muscles examined. There was no apparent fiber type predominance. Scattered ragged red fibers were seen, but this appeared to be a nonspecific finding of either muscle fiber regeneration or degeneration. These findings and potential contributing pathophysiologic mechanisms are discussed in relation to Duchenne muscular dystrophy.
John Wiley & Sons, Inc. eBooks, Apr 5, 2013
Merck/Veterinary Forensics: Animal Cruelty Investigations, 2013
Veterinary Forensic Pathology, Volume 2, 2018
Merck/Veterinary Forensics: Animal Cruelty Investigations, 2013
Blunt force trauma injuries occur during accidental and non-accidental events. The science of bio... more Blunt force trauma injuries occur during accidental and non-accidental events. The science of biomechanics explains the effect of forces, physiologic and nonphysiologic on living tissue. Even without using the calculations performed by biomechanical engineers in human blunt force trauma injury cases, veterinarians can apply the basic concepts of biomechanics to help understand and explain animal injury. Concepts such as severity of injury; pattern and type of injury; low-energy, high-energy, and very high-energy impacts; age of injury; minimum number of impacts; and repetitive injuries can be addressed by veterinarians evaluating an animal with blunt force trauma injuries.
The Toxicology of Aflatoxins, 1994
... Document details. Title Veterinary diseases related to aflatoxins. Authors Miller, DM; Wilson... more ... Document details. Title Veterinary diseases related to aflatoxins. Authors Miller, DM; Wilson, DM Editors Eaton, DL;Groopman, JD Book The toxicology of aflatoxins: human health, veterinary and agricultural significance. ... To learn more about our products please visit our website. ...
Merck/Veterinary Forensics: Animal Cruelty Investigations, 2013
Journal of Veterinary Diagnostic Investigation, 1995
During 1991 and 1992, 802 case submissions diagnosed as canine mast cell tumors were submitted to... more During 1991 and 1992, 802 case submissions diagnosed as canine mast cell tumors were submitted to the Athens Veterinary Diagnostic Laboratory. Eighteen of these submissions were from dogs of the Shar-Pei breed. Of these 18 cases, 5 occurred in Shar-Peis less than 2 years of age, 4 of these were poorly differentiated, and 4 out of 5 occurred in the inguinal or preputial area. Three mast cell tumors (grade I) occurred in Boxer/Boxer cross dogs, and 2 tumors (grade II) occurred in Cocker Spaniels younger than 2 years of age. Of the 23,315 histopathology submissions, only 164 were from Shar-Peis and 57 of these dogs were under 2 years of age.
Journal of Veterinary Diagnostic Investigation, 1995
Biotechnic & Histochemistry, 1996
Differential skeletal staining is an important part of developmental toxicologic studies. Traditi... more Differential skeletal staining is an important part of developmental toxicologic studies. Traditionally these studies have required time-consuming differentiation of one or both stains used and careful attention to the maceration step to prevent specimen destruction. We present a fully automated protocol which does not require differentiation of either dye and incorporates a controlled maceration step which is highly reproducible. This has resulted in high quality staining that is reproducible, stable, and can be done in volume with minimal personnel time. The process involves the staining of skinned, eviscerated specimens fixed in 95% ethanol. Using an automated tissue processor, the specimen is stained in alcian blue for 24 hr, macerated in 3% potassium hydroxide for 24 hr and stained with murexide for 24 hr. The specimens are cleared and preserved in glycerol. Within three days specimens have red stained bone and blue stained cartilage. The procedure was developed using 20-day-old Sprague-Dawley rat fetuses to evaluate the feasibility of using the procedure for teratology studies involving the fetal skeleton. Evenly stained specimens can be examined within three days and stored for years without loss of staining.
Journal of Veterinary Diagnostic Investigation, 2007
Sixteen animals affected in 2 outbreaks of pet food-associated renal failure (2 dogs in 2004; 10 ... more Sixteen animals affected in 2 outbreaks of pet food-associated renal failure (2 dogs in 2004; 10 cats and 4 dogs in 2007) were evaluated for histopathologic, toxicologic, and clinicopathologic changes. All 16 animals had clinical and laboratory evidence of uremia, including anorexia, vomiting, lethargy, polyuria, azotemia, and hyperphosphatemia. Where measured, serum hepatic enzyme concentrations were normal in animals from both outbreaks. All animals died or were euthanized because of severe uremia. Distal tubular lesions were present in all 16 animals, and unique polarizable crystals with striations were present in distal tubules or collecting ducts in all animals. The proximal tubules were largely unaffected. Crystals and histologic appearance were identical in both outbreaks. A chronic pattern of histologic change, characterized by interstitial fibrosis and inflammation, was observed in some affected animals. Melamine and cyanuric acid were present in renal tissue from both outb...
