Dr Anil Tumkur - Academia.edu (original) (raw)

Papers by Dr Anil Tumkur

Value in Health, Nov 1, 2011

Pharmacy Education, Jan 15, 2021

Objective: This paper describes the development and feasibility evaluation of a formative remote ... more Objective: This paper describes the development and feasibility evaluation of a formative remote objective structured clinical examination (OSCE) for second-year students in a four-year Bachelor of Pharmacy (B.Pharm.) honours programme. Methods. A fivestation remote formative OSCE was developed and implemented using Microsoft Teams. The authors used a post-OSCE evaluation, in combination with the results of a students' survey and comprehensive feedback from faculty. Results: A total of seventy second-year B.Pharm. (Hons.) students participated in the online OSCE. Based on the post-OSCE evaluation, about 80% of students agreed that the OSCE ran smoothly. Respondents agreement on the time allocated to complete each station varied between 63.6% and 81.8%. Time allocation for each station and internet connectivity were raised as the main concerns by both the students and the faculty. Conclusion: A remote online OSCE is a feasible strategy for assessment of various skills based on different tasks, reflecting the scope of practice for future pharmacists, and offers a promising direction towards the assessment of such practical skills. Online OSCE planning, development and evaluation are in themselves useful for clarifying assessment goals, processes, hindrances, and affordances COVID-19 SPECIAL COLLECTION

Journal of Clinical and Diagnostic Research, 2013

Introduction: Despite the undeniable clinical efficacy of drugeluting stents with durable polymer... more Introduction: Despite the undeniable clinical efficacy of drugeluting stents with durable polymers, concerns regarding their long-term safety have been raised, especially in more complex subsets. The Manipal-S Registry was designed to evaluate the safety and effectiveness of the biodegradable polymer coated Supralimus ® Sirolimus-Eluting Coronary Stent for the treatment of coronary artery disease, across a wide range of patients who are treated in real-life clinical practice. Methods: All the consecutive 116 patients who underwent singlevessel or multiple vessel percutaneous coronary interventions with the use of Supralimus ® sirolimus-eluting stents between September 2009 and December 2010, were included in this study. Patients were clinically followed-up at 1, 9, 12 and 24 months post-procedure. All clinical, procedural, and follow-up information were collected and analysed. In total 116 patients, 126 lesions were implanted with 144 stents which had an average stent length of 25.8±8.0 mm. The incidences of any major adverse cardiac and cerebral events at 1, 9, 12 and 24 months were 0, 5 (4.3%), 8 (6.9%), and 10 (8.6%) respectively. These 24-month results clearly provide evidence for safety and effectiveness of the Supralimus ® Sirolimus-eluting coronary stent system with the biodegradable polymer in real-life patients, even in those with acute myocardial infarctions.

Journal of Cancer Research and Therapeutics, 2013

Breast cancer is a leading problem in developing world and India can be considered as one of the ... more Breast cancer is a leading problem in developing world and India can be considered as one of the major contributors for incidence of breast cancer. In this article authors have reviewed quality of life studies on Indian breast cancer population. There are many factors which may hear common but cannot be neglected in case of Indian population. Policies and future directions to be implemented for breast cancer are also discussed.

Indian Journal of Pharmacy Practice, Dec 9, 2019

The purpose of this review was to evaluate the role of finasteride, a type-II 5α-reductase inhibi... more The purpose of this review was to evaluate the role of finasteride, a type-II 5α-reductase inhibitor in the prevention and treatment of androgenetic alopecia (AGA) in males. Finasteride inhibits 5α-reductase and reduce the biosynthesis of dihydrotestosterone (DHT). This inhibition marks a decrease in concentration of DHT and provides a novel and selective approach to androgen deprivation. Clinical trials have proven the safety and efficacy of tablet finasteride 1 mg for AGA. In this review, we discuss all aspects of finasteride, including dosing and indication, pharmacology, pharmacokinetics to its role in the treatment of AGA.

