Dr.Marzough Aziz Albalawi - Academia.edu (original) (raw)

Papers by Dr.Marzough Aziz Albalawi

Research paper thumbnail of The medicinal activity of lyophilized aqueous seed extract of Lepidium sativum L. in an androgenic alopecia model

Scientific Reports

This study evaluated the topical effect of Lepidium sativum lyophilized seed extract (LSLE) towar... more This study evaluated the topical effect of Lepidium sativum lyophilized seed extract (LSLE) towards Sustanon-induced alopecia in male adult Wistar albino rats in vivo, compared to minoxidil topical reference standard drug (MRD). LC–MS/MS together with molecular networking was used to profile the metabolites of LSLE. LSLE treated group revealed significant changes in alopecia related biomarkers, perturbation of androgenic markers; decline in testosterone level and elevation in 5α-reductase (5-AR); decline in the cholesterol level. On the other hand, LSLE treated group showed improvement in vascular markers; CTGF, FGF and VEGF. Groups treated topically with minoxidil and LSLE showed significant improvement in hair length. LC–MS/MS profile of LSLE tentatively identified 17 constituents: mainly glucosinolates, flavonoid glycosides, alkaloids and phenolic acids. The results point to the potential role of LSLE in the treatment of alopecia through decreasing 5(alpha)-dihydrotestosterone le...

Research paper thumbnail of Active and smart antimicrobial food packaging film composed of date palm kernels extract loaded carboxymethyl chitosan and carboxymethyl starch composite for prohibiting foodborne pathogens during fruits preservation

Research paper thumbnail of Betanin improves motor function and alleviates experimental Parkinsonism via downregulation of TLR4/MyD88/NF-κB pathway: Molecular docking and biological investigations

Biomedicine & Pharmacotherapy

Research paper thumbnail of Modification of edible chitosan/polyethylene glycol films fortified with date palm fruit waste extract as promising antimicrobial food packaging materials for fresh strawberry conservation

Research paper thumbnail of Ziziphus spina-christi Leaf-Derived Carbon Dots as a Fluorescence Nanosensor to Evaluate Rifaximin Antibacterial via Inner Filter Effect: Greenness and Whiteness Studies

Chemosensors

Rifaximin (RFX) is a non-absorbable antibiotic with broad-spectrum efficacy. It treats travelers’... more Rifaximin (RFX) is a non-absorbable antibiotic with broad-spectrum efficacy. It treats travelers’ diarrhea, irritable bowel syndrome, non-systematic bacterial diarrhea, bowel infections, overgrowth syndrome, and enteric infections. In this work, carbon dots prepared from Ziziphus spina-christi leaves’ powders are utilized as a green fluorometric biosensor for the assessment of RFX. The morphological lineaments of the prepared carbon dots were recognized by using TEM and SEM techniques. The prepared carbon dots manifest a fluorescence emission peak at 432 nm after an excitation fluorescence peak at 366 nm. The absorbance band of RFX (absorbance peaks at 370 nm and 443 nm) could be thoroughly overlapped with fluorescence excitation/emission bands of the produced carbon dots. A fluorometric tool has been designed and validated for the evaluation of RFX reliant on the inner filter effect methodology, in which the produced carbon dots act as an inner filter effect fluorophore and RFX as ...

Research paper thumbnail of Molecular docking of novel donor–π–acceptor dicyanomethylenedihydrofuran‐based fluorescent chromophores

Luminescence

A series of donor–π–acceptor dicyanomethylenedihydrofuran (DCDHF)‐based chromophores comprising d... more A series of donor–π–acceptor dicyanomethylenedihydrofuran (DCDHF)‐based chromophores comprising different π‐aryl bridges and different terminal groups was synthesized and characterized. The chromophores were synthesized via Knoevenagel condensation of the active methyl‐bearing DCDHF (electron acceptor) with a tertiary amine‐containing arylaldehyde (electron donor) in dry pyridine at room temperature in the presence of a few drops of acetic acid. The synthesis approach involved the development of phenyl(thienyl)vinyl‐bridged dicyanomethylenedihydrofuran dyes with a tertiary amine terminal group. Both absorption and emission spectra were explored. The strong emission properties detected using the synthesized chromophores could be attributed to intramolecular charge transfer. The chemical structures of the synthesized chromophores were verified using 1H/13C nuclear magnetic resonance and Fourier transform infrared spectroscopy. Both tertiary amine‐containing and arylaldehyde groups wer...

