Dr Jamaluddin Mahar - Academia.edu (original) (raw)
Papers by Dr Jamaluddin Mahar
Journal of The Iranian Chemical Society, Dec 13, 2019
Cisplatin is an important cytotoxic drug used in the treatment of a variety of human cancers. The... more Cisplatin is an important cytotoxic drug used in the treatment of a variety of human cancers. The limit of does is due to its toxic side effects. As we know, there is an important approach has used diethylthiocarbamate (detc) in combination with clsplatin Cl], in order to enhance the therapeutic efficacy of cisplatin. It has been suggested that a 1 * 1 platinum-detc complex may be responsible for the above mentioned protective effect. The diimine Pd (I[ > complexes of detc and amino acids have shown a good antitumor activity when tested against P388 lymphocytic leukemic cells [Z, 31. Taking into account the low toxicity of the above mentioned complexes, some similar structure complexes of dii&e (1, 10-phenantbroline and bipyridine) Pd (I[ > with amino acids (glycine, alanine, leucine, serine , asparagine , cystelne and methionine) and dithiocarbamates derived from amino acids (glycine, alanine and leucine) have been synthesized. The complexes have been characterized by chemical analysis, infrared, electronic , 'H and '% NMR spectroscopies. In the case of amino acids, cysteine and methi+ nine are bond to Pd (H > through the S atom and the N of the NH2 group, and the others through the terminal COO-and NH2 groups. The ligand of dithiocarbamate derivatives are bond to Pd (P > through two S atoms. The complexes have also been screened preliminary for in vitro cytotoxicity in Hela cell, and some results of them have also shown a good antitumor acticiy.
![Research paper thumbnail of ChemInform Abstract: C-H Arylation Using Acyl Thiourea Ligands: Applications in the Synthesis of 3,6-Diaryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles](https://attachments.academia-assets.com/111572279/thumbnails/1.jpg)
](ChemInform, May 1, 2016
4]triazolo[3,4-b][1,3,4]thiadiazoles.-An efficient and convenient phosphine-free C-arylation of t... more 4]triazolo[3,4-b][1,3,4]thiadiazoles.-An efficient and convenient phosphine-free C-arylation of triazolothiadiazoles (I) using a Pd/thiourea catalyst system is developed.
Journal of Fluorescence, 2020
A small set of four new fluorenyl chromophores (5-5a-c) was accomplished by stepwise nucleophilic... more A small set of four new fluorenyl chromophores (5-5a-c) was accomplished by stepwise nucleophilic substitution, Friedel-Crafts acylation, Ullman coupling, aldol condensation and cyclization reactions. The fluorene moiety was substituted at 2,7,9 and 9′ positions with diverse groups. The synthesized derivatives were characterized by FTIR, 1 H-NMR and 13 C-NMR spectroscopic techniques. The optical properties were evaluated by by UV-VIS absorption and Fluorescence studies. HOMO and LUMO energy levels were evaluated by electrochemical studies and were found at −5.37-5.83 eV and − 2.47-2.94 eV respectively with band gap energy values 2.88 to 2.91 eV. The band gap energy values suggested that these synthesized molecules can be manipulated in the designing of blue and green OLEDS.
Journal of the Chinese Chemical Society, 2017
A series of small organic molecules were synthesized by exploiting the bay and imide positions of... more A series of small organic molecules were synthesized by exploiting the bay and imide positions of the perylene nucleus. The synthesized compounds 1-11 were characterized by spectroscopic and elemental analyses. These molecules show yellowish color in solution and are highly soluble in dichloromethane. Compound 7 shows a bandgap of 1.7 eV and a Stokes shift of 27. From these results, we infer that this compound can serve as structural template in the design of organic electronics. Moreover, compound 7 shows higher T d (370 C) and T g (132 C) values, which reflect its high thermal stability.
