Dr. Tamseela Mumtaz - Academia.edu (original) (raw)

Papers by Dr. Tamseela Mumtaz

Journal of zoo biology, Dec 30, 2023

One of the significant aphid-eating predators that are natural is the ladybird beetle Coccinella ... more One of the significant aphid-eating predators that are natural is the ladybird beetle Coccinella septempunctata. C. septempunctata is a biological control agent and effective in integrated pest management strategies (IPM). In the development of IPM, chemical insecticides are routinely utilized, to boost crop protection and support the activity of biological control agents. Research on the relative toxicity of multiple insecticides on seven spotted ladybird beetle C. septempunctata L. instars was conducted in a lab environment to gauge the C. septempunctata's reaction to powerful insecticides. Six insecticides were treated as Spinetoram 120SC (0.4%/0.5L), Steward 150EC (0.86/0.5L), Coragen 200ml (0.4%/0.5L), Siphtoram 120SE (0.8/0.5L), Chlorfenapyr 36% (1.25/0.5L), and Lufenuron 50% (1.0/0.5L) to the 1 st , 2 nd , 3 rd , and 4 th instars of C. septempunctata. After 4, 12, 24, 48, and 72 hours of the treatment, the results of the proportional death were determined. Ongoing investigation was done at 60±5% RH and 25+2 o C. When administered on adult ladybird beetles, Lufenuron was detrimental in 99.4 % cases, Chlorfenapyr in 88.4% Steward in 85.5% of cases, Coragen in 83.2%, and Siphtoram in 77.6%, Spinetoram was very little hazardous substance based on the death rate, followed by, Coragen, Steward, Chlorfenapyr, and Lufenuron.

Journal of zoo biology, Jun 2, 2024

Pakistan Journal of Health Sciences

Preeclampsia is one of the most common, life-threatening complications of pregnancy that is relat... more Preeclampsia is one of the most common, life-threatening complications of pregnancy that is related to maternal as well as perinatal morbidity or mortality. One of the significant causes of preeclampsia is elevated blood pressure which is directly linked with concentrations of electrolytes in the blood. Objective: To evaluate the possible variations of electrolytes in preeclamptic pregnant females. Methods: A total of 90 pregnant females of 20 to 45 years of age were divided into three groups (n=30 in each group) viz normotensive, hypertensive, and preeclamptic pregnant females. All anthropometric and biophysical variables were measured. Among biochemical parameters, serum sodium, potassium, chloride, and calcium levels were determined using colorimetric assays while bicarbonate levels were determined by an enzymatic test using phosphoenolpyruvate carboxylase and a stable nicotinamide dihydrogen phosphate analogue. A comparison of serum electrolytes among different groups was execut...

PLOS ONE

The constant use of disease modifying anti rheumatic drugs affects the functioning of multiple or... more The constant use of disease modifying anti rheumatic drugs affects the functioning of multiple organs inside the body. Some drugs are more toxic than others. The present case control investigation was designed to evaluate the comparative toxicity of methotrexate and leflunomide on multiple organs in rheumatoid arthritis patients. For this purpose, 100 subjects with confirmed rheumatoid arthritis condition were recruited form tertiary care center. Whereas 50 age matched controls were recruited from the local healthy population. Participants of the study were categorized into three groups with equal numbers of subjects in each group (n = 50). Group 1 comprised rheumatoid arthritis patients on methotrexate treatment, group 2 included rheumatoid arthritis patients on leflunomide treatment and group 3 were healthy subjects. Cardiac and respiratory response was evaluated by monitoring blood pressure, pulse and breathing rate and spot oxygen saturation. Stress on liver was estimated by mea...

