Eloy Basany - Academia.edu (original) (raw)

Papers by Eloy Basany

Journal of Crohn's and Colitis, 2018

Cirugía Española (english Edition), Nov 1, 2014

Cá ncer de recto Linfoma Tumor del estroma gastrointestinal Sarcoma Tumores neuroendocrinos Tumor... more Cá ncer de recto Linfoma Tumor del estroma gastrointestinal Sarcoma Tumores neuroendocrinos Tumor carcinoide Carcinoma de cé lulas escamosas Revisió n de la literatura a b s t r a c t Most rectal neoplasms are adenocarcinomas, but there is a small percentage of tumors which are of other histological cell lines such as neuroendocrine tumors, sarcomas, lymphomas, and squamous cell carcinomas, which have special characteristics and different treatments. We have reviewed these rare tumors of the rectum from a clinical and surgical point of view.

Cirugía andaluza, May 8, 2020

Cirugía andaluza, May 8, 2020

WHO continues to monitor the situation closely for any changes that may affect this interim guida... more WHO continues to monitor the situation closely for any changes that may affect this interim guidance. Should any factors change, WHO will issue a further update. Otherwise, this interim guidance document will expire 2 years after the date of publication.

Gastroenterología y Hepatología, Feb 1, 2019

Anemia microcítica secundaria a úlcera anastomótica ileocólica Microcytic anemia due to ileocolic... more Anemia microcítica secundaria a úlcera anastomótica ileocólica Microcytic anemia due to ileocolic anastomotic ulcer

Si estudiamos el cáncer de recto por separado del cáncer de colon en España en el año 2006, supon... more Si estudiamos el cáncer de recto por separado del cáncer de colon en España en el año 2006, supone la onceava causa de muerte por cáncer, representando el 3,13% de las mismas (con 3.172 casos). En el hombre es la decima causa de muerte por cáncer (3,11% de todas las muertes por cáncer en los hombres con 1.959 casos) y en la mujer es la doceava causa de muerte por cáncer (3,16% de todas las muertes por cáncer en la mujer con 1.213 casos).

Colorectal Disease, Feb 7, 2012

Aim Surgical site infection (SSI) is the most common cause of morbidity after colorectal surgery... more Aim Surgical site infection (SSI) is the most common cause of morbidity after colorectal surgery. The aim of this study was to analyze risk factors for SSI in patients who had undergone surgery for rectal cancer.Method A multicentre observational study was carried out on 2131 patients operated on for rectal cancer between May 2006 and May 2009. Twenty‐nine centres were involved. SSI included wound infection and organ space infection within 30 days after the operation. Univariate and multivariate analyses were carried out to study possible risk factors for SSI.Results Wound infection and organ space infection were diagnosed in 8.9% and 10%, respectively, of patients. The anastomotic leakage rate was 8%. Multivariate analysis showed that wound infection was related to tumour stage, a converted laparoscopic procedure and open surgery. Organ space infection was related to Stage IV tumour, a tumour < 11 cm from the anal verge, low anterior resection and Hartmann’s procedure.Conclusion Rectal surgery for malignant disease is associated with a considerable rate of SSI. Wound infection and organ space infection are related to different factors and therefore should be evaluated separately.

Gastroenterología Y Hepatología (english Edition), Feb 1, 2019

Other gastrointestinal tract disorders include opportunistic infections that would cause chronic ... more Other gastrointestinal tract disorders include opportunistic infections that would cause chronic diarrhoea and Helicobacter pylori infection, associated with a 50-fold increase in the incidence of gastric cancer compared to the general population. 9 Last of all, gastrointestinal and hepatobiliary manifestations are common in patients with CVID, and we therefore suggest that investigations be guided by the morbidity/mortality they represent. 6. Jørgensen SF, Reims HM, Frydenlund D, Holm K, Paulsen V, Michelsen AE, et al. A cross-sectional study of the prevalence of gastrointestinal symptoms and pathology in patients with common variable immunodeficiency.