Journal of Toxicology and Environmental Health, 1987
The immunotoxicologic effects of d-limonene were determined. This naturally occurring substance i... more The immunotoxicologic effects of d-limonene were determined. This naturally occurring substance is widely used in food flavorings and is a common additive in cosmetics. In the present study, BALB/c mice were treated with d-limonene for 9 wk. Effects on T- and B-cell responses were determined after 4 and 8 wk of treatment. Concanavalin-A responses at 8 wk, but not 4 wk, were suppressed in treated mice. A similar trend was observed for phytohemagglutinin and lipopolysaccharide responses. Evidence was presented that d-limonene had polyclonal activator action. Mice primed with keyhole limpet hemocyanin (KLH) prior to initiation of d-limonene treatment had suppressed primary and secondary anti-KLH responses. Mice treated with d-limonene prior to KLH priming produced significant increased antibody responses. Additional evidence for polyclonal stimulation was obtained by histopathologic examination of secondary lymphoreticular tissue. Significant secondary follicle development and prominent lymphoid nodules and aggregates were found in the pancreas and intestinal mucosa, particularly apparent in mice receiving the highest d-limonene dosage. A subchronic LD50 study was conducted wherein BALB/c mice received 16 daily doses of d-limonene. An LD50 of approximately 0.0850 mg d-limonene/kg (corrected for 82% purity) was determined.
Merck/Veterinary Forensics: Animal Cruelty Investigations, 2012
John Wiley & Sons, Inc. eBooks, Apr 5, 2013
John Wiley & Sons, Inc. eBooks, Apr 5, 2013
John Wiley & Sons, Inc. eBooks, Apr 5, 2013
John Wiley & Sons, Inc. eBooks, Apr 5, 2013
John Wiley & Sons, Inc. eBooks, Apr 5, 2013
Muscle & Nerve, Sep 1, 1988
Clinicopathologic findings from two golden retriever dogs with an inherited, progressive, degener... more Clinicopathologic findings from two golden retriever dogs with an inherited, progressive, degenerative muscle disease that were studied until 27 and 40 months of age are described. Initial clinical signs included stilted gait and simultaneous advancement of their pelvic limbs. Further gait restriction and muscle hypertrophy eventually occurred. Serum creatine kinase was dramatically elevated (>I 0,000 U/L). There were persistent "spontaneous" high-frequency discharges (pseudomyotonia) on electromyographic evaluation. Features of both muscle fiber degeneration (hyaline fibers, myophagocytosis) and regeneration (small basophilic fibers) were seen on light microscopy. Similar ultrastructural changes (fiber hypercontraction, increased myoblasts) were present. On morphometric histochemical evaluation, mean fiber diameter of both type 1 and 2 fibers was increased compared with controls in two of three muscles examined. There was no apparent fiber type predominance. Scattered ragged red fibers were seen, but this appeared to be a nonspecific finding of either muscle fiber regeneration or degeneration. These findings and potential contributing pathophysiologic mechanisms are discussed in relation to Duchenne muscular dystrophy.
John Wiley & Sons, Inc. eBooks, Apr 5, 2013
Merck/Veterinary Forensics: Animal Cruelty Investigations, 2013
Veterinary Forensic Pathology, Volume 2, 2018
Merck/Veterinary Forensics: Animal Cruelty Investigations, 2013
Blunt force trauma injuries occur during accidental and non-accidental events. The science of bio... more Blunt force trauma injuries occur during accidental and non-accidental events. The science of biomechanics explains the effect of forces, physiologic and nonphysiologic on living tissue. Even without using the calculations performed by biomechanical engineers in human blunt force trauma injury cases, veterinarians can apply the basic concepts of biomechanics to help understand and explain animal injury. Concepts such as severity of injury; pattern and type of injury; low-energy, high-energy, and very high-energy impacts; age of injury; minimum number of impacts; and repetitive injuries can be addressed by veterinarians evaluating an animal with blunt force trauma injuries.
The Toxicology of Aflatoxins, 1994
... Document details. Title Veterinary diseases related to aflatoxins. Authors Miller, DM; Wilson... more ... Document details. Title Veterinary diseases related to aflatoxins. Authors Miller, DM; Wilson, DM Editors Eaton, DL;Groopman, JD Book The toxicology of aflatoxins: human health, veterinary and agricultural significance. ... To learn more about our products please visit our website. ...