Effect of angioplasty on quality of life in a tertiary care hospital of South India

Nigerian Journal of Cardiology, 2014

ABSTRACT

Indian Journal of Pharmacy Practice, Mar 1, 2016

Introduction: Medication disposal is an alarming issue today and gaining more and more awareness ... more Introduction: Medication disposal is an alarming issue today and gaining more and more awareness from the healthcare professionals as well as consumers. Pharmacists have the potential to be on the forefront of this movement as a healthcare professionals and pharmacists are in an admirable position to educate patients about safe drug disposal. Proper patient counselling on safe medication disposal can make a significant difference to public health and the environment. The knowledge on method of disposal of unused medicines is equally important as that of consumption of medicines. Objective: This article aims to provide a background, the importance and significance of proper medication disposal, describe the correct methods to dispose of unwanted and expired medications. Method: The information about methods of proper disposal as well as consequence of improper disposal was collected by extensive literature survey of all available resources. Conclusion: Till date, researchers have acknowledged many human and veterinary pharmaceutical compounds at serious concentrations in drinking water resources and they are a major contributor to environmental pollution. Emphasis is also given on pharmacist role in proper disposal of unwanted and expired medicine makes a significant impact on the environment as well as it prevents accident, poisoning and intentional violence. So it will lead to the welfare of society and trudge towards goal of 2020 health for all.

Pharmacy Education, 2021

Objective: This paper describes the development and feasibility evaluation of a formative remote ... more Objective: This paper describes the development and feasibility evaluation of a formative remote objective structured clinical examination (OSCE) for second-year students in a four-year Bachelor of Pharmacy (B.Pharm.) honours programme. Methods. A five- station remote formative OSCE was developed and implemented using Microsoft Teams. The authors used a post-OSCE evaluation, in combination with the results of a students’ survey and comprehensive feedback from faculty. Results: A total of seventy second-year B.Pharm. (Hons.) students participated in the online OSCE. Based on the post-OSCE evaluation, about 80% of students agreed that the OSCE ran smoothly. Respondents agreement on the time allocated to complete each station varied between 63.6% and 81.8%. Time allocation for each station and internet connectivity were raised as the main concerns by both the students and the faculty. Conclusion: A remote online OSCE is a feasible strategy for assessment of various skills based on diff...

Diabetes and Hypertension are diseases that can be debilitating and life-threatening if not wellc... more Diabetes and Hypertension are diseases that can be debilitating and life-threatening if not wellcontrolled respectively and the risk of complication further increases when both diseases co-exist in a patient. They can lead to various cardiovascular complications such as heart failure, coronary artery disease, myocardial infarction and stroke as well as nephropathy and neuropathy. According to CPG guideline Malaysia, there are two groups of drugs which are strongly recommended for treatment of diabetic hypertension, namely angiotensinconverting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs). Through this review, we hope to compare superiority of ACEI and ARB usage in diabetic patients with hypertension. The criteria for eligible studies were as follows: (i) RCT comparing the efficacy of ACEI or ARB with various classes of antihypertensive agents, ACEI versus ARB, different ARBs and combination use of ACEI and ARB in hypertensive patients with diabetes and (ii) pri...

Unethical Marketing Practices by Pharmaceutical Industry

The Pharmaceutical Market is regulated by various laws and rules across the world to ensure the p... more The Pharmaceutical Market is regulated by various laws and rules across the world to ensure the public, highest level of safety and efficacy. Necessity for regulation of the Pharmaceutical market arises from the unprecedented marketing practices by the manufacturers who try to influence the prescriber to expand the market share. The pressure by promoters and investor to improve the share value to create wealth for maximizing the returns on investment is no more a secret. The uncertainty in developing a block buster drug and high stakes with risk involved in research and development has made the industry to resolve on a shortcut strategy. The industry is grossly accused of involving in unethical pharmaceutical marketing practices causing a greater public harm. The current practices of pharmaceutical marketing by industries have become unacceptable as it is threatening the principle of practicing medicine.