Research paper thumbnail of Box-Behnken design based optimization of phenolic extractions from Polygonum equisetiforme roots linked to its antioxidant and antibacterial efficiencies

Frontiers in Sustainable Food Systems

PurposeThe Polygonum equisetifome is a prospective plant source of high protein, unsaturated fatt... more PurposeThe Polygonum equisetifome is a prospective plant source of high protein, unsaturated fatty acids, and useful safe bioactive molecules. Therefore, the aim of this study was to optimize the ultrasonic aqueous extraction of phenols from P. equisetifome roots using Box-Behnken design based statistical modeling, and to evaluate the antioxidant and antibacterial efficiencies of P. equisetifome root extracts against pathogenic bacteria.MethodsIn this study, the box-behnken design was used to optimize the extraction of phenols. The extraction temperature (30–70°C), ultrasound assisted extraction (UAE) time (1–9 min), and liquid-solid ratio (35–45 mL/g) were investigated as the factors that influence the phenolic yield (Y1) and their DPPH (1,1-diphenyl-2-picrylhydrazyl) scavenging activity (Y2).ResultsThe optimal conditions for both responses were 50°C, 5 min, and 40 mL/g. At these conditions, Y1 reached its maximum to be 45.321 mg GAE/g dry weight and Y2 to be 120.354 μmol Trolox/g ...

Research paper thumbnail of Tamarindus indica Extract as a Promising Antimicrobial and Antivirulence Therapy

Antibiotics

The worldwide crises from multi-drug-resistant (MDR) bacterial infections are pushing us to searc... more The worldwide crises from multi-drug-resistant (MDR) bacterial infections are pushing us to search for new alternative therapies. The renewed interest in medicinal plants has gained the attention of our research group. Tamarindus indica L. (T. indica) is one of the traditional medicines used for a wide range of diseases. Therefore, we evaluated the antimicrobial activities of ethanolic extract of T. indica. The inhibitions zones, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and fractional inhibitor concentration indices (FICI) against Gram+ve and −ve pathogens were detected. The bioactive compounds from T. indica extract were identified by mass spectroscopy, thin-layer chromatography, and bio-autographic assay. We performed scanning electron microscopy (SEM) and molecular docking studies to confirm possible mechanisms of actions and antivirulence activities, respectively. We found more promising antimicrobial activities against MDR pathogens with...

Research paper thumbnail of Novel arylazo nicotinate derivatives as effective antibacterial agents: Green synthesis, molecular modeling, and structure-activity relationship studies

Journal of Saudi Chemical Society

Peer review under responsibility of King Saud University. Production and hosting by Elsevier.

Research paper thumbnail of Synthesis, DFT Studies, Molecular Docking and Biological Activity Evaluation of Thiazole-Sulfonamide Derivatives as Potent Alzheimer’s Inhibitors

Molecules

Alzheimer’s disease is a major public brain condition that has resulted in many deaths, as reveal... more Alzheimer’s disease is a major public brain condition that has resulted in many deaths, as revealed by the World Health Organization (WHO). Conventional Alzheimer’s treatments such as chemotherapy, surgery, and radiotherapy are not very effective and are usually associated with several adverse effects. Therefore, it is necessary to find a new therapeutic approach that completely treats Alzheimer’s disease without many side effects. In this research project, we report the synthesis and biological activities of some new thiazole-bearing sulfonamide analogs (1–21) as potent anti-Alzheimer’s agents. Suitable characterization techniques were employed, and the density functional theory (DFT) computational approach, as well as in-silico molecular modeling, has been employed to assess the electronic properties and anti-Alzheimer’s potency of the analogs. All analogs exhibited a varied degree of inhibitory potential, but analog 1 was found to have excellent potency (IC50 = 0.10 ± 0.05 µM for...

