EDDY DE VEL - Academia.edu (original) (raw)
Papers by EDDY DE VEL
Introduction Bimodal hearing refers to the condition in which electrical hearing via a cochlear i... more Introduction Bimodal hearing refers to the condition in which electrical hearing via a cochlear implant (CI) is combined with acoustical, residual hearing in the non-implanted ear. Previous research demonstrated advantages in speech perception in noise and sound localization. Mechanisms underlying these benefits are still unclear. The objective of this study is to gain insight into developmental changes in binaural interaction with increasing bimodal experience. Methods One bimodal listeners (female, aged 62 years) is tested three, six and twelve months post-implantation. Binaural hearing is assessed by means of speech perception in noise tests, sound localization tests and questionnaires. Results Performance on binaural tasks improved with increasing experience with bimodal fitting. Conclusion These results suggest that the ability to combine electrical and acoustical signals improves with increasing bimodal experience. In addition to these behavioral measures, binaural interaction...
Background The unexplained variability in bimodal outcome impedes clinicians to provide evidence-... more Background The unexplained variability in bimodal outcome impedes clinicians to provide evidence-based counseling regarding contralateral hearing aid (HA) use. There is thus a need for measures of bimodal benefit. This study explores whether bimodal benefit can be assessed using the P300 event-related potential (ERP). Methods Cognitive P300 ERPs were recorded in five bimodal listeners using a low-frequency tonal contrast. Subjects counted the amount of deviant stimuli. The accuracy of the count served as a measure of behavioral performance. To assess the benefit of wearing a contralateral HA, CI-only and bimodal listening were compared. Results P300 ERPs were measurable and reproducible in four subjects. In these subjects, latencies decreased and amplitudes increased in bimodal versus CI-only listening. The subject with the largest improvement in the P300 ERP showed the largest improvement in behavioral performance. Conclusions This study suggests that CI-users generally benefit fro...
In order to develop a sensitive audiometric protocol for identifying ototoxicity in children, a r... more In order to develop a sensitive audiometric protocol for identifying ototoxicity in children, a retrospective study of 16 children treated with cisplatin and/or carboplatin was performed. Audiometric testing was done by means of pure-tone threshold audiometry (PTA), high-frequency audiometry (HFA), and distortion product otoacoustic emissions (DPOAEs). Cisplatin caused a sensorineural high-frequency hearing loss in the study group compared to the controls (p < 0.01). Sixty-six percent of the cisplatin patients had a grade 2 or 3 ototoxicity. However, ototoxicity was not found in the patients treated with carboplatin. An excellent correlation was found between DPOAE levels and results obtained by audiometry (r = 0.82). Patients exposed to cisplatin are at significant risk for the development of drug-induced sensorineural hearing loss. Because of the several advantages of DPOAEs (noninvasive, objective, rapid, easy to use, sensitive) this method should be added in the audiological ...
B-ENT, 2007
The aim of this study was to construct a rotational test protocol after exploring the stimulus pa... more The aim of this study was to construct a rotational test protocol after exploring the stimulus parameters of the rotatory vestibular test. Twenty-four normal subjects were submitted to three different rotational paradigms: the sinusoidal harmonic acceleration test (SHAT), the pseudorandom rotation test (PRRT), and the velocity step test (VST). We investigated the influence of frequency and velocity on gain, phase and asymmetry values for the SHAT and the PRRT. In the case of the VST, we examined the influence of velocity and deceleration on gain, slow component velocity at deceleration, time constant, nystagmus preponderance, and time constant asymmetry. Frequency affected the SHAT response parameters, with significant phase differences between the frequencies 0.01, 0.02, 0.05, 0.1, and 0.2 Hz, while velocity, if kept below 150 degrees/s, had no influence on the results. In the case of the VST, responses were influenced by stimulus velocity and not by stimulus deceleration, with sig...
Tijdschrift voor kindergeneeskunde, 2002
... Het merendeel (78,9%) van de deelnemers was jonger dan 35 jaar; de mediane leeftijd bedroeg 2... more ... Het merendeel (78,9%) van de deelnemers was jonger dan 35 jaar; de mediane leeftijd bedroeg 24 jaar. De I. Dhooge, en, (*) Dhooge I. MD, PhD, Heylbroeck Ph. MD, De Vel E. BA, Vinck B. MS, PhD, afdeling KNO en Hoofd-en Halschirurgie, Universitair Ziekenhuis Gent ...
