Dr. Seema Pant - Academia.edu (original) (raw)
Papers by Dr. Seema Pant
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry, Dec 1, 1997
Zenodo (CERN European Organization for Nuclear Research), Jul 31, 1991
ChemInform, Aug 19, 2010
ABSTRACT
![Research paper thumbnail of ChemInform Abstract: Syntheses of 1,5-Benzothiazepines. Part 33. Syntheses and Antimicrobial Studies of 10-Substituted-6-(4-methoxyphenyl)-6H-6a,7-dihydro-7- (4-methoxyphenyl/3,4-dimethoxyphenyl)[1]benzopyrano[3,4-c] [1,5]benzothiazepines](https://attachments.academia-assets.com/107265254/thumbnails/1.jpg)
](ChemInform, Jan 8, 2008
Two flavindogenides, 2-(4-methoxyphenyl)-3-(4-methoxybenzylidene)-flavanone, 8a and 2-(4-methoxyp... more Two flavindogenides, 2-(4-methoxyphenyl)-3-(4-methoxybenzylidene)-flavanone, 8a and 2-(4-methoxyphenyl)-3-(3,4-dimethoxybenzylidene)-flavanone 8b, are reacted with 5-substituted-2-aminobenzenethiols 3a-f (the substituents being halogens, fluoro, chloro or bromo, methyl and alkoxyls, methoxyl or ethoxyl), to give respective 12 new compounds, 10-substituted-6-(4-methoxyphenyl)-6H-6a, 7-dihydro-7-(4-methoxyphenyl/3,4-dimethoxyphenyl)[1]benzopyrano[3,4-c]-[1,5]benzothiazepines 10a-l in 55-67% yields. The products are characterized on the basis of analytical and spectral data. The synthesized compounds are screened for antimicrobial activity against the bacteria Staphylococcus aureus, Pseudomonas aeruginosa, and the fungus Candida albicans. All the methoxy-substituted benzopyranobenzothiazepines have showed moderate to comparable activity (using gatifloxin, natilmicin as reference standard) against the gram-positive bacteria S. aureus and the gram-negative bacteria P. aeruginosa. They have also showed significant antifungal activity (compared to fluconazole) against C. albicans, the maximum activity being that of the compound 10k having maximum methoxyl groups, while the fluoro compounds 10a and 10g are completely inactive.
ChemInform, Aug 12, 2010
ABSTRACT
ChemInform, Aug 18, 2010
ABSTRACT
ChemInform, Aug 18, 2010
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform, Aug 4, 2010
ABSTRACT
ChemInform, Jun 22, 2010
ABSTRACT
Phosphorus Sulfur and Silicon and The Related Elements, Jul 1, 1997
Syntheses of fluorinated 8-ethoxy/fluoro-2-carboxy-4-substituted ary-2,3-dihydro1,5-benzothiazepi... more Syntheses of fluorinated 8-ethoxy/fluoro-2-carboxy-4-substituted ary-2,3-dihydro1,5-benzothiazepines having substitutents as chloro, methyl and trifluoromethyl have been achieved by the reaction of 5-ethoxy/-fluoro-2-aminobenzenethiols with fluorinated 3-substituted benzoyl-2-propenoic acids in toluene with catalytic amount of trifluoroacetic acid. The progress of the reactions was monitored by t.1.c. studies. Structures of the title compounds are established by IR, PMR and mass spectral studies and microestimation data of nitrogen.