International Journal of Pharmacy and Pharmaceutical Sciences, 2016

Objective: Premenstrual syndrome (PMS) is the name given to a collection of physical, psychologic... more Objective: Premenstrual syndrome (PMS) is the name given to a collection of physical, psychological and behavioral symptoms that experienced by women during their late luteal phase of each menstrual cycle. This study was undertaken at Masterskill Global College to determine the prevalence of PMS, common premenstrual syndrome symptoms, and coping methods. It also highlights the impairment of life, social and emotional well beings. Methods: This is a cross-sectional descriptive study using the retrospective method, analyzing the incidence of PMS based on (ACOG) criteria. Results: The outcome of the study showed that 37% out of 300 samples diagnosed with PMS; 22% mild PMS. 9% moderate PMS and 5.3% severe PMS. 7% of the sample was diagnosed with Premenstrual Dysphoric Disorder (PMDD). The study finding suggested association of PMS severity with younger age group (P value<0.05), stressful lifestyles (P value<0.05), academic stress (P value<0.05) and sleeping problem (P value<...

Indian Journal of Pharmacy Practice, 2019

The purpose of this review was to evaluate the role of finasteride, a type-II 5α-reductase inhibi... more The purpose of this review was to evaluate the role of finasteride, a type-II 5α-reductase inhibitor in the prevention and treatment of androgenetic alopecia (AGA) in males. Finasteride inhibits 5α-reductase and reduce the biosynthesis of dihydrotestosterone (DHT). This inhibition marks a decrease in concentration of DHT and provides a novel and selective approach to androgen deprivation. Clinical trials have proven the safety and efficacy of tablet finasteride 1 mg for AGA. In this review, we discuss all aspects of finasteride, including dosing and indication, pharmacology, pharmacokinetics to its role in the treatment of AGA.

Value in Health, 2016

HBMR for the elderly (i.e. age≥ 65 years) were included. The primary outcomes were hospital admis... more HBMR for the elderly (i.e. age≥ 65 years) were included. The primary outcomes were hospital admissions and mortality, while secondary outcomes included other clinical (e.g. medication adherence) and economic measures (e.g. healthcare utilization costs, incremental cost-effectiveness ratios). Meta-analysis of the relative risks (RR) of hospital admissions and mortality was conducted, while a narrative summary was provided for the secondary outcomes. Results: The review identified 17 studies that included 27,591 participants (3,442 HBMR, 24,149 control) with follow up ranging from 3 to 24 months. Hospital admissions and mortality were reported in 16 and 12 studies respectively. Meta-analyses showed that hospital admissions (RR 0.96, 95% CI 0.84-1.09) and mortality (RR 0.93, 95% CI 0.73-1.19) were similar in HBMR compared with control. Three studies that reported cardiology specific outcomes demonstrated some benefits in the HBMR group (e.g. reduced heart failure related hospital admissions). Consequently, HBMR did not result in significant cost savings, nor was it cost-effective compared with control as reported in six studies. ConClusions: Current evidence suggests that pharmacist-provided HBMR does not provide significant clinical and economic benefits compared with usual care. Nonetheless, there is good theoretical basis for the role of HBMR and that the current lack of evidence of effectiveness and cost-effectiveness may be due to inadequately designed program and economic evaluation.

Fusidic Acid – Topical Antimicrobial in the Management of Staphylococcus Aureus

International Journal of Pharmacy and Pharmaceutical Sciences

Fusidic acid (FA) is derived from the fungus Fusidiumcoccineum which was originally isolated from... more Fusidic acid (FA) is derived from the fungus Fusidiumcoccineum which was originally isolated from monkey faeces and available in the market since 1962. FA inhibits bacterial protein synthesis by interference with elongation factor G (EF-G), which promotes translocation on the ribosome after peptide bond formation, preventing further elongation by inhibiting the GTPase function of the EF-G. The steroid like structure of FA confers good skin penetration and does not possess the unwanted side effects of steroids.