Otology & Neurotology, 2005
This study involved the assessment of the otologic and audiologic characteristics of a group of p... more This study involved the assessment of the otologic and audiologic characteristics of a group of patients with Turner syndrome. Prospective study consisting of a questionnaire (77 of 123 responders) and an otologic and audiologic evaluation in patients with Turner syndrome (41 participants). Tertiary academic medical setting. Children, adolescents, and adults with Turner syndrome (median age, 24 yr). Otomicroscopy, audiometry, immittance measurements, and diagnostic imaging. Otologic disease is an important characteristic in Turner syndrome. Sixty-six percent of the patients studied via the questionnaire reported a history of chronic or recurrent middle ear disease. Analysis of audiometric data in 40 patients tested reveals an equal amount of normal ears (38.8%) and pure sensorineural ears (38.8%), each constituting approximately one-third of the patient population. Pure conductive losses represent only one-fifth (21.3%) of auditory abnormality encountered. Careful follow-up during early childhood of children with Turner syndrome is necessary to detect middle ear disease and prevent sequelae. However, long-term periodic review is mandatory even after resolution of middle ear disease to detect sensorineural hearing loss.
European Archives of Oto-Rhino-Laryngology, 1996
In this study 23 patients with noise-induced hearing loss (NIHL) referred for medico-legal evalua... more In this study 23 patients with noise-induced hearing loss (NIHL) referred for medico-legal evaluation and a group of 18 cases with M6nihre's disease were evaluated audiologically using the middle-latency response (MLR). Cross-correlation functions were used to assess precisely MLR thresholds in low and middle frequencies. Cross-correlation data obtained from suprathreshold levels to below threshold levels were compared with the normal limits of parameters found at threshold levels, allowing us to determine the true MLR threshold. Our results revealed that this MLR threshold and visual detection thresholds were different in 18% of both the NIHL and M6nihre's disease groups. In this population the true MLR threshold was greater by 5 dB. These findings demonstrated that cross-correlation functions can enhance the sensitivity of the definition of the MLR threshold. True MLR thresholds were compared with subjective pure-tone audiometric (PTA) thresholds at the same frequencies (0.5, 1 and 2 kHz). The true MLR threshold and PTA threshold were in agreement within 10 dB in 91% of the NIHL group and all of the M~ni~re's disease group. The PTA threshold was greater by 15 dB or more in the remaining N1HL group. If a criterion of 15 dB discrepancy indicates non-organic hearing loss, it can be inferred that 9% of an N1HL population referred for medico-legal evaluation is exaggerating subjective audiometric thresholds.
Acta oto-rhino-laryngologica Belgica, 1980
Starting with a case report, the interest of the BERA for the diagnosis of acoustic tumor is exam... more Starting with a case report, the interest of the BERA for the diagnosis of acoustic tumor is examined. Moreover, factors being able to complicate a clear interpretation of the result (transmissional and sensorineural dysfunctions) are discussed. The conclusion is drawn that the E. Coch. G. offers a factor of greater precision in the use of the BERA as an oto-neurological diagnostic tool.
The Journal of Laryngology & Otology, 1983
American Journal of Otolaryngology, 2010
The purpose of this study is to present follow-up on a previously reported case of successful coc... more The purpose of this study is to present follow-up on a previously reported case of successful cochlear implantation in a patient with superficial siderosis. Study design: Retrospective case review. Results: For the first 6 years after implantation, the patient had maintained a successful result; however, she developed a progressive decline in the benefit from her implant. Conclusion: Benefit from cochlear implants in patients with superficial siderosis is variable and may not be long standing.
Introduction: A growing amount of cochlear implant (CI) users have contralateral residual hearing... more Introduction: A growing amount of cochlear implant (CI) users have contralateral residual hearing. These patients often benefit from wearing a contralateral hearing aid (bimodal hearing). Nevertheless, individual performance varies considerably. There is thus a need for measures of bimodal benefit. This study explores whether the cognitive P300 auditory event-related potential (ERP) can be used to assess bimodal benefit. Methods: Cognitive P300 ERPs were recorded using an oddball paradigm with a low-frequency tonal contrast. Subjects were asked to mentally count the amount of deviant stimuli. The accuracy of the stimulus count served as a measure of behavioral performance. Two experiments were conducted. Experiment 1 assessed the P300 ERP paradigm in twelve normal hearing young adults. Based on these results, the P300 ERP paradigm was adjusted as to record P300 in five bimodal listeners. Results: In four out of five bimodal listeners, the P300 ERP improved in bimodal compared to CI-...
