Dr. Ramninder Kaur - Academia.edu (original) (raw)
Papers by Dr. Ramninder Kaur
Zenodo (CERN European Organization for Nuclear Research), 2014
The traditional systems of medicine together with folklore medicine continue to play a significan... more The traditional systems of medicine together with folklore medicine continue to play a significant role in our health care system for the betterment of mankind. Sambucus nigra.Linn, frequently known as ‘Sweet elder’ belongs to family Caprifoliaceae. Sambucus species are being investigated for their potential benefits to health. It is one of the most attractive tree has been put to some useful purpose in Ayurveda, Homeopathic medicine and has become a cynosure of modern medicine. The plant is highly used traditionally in curing diverse disorders. Commonly it is used as astringent, antiviral and diuretic. Thus it holds a significant place because of its medicinal and other miscellaneous uses of economic values. This review particularly deals with the phytoconstituents, homeopathic importance of Sambucus nigra.Linn.
Zenodo (CERN European Organization for Nuclear Research), 2008
A novel series of 2-(4-bromo-2-formyl-phenoxy)acetyl amino acid and peptide analogs was synthesiz... more A novel series of 2-(4-bromo-2-formyl-phenoxy)acetyl amino acid and peptide analogs was synthesized by the coupling of 2-(4-bromo-2-formyl•phenoxy)acetic acid with different amino acid methyl ester hydrochlorides, dipeptide and tripeptide methyl esters using dicyclohexylcarbodiimide as the coupling agent and N-methylmorpholine as the base. Structures of all the newly synthesized compounds were elucidated on basis of IR, NMR and MS spectral data as well as elemental analysis. On pharmacological screening, some peptide derivatives were found to exhibit potent bioactivity against gram-negative bacterium Pseudomonas aeruginosa, pathogenic fungus Candida albicans and earthworms Megascoplex konkanensis, Pontoscotex corethruses and Eudrilus sp. Dermatophytes were found to be moderately sensitive towards the newly synthesized analogs. Hydrolyzed peptide derivatives displayed better antimicrobial activity in comparison to corresponding esters.
A series of 5-Bromo- 2-formyl phenoxyacetyl amino acids and peptides have been synthesized by cou... more A series of 5-Bromo- 2-formyl phenoxyacetyl amino acids and peptides have been synthesized by coupling of the 5-Bromo- 2-formyl phenoxyacetic acid with amino acid/methyl esters/dipeptides/ tripeptides using DCC as coupling agent and NMM as base. The structures were elucidated FTIR and 1 HNMR .The newly synthesized compounds were evaluated for their antibacterial, antifungal and anthelminitic activities. The compounds (2, 6, 11 and 13) were found to exihibit potent antibacterial activity against Bacillus subtilis, Staphylococcus aureus (gram positive bacteria) and Escherichia coli (gram negative) bacterias.The compounds (5, 6 and 13) were found to exihibit potent antifungal activity against Candida albicans and Aspergillus niger. The moderate to good anthelminitic activity was shown by the synthesized compounds (7 and 13) against Eudrilus spieces.
INTRODUCTON Peptides are generally considered to be poor drug candidates because of their low ora... more INTRODUCTON Peptides are generally considered to be poor drug candidates because of their low oral bioavailabilit y and propensity to be rapidly metabolized. The concept t ha a drug can be not orally available has become more and more accepted and as a consequence, some pharmaceutical companies have contribu ted in recent years to a revival of interest in peptides as poten tial drug candidates . New synthetic strategies to improve productivity and reduce metabolism of peptides, alo ng with alternative routes of administration, have bee n developed in recent years , and a large number of peptide-based drugs are now being marketed. ABSTRACT The decreasing number of approved drugs produced by the pharmaceutical industry, which has been accompanied by increasing expenses for R and D, dem ands alternative approaches to increase pharmaceuti cal R and D productivity. This situation has contribute d to a revival of interest in peptides as potential drug candidates. New synthetic strategies ...
INTRODUCTION In various indigenous and traditional sources of medicine plants have been extensive... more INTRODUCTION In various indigenous and traditional sources of medicine plants have been extensively used for treatments. Various parts of plants such as the leaves, fruits, the barks, roots and even the seeds ar being used for preparation of medicine. Sitaphal (Sugar-apple) is the fruit of Annona squamosa , Family: Annonaceae, and also cultivated for its edible fruit. It is originated in lowland Central America, where it is indigenous. It is also grown species of Annona and a native of known as custard apple (mainly Annona reticulata) in the Philippines. The genus name, ‘Annona’ is from the Latin word ‘anon’, which means ‘yearly produce’. The fruit is round to conical, 5–10 cm (2.0–3.9 in) in diameter ABSTRACT Sitaphal frequently known as Annona Squamosa belongs to family Annonaceae. The plant is highly used traditionally in curing diverse disorders. Sitaphal is a multipurpose tree with edible fruits. Commonl y it is used as cough and cold and sneezing nose, antibacterial, and anti-...