Heliyon, 2019
Carbon nanotubes (CNTs) are among the strongest and stiffest contender to be used as filler to el... more Carbon nanotubes (CNTs) are among the strongest and stiffest contender to be used as filler to elevate the properties of epoxy. The aim of this research work is to evaluate the structural, thermal, and morphological properties of multiwalled carbon nanotubes (MWCNTs) hybridized with silver, copper and silver/copper nanoparticles (Ag/CuNP) obtained via chemical reduction of aqueous salts assisted with sodium dodecyl sulphate (SDS) as stabilizing agent. The MWCNTs/NP was further incorporated in DGEBA (epoxy) using ethyl cellulose as hardener. Scanning electron microscopy (SEM) reveals micro structural analysis of the MWCNTs/NP hybrids. The Fourier transform infrared (FTIR) spectra prove the interactions between the NP and MWCNTs. Thermogravimetric analysis (TGA) shows that the MWCNTs/NP hybrids decompose at a much faster rate and the weight loss decreased considerably due to the presence of NP. X-ray diffraction (XRD) confirms the formation of NP on the surface of MWCNTs and X-ray photoelectron spectroscopy (XPS) confirms the full covering of MWCNTs/NP hybrids with DGEBA.
Tetrahedron: Asymmetry, 2017
Isoquinuclidines constitute the central structural nucleus of numerous biologically active natura... more Isoquinuclidines constitute the central structural nucleus of numerous biologically active natural products, for example, iboga alkaloids such as ibogamine and catharanthine as well as non-indole-containing alkaloids such as the dioscorine and the cannivonines. Furthermore, in medicinal and pharmaceutical chemistry, the isoquinuclidine core is commonly employed as a rigid azabicyclic scaffold, thus providing significant precursors in the synthesis of numerous valuable alkaloids. Summarizing well-organized approaches to access the chiral isoquinuclidine structural centerpiece signifies a significant endeavor not only for developing biologically active natural products but also enhancing biological researches that can lead to possible drug discovery. Over time, the values and methodologies for the asymmetric synthesis of chiral isoquinuclidines are increasing; hence to advance asymmetric synthesis, this review combines and discusses the pros and cons of each synthesis techniques from 2008. This review should be helpful for promoting further developments of asymmetric synthetic methodologies and for medicinal chemistry.
Bioorganic Chemistry, 2019
Hydroxy-5-((trimethylsilyl)ethynyl)phenyl)ethanone based α,β-unsaturated derivatives an alternate... more Hydroxy-5-((trimethylsilyl)ethynyl)phenyl)ethanone based α,β-unsaturated derivatives an alternate to non-sulfonamide carbonic anhydrase II inhibitors, synthesis via Sonogashira coupling, binding analysis, Lipinsk's rule validation
European journal of medicinal chemistry, Jan 6, 2017
Biscoumarin derivatives, a dimeric form of coumarin, are well known derivatives of coumarin, occu... more Biscoumarin derivatives, a dimeric form of coumarin, are well known derivatives of coumarin, occurred in the bioactive metabolites of marine and terrestrial organisms. On account of pharmacological and biological applications, biscoumarins have long been the subject of innumerable enzyme inhibition studies. In this review the pros and cons of enzyme inhibition studies of biscoumarins as urease inhibitors, aromatase inhibitors, NPPs, α-glucosidase inhibitors, α-amylase inhibitors, HIV-1 integrase inhibition, steroid sulfatase inhibitors and c-Met inhibitors are discussed in a systematic way. Moreover, the review discusses the structure activity relationship of biscoumarin scaffold with enzyme inhibitory potency which would unleash new avenues for further development. The purpose of the current review is to disclose the value of biscoumarins as potent and efficient enzyme inhibitor. This review provides a guideline to elaborate the diversity of biscoumarin inhibitors by exploring the ...