Research paper thumbnail of Detection of Indigo Carmine dye in juices via application of photoluminescent europium‐doped carbon dots from tannic acid

Research paper thumbnail of Determination of metanil yellow dye in turmeric powder using a unique fluorescence Europium doped carbon dots

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Research paper thumbnail of Essential Oils and COVID-19

Molecules

Herbal products are a major source of herbal medicines and other medicines. Essential oils have s... more Herbal products are a major source of herbal medicines and other medicines. Essential oils have shown various pharmacological activities, such as antiviral activity, and therefore are proposed to have potential activity against SARS-CoV-2. Due to their lipophilicity, essential oils can easily penetrate the viral membrane and cause the viral membrane to rupture. In addition, crude essential oils usually have many active constituents that can act on different parts of the virus including its cell entry, translation, transcription, and assembly. They have further beneficial pharmacological effects on the host’s respiratory system, including anti-inflammatory, immune regulation, bronchiectasis, and mucolytics. This review reported potential essential oils which could be promising drugs for COVID-19 eradication. Essential oils have many advantages because they are promising volatile antiviral molecules, making them potential drug targets for the prevention and treatment of COVID-19, whet...

Research paper thumbnail of Synthesis of New Triazole-Based Thiosemicarbazone Derivatives as Anti-Alzheimer’s Disease Candidates: Evidence-Based In Vitro Study

Molecules

Triazole-based thiosemicarbazone derivatives (6a–u) were synthesized then characterized by spectr... more Triazole-based thiosemicarbazone derivatives (6a–u) were synthesized then characterized by spectroscopic techniques, such as 1HNMR and 13CNMR and HRMS (ESI). Newly synthesized derivatives were screened in vitro for inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes. All derivatives (except 6c and 6d, which were found to be completely inactive) demonstrated moderate to good inhibitory effects ranging from 0.10 ± 0.050 to 12.20 ± 0.30 µM (for AChE) and 0.20 ± 0.10 to 14.10 ± 0.40 µM (for BuChE). The analogue 6i (IC50 = 0.10 ± 0.050 for AChE and IC50 = 0.20 ± 0.050 µM for BuChE), which had di-substitutions (2-nitro, 3-hydroxy groups) at ring B and tri-substitutions (2-nitro, 4,5-dichloro groups) at ring C, and analogue 6b (IC50 = 0.20 ± 0.10 µM for AChE and IC50 = 0.30 ± 0.10 µM for BuChE), which had di-Cl at 4,5, -NO2 groups at 2-position of phenyl ring B and hydroxy group at ortho-position of phenyl ring C, emerged as the most potent inh...

Research paper thumbnail of Benzimidazole Bearing Thiosemicarbazone Derivatives Act as Potent α-Amylase and α-Glucosidase Inhibitors; Synthesis, Bioactivity Screening and Molecular Docking Study

Molecules

Diabetes mellitus is one of the most chronic metabolic diseases. In the past few years, our resea... more Diabetes mellitus is one of the most chronic metabolic diseases. In the past few years, our research group has synthesized and evaluated libraries of heterocyclic analogs against α-glucosidase and α-amylase enzymes and found encouraging results. The current study comprises the evaluation of benzimidazole-bearing thiosemicarbazone as antidiabetic agents. A library of fifteen derivatives (7–21) was synthesized, characterized via different spectroscopic techniques such as HREI-MS, NMR, and screened against α-glucosidase and α-amylase enzymes. All derivatives exhibited excellent to good biological inhibitory potentials. Derivatives 19 (IC50 = 1.30 ± 0.20 µM and 1.20 ± 0.20 µM) and 20 (IC50 = 1.60 ± 0.20 µM and 1.10 ± 0.01 µM) were found to be the most potent among the series when compared with standard drug acarbose (IC50 = 11.29 ± 0.07 and 11.12 ± 0.15 µM, respectively). These derivatives may potentially serve as the lead candidates for the development of new therapeutic representative...

Research paper thumbnail of Genotype and age of industrial plant Jatropha curcas L. affect physico-chemical properties of seed oil

Frontiers in Energy Research

Jatropha curcas, has been established as a plant whose seeds contain a relatively high percentage... more Jatropha curcas, has been established as a plant whose seeds contain a relatively high percentage of oil that is suitable for biodiesel production, among other industrial applications. Seed oil properties of J. curcas may vary depending on soils, age of plant, genotype of the plant, and agro-climatic conditions of a specific geographical region. Studies under such conditions have not yet been conducted. The present study was aimed at investigating the effects of genotype and age of the plant on the physicochemical properties of its seed oil. The seed oil was extracted using n-hexane as a solvent in the Soxhlet extraction apparatus from seed kernel collected from different genotypes and plants of different ages. Oil content in the kernel ranged from 49.78–53.75% (w/w) among the seed samples depending on genetic materials and plant age. The oil content showed very little but significant differences in density and specific gravity among the samples. The highest free fatty acid (FAA) wa...