Marine organisms are important sources of bioactive molecules that have been used to treat variou... more Marine organisms are important sources of bioactive molecules that have been used to treat various diseases. Unusual marine environments are associated with chemical diversity, leading to a resource of novel active substances for the development of bioactive products. Recently, marine-derived bioactive peptides have attracted attention owing to their numerous beneficial effects. Moreover, several studies have reported that marine peptides exhibit various activities, such as antimicrobial, antifungal, antidiabetic, antitumor, antimalarial, antiprotozoal, antituberculosis, and antiviral activities. In the last several decades, studies of marine plants, animals, and microbes have revealed tremendous number of structurally diverse and bioactive secondary metabolites. In this review, we will present the structures and activities of peptides isolated from marine sources (sponges, algae, bacteria, fungi and fish).
International Journal of Advance Research, Ideas and Innovations in Technology, 2016
A popular example of opportunistic routing is the "delay tolerant" forwarding to vanet network wh... more A popular example of opportunistic routing is the "delay tolerant" forwarding to vanet network when a direct path to destination does not exist. The evaluation of this work is twofold. We implemented two prototypes on off-the-shelf hardware to show the technical feasibility of our opportunistic network concepts. Also, the prototypes were used to carry out a number of runtime measurements. Then, we developed a novel two-step simulation method for opportunistic data dissemination. The simulation combines real world user traces with artificial user mobility models, in order to model user movements more realistically. We investigate our opportunistic data dissemination process under various settings, including different communication ranges and user behavior pattern in this use Conventional routing in this case would just "drop" the packet. With opportunistic routing, a node acts upon the available information, in this thesis optimize the routing by centrality information then refine by ant colony met heuristics. In this method validate our approach on different parameter like overhead, throughput.
American Journal of Phytomedicine and Clinical Therapeutics, 2013
Marigolds were well known and valued by ancient people in South Asia. The bright orange and red c... more Marigolds were well known and valued by ancient people in South Asia. The bright orange and red colours of marigolds are seen everywhere in daily life of the Indian sub-continent. They are mainly decorative plants and the flowers are used in all kinds of ceremonies including weddings. Marigold has been occasionally used in South Asian medicine. Marigold leaves and flowers in particular have been used for various disorders. Marigold species are being investigated for their potential benefits to health. Now a days, they are being used for treatment of various diseases.
Iranian Journal of Pharmaceutical Research : IJPR, 2020
Synthesis of a natural proline-rich cyclopolypeptide - rolloamide A was carried out by coupling o... more Synthesis of a natural proline-rich cyclopolypeptide - rolloamide A was carried out by coupling of tri- and tetrapeptide units Boc-Phe-Pro-Val-OMe and Boc-Pro-Leu-Pro-Ile-OMe after proper deprotection at carboxyl and amino terminals using carbodiimide chemistry in alkaline environment followed by cyclization of linear heptapeptide segment in the presence of base. The structure of synthesized peptide was confirmed by spectral techniques including FTIR, 1H NMR, 13C NMR, MS analyses. Newly synthesized peptide was subjected to biological screening against pathogenic microbes and earthworms. Cyclopeptide 8 possessed promising activity against pathogenic fungi Candida albicans (ZOI: 24 mm, MIC: 6 μg/mL) and Gram-negative bacteria Pseudomonas aeruginosa (ZOI: 27 mm, MIC: 6 μg/mL) and Klebsiella pneumoniae (ZOI: 23 mm, MIC: 12.5 μg/mL), in comparison to reference drugs – griseofulvin (ZOI: 20 mm, MIC: 6 μg/mL) and ciprofloxacin (ZOI: 25 mm, MIC: 6 μg/mL/ZOI: 20 mm, MIC: 12.5 μg/mL). Also, n...