CERN European Organization for Nuclear Research - Zenodo, Jun 30, 1992
India Abroad, Oct 10, 2003
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry, 1993
India National Science Academy, 1997
<em>Department of Chemistry, University of Rajasthan, Jaipur-302 004<br> Manuscript r... more <em>Department of Chemistry, University of Rajasthan, Jaipur-302 004<br> Manuscript received 17 July 1991, revised 28 July 1993, accepted 3 August 1993</em> Syntheses of 1,5-Benzothiazepines. Part-IX. Syntheses of<br> 8-Substituted-4-(<em>p</em>-methoxyanilino)-2-methyl-1,5-<br> benzothiazepines
![Research paper thumbnail of Syntheses of 1,5-benzothiazepines. Part XL : Syntheses and antimicrobial studies of 10-substituted-6α, 7 -dihydro-6-( 4-methoxyphenyl/phenyl)-7 -(3-nitrophenyl)-6H- [1]benzopyrano[3,4-c][1,5]benzothiazepines](https://attachments.academia-assets.com/88462711/thumbnails/1.jpg)
](Department of Chemistry, LBS Government PG College, Kotputli-303 108, Jaipur, Rajasthan, India &l... more Department of Chemistry, LBS Government PG College, Kotputli-303 108, Jaipur, Rajasthan, India <em>E-mail </em>: drseemapant@yahoo.coro <em>Manuscript received 24 May 2011, revised 16 July 2012, accepted 03 October 2012</em> The reactions or exocyclic α,β-unsaturated ketones, the benzylidene flavanones, 3-(3-nitrobenzylidene)-4<em>'</em>- methoxyflavanone and 3-(3-nitrobenzylidene)flavanone, with 5-substituted-2-aminobenzenethiols, the substituents being halogeno, alkyl and alkoxyl, have been carried out in dry ethanol with catalytic amounts or trirtuoroacetic acid. The twelve new compounds, 10-substituted-6α,7-dihydro-6-( 4-methoxyphenyl/ phenyl)-7 -(3-nitrophenyl)-6<em>H-</em>[1] benzopyrano[3,4-<em> c</em>][1,5]benzothiazepines, were synthesized and characterized by microestimations for C, H, N and S and IR, NMR and mass spectral studies. The synthesized compounds were screened for antimicrobial activity against the ...
Department of Chemistry, L. B. S. Govt. P. G. College, Kotputli, J aipur, Rajasthan, India Depart... more Department of Chemistry, L. B. S. Govt. P. G. College, Kotputli, J aipur, Rajasthan, India Department of Chemistry, University of Rajasthan, Jaipur-302 004, Rajasthan, India E-mail : drumeshpant@yahoo.com Department of Microbiology, S. M. S. Medical College, Jaipur, Rajasthan, India Manuscript received 27 December 2006, revised 19 September 2007, accepted 17 December 2007 Reactions of the 5-substituted-2-aminobenzenethiols 4a-f with the α,β-unsaturated heterocyclic ketones 3a,b were carried out in dry ethanol saturated with dry <strong>HCI</strong> gas. The products 5a-l were characterized by microestimations for <strong>C, H, N, S</strong> and <strong>IR</strong>, <strong><sup>1</sup>H NMR,</strong> <strong><sup>13</sup>C</strong>, <strong>NMR, <sup>19</sup>F NMR</strong> and mass spectral studies. The synthesized compounds were screened for antimicrobial activity against the...
Department of Chemistry, L. B. S. Government P.G. College, Kotputli-303 108, Jaipur, Rajasthan, I... more Department of Chemistry, L. B. S. Government P.G. College, Kotputli-303 108, Jaipur, Rajasthan, India E-mail : drseemapant@yahoo.com Manuscript received 20 September 2013, revised 09 October 2014, accepted 05 January 2015 The syntheses of novel twelve 8-substituted-2,5-dihydro-2-(furan-2-yl)-4-(2-hydroxyphenyl/4-methylphenyl)-1,5- benzothiazepines have been carried out by the reactions of 5-substituted-2-aminobenzenethiols, the substituents being fluoro, chloro, bromo, methyl, methoxy or ethoxy, with the enolisable heterocyclic ketones, 3-(furan-2-yl)-1-(2- hydroxyphenyl/4-methylphenyl)-2-propenone in dry ethanol saturated with dry HCl; and characterized by analytical and spectral data comprising <strong>IR, <sup>1</sup>H NMR</strong> and mass spectral studies. On being screened for antimicrobial activity against the Gram-positive bacteria, <em>Staphylococcus aureus</em> and Gram-negative bacteria <em>Enterobacter cloacae</em>, <em&...