Introduction: Bimodal hearing refers to the condition in which electrical hearing via a cochlear ... more Introduction: Bimodal hearing refers to the condition in which electrical hearing via a cochlear implant (CI) is combined with residual hearing in the non-implanted ear. Psychoacoustic research demonstrates improvements in speech perception in noise and sound localization. There is however a large inter-subject variability in bimodal outcome, which may partly be explained by the capacity of the auditory brainstem to integrate electrical and acoustical signals. The present study suggests a technique to assess brainstem processing of bimodal stimulation. Methods: Ten bimodal listeners were included in the study. The non-implanted ear was stimulated acoustically, whereas the implanted ear was stimulated electrically. Before starting the ABR acquisition, the electrical and acoustical stimulation were pitch and loudness balanced. Subsequently, ABRs were recorded in response to monaural acoustical, monaural electrical, and bimodal stimulation. Results: Electrical ABRs were found in all su...
Introduction: Bimodal listeners combine a cochlear implant (CI) with a contralateral hearing aid ... more Introduction: Bimodal listeners combine a cochlear implant (CI) with a contralateral hearing aid (HA). Psychoacoustic research shows that bimodal listening can improve speech perception in noise, sound localization, and music appreciation. However, individual performance varies considerably. Many studies have examined bimodal benefit using behavioral measures. This study examines whether endogenous auditory evoked cortical responses can be used to assess bimodal benefit. Methods: Four experienced bimodal were included in the study. All subjects were implanted with either the Nucleus CI24RE(CA) or CI422 and wore a contralateral hearing aid. The cognitive P300 response was elicited using an oddball paradigm with a 500 Hz tone-burst as the standard and a 250 Hz tone-burst as the deviant stimulus. P300s were recorded in the CI-only (i.e. with the contralateral ear plugged) and bimodal condition (i.e. CI and HA). Results: Overall, P300 morphology was clearer in the bimodal than CI-only c...
Inleiding: Met de groeiende populatie ouderen neemt het aantal personen met ouderdomsslechthorend... more Inleiding: Met de groeiende populatie ouderen neemt het aantal personen met ouderdomsslechthorendheid gestaag toe. Hoewel ouderdomsslechthorendheid grotendeels te wijten is aan endocochleaire veranderingen, blijken ook degeneratieve verschijnselen ter hoogte van het centraal auditieve systeem bij te dragen tot deze vorm van slechthorendheid. De huidige studie onderzoekt de effecten van veroudering op een aspect van centraal auditieve verwerking, met name binaurale verwerking. Binaurale verwerking werd in deze studie onderzocht aan de hand van auditief opgewekte hersenstampotentialen (ABR). Literatuur toont namelijk aan dat verschillen tussen de binaurale ABR en de som van de linker en rechter ABR gerelateerd zijn aan binaurale processen. Methodologie: De huidige studie onderzocht bovengenoemde verschillen in proefpersonen van jonge (n=14), middelbare (n=14) en oudere leeftijd (n=14). ABRs werden opgemeten door middel van akoestische stimulatie ter hoogte van het linkeroor, het recht...
Introduction: Bimodal hearing refers to the condition in which electrical hearing via a cochlear ... more Introduction: Bimodal hearing refers to the condition in which electrical hearing via a cochlear implant (CI) is combined with residual hearing in the non-implanted ear. Several studies demonstrate improvements in speech perception in noise and sound localization. However, the mechanisms underlying these benefits are still unclear. The goal of this study is to gain insight into the processing of simultaneously presented electrical and acoustical signals using auditory brainstem responses (ABRs). Methods: Seven bimodal listeners were included. The non-implanted ear was stimulated with 500 Hz tone-bursts; the implanted ear with biphasic pulses. Before starting the ABR recording, the electrical stimulation was loudness- and pitch-balanced to 500 Hz tone-bursts presented at 45 dB SL. Subsequently, ABRs were recorded in response to monaural acoustical, monaural electrical and bimodal stimulation. The bimodal ABRs were then compared to the monaural responses. Results: Electrical ABRs were...
