Dr Olena Myronenko - Academia.edu (original) (raw)

Papers by Dr Olena Myronenko

Медична освіта, Apr 10, 2023

Медичні перспективи, Mar 30, 2022

Biological Markers in Fundamental and Clinical Medicine, Nov 7, 2019

Медичні перспективи, Mar 30, 2022

Systemic Hypertension, 2021

Background. Arterial hypertension is a modifiable risk factor for the development of life-threate... more Background. Arterial hypertension is a modifiable risk factor for the development of life-threatening cardiovascular complications. Early diagnosis and optimal treatment are the key to success in the fight against this pathology. Aim. To analyze the knowledge of senior medical students from different regions in the basic issues of hypertension. Materials and methods. The article presents the results of the first stage of the multicenter PHYSTARH study (the full name of the project is Physicians and undergraduates knowledge in arterial hypertension treatment). An anonymous questionnaire (pharmacoepidemiological survey) was conducted among 314 senior medical students from 6 cities of Russia and Ukraine. Results. The study revealed the average level of senior students knowledge. The average level of correct answers to the questions in the first part of the questionnaire was 49.4%. The minimum level of correct answers was obtained in the questions of determining hypertension by the valu...

Research Results in Pharmacology, 2018

Introduction. Community-acquired pneumonia (CAP) remains one of the most acute problems of bronch... more Introduction. Community-acquired pneumonia (CAP) remains one of the most acute problems of bronchopulmonary pathology being the 4th in the mortality structure (after cardiovascular, cerebrovascular diseases and malignant neoplasms) and the 1st among all fatalities from infectious diseases. Thanks to the scientific progress achieved in the antibiotic therapy and vaccine prophylaxis, the death toll has decreased four times compared to its rate during the “pre-antibiotic era“. However, nowadays there is a steadily increasing trend in the pneumonia mortality rate in Russia. The only possible way to increase efficacy of CAP treatment is timely initiated rational antibiotic therapy, considering the possible etiologies, risk factors and the severity of the patient’s condition. Materials and methods. The article represents the results of anonymous prospective surveys within the framework of the KNOCAP multi-centered research project aimed at accessing the knowledge on the fundamental issues...

Шпитальна хірургія. Журнал імені Л. Я. Ковальчука, 2018

Мета роботи: визначити ефективність впроваждення інноваційних технологій у педагогічний процес на... more Мета роботи: визначити ефективність впроваждення інноваційних технологій у педагогічний процес на кафедрі внутрішньої медицини 1 ДЗ «ДМА».

Медична освіта, 2018

Мета роботи – визначити роль різних виховних технологій, які використовують співробітники кафедри... more Мета роботи – визначити роль різних виховних технологій, які використовують співробітники кафедри внутрішньої медицини 1 Державного закладу “Дніпропетровська медична академія Міністерства охорони здоров’я України” (ДЗ “ДМА”), у формуванні особистості сучасного лікаря.Основна частина. Сучасне виховання в Україні повинне забезпечувати долучення молоді до світової й національної культури, до загальнолюдських цінностей. За формами й методами воно може впроваджуватися у різних напрямках – від навчання майбутніх лікарів щодо співпраці у рамках шкіл для хворих з різною хронічною патологією. Співробітники кафедри приділяють велику увагу всебічному вихованню майбутнього покоління лікарів і викладачів, добре розуміючи, що воно повинно бути не лише багато у чому обізнаним, а й емоційно здоровим та виваженим. Задля цієї мети молодь залучається до відвідувань театрів, музеїв міста, виставок робіт майстрів народної творчості тощо.Висновки. Різні виховні технології формують високоморальні якості...

Медична освіта, 2018

Мета роботи: визначити ефективність впроваждення інноваційних технологій у навчальний процес на к... more Мета роботи: визначити ефективність впроваждення інноваційних технологій у навчальний процес на кафедрі внутрішньої медицини 1 Державного закладу «Дніпропетровська медична академія Міністерства охорони здоров’я України» (ДЗ «ДМА»). Мета роботи – визначити ефективність впровадження інноваційних технологій у навчальний процес на кафедрі внутрішньої медицини 1 Державного закладу “Дніпропетровська медична академія Міністерства охорони здоров’я України” (ДЗ “ДМА”). Основна частина. Нові підходи до навчання студентів передбачають активацію творчих здібностей. Творчість передбачає нове бачення, тобто готовність відмовитися від звичних схем викладання навчального матеріалу та готовність до самозмінювання. Одне з найважливіших завдань вищої школи полягає в тому, щоб форми та методи навчання сприяли виявленню творчих здібностей та безперервному самовдосконаленню. Впровадження інноваційних освітніх технологій у рамках вищої медичної школи, у тому числі інтерактивних підходів до навчання студен...

