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Papers by Dr Fisun Akdeniz
3 P/ Psikiyatri Psikoloji Psikofarmakoloji Dergisi, 2003
![Research paper thumbnail of [Effects of valproate on male reproductive functions]](https://attachments.academia-assets.com/120657996/thumbnails/1.jpg)
](Türk psikiyatri dergisi = Turkish journal of psychiatry, 2009
Valproate is an antiepileptic commonly used in the treatment of psychiatric and neurologic diseas... more Valproate is an antiepileptic commonly used in the treatment of psychiatric and neurologic diseases. Some of the most frequently seen side effects affect the gastrointestinal, neurological, and hematological systems. Its side effects on reproductive functions have not been sufficiently studied. The use of valproate by females with bipolar disorder and epilepsy may cause menstrual cycle abnormalities, polycystic ovary syndrome, and hyperandrogenism. The effects on male reproductive functions have been researched only in epileptic patients and animals, and the results have been conflicting, because reproductive function abnormalities may be independent of the use of valproate and may be due to epilepsy itself. In the first part of this review reproductive function abnormalities due to epilepsy will be discussed, independent of the use of valproate or any other antiepileptic. Then, the results of research on valproate's effects on male reproductive functions (hormonal levels and sp...
Psychiatry Research, 2008
CLOZAPINE TREATMENT IN BIPOLAR AND SCHIZOAFFECTIVE DISORDERS: A RETROSPECTIVE STUDY Object: The a... more CLOZAPINE TREATMENT IN BIPOLAR AND SCHIZOAFFECTIVE DISORDERS: A RETROSPECTIVE STUDY Object: The aim of this study is to evaluate the sociodemographic and clinical features and efficacy of clozapine treatment in patients with bipolar disorder (BD) and schizoaffective disorder (SD). Method: Patients with DSM-IV diagnostic criteria for BD and SD on clozapine treatment for at least one year and followed up regularly were included in the study. We reviewed the patients' medical records and life-charts retrospectively. To assess the functioning of the patients, the Clinical Global Impression scale-A (CGI-A) and CGI-B and Global Assessment of Functioning (GAF) were performed preceding 3 months of clozapine treatment and current status. Results: Of 36 patients on clozapine treatment, 17 (46%) were diagnosed as BD and 19 (54%) were diagnosed as SD. The mean age of onset of illness was 24.0±6.4 years. The current mean age of the group was 40.8±9.0 years. Even though the mean duration of i...
Turkish Journal of Psychiatry, 2012
Turkish Journal of Psychiatry, 2010
ABSTRACT
Psychopathology, 2003
Objective: For the onset of illness and possible recurrence during the childbearing period, women... more Objective: For the onset of illness and possible recurrence during the childbearing period, women with bipolar disorder (BD) are at a higher risk. The aim of this study was to evaluate the impact of clinical and psychosocial factors associated with pregnancy and the postpartum period on the course of BD. Methods: The childbearing and illness history of 72 women with BD were assessed to determine mood episodes related to the childbearing period. Data was analyzed to evaluate the risk factors (clinical, obstetric and psychosocial factors) related with mood episodes during pregnancy and the postpartum period. Results: Data of 252 pregnancies and childbirths of 72 women with BD were included in the analysis. Twenty-three (32%) women with BD reported at least one mood episode during pregnancy or within 1 month after childbirth (childbearing-related episode, CBRE). Subjects with CBREs mean age at onset of illness and mean age at the time of assessment were significantly younger than subje...
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2003
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2006
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2006
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2004
Journal of Affective Disorders, 2005
European Psychiatry, 2009
Aim:The aim of this study is to evaluate the differences in dimensions of temperament between alc... more Aim:The aim of this study is to evaluate the differences in dimensions of temperament between alcohol dependent inpatients and healthy control subjects.Method:The study is consisted of 77 alcohol-dependent patients according to the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition and 80 healthy control subjects. Cloninger's Temperament and Character Inventory (TCI), Temperament Evaluation of Memphis, Pisa, Paris and San Diego Autoquestionnaire (TEMPS-A) scale and semi structured sociodemographic form were applied to the subjects after detoxification period.Results:Age and education level were similar rates in both alcohol dependent (mean age= 43.7 ± 10.1 and education level= 9.0 ± 4.2) and healthy control subjects (mean age: 42.5 ± 11.8 and education level: 10.2 ± 3.8). Alcohol-dependent patients were characterized by higher Novelty-Seeking (p=0.006) and Harm Avoidance (p=0.002) than non-psychiatric control subjects. Also, subjects suffering from Alcohol-depend...