Colorectal Disease, Oct 1, 2016

We read with interest the letter written by Sellars and co-workers regarding our recent retrospec... more We read with interest the letter written by Sellars and co-workers regarding our recent retrospective observational study comparing the short-term outcome between laparoscopic and open surgery for rectal cancer in octogenarians and younger patients (1) . Their concern was about the statistical significance of the difference found between older patients operated by laparoscopy and open surgery, in terms of grade C anastomotic leakage after logistic regression analysis (upon Cr-POSSUM value and surgical technique). This article is protected by copyright. All rights reserved.

Cirugía Española (english Edition), Apr 1, 2018

Introduction: Currently, there is growing interest in analyzing the results from surgical units a... more Introduction: Currently, there is growing interest in analyzing the results from surgical units and the implementation of quality standards in order to identify good healthcare practices. Due to this fact, the Spanish Association of Coloproctology (AECP) has developed a unit accreditation program that contemplates basic standards. The aim of this article is to evaluate and analyze the specific quality indicators for the surgical treatment of colorectal cancer, established by the program. Data were collected from colorectal units during the accreditation process. Methods: We analyzed prospectively collected data from elective colorectal surgeries at 18 Spanish coloproctology units during the period 2013-2017. Three main and four secondary quality indicators were considered. Colon and rectal surgeries were analyzed independently; furthermore, results were compared according to surgical approach. Results: A total of 3090 patients were included in the analysis. The global anastomotic leak rate was 7.8% (6.6% colon vs 10.6% rectum), while the surgical site infection rate was 12.6% (11.4% colon vs 14.8% rectum). Overall 30-day mortality was 2.3%, and anastomotic leakrelated mortality was 10.2%. There were higher surgical site infection and mortality rates in the patients operated by open approach, however there was no difference in the anastomotic leak rate when compared with minimally invasive approaches.

Digestive and Liver Disease, Aug 1, 2021

BACKGROUND In colon cancer (CC), surgery remains the mainstay of treatment with curative intent. ... more BACKGROUND In colon cancer (CC), surgery remains the mainstay of treatment with curative intent. Despite several clinical trials comparing open and laparoscopic approaches, data on long-term outcomes for stage III CC are lacking. METHODS This post-hoc analysis of the European PETACC8 randomized phase 3 trial included patients from 340 sites between December 2005 and November 2009, with long follow-up (median 7.56 years). Patients were randomly assigned to FOLFOX or FOLFOX+cetuximab after colonic resection. The surgical approach was left to the referring surgeon's discretion. RESULTS Among 2555 patients included, 1796 (70.29%) were operated on by open surgery and 759 (29.71%) by laparoscopy. The 5-year OS rate was better after laparoscopic resection (85.4%, 95%CI 82.5-87.7) than after open surgery (80.2%, 95%CI 78.2-82.0; p = 0.002). The 5-year DFS rate was also better after laparoscopy (p = 0.016). However, in multivariate analysis using a propensity matching, the surgical approach was not found to be an independent prognostic factor for OS or DFS. OS (p = 0.0243) and DFS (p = 0.035) were increased after laparoscopic surgery in KRAS/BRAF WT sub-group CONCLUSION: We showed that laparoscopic resection has comparable long-term outcomes to open surgery in patients with stage III CC. For those with RAS and BRAF WT CC, laparoscopic colectomy may favorably impact survival.

American Journal of Surgery, Aug 1, 2018

Subtotal colectomy versus left hemicolectomy for the elective treatment of splenic flexure coloni... more Subtotal colectomy versus left hemicolectomy for the elective treatment of splenic flexure colonic neoplasia ABSTRACT Background Optimal elective surgical treatment for splenic flexure neoplasm (SFN) is unclear. Subtotal colectomy (STC) and left hemicolectomy (LHC) are the two more common strategies used. Methods Observational multicentric study comparing postoperative morbidity, mortality and long-term survival on patients with SFN electively operated by STC versus LHC between 2003 and 2014. Results After revision of the databases, 144 patients were included (STC group, n=68; LHC group, n=76). No differences were found on epidemiological and surgical data. A higher global morbidity (58%vs37%, p=0.014), surgical morbidity (50%vs33%, p=0.037), postoperative ileus (37%vs20%, p=0.023) and harvested lymph nodes (26vs18, p=0.0001) were found on the STC group. No significant differences in complications according to severity, reoperation rate, hospital stay, mortality, recurrence or long-term survival were found between groups. Conclusions A higher surgical morbidity was found on the STC group, mainly due to mild postoperative ileus. No differences on long-term oncological results were found.