Diltiazem, the cardiovascular drug belonging to the 1,5-benzothiazepine series of compounds, is u... more Diltiazem, the cardiovascular drug belonging to the 1,5-benzothiazepine series of compounds, is useful in the treatment of angina pectoris and is useful in coronary vasodilation (Buckley et al, 1990),
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry, Dec 1, 1997
Zenodo (CERN European Organization for Nuclear Research), Jul 31, 1991
ChemInform, Aug 19, 2010
ABSTRACT
ChemInform, Jan 8, 2008
Two flavindogenides, 2-(4-methoxyphenyl)-3-(4-methoxybenzylidene)-flavanone, 8a and 2-(4-methoxyp... more Two flavindogenides, 2-(4-methoxyphenyl)-3-(4-methoxybenzylidene)-flavanone, 8a and 2-(4-methoxyphenyl)-3-(3,4-dimethoxybenzylidene)-flavanone 8b, are reacted with 5-substituted-2-aminobenzenethiols 3a-f (the substituents being halogens, fluoro, chloro or bromo, methyl and alkoxyls, methoxyl or ethoxyl), to give respective 12 new compounds, 10-substituted-6-(4-methoxyphenyl)-6H-6a, 7-dihydro-7-(4-methoxyphenyl/3,4-dimethoxyphenyl)[1]benzopyrano[3,4-c]-[1,5]benzothiazepines 10a-l in 55-67% yields. The products are characterized on the basis of analytical and spectral data. The synthesized compounds are screened for antimicrobial activity against the bacteria Staphylococcus aureus, Pseudomonas aeruginosa, and the fungus Candida albicans. All the methoxy-substituted benzopyranobenzothiazepines have showed moderate to comparable activity (using gatifloxin, natilmicin as reference standard) against the gram-positive bacteria S. aureus and the gram-negative bacteria P. aeruginosa. They have also showed significant antifungal activity (compared to fluconazole) against C. albicans, the maximum activity being that of the compound 10k having maximum methoxyl groups, while the fluoro compounds 10a and 10g are completely inactive.
ChemInform, Aug 12, 2010
ABSTRACT
ChemInform, Aug 18, 2010
ABSTRACT
ChemInform, Aug 18, 2010
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform, Aug 4, 2010
ABSTRACT
ChemInform, Jun 22, 2010
ABSTRACT
Phosphorus Sulfur and Silicon and The Related Elements, Jul 1, 1997
Syntheses of fluorinated 8-ethoxy/fluoro-2-carboxy-4-substituted ary-2,3-dihydro1,5-benzothiazepi... more Syntheses of fluorinated 8-ethoxy/fluoro-2-carboxy-4-substituted ary-2,3-dihydro1,5-benzothiazepines having substitutents as chloro, methyl and trifluoromethyl have been achieved by the reaction of 5-ethoxy/-fluoro-2-aminobenzenethiols with fluorinated 3-substituted benzoyl-2-propenoic acids in toluene with catalytic amount of trifluoroacetic acid. The progress of the reactions was monitored by t.1.c. studies. Structures of the title compounds are established by IR, PMR and mass spectral studies and microestimation data of nitrogen.