International Journal of Audiology, 2019
Objective: Bimodal listeners vary in the amount of benefit they receive from wearing the contrala... more Objective: Bimodal listeners vary in the amount of benefit they receive from wearing the contralateral hearing aid. This may partially depend on the listener's auditory processing capacities. The current study explores whether the P300 event-related potential can provide insight into the mechanisms underlying the benefits of wearing a contralateral hearing aid. Design: P300s were recorded using an oddball paradigm with 500 and 250 Hz tone-bursts as standard and deviant stimuli, respectively. Subjects counted the number of deviantsa measure of performance. N2b latencies, P300 latencies, N2b-P300 amplitudes, and performance were assessed during CI-only and bimodal listening. Study sample: Five bimodal listeners. Results: P300s were present in four subjects. Amplitudes were larger during bimodal listening (bimodal: 22.3 ± 4.83 mV, CI-only: 13.1 ± 3.86 mV). Both N2b and P300 latencies were shorter during bimodal (N2b: 265 ± 20.0 ms, P300: 551 ± 129.4 ms) than CI-only listening (N2b: 326 ± 42.2 ms, P300: 402 ± 38.4 ms). While performance often reached ceiling level, the difference between the standard and deviant was generally more salient during bimodal listening. Conclusions: This study provides a proof-of-concept, suggesting that P300s may provide insight into benefits that are not always measurable with behavioural tasks.
B-ENT, 2014
describe the results of a retrospective study of cochlear implantation (CI) in seven subjects wit... more describe the results of a retrospective study of cochlear implantation (CI) in seven subjects with Menière's disease. The subjects received either the Nucleus CI24RE(CA)/CI512 or the Advanced Bionics HiRes90K CI systems which use the ACE, MP3000, or HiRes S Fidelity 120 coding strategies. The audiometric measures included monosyllabic word lists (NVA) in quiet at 65 dB SPL and sentences in noise (LIST) at +10 dB SNR. The quality of life after implantation was assessed by means of the Nijmegen Cochlear Implant Questionnaire (NCIQ). After CI, the hearing of all subjects improved significantly (p < 0.001) as did their speech recognition (p = 0.018). Speech recognition in noise showed a mean improvement of 47%. The results were less clear for the treatment of vertigo associated with Menière's, as some patients continued to have vestibular attacks after implantation. On the NCIQ, subjects reported a mean quality of life after CI of 48.3%. This study clearly demonstrates that c...
International Journal of Audiology, 1998
Evaluation of cochlear hearing loss by means of transiently evoked otoacoustic emissions is alrea... more Evaluation of cochlear hearing loss by means of transiently evoked otoacoustic emissions is already established in clinical practice. However, accurate prediction of pure-tone thresholds is still questioned and is still regarded as troublesome. Both click- and tone-burst-evoked otoacoustic emissions at several intensity levels were measured and analysed in 157 ears from normally hearing and 432 ears from patients with different degrees of pure sensory hearing loss using the ILO88/92 equipment. Results of otoacoustic emissions (OAE), elicited by clicks and tone-bursts at centre frequencies from 1 to 5 kHz, were analysed using two different statistical methods. Both multivariate discriminant analysis and forward multiple regression analysis were used to determine which OAE variables were most discriminating and best at predicting hearing thresholds. We found that a limited set of variables obtained from both tone-burst and click measurements can accurately predict and categorize hearing loss levels up to a limit of 60 dB HL. We found correct classification scores of pure-tone thresholds between 500 and 4000 Hz up to 100 per cent when using combined click and tone-burst otoacoustic measurements. Prediction of pure-tone thresholds was correct with a maximum estimation error of 10 dB for audiometric octave frequencies between 500 and 4000 Hz. Measurements of multiple tone-bursts OAEs have a significant clinical advantage over the use of clicks alone for clinical applications, and a good classification and prediction of pure-tone thresholds with otoacoustic emissions is possible.
Objectives: To investigate plasticity in the binaural auditory system in bimodal listeners. Backg... more Objectives: To investigate plasticity in the binaural auditory system in bimodal listeners. Background: Bimodal hearing refers to the condition in which electric hearing via a cochlear implant (CI) is combined with residual hearing in the non-implanted ear. Psychoacoustic research suggests that bimodal listeners can benefit from binaural integration. There is, however, an unexplained variability in bimodal outcome. It is hypothesized that at least some of this variability can be explained by plasticity. It is expected that binaural interaction develops with increasing bimodal experience. Furthermore, subjects who wore bilateral hearing aids may be more likely to binaurally integrate electric and acoustic signals. We believe that the binaural interaction component derived from the auditory brainstem response (ABR-BIC) can be a useful technique to measure plastic changes during the first months of bimodal hearing. Methods: ABR-BICs are computed by subtracting the binaural response fro...