European Journal of Surgical Oncology

Supplementary Tables S1-S15. Table S1. Genes and positions analyzed by amplicon sequencing. Table... more Supplementary Tables S1-S15. Table S1. Genes and positions analyzed by amplicon sequencing. Table S2. Genes sequenced by Haloplex Target Enrichment System. Table S3. Antibodies. Table S4. Treatment-induced apoptosis in 10 primary patient-derived sphere cell cultures. Table S5. Genotype of patient-derived colorectal cancer models. Table S6. Exome sequencing of colorectal cancer patient-derived models. Table S7. Genes regulated by NVP-TNKS656 in PDX-P2. Table S8. Genes regulated by NVP-TNKS656 in PDX-P30. Table S9. Genes regulated by NVP-TNKS656 in PDX-P5. Table S10. Intestinal β-catenin/TCF signature in human CRC. Table S11. Genes regulated by β-catenin/FOXO3A signaling in human CRC. Table S12. Molecular profiling of 130 CRC tumors. Table S13. Clinicopathological data of 40 CRC patients treated with PI3K/AKT/mTOR inhibitors and their corresponding baseline tumor samples analyzed for mutations and nuclear β-catenin content. Table S14. Nuclear β-catenin content but not relevant mutatio...

PDF file - 248K, Distant metastasis generated by cells derived from patient 5.

Supporting Information. Supplementary methods to complete the information for gene expression, ge... more Supporting Information. Supplementary methods to complete the information for gene expression, genotyping, immunohistochemistry evaluation criteria and protein extraction. The file also contains legends for supplementary figures S1-S11 and supplementary tables S1-S15.

Colorectal Disease

AimThe primary aim of the study is to describe the variation in the operative and nonoperative ma... more AimThe primary aim of the study is to describe the variation in the operative and nonoperative management of emergency presentations of colon and rectal cancer in an international cohort. Secondary aims will be to develop a risk prediction model for mortality and primary anastomosis and validate risk criteria of large bowel obstruction (LBO) in patients with previously known colorectal cancer undergoing neoadjuvant chemotherapy or awaiting elective surgery.MethodThis prospective, multicentre audit will be conducted via the student‐ and trainee‐led EuroSurg Collaborative network internationally over 2023 with 90‐day follow‐up. Data will be collected on consecutive adult patients presenting to the hospital in an unplanned and urgent manner with colorectal cancer (CRC) due to malignant LBO, perforation, CRC‐related haemorrhage, or other related reasons. Primary outcome is 90‐day mortality. Secondary outcomes include rates of stomas, primary anastomosis, stenting, preoperative imaging, ...

Colorectal Disease

AimOperation time (OT) is a key operational factor influencing surgical outcomes. The present stu... more AimOperation time (OT) is a key operational factor influencing surgical outcomes. The present study aimed to analyse whether OT impacts on short‐term outcomes of minimally‐invasive right colectomies by assessing the role of surgical approach (robotic [RRC] or laparoscopic right colectomy [LRC]), and type of ileocolic anastomosis (i.e., intracorporal [IA] or extra‐corporal anastomosis [EA]).MethodsThis was a retrospective analysis of the Minimally‐invasivE surgery for oncological Right ColectomY (MERCY) Study Group database, which included adult patients with nonmetastatic right colon adenocarcinoma operated on by oncological RRC or LRC between January 2014 and December 2020. Univariate and multivariate analyses were used.ResultsThe study sample was composed of 1549 patients who were divided into three groups according to the OT quartiles: (1) First quartile, <135 min (n = 386); (2) Second and third quartiles, 135–199 min (n = 731); and (3) Fourth quartile ≥200 min (n = 432). The ...

