Elsa Dinsdale - Academia.edu (original) (raw)

Papers by Elsa Dinsdale

The Journal of Clinical Endocrinology & Metabolism

Context Vitamin D has been linked with glucose and lipid metabolism. Men with impaired gonadal fu... more Context Vitamin D has been linked with glucose and lipid metabolism. Men with impaired gonadal function have a higher risk of metabolic syndrome and mortality, and vitamin D status may be a reversible modulator. Objective Determine the effect of daily vitamin D and calcium supplementation for 150 days on glucose and lipid homeostasis in infertile men. Design A single-center, double-blinded, randomized clinical trial (NCT01304927), 307 infertile men were randomized (1:1) to a single dose of 300,000 IU cholecalciferol followed by 1,400 IU cholecalciferol + 500 mg of calcium daily (n=151) or placebo (n=156) for 150 days. Reported metabolic parameters including fasting plasma glucose, HbA1c, fasting serum insulin, homeostatic model assessment of insulin resistance (HOMA-IR), fasting plasma cholesterols and triglyceride were secondary endpoints. The primary endpoint semen quality has previously been reported. Results Men receiving vitamin D supplementation improved their vitamin D status...

Nutritional Influences on Bone Health, 2016

International journal of environmental research and public health, 2016

Over the past decade, our research group has characterized and used a mouse model to demonstrate ... more Over the past decade, our research group has characterized and used a mouse model to demonstrate that "nutritional programming" of bone development occurs when mice receive soy isoflavones (ISO) during the first days of life. Nutritional programming of bone development can be defined as the ability for diet during early life to set a trajectory for better or compromised bone health at adulthood. We have shown that CD-1 mice exposed to soy ISO during early neonatal life have higher bone mineral density (BMD) and greater trabecular inter-connectivity in long bones and lumbar spine at young adulthood. These skeletal sites also withstand greater forces before fracture. Because the chemical structure of ISO resembles that of 17-β-estradiol and can bind to estrogen receptors in reproductive tissues, it was prudent to expand analyses to include measures of reproductive health. This review highlights aspects of our studies in CD-1 mice to understand the early life programming effe...

The Faseb Journal, Apr 1, 2011

Journal of Nutrition, 2011

Soy-based infant formula (SBIF) can be a substantial source of soy isoflavones during early life.... more Soy-based infant formula (SBIF) can be a substantial source of soy isoflavones during early life. Because soy isoflavones have the capacity to mimic endogenous estrogen and thereby exert hormone-like effects, there is concern regarding reproductive health. The objectives were to determine if neonatal exposure to soy isoflavones altered reproductive health in females and, if so, whether such effects are transferred to subsequent generations. CD-1 mice were bred and F1 mouse offspring were cross-fostered at birth and randomized to 1 of 4 treatments: 7 mg soy isoflavones · kg body weight(-1) · d(-1) or corn oil from postnatal d (PND) 1 to 10 or from PND 1 to 21 (n = 8-13 females/group). Mice were subsequently bred to control males on PND 56 to obtain F2 females (n = 10-15/group). F1 mice that received isoflavones had ~15% greater body weight during wk 4-8 and markedly reduced fertility with a 55-60% success rate. Reduced fertility was associated with abnormal estrus cycles, fewer corpora lutea in ovaries, and increased incidence of hyperplasia and atypia in the uteri. Offspring (F2 mice) of isoflavone-treated F1 mice had ~15% higher body weight by wk 8 through 16 of age than controls and fertility was normal. In summary, early exposure to soy isoflavones resulting in serum isoflavone concentrations similar to human infants fed SBIF reduced fertility in F1 but not F2 mice and increased body weight in both generations of female offspring. Extrapolation of these findings to the human scenario are complex but can provide guidance for more fully understanding the implications for infants consuming SBIF.