Australian Journal of Basic and Applied Sciences
Present investigation describes the synthesis of a novel series of 3,4,5-trisubstitutedphenoxy ac... more Present investigation describes the synthesis of a novel series of 3,4,5-trisubstitutedphenoxy acetyl amino acids and peptides by coupling the 2-(4-chloro-3,5-dimethylphenoxy)acetic acid with different amino acid methyl ester hydrochlorides/peptide methyl esters using dicyclohexylcarbodiimide (DCC) as the coupling agent and N-methylmorpholine (NMM) as the base. The structures of peptide derivatives were elucidated by elemental analysis as well as FTIR, H NMR, C NMR and mass 11 3 spectral data. The newly synthesized compounds were also evaluated for their antibacterial, antifungal and anthelmintic potential. Compounds 6, 10 and 12 were found to possess potent anthelmintic activity against M. konkanensis, P. corethruses and Eudrilus sp. and compound 13 displayed better activity against pathogenic fungus C. albicans, in addition to potent antibacterial activity exhibited by compounds 8 and 10 against gram negative bacteria P. aeruginosa.
Advanced Techniques of Analytical Chemistry: Volume 1, 2022
Asian Journal of Chemistry, 2013
The sulfonamides belong to class of compounds that comprise at least five different classes of ph... more The sulfonamides belong to class of compounds that comprise at least five different classes of pharmacologically active agents 1. The basic sulfonamide group-SO2NH-occurs in various biological dynamic compounds including antimicrobial drugs, antithyroid agents, antitumor, antibiotics and inhibitors of carbonic anhydrase 2. Sulfonamides are widely used to treat microbial infections by inhibiting the growth of gram negative and gram positive bacteria, some protozoa and fungi 3. Clinically sulfonamides are used to treat several urinary tract infections and gastrointestinal infections 4. Sulfonamides that are aromatic or hetroaromatic are responsible for the inhibition of the growth of tumor cells. They act as antitumor agents by inhibiting the carbonic anhydrase. Sulfonamides are structurally similar to p-aminobenzoic acid (PABA) which is a cofactor that is needed by the bacteria for the synthesis of folic acid. Sulfonamides antibiotics inhibit the conversion of p-aminobenzoic acid into folic acid and thus ultimately inhibit the synthesis of purine
Marigolds were well known and valued by ancient people in South Asia. The bright orange and red c... more Marigolds were well known and valued by ancient people in South Asia. The bright orange and red colours of marigolds are seen everywhere in daily life of the Indian sub-continent. They are mainly decorative plants and the flowers are used in all kinds of ceremonies including weddings. Marigold has been occasionally used in South Asian medicine. Marigold leaves and flowers in particular have been used for various disorders. Marigold species are being investigated for their potential benefits to health. Now a days, they are being used for treatment of various diseases.
Zenodo (CERN European Organization for Nuclear Research), 2014
The traditional systems of medicine together with folklore medicine continue to play a significan... more The traditional systems of medicine together with folklore medicine continue to play a significant role in our health care system for the betterment of mankind. Sambucus nigra.Linn, frequently known as ‘Sweet elder’ belongs to family Caprifoliaceae. Sambucus species are being investigated for their potential benefits to health. It is one of the most attractive tree has been put to some useful purpose in Ayurveda, Homeopathic medicine and has become a cynosure of modern medicine. The plant is highly used traditionally in curing diverse disorders. Commonly it is used as astringent, antiviral and diuretic. Thus it holds a significant place because of its medicinal and other miscellaneous uses of economic values. This review particularly deals with the phytoconstituents, homeopathic importance of Sambucus nigra.Linn.
Zenodo (CERN European Organization for Nuclear Research), 2008
A novel series of 2-(4-bromo-2-formyl-phenoxy)acetyl amino acid and peptide analogs was synthesiz... more A novel series of 2-(4-bromo-2-formyl-phenoxy)acetyl amino acid and peptide analogs was synthesized by the coupling of 2-(4-bromo-2-formyl•phenoxy)acetic acid with different amino acid methyl ester hydrochlorides, dipeptide and tripeptide methyl esters using dicyclohexylcarbodiimide as the coupling agent and N-methylmorpholine as the base. Structures of all the newly synthesized compounds were elucidated on basis of IR, NMR and MS spectral data as well as elemental analysis. On pharmacological screening, some peptide derivatives were found to exhibit potent bioactivity against gram-negative bacterium Pseudomonas aeruginosa, pathogenic fungus Candida albicans and earthworms Megascoplex konkanensis, Pontoscotex corethruses and Eudrilus sp. Dermatophytes were found to be moderately sensitive towards the newly synthesized analogs. Hydrolyzed peptide derivatives displayed better antimicrobial activity in comparison to corresponding esters.