Introduction Bimodal hearing refers to the condition in which electrical hearing via a cochlear i... more Introduction Bimodal hearing refers to the condition in which electrical hearing via a cochlear implant (CI) is combined with acoustical, residual hearing in the non-implanted ear. Previous research demonstrated advantages in speech perception in noise and sound localization. Mechanisms underlying these benefits are still unclear. The objective of this study is to gain insight into developmental changes in binaural interaction with increasing bimodal experience. Methods One bimodal listeners (female, aged 62 years) is tested three, six and twelve months post-implantation. Binaural hearing is assessed by means of speech perception in noise tests, sound localization tests and questionnaires. Results Performance on binaural tasks improved with increasing experience with bimodal fitting. Conclusion These results suggest that the ability to combine electrical and acoustical signals improves with increasing bimodal experience. In addition to these behavioral measures, binaural interaction...
Background The unexplained variability in bimodal outcome impedes clinicians to provide evidence-... more Background The unexplained variability in bimodal outcome impedes clinicians to provide evidence-based counseling regarding contralateral hearing aid (HA) use. There is thus a need for measures of bimodal benefit. This study explores whether bimodal benefit can be assessed using the P300 event-related potential (ERP). Methods Cognitive P300 ERPs were recorded in five bimodal listeners using a low-frequency tonal contrast. Subjects counted the amount of deviant stimuli. The accuracy of the count served as a measure of behavioral performance. To assess the benefit of wearing a contralateral HA, CI-only and bimodal listening were compared. Results P300 ERPs were measurable and reproducible in four subjects. In these subjects, latencies decreased and amplitudes increased in bimodal versus CI-only listening. The subject with the largest improvement in the P300 ERP showed the largest improvement in behavioral performance. Conclusions This study suggests that CI-users generally benefit fro...
In order to develop a sensitive audiometric protocol for identifying ototoxicity in children, a r... more In order to develop a sensitive audiometric protocol for identifying ototoxicity in children, a retrospective study of 16 children treated with cisplatin and/or carboplatin was performed. Audiometric testing was done by means of pure-tone threshold audiometry (PTA), high-frequency audiometry (HFA), and distortion product otoacoustic emissions (DPOAEs). Cisplatin caused a sensorineural high-frequency hearing loss in the study group compared to the controls (p < 0.01). Sixty-six percent of the cisplatin patients had a grade 2 or 3 ototoxicity. However, ototoxicity was not found in the patients treated with carboplatin. An excellent correlation was found between DPOAE levels and results obtained by audiometry (r = 0.82). Patients exposed to cisplatin are at significant risk for the development of drug-induced sensorineural hearing loss. Because of the several advantages of DPOAEs (noninvasive, objective, rapid, easy to use, sensitive) this method should be added in the audiological ...
B-ENT, 2007
The aim of this study was to construct a rotational test protocol after exploring the stimulus pa... more The aim of this study was to construct a rotational test protocol after exploring the stimulus parameters of the rotatory vestibular test. Twenty-four normal subjects were submitted to three different rotational paradigms: the sinusoidal harmonic acceleration test (SHAT), the pseudorandom rotation test (PRRT), and the velocity step test (VST). We investigated the influence of frequency and velocity on gain, phase and asymmetry values for the SHAT and the PRRT. In the case of the VST, we examined the influence of velocity and deceleration on gain, slow component velocity at deceleration, time constant, nystagmus preponderance, and time constant asymmetry. Frequency affected the SHAT response parameters, with significant phase differences between the frequencies 0.01, 0.02, 0.05, 0.1, and 0.2 Hz, while velocity, if kept below 150 degrees/s, had no influence on the results. In the case of the VST, responses were influenced by stimulus velocity and not by stimulus deceleration, with sig...
Tijdschrift voor kindergeneeskunde, 2002
... Het merendeel (78,9%) van de deelnemers was jonger dan 35 jaar; de mediane leeftijd bedroeg 2... more ... Het merendeel (78,9%) van de deelnemers was jonger dan 35 jaar; de mediane leeftijd bedroeg 24 jaar. De I. Dhooge, en, (*) Dhooge I. MD, PhD, Heylbroeck Ph. MD, De Vel E. BA, Vinck B. MS, PhD, afdeling KNO en Hoofd-en Halschirurgie, Universitair Ziekenhuis Gent ...
