The cycloaddition reaction of non-stabilized azomethine ylides, generated through decarboxylation... more The cycloaddition reaction of non-stabilized azomethine ylides, generated through decarboxylation and deprotonation, with (E)-2-arylidene-1-tetralones as dipolarophile has been investigated. A high degree of regioselectivity has been observed in the synthesis of a new class of functionalised dispiroheterocyclic compounds bearing a tetralone, acenapthenequinone and oxindole framework.
Archives of Clinical Microbiology, 2021
Conclusion The results presented in this study and our previous studies indicate that RD-3 and ER... more Conclusion The results presented in this study and our previous studies indicate that RD-3 and ER-2 could be effective in the treatment of C. pneumoniae infections; however its clinical application will depend on its toxicity and pharmacokinetic properties.
A comparative study of the synthesis of novel dispiro pyrrolo/pyrrolizidino ring systems by the c... more A comparative study of the synthesis of novel dispiro pyrrolo/pyrrolizidino ring systems by the cycloaddition of azomethine ylides generated by a decarboxylative route from sarcosine/proline and isatin with the dipolarophile 9-arylidine-fluorene using four different methodologies is described. A solvent-free microwave-assisted approach gave products with the highest yields in a short time. Additionally, our solvent-free approach allowed the use of 4-N,N-dimethylaminobenzaldehyde, which failed to yield the desired cycloadducts under conventional approaches.
The cycloaddition reaction of non-stabilized azomethine ylides, generated through decarboxylation... more The cycloaddition reaction of non-stabilized azomethine ylides, generated through decarboxylation and deprotonation, with (E)-2-arylidene-1-tetralones as dipolarophile has been investigated. A high degree of regioselectivity has been observed in the synthesis of a new class of functionalised dispiroheterocyclic compounds bearing a tetralone, acenapthenequinone and oxindole framework.
Archives of Clinical Microbiology, 2021
Conclusion The results presented in this study and our previous studies indicate that RD-3 and ER... more Conclusion The results presented in this study and our previous studies indicate that RD-3 and ER-2 could be effective in the treatment of C. pneumoniae infections; however its clinical application will depend on its toxicity and pharmacokinetic properties.
A comparative study of the synthesis of novel dispiro pyrrolo/pyrrolizidino ring systems by the c... more A comparative study of the synthesis of novel dispiro pyrrolo/pyrrolizidino ring systems by the cycloaddition of azomethine ylides generated by a decarboxylative route from sarcosine/proline and isatin with the dipolarophile 9-arylidine-fluorene using four different methodologies is described. A solvent-free microwave-assisted approach gave products with the highest yields in a short time. Additionally, our solvent-free approach allowed the use of 4-N,N-dimethylaminobenzaldehyde, which failed to yield the desired cycloadducts under conventional approaches.