A series of 5-Bromo- 2-formyl phenoxyacetyl amino acids and peptides have been synthesized by cou... more A series of 5-Bromo- 2-formyl phenoxyacetyl amino acids and peptides have been synthesized by coupling of the 5-Bromo- 2-formyl phenoxyacetic acid with amino acid/methyl esters/dipeptides/ tripeptides using DCC as coupling agent and NMM as base. The structures were elucidated FTIR and 1 HNMR .The newly synthesized compounds were evaluated for their antibacterial, antifungal and anthelminitic activities. The compounds (2, 6, 11 and 13) were found to exihibit potent antibacterial activity against Bacillus subtilis, Staphylococcus aureus (gram positive bacteria) and Escherichia coli (gram negative) bacterias.The compounds (5, 6 and 13) were found to exihibit potent antifungal activity against Candida albicans and Aspergillus niger. The moderate to good anthelminitic activity was shown by the synthesized compounds (7 and 13) against Eudrilus spieces.
INTRODUCTON Peptides are generally considered to be poor drug candidates because of their low ora... more INTRODUCTON Peptides are generally considered to be poor drug candidates because of their low oral bioavailabilit y and propensity to be rapidly metabolized. The concept t ha a drug can be not orally available has become more and more accepted and as a consequence, some pharmaceutical companies have contribu ted in recent years to a revival of interest in peptides as poten tial drug candidates . New synthetic strategies to improve productivity and reduce metabolism of peptides, alo ng with alternative routes of administration, have bee n developed in recent years , and a large number of peptide-based drugs are now being marketed. ABSTRACT The decreasing number of approved drugs produced by the pharmaceutical industry, which has been accompanied by increasing expenses for R and D, dem ands alternative approaches to increase pharmaceuti cal R and D productivity. This situation has contribute d to a revival of interest in peptides as potential drug candidates. New synthetic strategies ...
INTRODUCTION In various indigenous and traditional sources of medicine plants have been extensive... more INTRODUCTION In various indigenous and traditional sources of medicine plants have been extensively used for treatments. Various parts of plants such as the leaves, fruits, the barks, roots and even the seeds ar being used for preparation of medicine. Sitaphal (Sugar-apple) is the fruit of Annona squamosa , Family: Annonaceae, and also cultivated for its edible fruit. It is originated in lowland Central America, where it is indigenous. It is also grown species of Annona and a native of known as custard apple (mainly Annona reticulata) in the Philippines. The genus name, ‘Annona’ is from the Latin word ‘anon’, which means ‘yearly produce’. The fruit is round to conical, 5–10 cm (2.0–3.9 in) in diameter ABSTRACT Sitaphal frequently known as Annona Squamosa belongs to family Annonaceae. The plant is highly used traditionally in curing diverse disorders. Sitaphal is a multipurpose tree with edible fruits. Commonl y it is used as cough and cold and sneezing nose, antibacterial, and anti-...
Marine organisms are important sources of bioactive molecules that have been used to treat variou... more Marine organisms are important sources of bioactive molecules that have been used to treat various diseases. Unusual marine environments are associated with chemical diversity, leading to a resource of novel active substances for the development of bioactive products. Recently, marine-derived bioactive peptides have attracted attention owing to their numerous beneficial effects. Moreover, several studies have reported that marine peptides exhibit various activities, such as antimicrobial, antifungal, antidiabetic, antitumor, antimalarial, antiprotozoal, antituberculosis, and antiviral activities. In the last several decades, studies of marine plants, animals, and microbes have revealed tremendous number of structurally diverse and bioactive secondary metabolites. In this review, we will present the structures and activities of peptides isolated from marine sources (sponges, algae, bacteria, fungi and fish).
International Journal of Advance Research, Ideas and Innovations in Technology, 2016
A popular example of opportunistic routing is the "delay tolerant" forwarding to vanet network wh... more A popular example of opportunistic routing is the "delay tolerant" forwarding to vanet network when a direct path to destination does not exist. The evaluation of this work is twofold. We implemented two prototypes on off-the-shelf hardware to show the technical feasibility of our opportunistic network concepts. Also, the prototypes were used to carry out a number of runtime measurements. Then, we developed a novel two-step simulation method for opportunistic data dissemination. The simulation combines real world user traces with artificial user mobility models, in order to model user movements more realistically. We investigate our opportunistic data dissemination process under various settings, including different communication ranges and user behavior pattern in this use Conventional routing in this case would just "drop" the packet. With opportunistic routing, a node acts upon the available information, in this thesis optimize the routing by centrality information then refine by ant colony met heuristics. In this method validate our approach on different parameter like overhead, throughput.