Research paper thumbnail of Synthesis and photophysical properties of new reactive fluorophenanthrenes

Comptes Rendus. Chimie, 2020

A series of six new suitably functionalized fluorophenanthrene derivatives were synthesized throu... more A series of six new suitably functionalized fluorophenanthrene derivatives were synthesized through a simple procedure, making use of inexpensive starting materials under mild conditions. The target phenanthrenes were characterized by 1 H and 13 C NMR and FT-IR spectroscopies. UV-Vis absorption and photoluminescence of these phenanthrenes were evaluated in solutions. A notable behavior and a strong fluorescence in the blue region of the visible spectrum were observed, making them potential candidates for organic light-emitting diode technology or advanced materials. Their electrochemical behavior was also experimentally examined in solution, demonstrating an important charge transfer interaction owing to their π-conjugated electronic system. Résumé. Une série de six nouveaux dérivés de fluorophénanathrène convenablement fonctionnalisés ont été synthétisés selon une procédure simple utilisant des réactifs peu coûteux dans des conditions douces. Les phénanthrènes cibles ont été caractérisés par RMN 1 H et 13 C et IR à transformée de Fourrier. L'étude de l'absorption UV-Vis et de la photoluminescence de ces phénanthrènes a été évaluée en solution montrant un comportement notable et une forte fluorescence dans la région bleue du spectre visible, ce qui permet de les considérer comme des candidats potentiels pour la technologie OLED ou des matériaux avancés. Leur comportement électrochimique a été aussi examiné expérimentalement en solution démontrant une interaction de transfert de charge importante grâce à leur système électronique π-conjugué.

Research paper thumbnail of Isolation of Rhamnocitrin Insecticide from Retamaraetam via Shephadex LH-20

IOSR Journal of Applied Chemistry, 2016

Retamaraetam is a medicinal herb growing wild in the mountain alkurvillage was collected in the f... more Retamaraetam is a medicinal herb growing wild in the mountain alkurvillage was collected in the flowering stage and after treatment in ways different methods of chromatography for isolated Rhamnocitrin has been purified bySephadex LH-20 and identified by spectroscopic methods (UV, NMR).showed that despite the differences in potency of Retamaraetamand Rhamnocitrinsubstances they were found to possess parallel regression lines. This may suggest that these extracts have the same mode of action against the tested insect larvae.

Research paper thumbnail of Anticancer and Antifolate Activities of Extracts of Six Saudi Arabian Wild Plants Used in Folk Medicine

Journal of Life Sciences, 2015

Six indigenous folk medicinal plants growing wild in the area of Tabuk, Saudi Arabia which were s... more Six indigenous folk medicinal plants growing wild in the area of Tabuk, Saudi Arabia which were selected for the study of their phytochemistry as well as their biological activities as antitumor and antifolate agents. Antitumor activities of methanol extracts of the six plants were measured in vitro using three human tumor cell lines (breast, lung and CNS cancers) while antifolate activities were assessed using commercial dihyrofolate reductase obtained from Sigma Co. Among the six plant extracts tested, the most remarkable were those of Caralluma sinaica and Fagonia tenuifolia. Caralluma extract showed strong antitumor activity (low GI 50) against the three human tumor cell lines. Fagonia extract, on the other hand, was quite inhibitory to the growth of CNS cancer and breast cancer cell lines but much less so against lung cancer cells. Extracts of both Sonchus oleraceus and Caralluma sinaica were strongly inhibitory to DHFR. These results suggest that the mechanism of anticancer activity of Caralluma plant is through DHFR inhibition but that of Fagonia may follow a different path.

Research paper thumbnail of Evaluation of Antibacterial and antifungal effects of novel hydroxamic acids Linked-natural amino acids

Egyptian Journal of Chemistry, 2017

A SERIES of new derivatives containing hydroxamic acids linked-amino acids has been synthesized a... more A SERIES of new derivatives containing hydroxamic acids linked-amino acids has been synthesized and fully characterized by spectroscopic techniques including; 1 H, 13 C, DEPT 135 and HRMS.These new compounds were tested for their antibacterial and antifungal activities.