International Journal of Food Properties, 2023

Apigenin (4,’5,7-trihydroxyflavone) is one of the most studied flavonoids with low toxicity and a... more Apigenin (4,’5,7-trihydroxyflavone) is one of the most studied flavonoids with low toxicity and abundantly present phenolic compound in the plant king-dom. The main sources of apigenin are fruits, vegetables, nuts, herbs, honey, and plant-based drinks like tea. Numerous plants produce apigenin as a secondary metabolite and its intake is strongly related to its anti- inflammatory propensities. The purpose of present review was to wade through the literature on the anti-inflammatory mechanisms of this metabo-lite in various diseases and summarize the key objectives as they appear. Existing literature reported that apigenin is a promising candidate in mana-ging a panoply of inflammatory-related diseases including cancer, diabetes, obesity, depression, insomnia, infection, and respiratory, cardiovascular, hepatoprotective, neurodegenerative, and skin diseases. Studies showed that apigenin significantly decreases the secretion of various proinflamma-tory cytokines specifically tumor necrosis factor (TNF)-α, IL-1β, IL-6, and IL-10. Moreover, apigenin effectively blocks the nitric oxide-mediated cyclooxygen-ase-2 expression and monocyte attachment and Prostaglandin by lowering iNOS and COX-2 in both microglial and macrophage mouse cells. Apigenin can slow the course of nonalcoholic fatty liver disease (NAFLD) in vivo by reducing high fat diet (HFD)-induced deposition of lipids and oxidative stress. It also controlled redox imbalances, suppress neuronal death and showed memory enhancement/learning skills and a reduction of fibrillar amyloid deposits with lowered insoluble Aβ concentrations in vivo. Taken together, it can be argued that apigenin can wane inflammation and thus offers a promising future in slowing down the development of chronic diseases and associated complications.

Pakistan Journal of Health Sciences

Indolent and aggressive hematopoietic cancer shed lot of Beta 2 microglobulin in interstitial flu... more Indolent and aggressive hematopoietic cancer shed lot of Beta 2 microglobulin in interstitial fluid thus increasing the level of B2M in hematological malignancies. Objectives: To set forward B2M as potential biomarker for the detection and stage of malignant lymphoma. Methods: Serum of newly diagnosed Hodgkin’s and non-Hodgkin’s lymphoma patients presented to physician prior to any surgical or medicinal treatment were collected and evaluated through sandwich type of ELISA for the possible elevation of B2M. B2M concentrations in healthy individual’s serum (control group) were also detected. Mean values of B2M in all three groups were compared by applying one-way analysis of variance to determine the significant difference. Results: The serum of Hodgkin’s Lymphoma patients depicted 5 folds higher B2M concentration than the healthy subjects, while NHL showed more concentration of circulating B2M where it was 6-fold higher than healthy subjects. Moreover, the advanced stage of the dise...

Pakistan Journal of Health Sciences, Aug 31, 2022

Membranes and Transport Mechanisms Cellular life depends on the movement of membrane ions. For ce... more Membranes and Transport Mechanisms Cellular life depends on the movement of membrane ions. For cells to continue functioning as they go through their life cycle, there must be a tremendous amount of exchange. Cell membranes are active structures rather than merely passive barriers separating cells from their surroundings. Cell membranes are known to be selectively permeable, allowing some chemicals to pass through while preventing others from doing so. Therefore, all cellular exchange activities can have active participation from cell membranes. Through the membrane interface, elements needed for cellular existence, communication among cells, and interaction between cells and their environment are taken in. Additionally, cells have the ability to direct and in uence input and export processes, as well as moderate the subsequent signal response. Effective drug transportation across cellular membranes is essential for all treatment procedures. The majority of medications used in cancer therapy require carrier proteins for their transmembrane transport, even though hydrophobic small molecules can enter the cell membrane through straightforward diffusion. As a result, many scientists concentrate on creating novel strategies to improve drug delivery and uptake into desired cells. A live cell's plasma membrane serves as its outer wall. Although it acts as a barrier, it also permits transport between the cell and its surroundings.

BioMed Research International, 2022

Pakistan Journal of Zoology, 2020

Authors' Contribution RY and TM planned and designed the research. RY performed the experiment an... more Authors' Contribution RY and TM planned and designed the research. RY performed the experiment and wrote the paper. NR provided technical support for the experiment. MAI helped in statistical analysis.

