Dr Andrea Leung - Academia.edu (original) (raw)

Dr Andrea Leung

Uploads

Papers by Dr Andrea Leung

Research paper thumbnail of FusobacteriumandEscherichia: models of colorectal cancer driven by microbiota and the utility of microbiota in colorectal cancer screening

Expert Review of Gastroenterology & Hepatology, 2015

Intestinal microbiota has emerging roles in the development of colorectal cancer (CRC). Intestina... more Intestinal microbiota has emerging roles in the development of colorectal cancer (CRC). Intestinal dysbiosis, with altered levels of specific bacteria, is consistently seen in CRC. The heart of the debate lies in whether these bacteria are a cause or consequence of CRC. Two bacteria in particular, Fusobacterium nucleatum and Escherichia coli, have consistently been associated with CRC. This review will examine evidence supporting oncogenic roles of F. nucleatum and E. coli. The proposed mechanisms of tumor formation follow two models: bacterial induced chronic inflammation leads to cell proliferation and tumor formation and virulence factors directly induce tumor formation. This review will further examine the potential for microbiota as biomarkers in CRC, with a focus on F. nucleatum.

Research paper thumbnail of Knowledge and Attitudes About Sterilization and Long-Acting Reversible Contraception

Maternal and Child Health Journal, 2021

Research paper thumbnail of FusobacteriumandEscherichia: models of colorectal cancer driven by microbiota and the utility of microbiota in colorectal cancer screening

Expert Review of Gastroenterology & Hepatology, 2015

Intestinal microbiota has emerging roles in the development of colorectal cancer (CRC). Intestina... more Intestinal microbiota has emerging roles in the development of colorectal cancer (CRC). Intestinal dysbiosis, with altered levels of specific bacteria, is consistently seen in CRC. The heart of the debate lies in whether these bacteria are a cause or consequence of CRC. Two bacteria in particular, Fusobacterium nucleatum and Escherichia coli, have consistently been associated with CRC. This review will examine evidence supporting oncogenic roles of F. nucleatum and E. coli. The proposed mechanisms of tumor formation follow two models: bacterial induced chronic inflammation leads to cell proliferation and tumor formation and virulence factors directly induce tumor formation. This review will further examine the potential for microbiota as biomarkers in CRC, with a focus on F. nucleatum.

Research paper thumbnail of Knowledge and Attitudes About Sterilization and Long-Acting Reversible Contraception

Maternal and Child Health Journal, 2021

Log In