Research paper thumbnail of The medicinal activity of lyophilized aqueous seed extract of Lepidium sativum L. in an androgenic alopecia model

Scientific Reports

This study evaluated the topical effect of Lepidium sativum lyophilized seed extract (LSLE) towar... more This study evaluated the topical effect of Lepidium sativum lyophilized seed extract (LSLE) towards Sustanon-induced alopecia in male adult Wistar albino rats in vivo, compared to minoxidil topical reference standard drug (MRD). LC–MS/MS together with molecular networking was used to profile the metabolites of LSLE. LSLE treated group revealed significant changes in alopecia related biomarkers, perturbation of androgenic markers; decline in testosterone level and elevation in 5α-reductase (5-AR); decline in the cholesterol level. On the other hand, LSLE treated group showed improvement in vascular markers; CTGF, FGF and VEGF. Groups treated topically with minoxidil and LSLE showed significant improvement in hair length. LC–MS/MS profile of LSLE tentatively identified 17 constituents: mainly glucosinolates, flavonoid glycosides, alkaloids and phenolic acids. The results point to the potential role of LSLE in the treatment of alopecia through decreasing 5(alpha)-dihydrotestosterone le...

Research paper thumbnail of Active and smart antimicrobial food packaging film composed of date palm kernels extract loaded carboxymethyl chitosan and carboxymethyl starch composite for prohibiting foodborne pathogens during fruits preservation

Research paper thumbnail of Betanin improves motor function and alleviates experimental Parkinsonism via downregulation of TLR4/MyD88/NF-κB pathway: Molecular docking and biological investigations

Biomedicine & Pharmacotherapy

Research paper thumbnail of Modification of edible chitosan/polyethylene glycol films fortified with date palm fruit waste extract as promising antimicrobial food packaging materials for fresh strawberry conservation

Research paper thumbnail of Ziziphus spina-christi Leaf-Derived Carbon Dots as a Fluorescence Nanosensor to Evaluate Rifaximin Antibacterial via Inner Filter Effect: Greenness and Whiteness Studies

Chemosensors

Rifaximin (RFX) is a non-absorbable antibiotic with broad-spectrum efficacy. It treats travelers’... more Rifaximin (RFX) is a non-absorbable antibiotic with broad-spectrum efficacy. It treats travelers’ diarrhea, irritable bowel syndrome, non-systematic bacterial diarrhea, bowel infections, overgrowth syndrome, and enteric infections. In this work, carbon dots prepared from Ziziphus spina-christi leaves’ powders are utilized as a green fluorometric biosensor for the assessment of RFX. The morphological lineaments of the prepared carbon dots were recognized by using TEM and SEM techniques. The prepared carbon dots manifest a fluorescence emission peak at 432 nm after an excitation fluorescence peak at 366 nm. The absorbance band of RFX (absorbance peaks at 370 nm and 443 nm) could be thoroughly overlapped with fluorescence excitation/emission bands of the produced carbon dots. A fluorometric tool has been designed and validated for the evaluation of RFX reliant on the inner filter effect methodology, in which the produced carbon dots act as an inner filter effect fluorophore and RFX as ...

Research paper thumbnail of Molecular docking of novel donor–π–acceptor dicyanomethylenedihydrofuran‐based fluorescent chromophores

Luminescence

A series of donor–π–acceptor dicyanomethylenedihydrofuran (DCDHF)‐based chromophores comprising d... more A series of donor–π–acceptor dicyanomethylenedihydrofuran (DCDHF)‐based chromophores comprising different π‐aryl bridges and different terminal groups was synthesized and characterized. The chromophores were synthesized via Knoevenagel condensation of the active methyl‐bearing DCDHF (electron acceptor) with a tertiary amine‐containing arylaldehyde (electron donor) in dry pyridine at room temperature in the presence of a few drops of acetic acid. The synthesis approach involved the development of phenyl(thienyl)vinyl‐bridged dicyanomethylenedihydrofuran dyes with a tertiary amine terminal group. Both absorption and emission spectra were explored. The strong emission properties detected using the synthesized chromophores could be attributed to intramolecular charge transfer. The chemical structures of the synthesized chromophores were verified using 1H/13C nuclear magnetic resonance and Fourier transform infrared spectroscopy. Both tertiary amine‐containing and arylaldehyde groups wer...