Zaporozhye Medical Journal, Oct 17, 2017

European Respiratory Journal, 2013

The aim of our study was to assess the efficacy of fenspiride (F) as complementary anti-inflammat... more The aim of our study was to assess the efficacy of fenspiride (F) as complementary anti-inflammatory therapy in combination with fenoteroly+ipratropium bromide (F+I) in patients COPD phenotype as chronic bronchitis. Study population: 20 pts with COPD A-B (13 males (65%), were studied over a 6-month treatment period. Mild age 49,02+11,32 year, duration of COPD 13,03+4,76. 1st gr.(10 pts) – combined therapy with F (160 mg/day) and F+I (200+80 mcg dayly). 2nd gr. (10 pts) – only F+I (400+160 mcg/day). Methods: the quality of life (QOL) was evaluated using the SGRQ. Functional status was accessed by pulmonary function test (PFT) and pneumotonometria, 6MWD test and Borg dyspnea scale. All studies as well as the SGRQ underwent again under the same condition in 6-months later. Results: significant increase was observed in all of the SGRQ domains in 1st gr (p<0,01). Changes in pulmonary functions were significantly correlated with activity, impact and total SGRQ scores (p<0,001). Redu...

European Respiratory Journal, 2011

Aim: To estimate the deepness, intensity and reversibility of structural changes in bronchial wal... more Aim: To estimate the deepness, intensity and reversibility of structural changes in bronchial walls in III-IV COPD stg with immunomorphological method using. Study disign: 42 pts (mean age 59±1.7 years) with COPD: I gr.- 30 pts with III stg (20 male), II gr.- 12 pts with IV stg (9 male). Bronchoscopy with consequent histology sampling and assessing by microscopy and immunohistochemistry (IHC) research was done for all pts. The following indexes were evaluated: Ki-67 (reflect proliferative potential and activity of epithelial regeneration); Cytokeratins 8 (Ctk) (as a marker of glandular epithelium); Ctk 34βE12 (squamous epithelium origin). Results: In Gr I all pts had been demonstrated intensive positive membrane reactions with Ctk 8 in uninjurious ciliary9s and basal epithelial cells and heterogeneous positive membrane reactions with Ctk 34βE12. The simultaneous co-expression of both types of cytokeratins indicates the reversibility of metaplasia.Histological investigation: hypertro...

Systematic Reviews in Pharmacy, 2020

Introduction: The relevance of work is dictated by the fact that arterial hypertension is often a... more Introduction: The relevance of work is dictated by the fact that arterial hypertension is often associated with other diseases and every physician and senior student should be aware of the contraindications to antihypertensive therapy (AT) in the most common nosologies – aV-block 2nd and 3rd degree, WPW-syndrome, gout, COPD and pregnancy. Aim: To analyze physicians’ and medical undergraduates’ knowledge of main contraindications to AH treatment. Material and Methods: During the multicenter study devoted to the assessment of physicians’ knowledge in treatment of AH (“PHYSTARH” study), 296 people from 5 Russian and Ukrainian cities were surveyed in 2017-2018: 44,9% – 6th grade students, 55,1% – physicians. Results and Discussion. The study revealed an insufficient level of students’ and doctors’ knowledge of main contraindications to AH treatment. Less than half of the respondents correctly identified drugs contraindicated in pregnancy, gout, aV-block 2nd and 3rd degree, WPW-syndrome ...

European Respiratory Journal, 2014

Dihydropyridine calcium antagonists (CA), primarily act on smooth muscles of arteries, i.e. are t... more Dihydropyridine calcium antagonists (CA), primarily act on smooth muscles of arteries, i.e. are typical peripheral vasodilators, reducing the pressure in the pulmonary artery. CA also able to reduce the synthesis of matrix metalloproteinase (MMP). One of the positive effects realized through positive employmenton the respiratory muscles (RM). The aim of the study was to evaluate effect of different therapy for COPD pts with RM dysfunction. Material. COPD patients with II stage were divided in to 4 groups:1st (berodual 2 puff 3 times per day) - 12 pts, 2nd (tiotropium 18 μg once daily) – 14 pts, 3d (formoteroly fumarat 12 μg twice daily) – 10 pts, 4th (berodual+amlodipini 5 mg) – 16 pts. Methods. Spirometry and pneumotonometry were performed by means MasterScreen Body/Diff (“Jaeger”, German). FEV1, PImax, PEmax and P0.1 were evaluated. Results. No significant differences in the level of FEV1, PEmax and P0.1 in groups of observations were observed either at baseline or at the end of t...