Otology & Neurotology, 2005
This study involved the assessment of the otologic and audiologic characteristics of a group of p... more This study involved the assessment of the otologic and audiologic characteristics of a group of patients with Turner syndrome. Prospective study consisting of a questionnaire (77 of 123 responders) and an otologic and audiologic evaluation in patients with Turner syndrome (41 participants). Tertiary academic medical setting. Children, adolescents, and adults with Turner syndrome (median age, 24 yr). Otomicroscopy, audiometry, immittance measurements, and diagnostic imaging. Otologic disease is an important characteristic in Turner syndrome. Sixty-six percent of the patients studied via the questionnaire reported a history of chronic or recurrent middle ear disease. Analysis of audiometric data in 40 patients tested reveals an equal amount of normal ears (38.8%) and pure sensorineural ears (38.8%), each constituting approximately one-third of the patient population. Pure conductive losses represent only one-fifth (21.3%) of auditory abnormality encountered. Careful follow-up during early childhood of children with Turner syndrome is necessary to detect middle ear disease and prevent sequelae. However, long-term periodic review is mandatory even after resolution of middle ear disease to detect sensorineural hearing loss.
European Archives of Oto-Rhino-Laryngology, 1996
In this study 23 patients with noise-induced hearing loss (NIHL) referred for medico-legal evalua... more In this study 23 patients with noise-induced hearing loss (NIHL) referred for medico-legal evaluation and a group of 18 cases with M6nihre's disease were evaluated audiologically using the middle-latency response (MLR). Cross-correlation functions were used to assess precisely MLR thresholds in low and middle frequencies. Cross-correlation data obtained from suprathreshold levels to below threshold levels were compared with the normal limits of parameters found at threshold levels, allowing us to determine the true MLR threshold. Our results revealed that this MLR threshold and visual detection thresholds were different in 18% of both the NIHL and M6nihre's disease groups. In this population the true MLR threshold was greater by 5 dB. These findings demonstrated that cross-correlation functions can enhance the sensitivity of the definition of the MLR threshold. True MLR thresholds were compared with subjective pure-tone audiometric (PTA) thresholds at the same frequencies (0.5, 1 and 2 kHz). The true MLR threshold and PTA threshold were in agreement within 10 dB in 91% of the NIHL group and all of the M~ni~re's disease group. The PTA threshold was greater by 15 dB or more in the remaining N1HL group. If a criterion of 15 dB discrepancy indicates non-organic hearing loss, it can be inferred that 9% of an N1HL population referred for medico-legal evaluation is exaggerating subjective audiometric thresholds.
Acta oto-rhino-laryngologica Belgica, 1980
Starting with a case report, the interest of the BERA for the diagnosis of acoustic tumor is exam... more Starting with a case report, the interest of the BERA for the diagnosis of acoustic tumor is examined. Moreover, factors being able to complicate a clear interpretation of the result (transmissional and sensorineural dysfunctions) are discussed. The conclusion is drawn that the E. Coch. G. offers a factor of greater precision in the use of the BERA as an oto-neurological diagnostic tool.
The Journal of Laryngology & Otology, 1983
American Journal of Otolaryngology, 2010
The purpose of this study is to present follow-up on a previously reported case of successful coc... more The purpose of this study is to present follow-up on a previously reported case of successful cochlear implantation in a patient with superficial siderosis. Study design: Retrospective case review. Results: For the first 6 years after implantation, the patient had maintained a successful result; however, she developed a progressive decline in the benefit from her implant. Conclusion: Benefit from cochlear implants in patients with superficial siderosis is variable and may not be long standing.
Introduction: A growing amount of cochlear implant (CI) users have contralateral residual hearing... more Introduction: A growing amount of cochlear implant (CI) users have contralateral residual hearing. These patients often benefit from wearing a contralateral hearing aid (bimodal hearing). Nevertheless, individual performance varies considerably. There is thus a need for measures of bimodal benefit. This study explores whether the cognitive P300 auditory event-related potential (ERP) can be used to assess bimodal benefit. Methods: Cognitive P300 ERPs were recorded using an oddball paradigm with a low-frequency tonal contrast. Subjects were asked to mentally count the amount of deviant stimuli. The accuracy of the stimulus count served as a measure of behavioral performance. Two experiments were conducted. Experiment 1 assessed the P300 ERP paradigm in twelve normal hearing young adults. Based on these results, the P300 ERP paradigm was adjusted as to record P300 in five bimodal listeners. Results: In four out of five bimodal listeners, the P300 ERP improved in bimodal compared to CI-...