Medical Reports & Case Studies, 2018

Introduction: Women often experienced ragged and unpredicted kind of behavior and hardly recogniz... more Introduction: Women often experienced ragged and unpredicted kind of behavior and hardly recognize their attitude as premenstrual syndrome. Adolescent girls are particularly naïve and unacquainted of the symptoms and if aware, hide due to shyness. Method: In this cross sectional study, a survey was conducted in educational institutes to determine the prevalence of various categories of PMS in young teen agers girls at different stages of their luteal phase. Predominance of PMS was finding out by applying Chi square test and significant incidences of PMS was observed. Result: PMS-A is recognized as a recurring phenomenon with most number of victims. Mild anxiety experienced by 38% respondents and severe mood swings affected more than 22% college going girls. PMS-H vie PMS-A having maximum numbers of females with complain of spartan type of fluid retention. Abdominal bloating and breast tenderness found as customary signs and 70% pubescent girls face these troubles before and during menstruation. Depression crying and fatigue are other major warning cryptograms of PMS. Conclusion: Frequency of premenstrual syndrome must be figure out in adolescent girls and they must educate about its indications, complications and outcomes to ensure the good quality of women health at their reproductive age.

Bangladesh Journal of Scientific and Industrial Research, 2015

Workers of textile industry are exposed to different hazardous chemicals that cause adverse effec... more Workers of textile industry are exposed to different hazardous chemicals that cause adverse effects on their health. As variations in plasma proteins are the best indicators of health status of the subjects, hence, we compared plasma protein fractions, resolved by SDS-PAGE of textile dyeing industry workers (n=30) with control subjects (n=30). Proteins were quantified by Total Lab Quant software and analyzed, statistically, by Student t-test. Thirteen protein fractions were detected ranging 250-17kDa. A significant increase in 132 and 53kDa fractions, whereas, a significant decrement in 87 and 66kDa fractions with a highly significant reduction in 112kDa fraction was observed. However, 250, 224, 43, 23, 19 and 17kDa protein fractions did not vary considerably. As some proteins circulate only during particular physiological or pathological circumstances and may serve as biomarkers of anomalies, the altered expressions of these biomolecules observed in textile dyeing industry workers ...

Pakistan Journal of Zoology, 2012

Delayed diagnosis in lymphoma deteriorates the health eminence resulting in pitiable prognosis an... more Delayed diagnosis in lymphoma deteriorates the health eminence resulting in pitiable prognosis and poor health management. The aim of the study is to estimate the burden and clinical presentation of lymphoma in Pakistan. A total of 334 newly diagnosed cases of lymphoma were registered in the study. Followed by histopathology, WHO classification and Ann Arbor staging was done to assign subtype and extent of disease. It was found that the incidence of non Hodgkin's lymphoma (71%) was greater than Hodgkin's disease (29%) and both present bimodal distribution in age. Male patients dominate female patients in both cases (2.5:1). Lymphadenopathy of cervical region is primary site in 44% of cases while 20% cases were extranodal. Histopathology show 66% mixed cellularity variant in Hodgkin's and 37% diffuse B cell pattern in Non Hodgkin's lymphoma. Ann Arbor staging reveals that 28% cases present with stage I and 38% show stage IV. To conclude, Non Hodgkin's lymphoma is ...

BioMed Research International

Perturbations in the actions of T3 and T4 influence the normal metabolic pathways. Responsiveness... more Perturbations in the actions of T3 and T4 influence the normal metabolic pathways. Responsiveness of lipid biomarkers like LDL-C, HDL-C, TC, TG, Apo-A, and Apo-B after rehabilitation of thyroid profile attaining euthyroid state was determined. A total of 179 age-matched subjects of both genders were recruited for this research. Sixty healthy controls, thirty-four subclinical, fifty overt hyperthyroid, and thirty-five follow-up subjects having 3 months of Carbimazole therapy were enrolled. Biochemical analysis was performed by chemistry analyzer, RIA, and ELISA. One-way ANOVA was applied for the statistical analysis, while significance ( P < 0.05 ) of means was compared by the Student-Newman-Keuls (SNK) test. Pronounced reduction ( P < 0.001 ) of cholesterol in overt as compared to control and subclinical was noticed, whereas marked improvement ( P < 0.001 ) was evidenced in follow-up. Prominent elevation ( P < 0.05 ) of TG in follow-up was evidenced as compared to contro...