Journal of Crohn's and Colitis, 2018

Cirugía Española (english Edition), Nov 1, 2014

Cá ncer de recto Linfoma Tumor del estroma gastrointestinal Sarcoma Tumores neuroendocrinos Tumor... more Cá ncer de recto Linfoma Tumor del estroma gastrointestinal Sarcoma Tumores neuroendocrinos Tumor carcinoide Carcinoma de cé lulas escamosas Revisió n de la literatura a b s t r a c t Most rectal neoplasms are adenocarcinomas, but there is a small percentage of tumors which are of other histological cell lines such as neuroendocrine tumors, sarcomas, lymphomas, and squamous cell carcinomas, which have special characteristics and different treatments. We have reviewed these rare tumors of the rectum from a clinical and surgical point of view.

Cirugía andaluza, May 8, 2020

Cirugía andaluza, May 8, 2020

WHO continues to monitor the situation closely for any changes that may affect this interim guida... more WHO continues to monitor the situation closely for any changes that may affect this interim guidance. Should any factors change, WHO will issue a further update. Otherwise, this interim guidance document will expire 2 years after the date of publication.

Gastroenterología y Hepatología, Feb 1, 2019

Anemia microcítica secundaria a úlcera anastomótica ileocólica Microcytic anemia due to ileocolic... more Anemia microcítica secundaria a úlcera anastomótica ileocólica Microcytic anemia due to ileocolic anastomotic ulcer

Si estudiamos el cáncer de recto por separado del cáncer de colon en España en el año 2006, supon... more Si estudiamos el cáncer de recto por separado del cáncer de colon en España en el año 2006, supone la onceava causa de muerte por cáncer, representando el 3,13% de las mismas (con 3.172 casos). En el hombre es la decima causa de muerte por cáncer (3,11% de todas las muertes por cáncer en los hombres con 1.959 casos) y en la mujer es la doceava causa de muerte por cáncer (3,16% de todas las muertes por cáncer en la mujer con 1.213 casos).

Colorectal Disease, Feb 7, 2012

Aim Surgical site infection (SSI) is the most common cause of morbidity after colorectal surgery... more Aim Surgical site infection (SSI) is the most common cause of morbidity after colorectal surgery. The aim of this study was to analyze risk factors for SSI in patients who had undergone surgery for rectal cancer.Method A multicentre observational study was carried out on 2131 patients operated on for rectal cancer between May 2006 and May 2009. Twenty‐nine centres were involved. SSI included wound infection and organ space infection within 30 days after the operation. Univariate and multivariate analyses were carried out to study possible risk factors for SSI.Results Wound infection and organ space infection were diagnosed in 8.9% and 10%, respectively, of patients. The anastomotic leakage rate was 8%. Multivariate analysis showed that wound infection was related to tumour stage, a converted laparoscopic procedure and open surgery. Organ space infection was related to Stage IV tumour, a tumour &lt; 11 cm from the anal verge, low anterior resection and Hartmann’s procedure.Conclusion Rectal surgery for malignant disease is associated with a considerable rate of SSI. Wound infection and organ space infection are related to different factors and therefore should be evaluated separately.

Gastroenterología Y Hepatología (english Edition), Feb 1, 2019

Other gastrointestinal tract disorders include opportunistic infections that would cause chronic ... more Other gastrointestinal tract disorders include opportunistic infections that would cause chronic diarrhoea and Helicobacter pylori infection, associated with a 50-fold increase in the incidence of gastric cancer compared to the general population. 9 Last of all, gastrointestinal and hepatobiliary manifestations are common in patients with CVID, and we therefore suggest that investigations be guided by the morbidity/mortality they represent. 6. Jørgensen SF, Reims HM, Frydenlund D, Holm K, Paulsen V, Michelsen AE, et al. A cross-sectional study of the prevalence of gastrointestinal symptoms and pathology in patients with common variable immunodeficiency.

