Dr.Satendra Kumar Dubey - Academia.edu (original) (raw)
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Papers by Dr.Satendra Kumar Dubey
International Journal of Pharmacy and Pharmaceutical Sciences, Mar 30, 2016
Objective: The objective of this study was to assess the prevalence of the components of psycholo... more Objective: The objective of this study was to assess the prevalence of the components of psychological stresses like depression, anxiety as a measure of the perception of the stress response (SR) and its influences on physiological functions in healthy human volunteers under various occupational stresses by using depression anxiety stress scale-21 (DASS-21). Methods: A total of 128 healthy subjects from various sites of Ooty were enrolled in this study, according to the inclusion-exclusion criteria in the study protocol. DASS-21 was administered to the subjects, by 'Questerview' method. The intensity of psychological stresses of depression, anxiety and other mental stress was measured. Results: The incidence of depression, anxiety and their components such as hopelessness, dysphoria, anhedonia, low self-esteem, autonomic arousal, musculoskeletal symptoms, etc. were found high in both men and women participants. In men blood pressures were 136.16±6.6; 84.34±6.4 and in women 130.5±3.9; 86.48±3.4 as systolic, diastolic respectively. The body temperatures and heart rate were not altered, but the respiratory rate was found significantly elevated. The abdominal breathing was 45.21% in men and 52.77% in women indicated poor adaptation response towards the perception of stress. Conclusion: The results are concluding high prevalence of moderate to high-level depression and anxiety indicated stress response triggers a cascade producing a series of changes in human vital physiological functions such as blood pressure, respiratory rate, heart rate were significantly higher. We suggest future researchers are potential for the cumulative health benefits of patients in secondary or tertiary level treatment.
Indian Journal of Pharmaceutical and Biological Research, 2014
Novel approaches to drug delivery and formulation using nanotechnology are revolutionizing the fu... more Novel approaches to drug delivery and formulation using nanotechnology are revolutionizing the future of medicine. The application of nanotechnology in medicine is offering many exciting possibilities in healthcare. Engineered nanoparticles and conjugation of monoclonal antibodies with anticancer drug Docetaxel have the potential to revolutionize the diagnosis and the therapy of its diseases, particularly by targeted delivery of anticancer drugs and imaging contrast agents. Prostate cancer, the second most common cancer in men, represents one of the major epidemiological problems, especially for patients in the advanced age. There is a substantial interest in developing therapeutic options for treatment of prostate cancer based on use of nanocarriers with the conjugation of drug and antibody, to overcome the lack of specificity of conventional chemotherapeutic agents as well as for the early detection of precancerous and malignant lesions. In this article, we highlight on the recent...
International Journal of Pharmacy and Pharmaceutical Sciences, Mar 30, 2016
Objective: The objective of this study was to assess the prevalence of the components of psycholo... more Objective: The objective of this study was to assess the prevalence of the components of psychological stresses like depression, anxiety as a measure of the perception of the stress response (SR) and its influences on physiological functions in healthy human volunteers under various occupational stresses by using depression anxiety stress scale-21 (DASS-21). Methods: A total of 128 healthy subjects from various sites of Ooty were enrolled in this study, according to the inclusion-exclusion criteria in the study protocol. DASS-21 was administered to the subjects, by 'Questerview' method. The intensity of psychological stresses of depression, anxiety and other mental stress was measured. Results: The incidence of depression, anxiety and their components such as hopelessness, dysphoria, anhedonia, low self-esteem, autonomic arousal, musculoskeletal symptoms, etc. were found high in both men and women participants. In men blood pressures were 136.16±6.6; 84.34±6.4 and in women 130.5±3.9; 86.48±3.4 as systolic, diastolic respectively. The body temperatures and heart rate were not altered, but the respiratory rate was found significantly elevated. The abdominal breathing was 45.21% in men and 52.77% in women indicated poor adaptation response towards the perception of stress. Conclusion: The results are concluding high prevalence of moderate to high-level depression and anxiety indicated stress response triggers a cascade producing a series of changes in human vital physiological functions such as blood pressure, respiratory rate, heart rate were significantly higher. We suggest future researchers are potential for the cumulative health benefits of patients in secondary or tertiary level treatment.
Indian Journal of Pharmaceutical and Biological Research, 2014
Novel approaches to drug delivery and formulation using nanotechnology are revolutionizing the fu... more Novel approaches to drug delivery and formulation using nanotechnology are revolutionizing the future of medicine. The application of nanotechnology in medicine is offering many exciting possibilities in healthcare. Engineered nanoparticles and conjugation of monoclonal antibodies with anticancer drug Docetaxel have the potential to revolutionize the diagnosis and the therapy of its diseases, particularly by targeted delivery of anticancer drugs and imaging contrast agents. Prostate cancer, the second most common cancer in men, represents one of the major epidemiological problems, especially for patients in the advanced age. There is a substantial interest in developing therapeutic options for treatment of prostate cancer based on use of nanocarriers with the conjugation of drug and antibody, to overcome the lack of specificity of conventional chemotherapeutic agents as well as for the early detection of precancerous and malignant lesions. In this article, we highlight on the recent...