European Respiratory Journal, 2011

The aim of our study was to study the efficacy of fenspiride (F) in the complex therapy of patien... more The aim of our study was to study the efficacy of fenspiride (F) in the complex therapy of patients with chronic obstructive pulmonary disease (COPD). Study population: COPD pts with I-II stages (n=20) were observed on an extent 6-month treatment period. Among them were 13 males (65%). Mild age 49,02±11,32 year, duration of COPD 13,03±4,76. 1st gr. (10 pts) – combined therapy with F (160 mg/day) and fenoteroly/ipratropium bromide (F+I) (200+80 mcg dayly). 2nd gr. (10 pts) – monotherapy with F+I. Methods: Spirometry and pneumotonometry were performed on days 1, 90 and 180 by means MasterScreen Body/Diff (“Jaeger”, German). Functional status was accessed by six-minute walk distance (6MWD) test and Borg dyspnea scale. The St. George9s Respiratory Questionnaire (SGRQ) data were determined before and after treatment period. Results : Significant increase in all of the SGRQ domains in pts of 1st gr (p 0.05). Conclusion: The study demonstrated greater efficacy of long-term complex therapy ...

European Respiratory Journal, 2011

Almost all patients with bronchial obstruction have respiratory muscles (RM) dysfunction of vario... more Almost all patients with bronchial obstruction have respiratory muscles (RM) dysfunction of various severity levels. The aim of our investigation was to evaluate the change of RM function in bronchial asthma (BA) and chronic obstructive pulmonary disease (COPD) patients on different stage of diseases. Study population: 48 COPD and 12 BA patients were included. Subjects were divide depending on a stage of disease. The mean age of COPD pts. is 52,33±0,70 years, 8 females (22,3%) and 28 (77,7%) males. In gr. with BA the mean age is 49,78±5,64 years, 5 females (41,7%) and 7 (58,3%) males. Methods: Spirometry and pneumotonometry were performed by means MasterScreen Body/Diff (“Jaeger”, German). FEV1 and PImax were evaluated. Results: Results are performed in table 1. View this table: Conclusion: We estimate the dysfunction of RM in all groups pts with BA and COPD. Correlation interrelation between FEV1 and PImax in pts with BA was positive (r=0,78), in COPD pts – negative (r=-0,94). We a...

Respiratory infections and bronchiectasis

Медична освіта, Apr 10, 2023

Медичні перспективи, Mar 30, 2022

Biological Markers in Fundamental and Clinical Medicine, Nov 7, 2019

Медичні перспективи, Mar 30, 2022

Systemic Hypertension, 2021

Background. Arterial hypertension is a modifiable risk factor for the development of life-threate... more Background. Arterial hypertension is a modifiable risk factor for the development of life-threatening cardiovascular complications. Early diagnosis and optimal treatment are the key to success in the fight against this pathology. Aim. To analyze the knowledge of senior medical students from different regions in the basic issues of hypertension. Materials and methods. The article presents the results of the first stage of the multicenter PHYSTARH study (the full name of the project is Physicians and undergraduates knowledge in arterial hypertension treatment). An anonymous questionnaire (pharmacoepidemiological survey) was conducted among 314 senior medical students from 6 cities of Russia and Ukraine. Results. The study revealed the average level of senior students knowledge. The average level of correct answers to the questions in the first part of the questionnaire was 49.4%. The minimum level of correct answers was obtained in the questions of determining hypertension by the valu...

Research Results in Pharmacology, 2018

Introduction. Community-acquired pneumonia (CAP) remains one of the most acute problems of bronch... more Introduction. Community-acquired pneumonia (CAP) remains one of the most acute problems of bronchopulmonary pathology being the 4th in the mortality structure (after cardiovascular, cerebrovascular diseases and malignant neoplasms) and the 1st among all fatalities from infectious diseases. Thanks to the scientific progress achieved in the antibiotic therapy and vaccine prophylaxis, the death toll has decreased four times compared to its rate during the “pre-antibiotic era“. However, nowadays there is a steadily increasing trend in the pneumonia mortality rate in Russia. The only possible way to increase efficacy of CAP treatment is timely initiated rational antibiotic therapy, considering the possible etiologies, risk factors and the severity of the patient’s condition. Materials and methods. The article represents the results of anonymous prospective surveys within the framework of the KNOCAP multi-centered research project aimed at accessing the knowledge on the fundamental issues...

Шпитальна хірургія. Журнал імені Л. Я. Ковальчука, 2018

Мета роботи: визначити ефективність впроваждення інноваційних технологій у педагогічний процес на... more Мета роботи: визначити ефективність впроваждення інноваційних технологій у педагогічний процес на кафедрі внутрішньої медицини 1 ДЗ «ДМА».