![Research paper thumbnail of Design and synthesis of 2,6-di(substituted phenyl)thiazolo[3,2-b]-1,2,4-triazoles as α-glucosidase and α-amylase inhibitors, co-relative Pharmacokinetics and 3D QSAR and risk analysis](https://attachments.academia-assets.com/90636045/thumbnails/1.jpg)
](Biomedicine & Pharmacotherapy, 2017
Ten fused heterocyclic derivatives bearing the 2,6-di(subsituted phenyl)thiazolo[3,2-b]-1,2,4-tri... more Ten fused heterocyclic derivatives bearing the 2,6-di(subsituted phenyl)thiazolo[3,2-b]-1,2,4-triazoles as central rings were synthesized and structures of the compounds were established by analytical and spectral data using FTIR, EI-MS, 1 H NMR and 13 C NMR techniques. In vitro inhibitory activities of synthesized compounds on a-amylase, a-glucosidase and a-burylcholinesterase (a-BuChE) were evaluated using a purified enzyme assays. Compound 5c demonstrated strong and selective a-amylase inhibitory activity (IC 50 = 1.1 mmol/g). 5 g exhibited excellent inhibition against a-glucosidase (IC 50 = 1.2 mmol/g) when compared with acarbose (IC 50 = 4.7 mmol/g) as a positive reference. Compound 5i was found to be most potent derivative against a-BuChE with the IC 50 of 1.5 mmol/g which was comparable to the value obtained for (4.7 mmol/g) positive control (i.e. galantamine hydrobromide). Molecular dockings of synthesized compounds into the binding sites of human pancreatic a-amylase, intestinal maltaseglucoamylase and neuronal a-butrylcholinesterase allowed to shed light on the affinity and binding mode of these novel inhibitors. Preliminary structure-activity relationship (SAR) studies were carried out to understand the relationship between molecular structural features and inhibition activities of synthesized derivatives. These data suggested that compounds 5c, 5 g and 5i are promising candidates for hitto-lead follow-up in the drug-discovery process for the treatment of Alzheimer's disease and hyperinsulinamia.
Dyes and Pigments, 2017
An Investigation of the effect of conjugation on fluorene based chromophores; Optoelectronic and ... more An Investigation of the effect of conjugation on fluorene based chromophores; Optoelectronic and electrochemical behavior
Chinese Chemical Letters, 2016
An efficient and convenient phosphine-free C-arylation of triazolothiadiazoles (I) using a Pd/thi... more An efficient and convenient phosphine-free C-arylation of triazolothiadiazoles (I) using a Pd/thiourea catalyst system is developed.
Carbazole is a photo and electro luminescent moiety having good thermal stability. Many carbazole... more Carbazole is a photo and electro luminescent moiety having good thermal stability. Many carbazole based molecules used in organic electronic for fabrication of electronic devices. Three new triazine and carbazole based dyes were prepared through a series of steps involving alkylation, bromination and coupling. All the compounds were characterized through IR, Hand C-NMR and elemental analysis. Different studies i.e. (photo physical, thermal and electrochemical) were performed in order to check their applicability for electronic devices. The results indicate that compounds emit in the range of blue-green with excellent thermal stability that make their use in devices favorable. Thus, linking of electron donating moieties to triazine improves the characteristic and renders their use feasible for organic electronics applications. Keywords— Optoelectronic, thermal, molecular materials,
Journal of The Iranian Chemical Society, Dec 13, 2019
Cisplatin is an important cytotoxic drug used in the treatment of a variety of human cancers. The... more Cisplatin is an important cytotoxic drug used in the treatment of a variety of human cancers. The limit of does is due to its toxic side effects. As we know, there is an important approach has used diethylthiocarbamate (detc) in combination with clsplatin Cl], in order to enhance the therapeutic efficacy of cisplatin. It has been suggested that a 1 * 1 platinum-detc complex may be responsible for the above mentioned protective effect. The diimine Pd (I[ > complexes of detc and amino acids have shown a good antitumor activity when tested against P388 lymphocytic leukemic cells [Z, 31. Taking into account the low toxicity of the above mentioned complexes, some similar structure complexes of dii&e (1, 10-phenantbroline and bipyridine) Pd (I[ > with amino acids (glycine, alanine, leucine, serine , asparagine , cystelne and methionine) and dithiocarbamates derived from amino acids (glycine, alanine and leucine) have been synthesized. The complexes have been characterized by chemical analysis, infrared, electronic , 'H and '% NMR spectroscopies. In the case of amino acids, cysteine and methi+ nine are bond to Pd (H > through the S atom and the N of the NH2 group, and the others through the terminal COO-and NH2 groups. The ligand of dithiocarbamate derivatives are bond to Pd (P > through two S atoms. The complexes have also been screened preliminary for in vitro cytotoxicity in Hela cell, and some results of them have also shown a good antitumor acticiy.
ChemInform, May 1, 2016
4]triazolo[3,4-b][1,3,4]thiadiazoles.-An efficient and convenient phosphine-free C-arylation of t... more 4]triazolo[3,4-b][1,3,4]thiadiazoles.-An efficient and convenient phosphine-free C-arylation of triazolothiadiazoles (I) using a Pd/thiourea catalyst system is developed.