Research paper thumbnail of Box-Behnken design based optimization of phenolic extractions from Polygonum equisetiforme roots linked to its antioxidant and antibacterial efficiencies

Frontiers in Sustainable Food Systems

PurposeThe Polygonum equisetifome is a prospective plant source of high protein, unsaturated fatt... more PurposeThe Polygonum equisetifome is a prospective plant source of high protein, unsaturated fatty acids, and useful safe bioactive molecules. Therefore, the aim of this study was to optimize the ultrasonic aqueous extraction of phenols from P. equisetifome roots using Box-Behnken design based statistical modeling, and to evaluate the antioxidant and antibacterial efficiencies of P. equisetifome root extracts against pathogenic bacteria.MethodsIn this study, the box-behnken design was used to optimize the extraction of phenols. The extraction temperature (30–70°C), ultrasound assisted extraction (UAE) time (1–9 min), and liquid-solid ratio (35–45 mL/g) were investigated as the factors that influence the phenolic yield (Y1) and their DPPH (1,1-diphenyl-2-picrylhydrazyl) scavenging activity (Y2).ResultsThe optimal conditions for both responses were 50°C, 5 min, and 40 mL/g. At these conditions, Y1 reached its maximum to be 45.321 mg GAE/g dry weight and Y2 to be 120.354 μmol Trolox/g ...

Research paper thumbnail of Tamarindus indica Extract as a Promising Antimicrobial and Antivirulence Therapy

Antibiotics

The worldwide crises from multi-drug-resistant (MDR) bacterial infections are pushing us to searc... more The worldwide crises from multi-drug-resistant (MDR) bacterial infections are pushing us to search for new alternative therapies. The renewed interest in medicinal plants has gained the attention of our research group. Tamarindus indica L. (T. indica) is one of the traditional medicines used for a wide range of diseases. Therefore, we evaluated the antimicrobial activities of ethanolic extract of T. indica. The inhibitions zones, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and fractional inhibitor concentration indices (FICI) against Gram+ve and −ve pathogens were detected. The bioactive compounds from T. indica extract were identified by mass spectroscopy, thin-layer chromatography, and bio-autographic assay. We performed scanning electron microscopy (SEM) and molecular docking studies to confirm possible mechanisms of actions and antivirulence activities, respectively. We found more promising antimicrobial activities against MDR pathogens with...

Research paper thumbnail of Novel arylazo nicotinate derivatives as effective antibacterial agents: Green synthesis, molecular modeling, and structure-activity relationship studies

Journal of Saudi Chemical Society

Peer review under responsibility of King Saud University. Production and hosting by Elsevier.

Research paper thumbnail of Synthesis, DFT Studies, Molecular Docking and Biological Activity Evaluation of Thiazole-Sulfonamide Derivatives as Potent Alzheimer’s Inhibitors

Molecules

Alzheimer’s disease is a major public brain condition that has resulted in many deaths, as reveal... more Alzheimer’s disease is a major public brain condition that has resulted in many deaths, as revealed by the World Health Organization (WHO). Conventional Alzheimer’s treatments such as chemotherapy, surgery, and radiotherapy are not very effective and are usually associated with several adverse effects. Therefore, it is necessary to find a new therapeutic approach that completely treats Alzheimer’s disease without many side effects. In this research project, we report the synthesis and biological activities of some new thiazole-bearing sulfonamide analogs (1–21) as potent anti-Alzheimer’s agents. Suitable characterization techniques were employed, and the density functional theory (DFT) computational approach, as well as in-silico molecular modeling, has been employed to assess the electronic properties and anti-Alzheimer’s potency of the analogs. All analogs exhibited a varied degree of inhibitory potential, but analog 1 was found to have excellent potency (IC50 = 0.10 ± 0.05 µM for...