American Journal of Phytomedicine and Clinical Therapeutics, 2013
Marigolds were well known and valued by ancient people in South Asia. The bright orange and red c... more Marigolds were well known and valued by ancient people in South Asia. The bright orange and red colours of marigolds are seen everywhere in daily life of the Indian sub-continent. They are mainly decorative plants and the flowers are used in all kinds of ceremonies including weddings. Marigold has been occasionally used in South Asian medicine. Marigold leaves and flowers in particular have been used for various disorders. Marigold species are being investigated for their potential benefits to health. Now a days, they are being used for treatment of various diseases.
Iranian Journal of Pharmaceutical Research : IJPR, 2020
Synthesis of a natural proline-rich cyclopolypeptide - rolloamide A was carried out by coupling o... more Synthesis of a natural proline-rich cyclopolypeptide - rolloamide A was carried out by coupling of tri- and tetrapeptide units Boc-Phe-Pro-Val-OMe and Boc-Pro-Leu-Pro-Ile-OMe after proper deprotection at carboxyl and amino terminals using carbodiimide chemistry in alkaline environment followed by cyclization of linear heptapeptide segment in the presence of base. The structure of synthesized peptide was confirmed by spectral techniques including FTIR, 1H NMR, 13C NMR, MS analyses. Newly synthesized peptide was subjected to biological screening against pathogenic microbes and earthworms. Cyclopeptide 8 possessed promising activity against pathogenic fungi Candida albicans (ZOI: 24 mm, MIC: 6 μg/mL) and Gram-negative bacteria Pseudomonas aeruginosa (ZOI: 27 mm, MIC: 6 μg/mL) and Klebsiella pneumoniae (ZOI: 23 mm, MIC: 12.5 μg/mL), in comparison to reference drugs – griseofulvin (ZOI: 20 mm, MIC: 6 μg/mL) and ciprofloxacin (ZOI: 25 mm, MIC: 6 μg/mL/ZOI: 20 mm, MIC: 12.5 μg/mL). Also, n...
Australian Journal of Basic and Applied Sciences
Present investigation describes the synthesis of a novel series of 3,4,5-trisubstitutedphenoxy ac... more Present investigation describes the synthesis of a novel series of 3,4,5-trisubstitutedphenoxy acetyl amino acids and peptides by coupling the 2-(4-chloro-3,5-dimethylphenoxy)acetic acid with different amino acid methyl ester hydrochlorides/peptide methyl esters using dicyclohexylcarbodiimide (DCC) as the coupling agent and N-methylmorpholine (NMM) as the base. The structures of peptide derivatives were elucidated by elemental analysis as well as FTIR, H NMR, C NMR and mass 11 3 spectral data. The newly synthesized compounds were also evaluated for their antibacterial, antifungal and anthelmintic potential. Compounds 6, 10 and 12 were found to possess potent anthelmintic activity against M. konkanensis, P. corethruses and Eudrilus sp. and compound 13 displayed better activity against pathogenic fungus C. albicans, in addition to potent antibacterial activity exhibited by compounds 8 and 10 against gram negative bacteria P. aeruginosa.
Advanced Techniques of Analytical Chemistry: Volume 1, 2022
Asian Journal of Chemistry, 2013
The sulfonamides belong to class of compounds that comprise at least five different classes of ph... more The sulfonamides belong to class of compounds that comprise at least five different classes of pharmacologically active agents 1. The basic sulfonamide group-SO2NH-occurs in various biological dynamic compounds including antimicrobial drugs, antithyroid agents, antitumor, antibiotics and inhibitors of carbonic anhydrase 2. Sulfonamides are widely used to treat microbial infections by inhibiting the growth of gram negative and gram positive bacteria, some protozoa and fungi 3. Clinically sulfonamides are used to treat several urinary tract infections and gastrointestinal infections 4. Sulfonamides that are aromatic or hetroaromatic are responsible for the inhibition of the growth of tumor cells. They act as antitumor agents by inhibiting the carbonic anhydrase. Sulfonamides are structurally similar to p-aminobenzoic acid (PABA) which is a cofactor that is needed by the bacteria for the synthesis of folic acid. Sulfonamides antibiotics inhibit the conversion of p-aminobenzoic acid into folic acid and thus ultimately inhibit the synthesis of purine
Marigolds were well known and valued by ancient people in South Asia. The bright orange and red c... more Marigolds were well known and valued by ancient people in South Asia. The bright orange and red colours of marigolds are seen everywhere in daily life of the Indian sub-continent. They are mainly decorative plants and the flowers are used in all kinds of ceremonies including weddings. Marigold has been occasionally used in South Asian medicine. Marigold leaves and flowers in particular have been used for various disorders. Marigold species are being investigated for their potential benefits to health. Now a days, they are being used for treatment of various diseases.