Journal of Fluorescence, 2020
A small set of four new fluorenyl chromophores (5-5a-c) was accomplished by stepwise nucleophilic... more A small set of four new fluorenyl chromophores (5-5a-c) was accomplished by stepwise nucleophilic substitution, Friedel-Crafts acylation, Ullman coupling, aldol condensation and cyclization reactions. The fluorene moiety was substituted at 2,7,9 and 9′ positions with diverse groups. The synthesized derivatives were characterized by FTIR, 1 H-NMR and 13 C-NMR spectroscopic techniques. The optical properties were evaluated by by UV-VIS absorption and Fluorescence studies. HOMO and LUMO energy levels were evaluated by electrochemical studies and were found at −5.37-5.83 eV and − 2.47-2.94 eV respectively with band gap energy values 2.88 to 2.91 eV. The band gap energy values suggested that these synthesized molecules can be manipulated in the designing of blue and green OLEDS.
Journal of the Chinese Chemical Society, 2017
A series of small organic molecules were synthesized by exploiting the bay and imide positions of... more A series of small organic molecules were synthesized by exploiting the bay and imide positions of the perylene nucleus. The synthesized compounds 1-11 were characterized by spectroscopic and elemental analyses. These molecules show yellowish color in solution and are highly soluble in dichloromethane. Compound 7 shows a bandgap of 1.7 eV and a Stokes shift of 27. From these results, we infer that this compound can serve as structural template in the design of organic electronics. Moreover, compound 7 shows higher T d (370 C) and T g (132 C) values, which reflect its high thermal stability.
Heliyon, 2019
Carbon nanotubes (CNTs) are among the strongest and stiffest contender to be used as filler to el... more Carbon nanotubes (CNTs) are among the strongest and stiffest contender to be used as filler to elevate the properties of epoxy. The aim of this research work is to evaluate the structural, thermal, and morphological properties of multiwalled carbon nanotubes (MWCNTs) hybridized with silver, copper and silver/copper nanoparticles (Ag/CuNP) obtained via chemical reduction of aqueous salts assisted with sodium dodecyl sulphate (SDS) as stabilizing agent. The MWCNTs/NP was further incorporated in DGEBA (epoxy) using ethyl cellulose as hardener. Scanning electron microscopy (SEM) reveals micro structural analysis of the MWCNTs/NP hybrids. The Fourier transform infrared (FTIR) spectra prove the interactions between the NP and MWCNTs. Thermogravimetric analysis (TGA) shows that the MWCNTs/NP hybrids decompose at a much faster rate and the weight loss decreased considerably due to the presence of NP. X-ray diffraction (XRD) confirms the formation of NP on the surface of MWCNTs and X-ray photoelectron spectroscopy (XPS) confirms the full covering of MWCNTs/NP hybrids with DGEBA.
Tetrahedron: Asymmetry, 2017
Isoquinuclidines constitute the central structural nucleus of numerous biologically active natura... more Isoquinuclidines constitute the central structural nucleus of numerous biologically active natural products, for example, iboga alkaloids such as ibogamine and catharanthine as well as non-indole-containing alkaloids such as the dioscorine and the cannivonines. Furthermore, in medicinal and pharmaceutical chemistry, the isoquinuclidine core is commonly employed as a rigid azabicyclic scaffold, thus providing significant precursors in the synthesis of numerous valuable alkaloids. Summarizing well-organized approaches to access the chiral isoquinuclidine structural centerpiece signifies a significant endeavor not only for developing biologically active natural products but also enhancing biological researches that can lead to possible drug discovery. Over time, the values and methodologies for the asymmetric synthesis of chiral isoquinuclidines are increasing; hence to advance asymmetric synthesis, this review combines and discusses the pros and cons of each synthesis techniques from 2008. This review should be helpful for promoting further developments of asymmetric synthetic methodologies and for medicinal chemistry.