CERN European Organization for Nuclear Research - Zenodo, Jun 30, 1992
India Abroad, Oct 10, 2003
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry, 1993
India National Science Academy, 1997
<em>Department of Chemistry, University of Rajasthan, Jaipur-302 004<br> Manuscript r... more <em>Department of Chemistry, University of Rajasthan, Jaipur-302 004<br> Manuscript received 17 July 1991, revised 28 July 1993, accepted 3 August 1993</em> Syntheses of 1,5-Benzothiazepines. Part-IX. Syntheses of<br> 8-Substituted-4-(<em>p</em>-methoxyanilino)-2-methyl-1,5-<br> benzothiazepines
Department of Chemistry, LBS Government PG College, Kotputli-303 108, Jaipur, Rajasthan, India &l... more Department of Chemistry, LBS Government PG College, Kotputli-303 108, Jaipur, Rajasthan, India <em>E-mail </em>: drseemapant@yahoo.coro <em>Manuscript received 24 May 2011, revised 16 July 2012, accepted 03 October 2012</em> The reactions or exocyclic α,β-unsaturated ketones, the benzylidene flavanones, 3-(3-nitrobenzylidene)-4<em>'</em>- methoxyflavanone and 3-(3-nitrobenzylidene)flavanone, with 5-substituted-2-aminobenzenethiols, the substituents being halogeno, alkyl and alkoxyl, have been carried out in dry ethanol with catalytic amounts or trirtuoroacetic acid. The twelve new compounds, 10-substituted-6α,7-dihydro-6-( 4-methoxyphenyl/ phenyl)-7 -(3-nitrophenyl)-6<em>H-</em>[1] benzopyrano[3,4-<em> c</em>][1,5]benzothiazepines, were synthesized and characterized by microestimations for C, H, N and S and IR, NMR and mass spectral studies. The synthesized compounds were screened for antimicrobial activity against the ...
Department of Chemistry, L. B. S. Govt. P. G. College, Kotputli, J aipur, Rajasthan, India Depart... more Department of Chemistry, L. B. S. Govt. P. G. College, Kotputli, J aipur, Rajasthan, India Department of Chemistry, University of Rajasthan, Jaipur-302 004, Rajasthan, India E-mail : drumeshpant@yahoo.com Department of Microbiology, S. M. S. Medical College, Jaipur, Rajasthan, India Manuscript received 27 December 2006, revised 19 September 2007, accepted 17 December 2007 Reactions of the 5-substituted-2-aminobenzenethiols 4a-f with the α,β-unsaturated heterocyclic ketones 3a,b were carried out in dry ethanol saturated with dry <strong>HCI</strong> gas. The products 5a-l were characterized by microestimations for <strong>C, H, N, S</strong> and <strong>IR</strong>, <strong><sup>1</sup>H NMR,</strong> <strong><sup>13</sup>C</strong>, <strong>NMR, <sup>19</sup>F NMR</strong> and mass spectral studies. The synthesized compounds were screened for antimicrobial activity against the...
Department of Chemistry, L. B. S. Government P.G. College, Kotputli-303 108, Jaipur, Rajasthan, I... more Department of Chemistry, L. B. S. Government P.G. College, Kotputli-303 108, Jaipur, Rajasthan, India E-mail : drseemapant@yahoo.com Manuscript received 20 September 2013, revised 09 October 2014, accepted 05 January 2015 The syntheses of novel twelve 8-substituted-2,5-dihydro-2-(furan-2-yl)-4-(2-hydroxyphenyl/4-methylphenyl)-1,5- benzothiazepines have been carried out by the reactions of 5-substituted-2-aminobenzenethiols, the substituents being fluoro, chloro, bromo, methyl, methoxy or ethoxy, with the enolisable heterocyclic ketones, 3-(furan-2-yl)-1-(2- hydroxyphenyl/4-methylphenyl)-2-propenone in dry ethanol saturated with dry HCl; and characterized by analytical and spectral data comprising <strong>IR, <sup>1</sup>H NMR</strong> and mass spectral studies. On being screened for antimicrobial activity against the Gram-positive bacteria, <em>Staphylococcus aureus</em> and Gram-negative bacteria <em>Enterobacter cloacae</em>, <em&...
Diltiazem, the cardiovascular drug belonging to the 1,5-benzothiazepine series of compounds, is u... more Diltiazem, the cardiovascular drug belonging to the 1,5-benzothiazepine series of compounds, is useful in the treatment of angina pectoris and is useful in coronary vasodilation (Buckley et al, 1990),