Abstracts2013 online issue-article 55 Manipal-S Registry EuroIntervention

Value in Health, 2015

A43 as lower amputation rates (BLCC:-27.6% p= 0.04, HFDS:-22.2% p= 0.19) during the 18-month foll... more A43 as lower amputation rates (BLCC:-27.6% p= 0.04, HFDS:-22.2% p= 0.19) during the 18-month follow-up period. While BLCC and HFDS patients did have higher costs for outpatient services (BLCC:

Value in Health, 2014

Persistence (therapy duration) was defined as number of days between the first and last available... more Persistence (therapy duration) was defined as number of days between the first and last available medication. Adherence was assessed using the medication possession ratio (MPR), defined as the number of days with statin therapy on hand divided by duration of statin therapy. Results: A total of 3,417 patients met the inclusion criteria. The most common statins received were atorvastatin (32.43%), rosuvastatin (22.21%), and pravastatin (20.00%). At initiation, mean(SD) dose (mg/day) was 9.00(3.66) for atorvastatin, 2.97(1.50) for rosuvastatin, and 9.12(3.09) for pravastatin. The percentage of patients with dose titration was low (range: 1.02% for simvastatin to 5.01% for rosuvastatin). Mean(SD) persistence ranged from 460.77(270.26) days for fluvastatin to 540.08(247.51) days for atorvastatin. Mean(SD) MPR ranged from 0.90(0.16) for rosuvastatin to 0.95(0.11) for fluvastatin. When MPR was alternatively measured over the entire 24 month follow-up period, mean(SD) MPR ranged from 0.75(0.29) for rosuvastatin to 0.80(0.26) for fluvastatin. ConClusions: Statin titration among Japanese patients with HRVD was rare, and most patients remained on the lowest dosage available during follow-up. Although statin adherence was good, these findings raise potential concerns about under-treatment/under-management of HRVD in Japan.

Effect of angioplasty on quality of life in a tertiary care hospital of South India

Nigerian Journal of Cardiology, 2014

ABSTRACT

Value in Health, Nov 1, 2011

Pharmacy Education, Jan 15, 2021

Objective: This paper describes the development and feasibility evaluation of a formative remote ... more Objective: This paper describes the development and feasibility evaluation of a formative remote objective structured clinical examination (OSCE) for second-year students in a four-year Bachelor of Pharmacy (B.Pharm.) honours programme. Methods. A fivestation remote formative OSCE was developed and implemented using Microsoft Teams. The authors used a post-OSCE evaluation, in combination with the results of a students' survey and comprehensive feedback from faculty. Results: A total of seventy second-year B.Pharm. (Hons.) students participated in the online OSCE. Based on the post-OSCE evaluation, about 80% of students agreed that the OSCE ran smoothly. Respondents agreement on the time allocated to complete each station varied between 63.6% and 81.8%. Time allocation for each station and internet connectivity were raised as the main concerns by both the students and the faculty. Conclusion: A remote online OSCE is a feasible strategy for assessment of various skills based on different tasks, reflecting the scope of practice for future pharmacists, and offers a promising direction towards the assessment of such practical skills. Online OSCE planning, development and evaluation are in themselves useful for clarifying assessment goals, processes, hindrances, and affordances COVID-19 SPECIAL COLLECTION