Colorectal Disease, Oct 1, 2016

We read with interest the letter written by Sellars and co-workers regarding our recent retrospec... more We read with interest the letter written by Sellars and co-workers regarding our recent retrospective observational study comparing the short-term outcome between laparoscopic and open surgery for rectal cancer in octogenarians and younger patients (1) . Their concern was about the statistical significance of the difference found between older patients operated by laparoscopy and open surgery, in terms of grade C anastomotic leakage after logistic regression analysis (upon Cr-POSSUM value and surgical technique). This article is protected by copyright. All rights reserved.

Cirugía Española (english Edition), Apr 1, 2018

Introduction: Currently, there is growing interest in analyzing the results from surgical units a... more Introduction: Currently, there is growing interest in analyzing the results from surgical units and the implementation of quality standards in order to identify good healthcare practices. Due to this fact, the Spanish Association of Coloproctology (AECP) has developed a unit accreditation program that contemplates basic standards. The aim of this article is to evaluate and analyze the specific quality indicators for the surgical treatment of colorectal cancer, established by the program. Data were collected from colorectal units during the accreditation process. Methods: We analyzed prospectively collected data from elective colorectal surgeries at 18 Spanish coloproctology units during the period 2013-2017. Three main and four secondary quality indicators were considered. Colon and rectal surgeries were analyzed independently; furthermore, results were compared according to surgical approach. Results: A total of 3090 patients were included in the analysis. The global anastomotic leak rate was 7.8% (6.6% colon vs 10.6% rectum), while the surgical site infection rate was 12.6% (11.4% colon vs 14.8% rectum). Overall 30-day mortality was 2.3%, and anastomotic leakrelated mortality was 10.2%. There were higher surgical site infection and mortality rates in the patients operated by open approach, however there was no difference in the anastomotic leak rate when compared with minimally invasive approaches.

Digestive and Liver Disease, Aug 1, 2021

BACKGROUND In colon cancer (CC), surgery remains the mainstay of treatment with curative intent. ... more BACKGROUND In colon cancer (CC), surgery remains the mainstay of treatment with curative intent. Despite several clinical trials comparing open and laparoscopic approaches, data on long-term outcomes for stage III CC are lacking. METHODS This post-hoc analysis of the European PETACC8 randomized phase 3 trial included patients from 340 sites between December 2005 and November 2009, with long follow-up (median 7.56 years). Patients were randomly assigned to FOLFOX or FOLFOX+cetuximab after colonic resection. The surgical approach was left to the referring surgeon's discretion. RESULTS Among 2555 patients included, 1796 (70.29%) were operated on by open surgery and 759 (29.71%) by laparoscopy. The 5-year OS rate was better after laparoscopic resection (85.4%, 95%CI 82.5-87.7) than after open surgery (80.2%, 95%CI 78.2-82.0; p = 0.002). The 5-year DFS rate was also better after laparoscopy (p = 0.016). However, in multivariate analysis using a propensity matching, the surgical approach was not found to be an independent prognostic factor for OS or DFS. OS (p = 0.0243) and DFS (p = 0.035) were increased after laparoscopic surgery in KRAS/BRAF WT sub-group CONCLUSION: We showed that laparoscopic resection has comparable long-term outcomes to open surgery in patients with stage III CC. For those with RAS and BRAF WT CC, laparoscopic colectomy may favorably impact survival.

American Journal of Surgery, Aug 1, 2018

Subtotal colectomy versus left hemicolectomy for the elective treatment of splenic flexure coloni... more Subtotal colectomy versus left hemicolectomy for the elective treatment of splenic flexure colonic neoplasia ABSTRACT Background Optimal elective surgical treatment for splenic flexure neoplasm (SFN) is unclear. Subtotal colectomy (STC) and left hemicolectomy (LHC) are the two more common strategies used. Methods Observational multicentric study comparing postoperative morbidity, mortality and long-term survival on patients with SFN electively operated by STC versus LHC between 2003 and 2014. Results After revision of the databases, 144 patients were included (STC group, n=68; LHC group, n=76). No differences were found on epidemiological and surgical data. A higher global morbidity (58%vs37%, p=0.014), surgical morbidity (50%vs33%, p=0.037), postoperative ileus (37%vs20%, p=0.023) and harvested lymph nodes (26vs18, p=0.0001) were found on the STC group. No significant differences in complications according to severity, reoperation rate, hospital stay, mortality, recurrence or long-term survival were found between groups. Conclusions A higher surgical morbidity was found on the STC group, mainly due to mild postoperative ileus. No differences on long-term oncological results were found.