Journal of zoo biology, Dec 30, 2023

One of the significant aphid-eating predators that are natural is the ladybird beetle Coccinella ... more One of the significant aphid-eating predators that are natural is the ladybird beetle Coccinella septempunctata. C. septempunctata is a biological control agent and effective in integrated pest management strategies (IPM). In the development of IPM, chemical insecticides are routinely utilized, to boost crop protection and support the activity of biological control agents. Research on the relative toxicity of multiple insecticides on seven spotted ladybird beetle C. septempunctata L. instars was conducted in a lab environment to gauge the C. septempunctata's reaction to powerful insecticides. Six insecticides were treated as Spinetoram 120SC (0.4%/0.5L), Steward 150EC (0.86/0.5L), Coragen 200ml (0.4%/0.5L), Siphtoram 120SE (0.8/0.5L), Chlorfenapyr 36% (1.25/0.5L), and Lufenuron 50% (1.0/0.5L) to the 1 st , 2 nd , 3 rd , and 4 th instars of C. septempunctata. After 4, 12, 24, 48, and 72 hours of the treatment, the results of the proportional death were determined. Ongoing investigation was done at 60±5% RH and 25+2 o C. When administered on adult ladybird beetles, Lufenuron was detrimental in 99.4 % cases, Chlorfenapyr in 88.4% Steward in 85.5% of cases, Coragen in 83.2%, and Siphtoram in 77.6%, Spinetoram was very little hazardous substance based on the death rate, followed by, Coragen, Steward, Chlorfenapyr, and Lufenuron.

Journal of zoo biology, Jun 2, 2024

Pakistan Journal of Health Sciences

Preeclampsia is one of the most common, life-threatening complications of pregnancy that is relat... more Preeclampsia is one of the most common, life-threatening complications of pregnancy that is related to maternal as well as perinatal morbidity or mortality. One of the significant causes of preeclampsia is elevated blood pressure which is directly linked with concentrations of electrolytes in the blood. Objective: To evaluate the possible variations of electrolytes in preeclamptic pregnant females. Methods: A total of 90 pregnant females of 20 to 45 years of age were divided into three groups (n=30 in each group) viz normotensive, hypertensive, and preeclamptic pregnant females. All anthropometric and biophysical variables were measured. Among biochemical parameters, serum sodium, potassium, chloride, and calcium levels were determined using colorimetric assays while bicarbonate levels were determined by an enzymatic test using phosphoenolpyruvate carboxylase and a stable nicotinamide dihydrogen phosphate analogue. A comparison of serum electrolytes among different groups was execut...

PLOS ONE

The constant use of disease modifying anti rheumatic drugs affects the functioning of multiple or... more The constant use of disease modifying anti rheumatic drugs affects the functioning of multiple organs inside the body. Some drugs are more toxic than others. The present case control investigation was designed to evaluate the comparative toxicity of methotrexate and leflunomide on multiple organs in rheumatoid arthritis patients. For this purpose, 100 subjects with confirmed rheumatoid arthritis condition were recruited form tertiary care center. Whereas 50 age matched controls were recruited from the local healthy population. Participants of the study were categorized into three groups with equal numbers of subjects in each group (n = 50). Group 1 comprised rheumatoid arthritis patients on methotrexate treatment, group 2 included rheumatoid arthritis patients on leflunomide treatment and group 3 were healthy subjects. Cardiac and respiratory response was evaluated by monitoring blood pressure, pulse and breathing rate and spot oxygen saturation. Stress on liver was estimated by mea...