Journal of Clinical and Diagnostic Research, 2013

Introduction: Despite the undeniable clinical efficacy of drugeluting stents with durable polymer... more Introduction: Despite the undeniable clinical efficacy of drugeluting stents with durable polymers, concerns regarding their long-term safety have been raised, especially in more complex subsets. The Manipal-S Registry was designed to evaluate the safety and effectiveness of the biodegradable polymer coated Supralimus ® Sirolimus-Eluting Coronary Stent for the treatment of coronary artery disease, across a wide range of patients who are treated in real-life clinical practice. Methods: All the consecutive 116 patients who underwent singlevessel or multiple vessel percutaneous coronary interventions with the use of Supralimus ® sirolimus-eluting stents between September 2009 and December 2010, were included in this study. Patients were clinically followed-up at 1, 9, 12 and 24 months post-procedure. All clinical, procedural, and follow-up information were collected and analysed. In total 116 patients, 126 lesions were implanted with 144 stents which had an average stent length of 25.8±8.0 mm. The incidences of any major adverse cardiac and cerebral events at 1, 9, 12 and 24 months were 0, 5 (4.3%), 8 (6.9%), and 10 (8.6%) respectively. These 24-month results clearly provide evidence for safety and effectiveness of the Supralimus ® Sirolimus-eluting coronary stent system with the biodegradable polymer in real-life patients, even in those with acute myocardial infarctions.

Journal of Cancer Research and Therapeutics, 2013

Breast cancer is a leading problem in developing world and India can be considered as one of the ... more Breast cancer is a leading problem in developing world and India can be considered as one of the major contributors for incidence of breast cancer. In this article authors have reviewed quality of life studies on Indian breast cancer population. There are many factors which may hear common but cannot be neglected in case of Indian population. Policies and future directions to be implemented for breast cancer are also discussed.

Indian Journal of Pharmacy Practice, Dec 9, 2019

The purpose of this review was to evaluate the role of finasteride, a type-II 5α-reductase inhibi... more The purpose of this review was to evaluate the role of finasteride, a type-II 5α-reductase inhibitor in the prevention and treatment of androgenetic alopecia (AGA) in males. Finasteride inhibits 5α-reductase and reduce the biosynthesis of dihydrotestosterone (DHT). This inhibition marks a decrease in concentration of DHT and provides a novel and selective approach to androgen deprivation. Clinical trials have proven the safety and efficacy of tablet finasteride 1 mg for AGA. In this review, we discuss all aspects of finasteride, including dosing and indication, pharmacology, pharmacokinetics to its role in the treatment of AGA.

Effect of angioplasty on quality of life in a tertiary care hospital of South India

Nigerian Journal of Cardiology, 2014

ABSTRACT

Indian Journal of Pharmacy Practice, Mar 1, 2016

Introduction: Medication disposal is an alarming issue today and gaining more and more awareness ... more Introduction: Medication disposal is an alarming issue today and gaining more and more awareness from the healthcare professionals as well as consumers. Pharmacists have the potential to be on the forefront of this movement as a healthcare professionals and pharmacists are in an admirable position to educate patients about safe drug disposal. Proper patient counselling on safe medication disposal can make a significant difference to public health and the environment. The knowledge on method of disposal of unused medicines is equally important as that of consumption of medicines. Objective: This article aims to provide a background, the importance and significance of proper medication disposal, describe the correct methods to dispose of unwanted and expired medications. Method: The information about methods of proper disposal as well as consequence of improper disposal was collected by extensive literature survey of all available resources. Conclusion: Till date, researchers have acknowledged many human and veterinary pharmaceutical compounds at serious concentrations in drinking water resources and they are a major contributor to environmental pollution. Emphasis is also given on pharmacist role in proper disposal of unwanted and expired medicine makes a significant impact on the environment as well as it prevents accident, poisoning and intentional violence. So it will lead to the welfare of society and trudge towards goal of 2020 health for all.

Pharmacy Education, 2021

Objective: This paper describes the development and feasibility evaluation of a formative remote ... more Objective: This paper describes the development and feasibility evaluation of a formative remote objective structured clinical examination (OSCE) for second-year students in a four-year Bachelor of Pharmacy (B.Pharm.) honours programme. Methods. A five- station remote formative OSCE was developed and implemented using Microsoft Teams. The authors used a post-OSCE evaluation, in combination with the results of a students’ survey and comprehensive feedback from faculty. Results: A total of seventy second-year B.Pharm. (Hons.) students participated in the online OSCE. Based on the post-OSCE evaluation, about 80% of students agreed that the OSCE ran smoothly. Respondents agreement on the time allocated to complete each station varied between 63.6% and 81.8%. Time allocation for each station and internet connectivity were raised as the main concerns by both the students and the faculty. Conclusion: A remote online OSCE is a feasible strategy for assessment of various skills based on diff...