Introduction: Bimodal hearing refers to the condition in which electrical hearing via a cochlear ... more Introduction: Bimodal hearing refers to the condition in which electrical hearing via a cochlear implant (CI) is combined with residual hearing in the non-implanted ear. Psychoacoustic research demonstrates improvements in speech perception in noise and sound localization. There is however a large inter-subject variability in bimodal outcome, which may partly be explained by the capacity of the auditory brainstem to integrate electrical and acoustical signals. The present study suggests a technique to assess brainstem processing of bimodal stimulation. Methods: Ten bimodal listeners were included in the study. The non-implanted ear was stimulated acoustically, whereas the implanted ear was stimulated electrically. Before starting the ABR acquisition, the electrical and acoustical stimulation were pitch and loudness balanced. Subsequently, ABRs were recorded in response to monaural acoustical, monaural electrical, and bimodal stimulation. Results: Electrical ABRs were found in all su...
Introduction: Bimodal listeners combine a cochlear implant (CI) with a contralateral hearing aid ... more Introduction: Bimodal listeners combine a cochlear implant (CI) with a contralateral hearing aid (HA). Psychoacoustic research shows that bimodal listening can improve speech perception in noise, sound localization, and music appreciation. However, individual performance varies considerably. Many studies have examined bimodal benefit using behavioral measures. This study examines whether endogenous auditory evoked cortical responses can be used to assess bimodal benefit. Methods: Four experienced bimodal were included in the study. All subjects were implanted with either the Nucleus CI24RE(CA) or CI422 and wore a contralateral hearing aid. The cognitive P300 response was elicited using an oddball paradigm with a 500 Hz tone-burst as the standard and a 250 Hz tone-burst as the deviant stimulus. P300s were recorded in the CI-only (i.e. with the contralateral ear plugged) and bimodal condition (i.e. CI and HA). Results: Overall, P300 morphology was clearer in the bimodal than CI-only c...
Inleiding: Met de groeiende populatie ouderen neemt het aantal personen met ouderdomsslechthorend... more Inleiding: Met de groeiende populatie ouderen neemt het aantal personen met ouderdomsslechthorendheid gestaag toe. Hoewel ouderdomsslechthorendheid grotendeels te wijten is aan endocochleaire veranderingen, blijken ook degeneratieve verschijnselen ter hoogte van het centraal auditieve systeem bij te dragen tot deze vorm van slechthorendheid. De huidige studie onderzoekt de effecten van veroudering op een aspect van centraal auditieve verwerking, met name binaurale verwerking. Binaurale verwerking werd in deze studie onderzocht aan de hand van auditief opgewekte hersenstampotentialen (ABR). Literatuur toont namelijk aan dat verschillen tussen de binaurale ABR en de som van de linker en rechter ABR gerelateerd zijn aan binaurale processen. Methodologie: De huidige studie onderzocht bovengenoemde verschillen in proefpersonen van jonge (n=14), middelbare (n=14) en oudere leeftijd (n=14). ABRs werden opgemeten door middel van akoestische stimulatie ter hoogte van het linkeroor, het recht...
Introduction: Bimodal hearing refers to the condition in which electrical hearing via a cochlear ... more Introduction: Bimodal hearing refers to the condition in which electrical hearing via a cochlear implant (CI) is combined with residual hearing in the non-implanted ear. Several studies demonstrate improvements in speech perception in noise and sound localization. However, the mechanisms underlying these benefits are still unclear. The goal of this study is to gain insight into the processing of simultaneously presented electrical and acoustical signals using auditory brainstem responses (ABRs). Methods: Seven bimodal listeners were included. The non-implanted ear was stimulated with 500 Hz tone-bursts; the implanted ear with biphasic pulses. Before starting the ABR recording, the electrical stimulation was loudness- and pitch-balanced to 500 Hz tone-bursts presented at 45 dB SL. Subsequently, ABRs were recorded in response to monaural acoustical, monaural electrical and bimodal stimulation. The bimodal ABRs were then compared to the monaural responses. Results: Electrical ABRs were...