Research paper thumbnail of Detection of Indigo Carmine dye in juices via application of photoluminescent europium‐doped carbon dots from tannic acid

Research paper thumbnail of Determination of metanil yellow dye in turmeric powder using a unique fluorescence Europium doped carbon dots

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Research paper thumbnail of Essential Oils and COVID-19

Molecules

Herbal products are a major source of herbal medicines and other medicines. Essential oils have s... more Herbal products are a major source of herbal medicines and other medicines. Essential oils have shown various pharmacological activities, such as antiviral activity, and therefore are proposed to have potential activity against SARS-CoV-2. Due to their lipophilicity, essential oils can easily penetrate the viral membrane and cause the viral membrane to rupture. In addition, crude essential oils usually have many active constituents that can act on different parts of the virus including its cell entry, translation, transcription, and assembly. They have further beneficial pharmacological effects on the host’s respiratory system, including anti-inflammatory, immune regulation, bronchiectasis, and mucolytics. This review reported potential essential oils which could be promising drugs for COVID-19 eradication. Essential oils have many advantages because they are promising volatile antiviral molecules, making them potential drug targets for the prevention and treatment of COVID-19, whet...

Research paper thumbnail of Synthesis of New Triazole-Based Thiosemicarbazone Derivatives as Anti-Alzheimer’s Disease Candidates: Evidence-Based In Vitro Study

Molecules

Triazole-based thiosemicarbazone derivatives (6a–u) were synthesized then characterized by spectr... more Triazole-based thiosemicarbazone derivatives (6a–u) were synthesized then characterized by spectroscopic techniques, such as 1HNMR and 13CNMR and HRMS (ESI). Newly synthesized derivatives were screened in vitro for inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes. All derivatives (except 6c and 6d, which were found to be completely inactive) demonstrated moderate to good inhibitory effects ranging from 0.10 ± 0.050 to 12.20 ± 0.30 µM (for AChE) and 0.20 ± 0.10 to 14.10 ± 0.40 µM (for BuChE). The analogue 6i (IC50 = 0.10 ± 0.050 for AChE and IC50 = 0.20 ± 0.050 µM for BuChE), which had di-substitutions (2-nitro, 3-hydroxy groups) at ring B and tri-substitutions (2-nitro, 4,5-dichloro groups) at ring C, and analogue 6b (IC50 = 0.20 ± 0.10 µM for AChE and IC50 = 0.30 ± 0.10 µM for BuChE), which had di-Cl at 4,5, -NO2 groups at 2-position of phenyl ring B and hydroxy group at ortho-position of phenyl ring C, emerged as the most potent inh...

Research paper thumbnail of Benzimidazole Bearing Thiosemicarbazone Derivatives Act as Potent α-Amylase and α-Glucosidase Inhibitors; Synthesis, Bioactivity Screening and Molecular Docking Study

Molecules

Diabetes mellitus is one of the most chronic metabolic diseases. In the past few years, our resea... more Diabetes mellitus is one of the most chronic metabolic diseases. In the past few years, our research group has synthesized and evaluated libraries of heterocyclic analogs against α-glucosidase and α-amylase enzymes and found encouraging results. The current study comprises the evaluation of benzimidazole-bearing thiosemicarbazone as antidiabetic agents. A library of fifteen derivatives (7–21) was synthesized, characterized via different spectroscopic techniques such as HREI-MS, NMR, and screened against α-glucosidase and α-amylase enzymes. All derivatives exhibited excellent to good biological inhibitory potentials. Derivatives 19 (IC50 = 1.30 ± 0.20 µM and 1.20 ± 0.20 µM) and 20 (IC50 = 1.60 ± 0.20 µM and 1.10 ± 0.01 µM) were found to be the most potent among the series when compared with standard drug acarbose (IC50 = 11.29 ± 0.07 and 11.12 ± 0.15 µM, respectively). These derivatives may potentially serve as the lead candidates for the development of new therapeutic representative...

Research paper thumbnail of Genotype and age of industrial plant Jatropha curcas L. affect physico-chemical properties of seed oil

Frontiers in Energy Research

Jatropha curcas, has been established as a plant whose seeds contain a relatively high percentage... more Jatropha curcas, has been established as a plant whose seeds contain a relatively high percentage of oil that is suitable for biodiesel production, among other industrial applications. Seed oil properties of J. curcas may vary depending on soils, age of plant, genotype of the plant, and agro-climatic conditions of a specific geographical region. Studies under such conditions have not yet been conducted. The present study was aimed at investigating the effects of genotype and age of the plant on the physicochemical properties of its seed oil. The seed oil was extracted using n-hexane as a solvent in the Soxhlet extraction apparatus from seed kernel collected from different genotypes and plants of different ages. Oil content in the kernel ranged from 49.78–53.75% (w/w) among the seed samples depending on genetic materials and plant age. The oil content showed very little but significant differences in density and specific gravity among the samples. The highest free fatty acid (FAA) wa...