Медична освіта, 2018

Мета роботи – визначити роль різних виховних технологій, які використовують співробітники кафедри... more Мета роботи – визначити роль різних виховних технологій, які використовують співробітники кафедри внутрішньої медицини 1 Державного закладу “Дніпропетровська медична академія Міністерства охорони здоров’я України” (ДЗ “ДМА”), у формуванні особистості сучасного лікаря.Основна частина. Сучасне виховання в Україні повинне забезпечувати долучення молоді до світової й національної культури, до загальнолюдських цінностей. За формами й методами воно може впроваджуватися у різних напрямках – від навчання майбутніх лікарів щодо співпраці у рамках шкіл для хворих з різною хронічною патологією. Співробітники кафедри приділяють велику увагу всебічному вихованню майбутнього покоління лікарів і викладачів, добре розуміючи, що воно повинно бути не лише багато у чому обізнаним, а й емоційно здоровим та виваженим. Задля цієї мети молодь залучається до відвідувань театрів, музеїв міста, виставок робіт майстрів народної творчості тощо.Висновки. Різні виховні технології формують високоморальні якості...

Медична освіта, 2018

Мета роботи: визначити ефективність впроваждення інноваційних технологій у навчальний процес на к... more Мета роботи: визначити ефективність впроваждення інноваційних технологій у навчальний процес на кафедрі внутрішньої медицини 1 Державного закладу «Дніпропетровська медична академія Міністерства охорони здоров’я України» (ДЗ «ДМА»). Мета роботи – визначити ефективність впровадження інноваційних технологій у навчальний процес на кафедрі внутрішньої медицини 1 Державного закладу “Дніпропетровська медична академія Міністерства охорони здоров’я України” (ДЗ “ДМА”). Основна частина. Нові підходи до навчання студентів передбачають активацію творчих здібностей. Творчість передбачає нове бачення, тобто готовність відмовитися від звичних схем викладання навчального матеріалу та готовність до самозмінювання. Одне з найважливіших завдань вищої школи полягає в тому, щоб форми та методи навчання сприяли виявленню творчих здібностей та безперервному самовдосконаленню. Впровадження інноваційних освітніх технологій у рамках вищої медичної школи, у тому числі інтерактивних підходів до навчання студен...

Zaporozhye Medical Journal, Oct 17, 2017

European Respiratory Journal, 2013

The aim of our study was to assess the efficacy of fenspiride (F) as complementary anti-inflammat... more The aim of our study was to assess the efficacy of fenspiride (F) as complementary anti-inflammatory therapy in combination with fenoteroly+ipratropium bromide (F+I) in patients COPD phenotype as chronic bronchitis. Study population: 20 pts with COPD A-B (13 males (65%), were studied over a 6-month treatment period. Mild age 49,02+11,32 year, duration of COPD 13,03+4,76. 1st gr.(10 pts) – combined therapy with F (160 mg/day) and F+I (200+80 mcg dayly). 2nd gr. (10 pts) – only F+I (400+160 mcg/day). Methods: the quality of life (QOL) was evaluated using the SGRQ. Functional status was accessed by pulmonary function test (PFT) and pneumotonometria, 6MWD test and Borg dyspnea scale. All studies as well as the SGRQ underwent again under the same condition in 6-months later. Results: significant increase was observed in all of the SGRQ domains in 1st gr (p<0,01). Changes in pulmonary functions were significantly correlated with activity, impact and total SGRQ scores (p<0,001). Redu...

European Respiratory Journal, 2011

Aim: To estimate the deepness, intensity and reversibility of structural changes in bronchial wal... more Aim: To estimate the deepness, intensity and reversibility of structural changes in bronchial walls in III-IV COPD stg with immunomorphological method using. Study disign: 42 pts (mean age 59±1.7 years) with COPD: I gr.- 30 pts with III stg (20 male), II gr.- 12 pts with IV stg (9 male). Bronchoscopy with consequent histology sampling and assessing by microscopy and immunohistochemistry (IHC) research was done for all pts. The following indexes were evaluated: Ki-67 (reflect proliferative potential and activity of epithelial regeneration); Cytokeratins 8 (Ctk) (as a marker of glandular epithelium); Ctk 34βE12 (squamous epithelium origin). Results: In Gr I all pts had been demonstrated intensive positive membrane reactions with Ctk 8 in uninjurious ciliary9s and basal epithelial cells and heterogeneous positive membrane reactions with Ctk 34βE12. The simultaneous co-expression of both types of cytokeratins indicates the reversibility of metaplasia.Histological investigation: hypertro...