International Journal of Audiology, 2019
Objective: Bimodal listeners vary in the amount of benefit they receive from wearing the contrala... more Objective: Bimodal listeners vary in the amount of benefit they receive from wearing the contralateral hearing aid. This may partially depend on the listener's auditory processing capacities. The current study explores whether the P300 event-related potential can provide insight into the mechanisms underlying the benefits of wearing a contralateral hearing aid. Design: P300s were recorded using an oddball paradigm with 500 and 250 Hz tone-bursts as standard and deviant stimuli, respectively. Subjects counted the number of deviantsa measure of performance. N2b latencies, P300 latencies, N2b-P300 amplitudes, and performance were assessed during CI-only and bimodal listening. Study sample: Five bimodal listeners. Results: P300s were present in four subjects. Amplitudes were larger during bimodal listening (bimodal: 22.3 ± 4.83 mV, CI-only: 13.1 ± 3.86 mV). Both N2b and P300 latencies were shorter during bimodal (N2b: 265 ± 20.0 ms, P300: 551 ± 129.4 ms) than CI-only listening (N2b: 326 ± 42.2 ms, P300: 402 ± 38.4 ms). While performance often reached ceiling level, the difference between the standard and deviant was generally more salient during bimodal listening. Conclusions: This study provides a proof-of-concept, suggesting that P300s may provide insight into benefits that are not always measurable with behavioural tasks.
B-ENT, 2014
describe the results of a retrospective study of cochlear implantation (CI) in seven subjects wit... more describe the results of a retrospective study of cochlear implantation (CI) in seven subjects with Menière's disease. The subjects received either the Nucleus CI24RE(CA)/CI512 or the Advanced Bionics HiRes90K CI systems which use the ACE, MP3000, or HiRes S Fidelity 120 coding strategies. The audiometric measures included monosyllabic word lists (NVA) in quiet at 65 dB SPL and sentences in noise (LIST) at +10 dB SNR. The quality of life after implantation was assessed by means of the Nijmegen Cochlear Implant Questionnaire (NCIQ). After CI, the hearing of all subjects improved significantly (p < 0.001) as did their speech recognition (p = 0.018). Speech recognition in noise showed a mean improvement of 47%. The results were less clear for the treatment of vertigo associated with Menière's, as some patients continued to have vestibular attacks after implantation. On the NCIQ, subjects reported a mean quality of life after CI of 48.3%. This study clearly demonstrates that c...
International Journal of Audiology, 1998
Evaluation of cochlear hearing loss by means of transiently evoked otoacoustic emissions is alrea... more Evaluation of cochlear hearing loss by means of transiently evoked otoacoustic emissions is already established in clinical practice. However, accurate prediction of pure-tone thresholds is still questioned and is still regarded as troublesome. Both click- and tone-burst-evoked otoacoustic emissions at several intensity levels were measured and analysed in 157 ears from normally hearing and 432 ears from patients with different degrees of pure sensory hearing loss using the ILO88/92 equipment. Results of otoacoustic emissions (OAE), elicited by clicks and tone-bursts at centre frequencies from 1 to 5 kHz, were analysed using two different statistical methods. Both multivariate discriminant analysis and forward multiple regression analysis were used to determine which OAE variables were most discriminating and best at predicting hearing thresholds. We found that a limited set of variables obtained from both tone-burst and click measurements can accurately predict and categorize hearing loss levels up to a limit of 60 dB HL. We found correct classification scores of pure-tone thresholds between 500 and 4000 Hz up to 100 per cent when using combined click and tone-burst otoacoustic measurements. Prediction of pure-tone thresholds was correct with a maximum estimation error of 10 dB for audiometric octave frequencies between 500 and 4000 Hz. Measurements of multiple tone-bursts OAEs have a significant clinical advantage over the use of clicks alone for clinical applications, and a good classification and prediction of pure-tone thresholds with otoacoustic emissions is possible.
Objectives: To investigate plasticity in the binaural auditory system in bimodal listeners. Backg... more Objectives: To investigate plasticity in the binaural auditory system in bimodal listeners. Background: Bimodal hearing refers to the condition in which electric hearing via a cochlear implant (CI) is combined with residual hearing in the non-implanted ear. Psychoacoustic research suggests that bimodal listeners can benefit from binaural integration. There is, however, an unexplained variability in bimodal outcome. It is hypothesized that at least some of this variability can be explained by plasticity. It is expected that binaural interaction develops with increasing bimodal experience. Furthermore, subjects who wore bilateral hearing aids may be more likely to binaurally integrate electric and acoustic signals. We believe that the binaural interaction component derived from the auditory brainstem response (ABR-BIC) can be a useful technique to measure plastic changes during the first months of bimodal hearing. Methods: ABR-BICs are computed by subtracting the binaural response fro...