Research paper thumbnail of Synthesis and photophysical properties of new reactive fluorophenanthrenes

Comptes Rendus. Chimie, 2020

A series of six new suitably functionalized fluorophenanthrene derivatives were synthesized throu... more A series of six new suitably functionalized fluorophenanthrene derivatives were synthesized through a simple procedure, making use of inexpensive starting materials under mild conditions. The target phenanthrenes were characterized by 1 H and 13 C NMR and FT-IR spectroscopies. UV-Vis absorption and photoluminescence of these phenanthrenes were evaluated in solutions. A notable behavior and a strong fluorescence in the blue region of the visible spectrum were observed, making them potential candidates for organic light-emitting diode technology or advanced materials. Their electrochemical behavior was also experimentally examined in solution, demonstrating an important charge transfer interaction owing to their π-conjugated electronic system. Résumé. Une série de six nouveaux dérivés de fluorophénanathrène convenablement fonctionnalisés ont été synthétisés selon une procédure simple utilisant des réactifs peu coûteux dans des conditions douces. Les phénanthrènes cibles ont été caractérisés par RMN 1 H et 13 C et IR à transformée de Fourrier. L'étude de l'absorption UV-Vis et de la photoluminescence de ces phénanthrènes a été évaluée en solution montrant un comportement notable et une forte fluorescence dans la région bleue du spectre visible, ce qui permet de les considérer comme des candidats potentiels pour la technologie OLED ou des matériaux avancés. Leur comportement électrochimique a été aussi examiné expérimentalement en solution démontrant une interaction de transfert de charge importante grâce à leur système électronique π-conjugué.

Research paper thumbnail of Isolation of Rhamnocitrin Insecticide from Retamaraetam via Shephadex LH-20

IOSR Journal of Applied Chemistry, 2016

Retamaraetam is a medicinal herb growing wild in the mountain alkurvillage was collected in the f... more Retamaraetam is a medicinal herb growing wild in the mountain alkurvillage was collected in the flowering stage and after treatment in ways different methods of chromatography for isolated Rhamnocitrin has been purified bySephadex LH-20 and identified by spectroscopic methods (UV, NMR).showed that despite the differences in potency of Retamaraetamand Rhamnocitrinsubstances they were found to possess parallel regression lines. This may suggest that these extracts have the same mode of action against the tested insect larvae.

Research paper thumbnail of Anticancer and Antifolate Activities of Extracts of Six Saudi Arabian Wild Plants Used in Folk Medicine

Journal of Life Sciences, 2015

Six indigenous folk medicinal plants growing wild in the area of Tabuk, Saudi Arabia which were s... more Six indigenous folk medicinal plants growing wild in the area of Tabuk, Saudi Arabia which were selected for the study of their phytochemistry as well as their biological activities as antitumor and antifolate agents. Antitumor activities of methanol extracts of the six plants were measured in vitro using three human tumor cell lines (breast, lung and CNS cancers) while antifolate activities were assessed using commercial dihyrofolate reductase obtained from Sigma Co. Among the six plant extracts tested, the most remarkable were those of Caralluma sinaica and Fagonia tenuifolia. Caralluma extract showed strong antitumor activity (low GI 50) against the three human tumor cell lines. Fagonia extract, on the other hand, was quite inhibitory to the growth of CNS cancer and breast cancer cell lines but much less so against lung cancer cells. Extracts of both Sonchus oleraceus and Caralluma sinaica were strongly inhibitory to DHFR. These results suggest that the mechanism of anticancer activity of Caralluma plant is through DHFR inhibition but that of Fagonia may follow a different path.

Research paper thumbnail of Evaluation of Antibacterial and antifungal effects of novel hydroxamic acids Linked-natural amino acids

Egyptian Journal of Chemistry, 2017

A SERIES of new derivatives containing hydroxamic acids linked-amino acids has been synthesized a... more A SERIES of new derivatives containing hydroxamic acids linked-amino acids has been synthesized and fully characterized by spectroscopic techniques including; 1 H, 13 C, DEPT 135 and HRMS.These new compounds were tested for their antibacterial and antifungal activities.