Journal of Developmental Origins of Health and Disease, 2012

ABSTRACT Exposure to isoflavones (ISO), abundant in soy protein infant formula, for the first 5 d... more ABSTRACT Exposure to isoflavones (ISO), abundant in soy protein infant formula, for the first 5 days of life results in higher bone mineral density (BMD), greater trabecular connectivity and higher peak load of lumbar vertebrae (LV) at adulthood. The effect of lengthening the duration of exposure to ISO on bone development has not been studied. This study determined if providing ISO for the first 21 days of life, which more closely mimics the duration that infants are fed soy protein formula, results in higher BMD, improved bone structure and greater strength in femurs and LV than a 5-day protocol. Female CD-1 mice were randomized to subcutaneous injections of ISO (7 mg/kg body weight/day) or corn oil from postnatal day 1 to 21. BMD, structure and strength were measured at the femur and LV at 4 months of age, representing young adulthood. At the LV, exposure to ISO resulted in higher (P < 0.05) BMD, trabecular connectivity and peak load compared with control (CON). Exposure to ISO also resulted in higher (P < 0.05) whole femur BMD, higher (P < 0.05) bone volume/total volume and lower (P < 0.05) trabecular separation at the femur neck, as well as greater (P < 0.05) peak load at femur midpoint and femur neck compared with the CON group. Exposure to ISO throughout suckling has favorable effects on LV outcomes, and, unlike previous studies using 5-day exposure to ISO, femur outcomes are also improved. Duration of exposure should be considered when using the CD-1 mouse to model the effect of early life exposure of infants to ISO.

Acta Paediatrica, 2015

Necrotising enterocolitis (NEC) is associated with high morbidity and mortality. The aim of this ... more Necrotising enterocolitis (NEC) is associated with high morbidity and mortality. The aim of this study was to identify predictors of intestinal failure (IF), morbidity and mortality following NEC. We performed a retrospective study of all neonates treated for NEC stage II or greater at a tertiary referral NICU between 2000 and 2009. Demographic data, need for surgery, residual bowel length and rates of bacteraemia, cholestasis, IF and mortality were analysed. During the 10-year period, 301 patients were referred with NEC and 152 had surgical intervention. Overall mortality was 32%. Of the 230 infants who survived >42 days, 97 (42%) had IF at 42 days, decreasing to 15% at >90 days. The rate of IF was significantly higher in the surgical group than the medical group (OR 2.04, 95% CI, 1.25 - 3.35, p<0.004), but 23% of the medically treated infants with NEC also developed IF. There was a significant relationship between IF and gram-negative bacteraemia, the need for surgery, cholestasis, liver failure and mortality. Intestinal failure occurred in a significant proportion of infants with NEC. Predictors for IF among infants with NEC were low birth weight, low gestational age, need for surgical intervention and gram-negative bacteraemia. This article is protected by copyright. All rights reserved.

The Journal of Clinical Endocrinology & Metabolism

Context Vitamin D has been linked with glucose and lipid metabolism. Men with impaired gonadal fu... more Context Vitamin D has been linked with glucose and lipid metabolism. Men with impaired gonadal function have a higher risk of metabolic syndrome and mortality, and vitamin D status may be a reversible modulator. Objective Determine the effect of daily vitamin D and calcium supplementation for 150 days on glucose and lipid homeostasis in infertile men. Design A single-center, double-blinded, randomized clinical trial (NCT01304927), 307 infertile men were randomized (1:1) to a single dose of 300,000 IU cholecalciferol followed by 1,400 IU cholecalciferol + 500 mg of calcium daily (n=151) or placebo (n=156) for 150 days. Reported metabolic parameters including fasting plasma glucose, HbA1c, fasting serum insulin, homeostatic model assessment of insulin resistance (HOMA-IR), fasting plasma cholesterols and triglyceride were secondary endpoints. The primary endpoint semen quality has previously been reported. Results Men receiving vitamin D supplementation improved their vitamin D status...

Nutritional Influences on Bone Health, 2016

International journal of environmental research and public health, 2016

Over the past decade, our research group has characterized and used a mouse model to demonstrate ... more Over the past decade, our research group has characterized and used a mouse model to demonstrate that "nutritional programming" of bone development occurs when mice receive soy isoflavones (ISO) during the first days of life. Nutritional programming of bone development can be defined as the ability for diet during early life to set a trajectory for better or compromised bone health at adulthood. We have shown that CD-1 mice exposed to soy ISO during early neonatal life have higher bone mineral density (BMD) and greater trabecular inter-connectivity in long bones and lumbar spine at young adulthood. These skeletal sites also withstand greater forces before fracture. Because the chemical structure of ISO resembles that of 17-β-estradiol and can bind to estrogen receptors in reproductive tissues, it was prudent to expand analyses to include measures of reproductive health. This review highlights aspects of our studies in CD-1 mice to understand the early life programming effe...