International Journal of Food Properties, 2023

Apigenin (4,’5,7-trihydroxyflavone) is one of the most studied flavonoids with low toxicity and a... more Apigenin (4,’5,7-trihydroxyflavone) is one of the most studied flavonoids with low toxicity and abundantly present phenolic compound in the plant king-dom. The main sources of apigenin are fruits, vegetables, nuts, herbs, honey, and plant-based drinks like tea. Numerous plants produce apigenin as a secondary metabolite and its intake is strongly related to its anti- inflammatory propensities. The purpose of present review was to wade through the literature on the anti-inflammatory mechanisms of this metabo-lite in various diseases and summarize the key objectives as they appear. Existing literature reported that apigenin is a promising candidate in mana-ging a panoply of inflammatory-related diseases including cancer, diabetes, obesity, depression, insomnia, infection, and respiratory, cardiovascular, hepatoprotective, neurodegenerative, and skin diseases. Studies showed that apigenin significantly decreases the secretion of various proinflamma-tory cytokines specifically tumor necrosis factor (TNF)-α, IL-1β, IL-6, and IL-10. Moreover, apigenin effectively blocks the nitric oxide-mediated cyclooxygen-ase-2 expression and monocyte attachment and Prostaglandin by lowering iNOS and COX-2 in both microglial and macrophage mouse cells. Apigenin can slow the course of nonalcoholic fatty liver disease (NAFLD) in vivo by reducing high fat diet (HFD)-induced deposition of lipids and oxidative stress. It also controlled redox imbalances, suppress neuronal death and showed memory enhancement/learning skills and a reduction of fibrillar amyloid deposits with lowered insoluble Aβ concentrations in vivo. Taken together, it can be argued that apigenin can wane inflammation and thus offers a promising future in slowing down the development of chronic diseases and associated complications.

Pakistan Journal of Health Sciences

Indolent and aggressive hematopoietic cancer shed lot of Beta 2 microglobulin in interstitial flu... more Indolent and aggressive hematopoietic cancer shed lot of Beta 2 microglobulin in interstitial fluid thus increasing the level of B2M in hematological malignancies. Objectives: To set forward B2M as potential biomarker for the detection and stage of malignant lymphoma. Methods: Serum of newly diagnosed Hodgkin’s and non-Hodgkin’s lymphoma patients presented to physician prior to any surgical or medicinal treatment were collected and evaluated through sandwich type of ELISA for the possible elevation of B2M. B2M concentrations in healthy individual’s serum (control group) were also detected. Mean values of B2M in all three groups were compared by applying one-way analysis of variance to determine the significant difference. Results: The serum of Hodgkin’s Lymphoma patients depicted 5 folds higher B2M concentration than the healthy subjects, while NHL showed more concentration of circulating B2M where it was 6-fold higher than healthy subjects. Moreover, the advanced stage of the dise...

Pakistan Journal of Health Sciences, Aug 31, 2022

Membranes and Transport Mechanisms Cellular life depends on the movement of membrane ions. For ce... more Membranes and Transport Mechanisms Cellular life depends on the movement of membrane ions. For cells to continue functioning as they go through their life cycle, there must be a tremendous amount of exchange. Cell membranes are active structures rather than merely passive barriers separating cells from their surroundings. Cell membranes are known to be selectively permeable, allowing some chemicals to pass through while preventing others from doing so. Therefore, all cellular exchange activities can have active participation from cell membranes. Through the membrane interface, elements needed for cellular existence, communication among cells, and interaction between cells and their environment are taken in. Additionally, cells have the ability to direct and in uence input and export processes, as well as moderate the subsequent signal response. Effective drug transportation across cellular membranes is essential for all treatment procedures. The majority of medications used in cancer therapy require carrier proteins for their transmembrane transport, even though hydrophobic small molecules can enter the cell membrane through straightforward diffusion. As a result, many scientists concentrate on creating novel strategies to improve drug delivery and uptake into desired cells. A live cell's plasma membrane serves as its outer wall. Although it acts as a barrier, it also permits transport between the cell and its surroundings.

BioMed Research International, 2022

Pakistan Journal of Zoology, 2020

Authors' Contribution RY and TM planned and designed the research. RY performed the experiment an... more Authors' Contribution RY and TM planned and designed the research. RY performed the experiment and wrote the paper. NR provided technical support for the experiment. MAI helped in statistical analysis.