Diabetes and Hypertension are diseases that can be debilitating and life-threatening if not wellc... more Diabetes and Hypertension are diseases that can be debilitating and life-threatening if not wellcontrolled respectively and the risk of complication further increases when both diseases co-exist in a patient. They can lead to various cardiovascular complications such as heart failure, coronary artery disease, myocardial infarction and stroke as well as nephropathy and neuropathy. According to CPG guideline Malaysia, there are two groups of drugs which are strongly recommended for treatment of diabetic hypertension, namely angiotensinconverting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs). Through this review, we hope to compare superiority of ACEI and ARB usage in diabetic patients with hypertension. The criteria for eligible studies were as follows: (i) RCT comparing the efficacy of ACEI or ARB with various classes of antihypertensive agents, ACEI versus ARB, different ARBs and combination use of ACEI and ARB in hypertensive patients with diabetes and (ii) pri...

Unethical Marketing Practices by Pharmaceutical Industry

The Pharmaceutical Market is regulated by various laws and rules across the world to ensure the p... more The Pharmaceutical Market is regulated by various laws and rules across the world to ensure the public, highest level of safety and efficacy. Necessity for regulation of the Pharmaceutical market arises from the unprecedented marketing practices by the manufacturers who try to influence the prescriber to expand the market share. The pressure by promoters and investor to improve the share value to create wealth for maximizing the returns on investment is no more a secret. The uncertainty in developing a block buster drug and high stakes with risk involved in research and development has made the industry to resolve on a shortcut strategy. The industry is grossly accused of involving in unethical pharmaceutical marketing practices causing a greater public harm. The current practices of pharmaceutical marketing by industries have become unacceptable as it is threatening the principle of practicing medicine.

International Journal of Pharmacy and Pharmaceutical Sciences, 2016

Objective: Premenstrual syndrome (PMS) is the name given to a collection of physical, psychologic... more Objective: Premenstrual syndrome (PMS) is the name given to a collection of physical, psychological and behavioral symptoms that experienced by women during their late luteal phase of each menstrual cycle. This study was undertaken at Masterskill Global College to determine the prevalence of PMS, common premenstrual syndrome symptoms, and coping methods. It also highlights the impairment of life, social and emotional well beings. Methods: This is a cross-sectional descriptive study using the retrospective method, analyzing the incidence of PMS based on (ACOG) criteria. Results: The outcome of the study showed that 37% out of 300 samples diagnosed with PMS; 22% mild PMS. 9% moderate PMS and 5.3% severe PMS. 7% of the sample was diagnosed with Premenstrual Dysphoric Disorder (PMDD). The study finding suggested association of PMS severity with younger age group (P value<0.05), stressful lifestyles (P value<0.05), academic stress (P value<0.05) and sleeping problem (P value<...

Indian Journal of Pharmacy Practice, 2019

The purpose of this review was to evaluate the role of finasteride, a type-II 5α-reductase inhibi... more The purpose of this review was to evaluate the role of finasteride, a type-II 5α-reductase inhibitor in the prevention and treatment of androgenetic alopecia (AGA) in males. Finasteride inhibits 5α-reductase and reduce the biosynthesis of dihydrotestosterone (DHT). This inhibition marks a decrease in concentration of DHT and provides a novel and selective approach to androgen deprivation. Clinical trials have proven the safety and efficacy of tablet finasteride 1 mg for AGA. In this review, we discuss all aspects of finasteride, including dosing and indication, pharmacology, pharmacokinetics to its role in the treatment of AGA.