Merck/Veterinary Forensics: Animal Cruelty Investigations, 2013
Journal of Veterinary Diagnostic Investigation, 1995
During 1991 and 1992, 802 case submissions diagnosed as canine mast cell tumors were submitted to... more During 1991 and 1992, 802 case submissions diagnosed as canine mast cell tumors were submitted to the Athens Veterinary Diagnostic Laboratory. Eighteen of these submissions were from dogs of the Shar-Pei breed. Of these 18 cases, 5 occurred in Shar-Peis less than 2 years of age, 4 of these were poorly differentiated, and 4 out of 5 occurred in the inguinal or preputial area. Three mast cell tumors (grade I) occurred in Boxer/Boxer cross dogs, and 2 tumors (grade II) occurred in Cocker Spaniels younger than 2 years of age. Of the 23,315 histopathology submissions, only 164 were from Shar-Peis and 57 of these dogs were under 2 years of age.
Journal of Veterinary Diagnostic Investigation, 1995
Biotechnic & Histochemistry, 1996
Differential skeletal staining is an important part of developmental toxicologic studies. Traditi... more Differential skeletal staining is an important part of developmental toxicologic studies. Traditionally these studies have required time-consuming differentiation of one or both stains used and careful attention to the maceration step to prevent specimen destruction. We present a fully automated protocol which does not require differentiation of either dye and incorporates a controlled maceration step which is highly reproducible. This has resulted in high quality staining that is reproducible, stable, and can be done in volume with minimal personnel time. The process involves the staining of skinned, eviscerated specimens fixed in 95% ethanol. Using an automated tissue processor, the specimen is stained in alcian blue for 24 hr, macerated in 3% potassium hydroxide for 24 hr and stained with murexide for 24 hr. The specimens are cleared and preserved in glycerol. Within three days specimens have red stained bone and blue stained cartilage. The procedure was developed using 20-day-old Sprague-Dawley rat fetuses to evaluate the feasibility of using the procedure for teratology studies involving the fetal skeleton. Evenly stained specimens can be examined within three days and stored for years without loss of staining.
Journal of Veterinary Diagnostic Investigation, 2007
Sixteen animals affected in 2 outbreaks of pet food-associated renal failure (2 dogs in 2004; 10 ... more Sixteen animals affected in 2 outbreaks of pet food-associated renal failure (2 dogs in 2004; 10 cats and 4 dogs in 2007) were evaluated for histopathologic, toxicologic, and clinicopathologic changes. All 16 animals had clinical and laboratory evidence of uremia, including anorexia, vomiting, lethargy, polyuria, azotemia, and hyperphosphatemia. Where measured, serum hepatic enzyme concentrations were normal in animals from both outbreaks. All animals died or were euthanized because of severe uremia. Distal tubular lesions were present in all 16 animals, and unique polarizable crystals with striations were present in distal tubules or collecting ducts in all animals. The proximal tubules were largely unaffected. Crystals and histologic appearance were identical in both outbreaks. A chronic pattern of histologic change, characterized by interstitial fibrosis and inflammation, was observed in some affected animals. Melamine and cyanuric acid were present in renal tissue from both outb...
Journal of Toxicology and Environmental Health, 1987
The immunotoxicologic effects of d-limonene were determined. This naturally occurring substance i... more The immunotoxicologic effects of d-limonene were determined. This naturally occurring substance is widely used in food flavorings and is a common additive in cosmetics. In the present study, BALB/c mice were treated with d-limonene for 9 wk. Effects on T- and B-cell responses were determined after 4 and 8 wk of treatment. Concanavalin-A responses at 8 wk, but not 4 wk, were suppressed in treated mice. A similar trend was observed for phytohemagglutinin and lipopolysaccharide responses. Evidence was presented that d-limonene had polyclonal activator action. Mice primed with keyhole limpet hemocyanin (KLH) prior to initiation of d-limonene treatment had suppressed primary and secondary anti-KLH responses. Mice treated with d-limonene prior to KLH priming produced significant increased antibody responses. Additional evidence for polyclonal stimulation was obtained by histopathologic examination of secondary lymphoreticular tissue. Significant secondary follicle development and prominent lymphoid nodules and aggregates were found in the pancreas and intestinal mucosa, particularly apparent in mice receiving the highest d-limonene dosage. A subchronic LD50 study was conducted wherein BALB/c mice received 16 daily doses of d-limonene. An LD50 of approximately 0.0850 mg d-limonene/kg (corrected for 82% purity) was determined.
Merck/Veterinary Forensics: Animal Cruelty Investigations, 2012