Medical Reports & Case Studies, 2018

Introduction: Women often experienced ragged and unpredicted kind of behavior and hardly recogniz... more Introduction: Women often experienced ragged and unpredicted kind of behavior and hardly recognize their attitude as premenstrual syndrome. Adolescent girls are particularly naïve and unacquainted of the symptoms and if aware, hide due to shyness. Method: In this cross sectional study, a survey was conducted in educational institutes to determine the prevalence of various categories of PMS in young teen agers girls at different stages of their luteal phase. Predominance of PMS was finding out by applying Chi square test and significant incidences of PMS was observed. Result: PMS-A is recognized as a recurring phenomenon with most number of victims. Mild anxiety experienced by 38% respondents and severe mood swings affected more than 22% college going girls. PMS-H vie PMS-A having maximum numbers of females with complain of spartan type of fluid retention. Abdominal bloating and breast tenderness found as customary signs and 70% pubescent girls face these troubles before and during menstruation. Depression crying and fatigue are other major warning cryptograms of PMS. Conclusion: Frequency of premenstrual syndrome must be figure out in adolescent girls and they must educate about its indications, complications and outcomes to ensure the good quality of women health at their reproductive age.

Bangladesh Journal of Scientific and Industrial Research, 2015

Workers of textile industry are exposed to different hazardous chemicals that cause adverse effec... more Workers of textile industry are exposed to different hazardous chemicals that cause adverse effects on their health. As variations in plasma proteins are the best indicators of health status of the subjects, hence, we compared plasma protein fractions, resolved by SDS-PAGE of textile dyeing industry workers (n=30) with control subjects (n=30). Proteins were quantified by Total Lab Quant software and analyzed, statistically, by Student t-test. Thirteen protein fractions were detected ranging 250-17kDa. A significant increase in 132 and 53kDa fractions, whereas, a significant decrement in 87 and 66kDa fractions with a highly significant reduction in 112kDa fraction was observed. However, 250, 224, 43, 23, 19 and 17kDa protein fractions did not vary considerably. As some proteins circulate only during particular physiological or pathological circumstances and may serve as biomarkers of anomalies, the altered expressions of these biomolecules observed in textile dyeing industry workers ...

Pakistan Journal of Zoology, 2012

Delayed diagnosis in lymphoma deteriorates the health eminence resulting in pitiable prognosis an... more Delayed diagnosis in lymphoma deteriorates the health eminence resulting in pitiable prognosis and poor health management. The aim of the study is to estimate the burden and clinical presentation of lymphoma in Pakistan. A total of 334 newly diagnosed cases of lymphoma were registered in the study. Followed by histopathology, WHO classification and Ann Arbor staging was done to assign subtype and extent of disease. It was found that the incidence of non Hodgkin's lymphoma (71%) was greater than Hodgkin's disease (29%) and both present bimodal distribution in age. Male patients dominate female patients in both cases (2.5:1). Lymphadenopathy of cervical region is primary site in 44% of cases while 20% cases were extranodal. Histopathology show 66% mixed cellularity variant in Hodgkin's and 37% diffuse B cell pattern in Non Hodgkin's lymphoma. Ann Arbor staging reveals that 28% cases present with stage I and 38% show stage IV. To conclude, Non Hodgkin's lymphoma is ...

BioMed Research International

Perturbations in the actions of T3 and T4 influence the normal metabolic pathways. Responsiveness... more Perturbations in the actions of T3 and T4 influence the normal metabolic pathways. Responsiveness of lipid biomarkers like LDL-C, HDL-C, TC, TG, Apo-A, and Apo-B after rehabilitation of thyroid profile attaining euthyroid state was determined. A total of 179 age-matched subjects of both genders were recruited for this research. Sixty healthy controls, thirty-four subclinical, fifty overt hyperthyroid, and thirty-five follow-up subjects having 3 months of Carbimazole therapy were enrolled. Biochemical analysis was performed by chemistry analyzer, RIA, and ELISA. One-way ANOVA was applied for the statistical analysis, while significance ( P < 0.05 ) of means was compared by the Student-Newman-Keuls (SNK) test. Pronounced reduction ( P < 0.001 ) of cholesterol in overt as compared to control and subclinical was noticed, whereas marked improvement ( P < 0.001 ) was evidenced in follow-up. Prominent elevation ( P < 0.05 ) of TG in follow-up was evidenced as compared to contro...