Current Opinion in Psychiatry, 2010
Significant sex differences have been described for mental disorders in terms of prevalence, symp... more Significant sex differences have been described for mental disorders in terms of prevalence, symptom presentation and prescription of psychotropic medication. Most of the published studies and reviews emphasize the impact of female-specific reproductive events on the course of the mental illness or sex difference of the adverse effects of psychotropic medication or the concerns about treatment of female patients during the perinatal period. Different from other reviews, we will summarize the effects of current mental disorder/psychotropic medication on the female-specific reproduction-related events (such as menstrual regularity, pregnancy, postpartum period and menopause). A number of recent studies have highlighted the adverse effects of psychotropic agents on the female reproductive system, especially on the regularity of the menstrual cycle or on the female gonadal hormones. Without any medication, disturbances of the female gonadal system are observed especially among severely mentally ill female patients. In the studies, the prevalence of female-specific gonadal abnormalities and their mechanism of action, prevention and recommendations are given in detail. The field of reproductive psychiatry is rapidly evolving. There is increasing evidence that clinicians should be aware of female medical health while treating severely mentally ill female patients. Analyzing the present data will further advance our understanding of treatment safety and impact of untreated mental illness in women.
Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2011
Bipolar Disorders, 2007
Objectives: Cognitive dysfunctions in several domains were proposed to be trait markers of bipol... more Objectives: Cognitive dysfunctions in several domains were proposed to be trait markers of bipolar patients. The aim of this study was to evaluate the effect of previous psychotic features on neuropsychological measures, including sustained attention, in remitted bipolar patients.Methods: The study participants were 40 euthymic psychotic, 25 non‐psychotic bipolar I patients and 30 healthy control subjects. Participants were assessed with a battery of neuropsychological tests targeting attention, executive functions, psychomotor speed, verbal learning and memory.Results: Euthymic psychotic bipolar patients performed worse than controls on most of the measures, after controlling for the confounding effects of education, age and residual symptoms. Non‐psychotic patients were also impaired on tasks of attention, fluency and psychomotor speed. ‘Number of Wisconsin Card Sorting Test (WCST) categories’ achieved was the only measure on which psychotic patients performed significantly wor...
Bipolar Disorders, 2004
In the present study, we aimed to evaluate menstrually related symptom changes in euthymic women ... more In the present study, we aimed to evaluate menstrually related symptom changes in euthymic women with treatment-responsive bipolar disorder (BD) compared with healthy control subjects and investigate the presence of premenstrual dysphoric disorder (PMDD). Thirty-four euthymic women with treatment-responsive BD on mood-stabilizers (lithium and/or valproate) for at least 6 months and 35 control subjects with no history of medical/mental disorder between ages of 18 and 35 years with regular menstrual cycles were prospectively followed up for at least two consecutive menstrual cycles using the Daily Record of Severity of Problems-Short Form (DRSP). Each subject was administered the retrospective self-report questionnaire, Premenstrual Assessment Form (PAF), in the first postmenstrual phase of the menstrual cycle. Venous blood samples were collected between 19 and 22 days of menstrual cycle to evaluate ovulation by measuring the serum progesterone levels. The differences in mean age, age of onset of menses, cycle length and bleeding length did not appear to be significantly meaningful between groups. In the retrospective assessment of premenstrual symptom changes, controls complained more than women with BD. More controls showed a 30% change in DRSP and in depressive and physical sub-groups than the women with BD. Controls demonstrated a significant increase compared with treatment-responsive BD patients in total, depressive, anxiety and attention sub-group scores of DRSP from the postmenstrual to the premenstrual phase, whereas the scores of vegetative symptoms of controls and women with BD did not differ significantly during one cycle or both. Significant menstrual cycle effect was observed in both groups. Within the limitations of the study, the results suggest that ongoing mood-stabilizing treatment may have a prophylactic effect against premenstrual symptom changes in women with treatment-responsive BD.
