Dr.P.Caroline Mary AVASC - Academia.edu (original) (raw)
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Papers by Dr.P.Caroline Mary AVASC
International Journal of Fuzzy Mathematical Archive
In this paper the polynomial interpolation of triangular fuzzy number is discussed. First general... more In this paper the polynomial interpolation of triangular fuzzy number is discussed. First general form of the polynomial with fuzzy coefficients is proposed. The hermite interpolation method is studied with triangular fuzzy number an example is provided to illustrate the algorithm.
Malaya Journal of Matematik, 2019
In this paper the polynomial interpolation of triangular fuzzy number is discussed. First general... more In this paper the polynomial interpolation of triangular fuzzy number is discussed. First general form of the polynomial with fuzzy coefficients is proposed. The Stirling interpolation method is studied with triangular fuzzy number an example is provided to illustrate the algorithm.
Diabetologia, Aug 29, 2018
The CD28/B7 interaction is critical for both effector T cell activation and forkhead box P3 (FOXP... more The CD28/B7 interaction is critical for both effector T cell activation and forkhead box P3 (FOXP3) regulatory T cell (Treg) generation and homeostasis, which complicates the therapeutic use of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)-immunoglobulin fusion protein (CTLA-4Ig) in autoimmunity. Here, we evaluated the impact of a simultaneous and selective blockade of the CD28 and mammalian target of rapamycin (mTOR) pathways in the NOD mouse model of type 1 diabetes. NOD mice were treated with PEGylated anti-CD28 Fab' antibody fragments (PV1-polyethylene glycol [PEG], 10 mg/kg i.p., twice weekly), rapamycin (1 mg/kg i.p., twice weekly) or a combination of both drugs. Diabetes incidence, pancreatic islet infiltration and autoreactive T cell responses were analysed. We report that 4 week administration of PV1-PEG combined with rapamycin effectively controlled the progression of autoimmune diabetes in NOD mice at 10 weeks of age by reducing T cell activation and migration ...
International Journal of Fuzzy Mathematical Archive
In this paper the polynomial interpolation of triangular fuzzy number is discussed. First general... more In this paper the polynomial interpolation of triangular fuzzy number is discussed. First general form of the polynomial with fuzzy coefficients is proposed. The hermite interpolation method is studied with triangular fuzzy number an example is provided to illustrate the algorithm.
Malaya Journal of Matematik, 2019
In this paper the polynomial interpolation of triangular fuzzy number is discussed. First general... more In this paper the polynomial interpolation of triangular fuzzy number is discussed. First general form of the polynomial with fuzzy coefficients is proposed. The Stirling interpolation method is studied with triangular fuzzy number an example is provided to illustrate the algorithm.
Diabetologia, Aug 29, 2018
The CD28/B7 interaction is critical for both effector T cell activation and forkhead box P3 (FOXP... more The CD28/B7 interaction is critical for both effector T cell activation and forkhead box P3 (FOXP3) regulatory T cell (Treg) generation and homeostasis, which complicates the therapeutic use of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)-immunoglobulin fusion protein (CTLA-4Ig) in autoimmunity. Here, we evaluated the impact of a simultaneous and selective blockade of the CD28 and mammalian target of rapamycin (mTOR) pathways in the NOD mouse model of type 1 diabetes. NOD mice were treated with PEGylated anti-CD28 Fab' antibody fragments (PV1-polyethylene glycol [PEG], 10 mg/kg i.p., twice weekly), rapamycin (1 mg/kg i.p., twice weekly) or a combination of both drugs. Diabetes incidence, pancreatic islet infiltration and autoreactive T cell responses were analysed. We report that 4 week administration of PV1-PEG combined with rapamycin effectively controlled the progression of autoimmune diabetes in NOD mice at 10 weeks of age by reducing T cell activation and migration ...