Systematic Reviews in Pharmacy, 2020

Introduction: The relevance of work is dictated by the fact that arterial hypertension is often a... more Introduction: The relevance of work is dictated by the fact that arterial hypertension is often associated with other diseases and every physician and senior student should be aware of the contraindications to antihypertensive therapy (AT) in the most common nosologies – aV-block 2nd and 3rd degree, WPW-syndrome, gout, COPD and pregnancy. Aim: To analyze physicians’ and medical undergraduates’ knowledge of main contraindications to AH treatment. Material and Methods: During the multicenter study devoted to the assessment of physicians’ knowledge in treatment of AH (“PHYSTARH” study), 296 people from 5 Russian and Ukrainian cities were surveyed in 2017-2018: 44,9% – 6th grade students, 55,1% – physicians. Results and Discussion. The study revealed an insufficient level of students’ and doctors’ knowledge of main contraindications to AH treatment. Less than half of the respondents correctly identified drugs contraindicated in pregnancy, gout, aV-block 2nd and 3rd degree, WPW-syndrome ...

European Respiratory Journal, 2014

Dihydropyridine calcium antagonists (CA), primarily act on smooth muscles of arteries, i.e. are t... more Dihydropyridine calcium antagonists (CA), primarily act on smooth muscles of arteries, i.e. are typical peripheral vasodilators, reducing the pressure in the pulmonary artery. CA also able to reduce the synthesis of matrix metalloproteinase (MMP). One of the positive effects realized through positive employmenton the respiratory muscles (RM). The aim of the study was to evaluate effect of different therapy for COPD pts with RM dysfunction. Material. COPD patients with II stage were divided in to 4 groups:1st (berodual 2 puff 3 times per day) - 12 pts, 2nd (tiotropium 18 μg once daily) – 14 pts, 3d (formoteroly fumarat 12 μg twice daily) – 10 pts, 4th (berodual+amlodipini 5 mg) – 16 pts. Methods. Spirometry and pneumotonometry were performed by means MasterScreen Body/Diff (“Jaeger”, German). FEV1, PImax, PEmax and P0.1 were evaluated. Results. No significant differences in the level of FEV1, PEmax and P0.1 in groups of observations were observed either at baseline or at the end of t...

European Respiratory Journal, 2011

The aim of our study was to study the efficacy of fenspiride (F) in the complex therapy of patien... more The aim of our study was to study the efficacy of fenspiride (F) in the complex therapy of patients with chronic obstructive pulmonary disease (COPD). Study population: COPD pts with I-II stages (n=20) were observed on an extent 6-month treatment period. Among them were 13 males (65%). Mild age 49,02±11,32 year, duration of COPD 13,03±4,76. 1st gr. (10 pts) – combined therapy with F (160 mg/day) and fenoteroly/ipratropium bromide (F+I) (200+80 mcg dayly). 2nd gr. (10 pts) – monotherapy with F+I. Methods: Spirometry and pneumotonometry were performed on days 1, 90 and 180 by means MasterScreen Body/Diff (“Jaeger”, German). Functional status was accessed by six-minute walk distance (6MWD) test and Borg dyspnea scale. The St. George9s Respiratory Questionnaire (SGRQ) data were determined before and after treatment period. Results : Significant increase in all of the SGRQ domains in pts of 1st gr (p 0.05). Conclusion: The study demonstrated greater efficacy of long-term complex therapy ...

European Respiratory Journal, 2011

Almost all patients with bronchial obstruction have respiratory muscles (RM) dysfunction of vario... more Almost all patients with bronchial obstruction have respiratory muscles (RM) dysfunction of various severity levels. The aim of our investigation was to evaluate the change of RM function in bronchial asthma (BA) and chronic obstructive pulmonary disease (COPD) patients on different stage of diseases. Study population: 48 COPD and 12 BA patients were included. Subjects were divide depending on a stage of disease. The mean age of COPD pts. is 52,33±0,70 years, 8 females (22,3%) and 28 (77,7%) males. In gr. with BA the mean age is 49,78±5,64 years, 5 females (41,7%) and 7 (58,3%) males. Methods: Spirometry and pneumotonometry were performed by means MasterScreen Body/Diff (“Jaeger”, German). FEV1 and PImax were evaluated. Results: Results are performed in table 1. View this table: Conclusion: We estimate the dysfunction of RM in all groups pts with BA and COPD. Correlation interrelation between FEV1 and PImax in pts with BA was positive (r=0,78), in COPD pts – negative (r=-0,94). We a...

Respiratory infections and bronchiectasis