Archives of Medical Research, 2004
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2003
3 P/ Psikiyatri Psikoloji Psikofarmakoloji Dergisi, 2003
Türk psikiyatri dergisi = Turkish journal of psychiatry, 2009
Valproate is an antiepileptic commonly used in the treatment of psychiatric and neurologic diseas... more Valproate is an antiepileptic commonly used in the treatment of psychiatric and neurologic diseases. Some of the most frequently seen side effects affect the gastrointestinal, neurological, and hematological systems. Its side effects on reproductive functions have not been sufficiently studied. The use of valproate by females with bipolar disorder and epilepsy may cause menstrual cycle abnormalities, polycystic ovary syndrome, and hyperandrogenism. The effects on male reproductive functions have been researched only in epileptic patients and animals, and the results have been conflicting, because reproductive function abnormalities may be independent of the use of valproate and may be due to epilepsy itself. In the first part of this review reproductive function abnormalities due to epilepsy will be discussed, independent of the use of valproate or any other antiepileptic. Then, the results of research on valproate's effects on male reproductive functions (hormonal levels and sp...
Psychiatry Research, 2008
CLOZAPINE TREATMENT IN BIPOLAR AND SCHIZOAFFECTIVE DISORDERS: A RETROSPECTIVE STUDY Object: The a... more CLOZAPINE TREATMENT IN BIPOLAR AND SCHIZOAFFECTIVE DISORDERS: A RETROSPECTIVE STUDY Object: The aim of this study is to evaluate the sociodemographic and clinical features and efficacy of clozapine treatment in patients with bipolar disorder (BD) and schizoaffective disorder (SD). Method: Patients with DSM-IV diagnostic criteria for BD and SD on clozapine treatment for at least one year and followed up regularly were included in the study. We reviewed the patients' medical records and life-charts retrospectively. To assess the functioning of the patients, the Clinical Global Impression scale-A (CGI-A) and CGI-B and Global Assessment of Functioning (GAF) were performed preceding 3 months of clozapine treatment and current status. Results: Of 36 patients on clozapine treatment, 17 (46%) were diagnosed as BD and 19 (54%) were diagnosed as SD. The mean age of onset of illness was 24.0±6.4 years. The current mean age of the group was 40.8±9.0 years. Even though the mean duration of i...
Turkish Journal of Psychiatry, 2012
Turkish Journal of Psychiatry, 2010
ABSTRACT
Psychopathology, 2003
Objective: For the onset of illness and possible recurrence during the childbearing period, women... more Objective: For the onset of illness and possible recurrence during the childbearing period, women with bipolar disorder (BD) are at a higher risk. The aim of this study was to evaluate the impact of clinical and psychosocial factors associated with pregnancy and the postpartum period on the course of BD. Methods: The childbearing and illness history of 72 women with BD were assessed to determine mood episodes related to the childbearing period. Data was analyzed to evaluate the risk factors (clinical, obstetric and psychosocial factors) related with mood episodes during pregnancy and the postpartum period. Results: Data of 252 pregnancies and childbirths of 72 women with BD were included in the analysis. Twenty-three (32%) women with BD reported at least one mood episode during pregnancy or within 1 month after childbirth (childbearing-related episode, CBRE). Subjects with CBREs mean age at onset of illness and mean age at the time of assessment were significantly younger than subje...
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2003
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2006
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2006
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2004
Journal of Affective Disorders, 2005
European Psychiatry, 2009
Aim:The aim of this study is to evaluate the differences in dimensions of temperament between alc... more Aim:The aim of this study is to evaluate the differences in dimensions of temperament between alcohol dependent inpatients and healthy control subjects.Method:The study is consisted of 77 alcohol-dependent patients according to the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition and 80 healthy control subjects. Cloninger's Temperament and Character Inventory (TCI), Temperament Evaluation of Memphis, Pisa, Paris and San Diego Autoquestionnaire (TEMPS-A) scale and semi structured sociodemographic form were applied to the subjects after detoxification period.Results:Age and education level were similar rates in both alcohol dependent (mean age= 43.7 ± 10.1 and education level= 9.0 ± 4.2) and healthy control subjects (mean age: 42.5 ± 11.8 and education level: 10.2 ± 3.8). Alcohol-dependent patients were characterized by higher Novelty-Seeking (p=0.006) and Harm Avoidance (p=0.002) than non-psychiatric control subjects. Also, subjects suffering from Alcohol-depend...