Bioorganic Chemistry, 2019
Hydroxy-5-((trimethylsilyl)ethynyl)phenyl)ethanone based α,β-unsaturated derivatives an alternate... more Hydroxy-5-((trimethylsilyl)ethynyl)phenyl)ethanone based α,β-unsaturated derivatives an alternate to non-sulfonamide carbonic anhydrase II inhibitors, synthesis via Sonogashira coupling, binding analysis, Lipinsk's rule validation
European journal of medicinal chemistry, Jan 6, 2017
Biscoumarin derivatives, a dimeric form of coumarin, are well known derivatives of coumarin, occu... more Biscoumarin derivatives, a dimeric form of coumarin, are well known derivatives of coumarin, occurred in the bioactive metabolites of marine and terrestrial organisms. On account of pharmacological and biological applications, biscoumarins have long been the subject of innumerable enzyme inhibition studies. In this review the pros and cons of enzyme inhibition studies of biscoumarins as urease inhibitors, aromatase inhibitors, NPPs, α-glucosidase inhibitors, α-amylase inhibitors, HIV-1 integrase inhibition, steroid sulfatase inhibitors and c-Met inhibitors are discussed in a systematic way. Moreover, the review discusses the structure activity relationship of biscoumarin scaffold with enzyme inhibitory potency which would unleash new avenues for further development. The purpose of the current review is to disclose the value of biscoumarins as potent and efficient enzyme inhibitor. This review provides a guideline to elaborate the diversity of biscoumarin inhibitors by exploring the ...
Biomedicine & Pharmacotherapy, 2017
Ten fused heterocyclic derivatives bearing the 2,6-di(subsituted phenyl)thiazolo[3,2-b]-1,2,4-tri... more Ten fused heterocyclic derivatives bearing the 2,6-di(subsituted phenyl)thiazolo[3,2-b]-1,2,4-triazoles as central rings were synthesized and structures of the compounds were established by analytical and spectral data using FTIR, EI-MS, 1 H NMR and 13 C NMR techniques. In vitro inhibitory activities of synthesized compounds on a-amylase, a-glucosidase and a-burylcholinesterase (a-BuChE) were evaluated using a purified enzyme assays. Compound 5c demonstrated strong and selective a-amylase inhibitory activity (IC 50 = 1.1 mmol/g). 5 g exhibited excellent inhibition against a-glucosidase (IC 50 = 1.2 mmol/g) when compared with acarbose (IC 50 = 4.7 mmol/g) as a positive reference. Compound 5i was found to be most potent derivative against a-BuChE with the IC 50 of 1.5 mmol/g which was comparable to the value obtained for (4.7 mmol/g) positive control (i.e. galantamine hydrobromide). Molecular dockings of synthesized compounds into the binding sites of human pancreatic a-amylase, intestinal maltaseglucoamylase and neuronal a-butrylcholinesterase allowed to shed light on the affinity and binding mode of these novel inhibitors. Preliminary structure-activity relationship (SAR) studies were carried out to understand the relationship between molecular structural features and inhibition activities of synthesized derivatives. These data suggested that compounds 5c, 5 g and 5i are promising candidates for hitto-lead follow-up in the drug-discovery process for the treatment of Alzheimer's disease and hyperinsulinamia.
Dyes and Pigments, 2017
An Investigation of the effect of conjugation on fluorene based chromophores; Optoelectronic and ... more An Investigation of the effect of conjugation on fluorene based chromophores; Optoelectronic and electrochemical behavior
Chinese Chemical Letters, 2016
An efficient and convenient phosphine-free C-arylation of triazolothiadiazoles (I) using a Pd/thi... more An efficient and convenient phosphine-free C-arylation of triazolothiadiazoles (I) using a Pd/thiourea catalyst system is developed.
Carbazole is a photo and electro luminescent moiety having good thermal stability. Many carbazole... more Carbazole is a photo and electro luminescent moiety having good thermal stability. Many carbazole based molecules used in organic electronic for fabrication of electronic devices. Three new triazine and carbazole based dyes were prepared through a series of steps involving alkylation, bromination and coupling. All the compounds were characterized through IR, Hand C-NMR and elemental analysis. Different studies i.e. (photo physical, thermal and electrochemical) were performed in order to check their applicability for electronic devices. The results indicate that compounds emit in the range of blue-green with excellent thermal stability that make their use in devices favorable. Thus, linking of electron donating moieties to triazine improves the characteristic and renders their use feasible for organic electronics applications. Keywords— Optoelectronic, thermal, molecular materials,