The Faseb Journal, Apr 1, 2011

Journal of Nutrition, 2011

Soy-based infant formula (SBIF) can be a substantial source of soy isoflavones during early life.... more Soy-based infant formula (SBIF) can be a substantial source of soy isoflavones during early life. Because soy isoflavones have the capacity to mimic endogenous estrogen and thereby exert hormone-like effects, there is concern regarding reproductive health. The objectives were to determine if neonatal exposure to soy isoflavones altered reproductive health in females and, if so, whether such effects are transferred to subsequent generations. CD-1 mice were bred and F1 mouse offspring were cross-fostered at birth and randomized to 1 of 4 treatments: 7 mg soy isoflavones · kg body weight(-1) · d(-1) or corn oil from postnatal d (PND) 1 to 10 or from PND 1 to 21 (n = 8-13 females/group). Mice were subsequently bred to control males on PND 56 to obtain F2 females (n = 10-15/group). F1 mice that received isoflavones had ~15% greater body weight during wk 4-8 and markedly reduced fertility with a 55-60% success rate. Reduced fertility was associated with abnormal estrus cycles, fewer corpora lutea in ovaries, and increased incidence of hyperplasia and atypia in the uteri. Offspring (F2 mice) of isoflavone-treated F1 mice had ~15% higher body weight by wk 8 through 16 of age than controls and fertility was normal. In summary, early exposure to soy isoflavones resulting in serum isoflavone concentrations similar to human infants fed SBIF reduced fertility in F1 but not F2 mice and increased body weight in both generations of female offspring. Extrapolation of these findings to the human scenario are complex but can provide guidance for more fully understanding the implications for infants consuming SBIF.

Journal of Developmental Origins of Health and Disease, 2012

ABSTRACT Exposure to isoflavones (ISO), abundant in soy protein infant formula, for the first 5 d... more ABSTRACT Exposure to isoflavones (ISO), abundant in soy protein infant formula, for the first 5 days of life results in higher bone mineral density (BMD), greater trabecular connectivity and higher peak load of lumbar vertebrae (LV) at adulthood. The effect of lengthening the duration of exposure to ISO on bone development has not been studied. This study determined if providing ISO for the first 21 days of life, which more closely mimics the duration that infants are fed soy protein formula, results in higher BMD, improved bone structure and greater strength in femurs and LV than a 5-day protocol. Female CD-1 mice were randomized to subcutaneous injections of ISO (7 mg/kg body weight/day) or corn oil from postnatal day 1 to 21. BMD, structure and strength were measured at the femur and LV at 4 months of age, representing young adulthood. At the LV, exposure to ISO resulted in higher (P < 0.05) BMD, trabecular connectivity and peak load compared with control (CON). Exposure to ISO also resulted in higher (P < 0.05) whole femur BMD, higher (P < 0.05) bone volume/total volume and lower (P < 0.05) trabecular separation at the femur neck, as well as greater (P < 0.05) peak load at femur midpoint and femur neck compared with the CON group. Exposure to ISO throughout suckling has favorable effects on LV outcomes, and, unlike previous studies using 5-day exposure to ISO, femur outcomes are also improved. Duration of exposure should be considered when using the CD-1 mouse to model the effect of early life exposure of infants to ISO.

Acta Paediatrica, 2015

Necrotising enterocolitis (NEC) is associated with high morbidity and mortality. The aim of this ... more Necrotising enterocolitis (NEC) is associated with high morbidity and mortality. The aim of this study was to identify predictors of intestinal failure (IF), morbidity and mortality following NEC. We performed a retrospective study of all neonates treated for NEC stage II or greater at a tertiary referral NICU between 2000 and 2009. Demographic data, need for surgery, residual bowel length and rates of bacteraemia, cholestasis, IF and mortality were analysed. During the 10-year period, 301 patients were referred with NEC and 152 had surgical intervention. Overall mortality was 32%. Of the 230 infants who survived >42 days, 97 (42%) had IF at 42 days, decreasing to 15% at >90 days. The rate of IF was significantly higher in the surgical group than the medical group (OR 2.04, 95% CI, 1.25 - 3.35, p<0.004), but 23% of the medically treated infants with NEC also developed IF. There was a significant relationship between IF and gram-negative bacteraemia, the need for surgery, cholestasis, liver failure and mortality. Intestinal failure occurred in a significant proportion of infants with NEC. Predictors for IF among infants with NEC were low birth weight, low gestational age, need for surgical intervention and gram-negative bacteraemia. This article is protected by copyright. All rights reserved.