European Journal of Surgical Oncology

Supplementary Tables S1-S15. Table S1. Genes and positions analyzed by amplicon sequencing. Table... more Supplementary Tables S1-S15. Table S1. Genes and positions analyzed by amplicon sequencing. Table S2. Genes sequenced by Haloplex Target Enrichment System. Table S3. Antibodies. Table S4. Treatment-induced apoptosis in 10 primary patient-derived sphere cell cultures. Table S5. Genotype of patient-derived colorectal cancer models. Table S6. Exome sequencing of colorectal cancer patient-derived models. Table S7. Genes regulated by NVP-TNKS656 in PDX-P2. Table S8. Genes regulated by NVP-TNKS656 in PDX-P30. Table S9. Genes regulated by NVP-TNKS656 in PDX-P5. Table S10. Intestinal β-catenin/TCF signature in human CRC. Table S11. Genes regulated by β-catenin/FOXO3A signaling in human CRC. Table S12. Molecular profiling of 130 CRC tumors. Table S13. Clinicopathological data of 40 CRC patients treated with PI3K/AKT/mTOR inhibitors and their corresponding baseline tumor samples analyzed for mutations and nuclear β-catenin content. Table S14. Nuclear β-catenin content but not relevant mutatio...

PDF file - 248K, Distant metastasis generated by cells derived from patient 5.

Supporting Information. Supplementary methods to complete the information for gene expression, ge... more Supporting Information. Supplementary methods to complete the information for gene expression, genotyping, immunohistochemistry evaluation criteria and protein extraction. The file also contains legends for supplementary figures S1-S11 and supplementary tables S1-S15.

Colorectal Disease

AimThe primary aim of the study is to describe the variation in the operative and nonoperative ma... more AimThe primary aim of the study is to describe the variation in the operative and nonoperative management of emergency presentations of colon and rectal cancer in an international cohort. Secondary aims will be to develop a risk prediction model for mortality and primary anastomosis and validate risk criteria of large bowel obstruction (LBO) in patients with previously known colorectal cancer undergoing neoadjuvant chemotherapy or awaiting elective surgery.MethodThis prospective, multicentre audit will be conducted via the student‐ and trainee‐led EuroSurg Collaborative network internationally over 2023 with 90‐day follow‐up. Data will be collected on consecutive adult patients presenting to the hospital in an unplanned and urgent manner with colorectal cancer (CRC) due to malignant LBO, perforation, CRC‐related haemorrhage, or other related reasons. Primary outcome is 90‐day mortality. Secondary outcomes include rates of stomas, primary anastomosis, stenting, preoperative imaging, ...

Colorectal Disease

AimOperation time (OT) is a key operational factor influencing surgical outcomes. The present stu... more AimOperation time (OT) is a key operational factor influencing surgical outcomes. The present study aimed to analyse whether OT impacts on short‐term outcomes of minimally‐invasive right colectomies by assessing the role of surgical approach (robotic [RRC] or laparoscopic right colectomy [LRC]), and type of ileocolic anastomosis (i.e., intracorporal [IA] or extra‐corporal anastomosis [EA]).MethodsThis was a retrospective analysis of the Minimally‐invasivE surgery for oncological Right ColectomY (MERCY) Study Group database, which included adult patients with nonmetastatic right colon adenocarcinoma operated on by oncological RRC or LRC between January 2014 and December 2020. Univariate and multivariate analyses were used.ResultsThe study sample was composed of 1549 patients who were divided into three groups according to the OT quartiles: (1) First quartile, <135 min (n = 386); (2) Second and third quartiles, 135–199 min (n = 731); and (3) Fourth quartile ≥200 min (n = 432). The ...