Current Opinion in Psychiatry, 2010
Significant sex differences have been described for mental disorders in terms of prevalence, symp... more Significant sex differences have been described for mental disorders in terms of prevalence, symptom presentation and prescription of psychotropic medication. Most of the published studies and reviews emphasize the impact of female-specific reproductive events on the course of the mental illness or sex difference of the adverse effects of psychotropic medication or the concerns about treatment of female patients during the perinatal period. Different from other reviews, we will summarize the effects of current mental disorder/psychotropic medication on the female-specific reproduction-related events (such as menstrual regularity, pregnancy, postpartum period and menopause). A number of recent studies have highlighted the adverse effects of psychotropic agents on the female reproductive system, especially on the regularity of the menstrual cycle or on the female gonadal hormones. Without any medication, disturbances of the female gonadal system are observed especially among severely mentally ill female patients. In the studies, the prevalence of female-specific gonadal abnormalities and their mechanism of action, prevention and recommendations are given in detail. The field of reproductive psychiatry is rapidly evolving. There is increasing evidence that clinicians should be aware of female medical health while treating severely mentally ill female patients. Analyzing the present data will further advance our understanding of treatment safety and impact of untreated mental illness in women.
Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2011
Bipolar Disorders, 2007
Objectives: Cognitive dysfunctions in several domains were proposed to be trait markers of bipol... more Objectives: Cognitive dysfunctions in several domains were proposed to be trait markers of bipolar patients. The aim of this study was to evaluate the effect of previous psychotic features on neuropsychological measures, including sustained attention, in remitted bipolar patients.Methods: The study participants were 40 euthymic psychotic, 25 non‐psychotic bipolar I patients and 30 healthy control subjects. Participants were assessed with a battery of neuropsychological tests targeting attention, executive functions, psychomotor speed, verbal learning and memory.Results: Euthymic psychotic bipolar patients performed worse than controls on most of the measures, after controlling for the confounding effects of education, age and residual symptoms. Non‐psychotic patients were also impaired on tasks of attention, fluency and psychomotor speed. ‘Number of Wisconsin Card Sorting Test (WCST) categories’ achieved was the only measure on which psychotic patients performed significantly wor...
Bipolar Disorders, 2004
In the present study, we aimed to evaluate menstrually related symptom changes in euthymic women ... more In the present study, we aimed to evaluate menstrually related symptom changes in euthymic women with treatment-responsive bipolar disorder (BD) compared with healthy control subjects and investigate the presence of premenstrual dysphoric disorder (PMDD). Thirty-four euthymic women with treatment-responsive BD on mood-stabilizers (lithium and/or valproate) for at least 6 months and 35 control subjects with no history of medical/mental disorder between ages of 18 and 35 years with regular menstrual cycles were prospectively followed up for at least two consecutive menstrual cycles using the Daily Record of Severity of Problems-Short Form (DRSP). Each subject was administered the retrospective self-report questionnaire, Premenstrual Assessment Form (PAF), in the first postmenstrual phase of the menstrual cycle. Venous blood samples were collected between 19 and 22 days of menstrual cycle to evaluate ovulation by measuring the serum progesterone levels. The differences in mean age, age of onset of menses, cycle length and bleeding length did not appear to be significantly meaningful between groups. In the retrospective assessment of premenstrual symptom changes, controls complained more than women with BD. More controls showed a 30% change in DRSP and in depressive and physical sub-groups than the women with BD. Controls demonstrated a significant increase compared with treatment-responsive BD patients in total, depressive, anxiety and attention sub-group scores of DRSP from the postmenstrual to the premenstrual phase, whereas the scores of vegetative symptoms of controls and women with BD did not differ significantly during one cycle or both. Significant menstrual cycle effect was observed in both groups. Within the limitations of the study, the results suggest that ongoing mood-stabilizing treatment may have a prophylactic effect against premenstrual symptom changes in women with treatment-responsive BD.
Archives of Medical Research, 2004
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2003