Value in Health, 2016

HBMR for the elderly (i.e. age≥ 65 years) were included. The primary outcomes were hospital admis... more HBMR for the elderly (i.e. age≥ 65 years) were included. The primary outcomes were hospital admissions and mortality, while secondary outcomes included other clinical (e.g. medication adherence) and economic measures (e.g. healthcare utilization costs, incremental cost-effectiveness ratios). Meta-analysis of the relative risks (RR) of hospital admissions and mortality was conducted, while a narrative summary was provided for the secondary outcomes. Results: The review identified 17 studies that included 27,591 participants (3,442 HBMR, 24,149 control) with follow up ranging from 3 to 24 months. Hospital admissions and mortality were reported in 16 and 12 studies respectively. Meta-analyses showed that hospital admissions (RR 0.96, 95% CI 0.84-1.09) and mortality (RR 0.93, 95% CI 0.73-1.19) were similar in HBMR compared with control. Three studies that reported cardiology specific outcomes demonstrated some benefits in the HBMR group (e.g. reduced heart failure related hospital admissions). Consequently, HBMR did not result in significant cost savings, nor was it cost-effective compared with control as reported in six studies. ConClusions: Current evidence suggests that pharmacist-provided HBMR does not provide significant clinical and economic benefits compared with usual care. Nonetheless, there is good theoretical basis for the role of HBMR and that the current lack of evidence of effectiveness and cost-effectiveness may be due to inadequately designed program and economic evaluation.

Fusidic Acid – Topical Antimicrobial in the Management of Staphylococcus Aureus

International Journal of Pharmacy and Pharmaceutical Sciences

Fusidic acid (FA) is derived from the fungus Fusidiumcoccineum which was originally isolated from... more Fusidic acid (FA) is derived from the fungus Fusidiumcoccineum which was originally isolated from monkey faeces and available in the market since 1962. FA inhibits bacterial protein synthesis by interference with elongation factor G (EF-G), which promotes translocation on the ribosome after peptide bond formation, preventing further elongation by inhibiting the GTPase function of the EF-G. The steroid like structure of FA confers good skin penetration and does not possess the unwanted side effects of steroids.

Abstracts2013 online issue-article 55 Manipal-S Registry EuroIntervention

Value in Health, 2015

A43 as lower amputation rates (BLCC:-27.6% p= 0.04, HFDS:-22.2% p= 0.19) during the 18-month foll... more A43 as lower amputation rates (BLCC:-27.6% p= 0.04, HFDS:-22.2% p= 0.19) during the 18-month follow-up period. While BLCC and HFDS patients did have higher costs for outpatient services (BLCC:

Value in Health, 2014

Persistence (therapy duration) was defined as number of days between the first and last available... more Persistence (therapy duration) was defined as number of days between the first and last available medication. Adherence was assessed using the medication possession ratio (MPR), defined as the number of days with statin therapy on hand divided by duration of statin therapy. Results: A total of 3,417 patients met the inclusion criteria. The most common statins received were atorvastatin (32.43%), rosuvastatin (22.21%), and pravastatin (20.00%). At initiation, mean(SD) dose (mg/day) was 9.00(3.66) for atorvastatin, 2.97(1.50) for rosuvastatin, and 9.12(3.09) for pravastatin. The percentage of patients with dose titration was low (range: 1.02% for simvastatin to 5.01% for rosuvastatin). Mean(SD) persistence ranged from 460.77(270.26) days for fluvastatin to 540.08(247.51) days for atorvastatin. Mean(SD) MPR ranged from 0.90(0.16) for rosuvastatin to 0.95(0.11) for fluvastatin. When MPR was alternatively measured over the entire 24 month follow-up period, mean(SD) MPR ranged from 0.75(0.29) for rosuvastatin to 0.80(0.26) for fluvastatin. ConClusions: Statin titration among Japanese patients with HRVD was rare, and most patients remained on the lowest dosage available during follow-up. Although statin adherence was good, these findings raise potential concerns about under-treatment/under-management of HRVD in Japan.

Effect of angioplasty on quality of life in a tertiary care hospital of South India

Nigerian Journal of Cardiology, 2014

ABSTRACT