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Papers by ELIJAH OLADAPO OYINLOYE

Research paper thumbnail of Evaluation of phytochemical constituents, total phenolic contents and in vitro antioxidant activities of Mucuna pruriens fractions leaves

Journal of Phytomedicine and Therapeutics, Jun 28, 2023

Research paper thumbnail of Protective role of dichloromethane extract of solanum dasyphyllumin in gentamicin induced nephrotoxicity in mice

ACTA Pharmaceutica Sciencia, 2020

Gentamicin belong to the aminoglycoside antibiotic, which has a broad spectrum activities against... more Gentamicin belong to the aminoglycoside antibiotic, which has a broad spectrum activities against gram positive and gram negative bacteria, but most effective in the treatment of gram negative bacteria. Gentamicin can withstand ABSTRACT This study investigated the effect of dichloromethane extract of Solanum dasyphyllum on gentamicin-induced nephrotoxicity in mice. Thirty mice were randomly divided into six groups (Groups 1-6, 5 each). Nephrotoxicity was induced using 100 mg/kg gentamicin administered intraperitoneally with concomitant administration of different doses of dichloromethane Solanum dasyphyllum extract (SdDMF) (100, 200, and 400mg/kg respectively) orally for 8 days. After the treatment, blood samples were obtained, allowed to clot, and centrifuged to obtain the serum which was used to determine urea, creatinine, and blood urea nitrogen (BUN). Kidney tissue malondialdehyde (MDA) and glutathione (GSH) concentrations; and catalase (CAT) activities were also determined. Result revealed a decrease in tissue MDA, serum creatinine, urea, and BUN in the extract-treated groups. Also, increased tissue CAT activities and GSH concentrations were observed in the extract-treated groups. In conclusion, this study showed that SdDMF can be reno-protective and effectively inhibit gentamicin-induced nephrotoxicity.

Research paper thumbnail of Citrus aurantifolia (Chrism.) Swingle Peel Extract attenuate nephrotoxicity induced by doxorubicin

Pharmacological research. Modern Chinese medicine, Mar 1, 2024

Research paper thumbnail of Evaluation of phytochemical constituents, total phenolic contents and in vitro antioxidant activities of Mucuna pruriens fractions leaves

Journal of Phytomedicine and Therapeutics

Mucuna pruriens is a tropical annual climbing legume plant used in traditional medicine systems t... more Mucuna pruriens is a tropical annual climbing legume plant used in traditional medicine systems to treat diabetes, arthritis, dysentery, hematinics, inflammation, and cardiovascular conditions. The present study investigates the phytochemical constituents, phenolic contents and in vitro, antioxidant potentials of M. pruriens leaf fractions using spectrophotometric methods. Phytochemical screening of hexane, chloroform, ethyl acetate, and methanol fractions of M. pruriens was determined using standard methods. The antioxidant activities of the fractions were assessed against total phenolic contents, total antioxidant contents, ferric ion reducing antioxidant power assay, and 1,1-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity using standard protocols. Phytochemical screening showed that only the ethyl acetate fraction of M. pruriens leaves contain all the phytochemical constituents tested for, saponins, tannins, flavonoids, cardiac glycosides, anthraquinones, terpenoids, steroid...

Research paper thumbnail of Toxicological evaluation of hydroethanol leaf extract of Pupalia lappacea (Linn.) Juss. (Amaranthaceae) in rodents

Drug Metabolism and Personalized Therapy

Objectives Several studies have established the ethnobotanical benefits of Pupalia lappacea (PL) ... more Objectives Several studies have established the ethnobotanical benefits of Pupalia lappacea (PL) in laboratory animals without extensive toxicological evaluation of its safety profiles. Thus, an extensive toxicological investigation of sub-chronic oral administration of the hydroethanol leaf extract of P. lappacea in rodents was carried out in this study. Methods Different groups of rats were treated orally with the extract (10, 50 and 250 mg/kg) daily for 90 consecutive days. The control group received distilled water (10 mL/kg). After 90 days, some rats were left for additional 30 days without treatment for reversibility study. Blood and organs samples were collected for different evaluations at the end of study periods. Results The extract decreased the bodyweights, feeding and water intakes in female rats. PL increased the weights of the liver and kidney in male rats. PL increased the red blood cell (RBC), packed cell volume (PCV), hemoglobin (Hb), triglycerides (TRIG), choleste...

Research paper thumbnail of Hypolipidaemic Potentials of Vernonia amygdalina (Bitter Leaf) in male albino rats fed high-sucrose diet

Background: Increasing prevalence of obesity, overweight and metabolic syndrome secondary to exce... more Background: Increasing prevalence of obesity, overweight and metabolic syndrome secondary to excessive consumption of a high-sucrose and high-fat diet is a major global health problem. Objective: This study was meant to determine the h ypolipidaemic potentials of phytochemicals present in Vernonia amygdalina (Bitter leaf) in obese rats . Method: Thirty-two (6 weeks old, weighing 150-160g) male Wistar rats, were randomly selected and grouped into four: with eight rats in each group. The rats in the control group were fed normal rat chow and water while the three experimental groups were fed the various compounded diets and water ad libitum . At the end of 12th week, the animals fasted overnight, and Oral Glucose Tolerance Test (OGTT) was performed in some while others were anaesthetized using diethyl ether. Fasting plasma, liver tissue lipid and lipoprotein levels were determined, and LDL-C was calculated. Result: Rapid weight gain (89.9%) was recorded in rats fed High Sucrose Diet [...

Research paper thumbnail of Evaluation of phytochemical constituents, total phenolic contents and in vitro antioxidant activities of Mucuna pruriens fractions leaves

Journal of Phytomedicine and Therapeutics, Jun 28, 2023

Research paper thumbnail of Protective role of dichloromethane extract of solanum dasyphyllumin in gentamicin induced nephrotoxicity in mice

ACTA Pharmaceutica Sciencia, 2020

Gentamicin belong to the aminoglycoside antibiotic, which has a broad spectrum activities against... more Gentamicin belong to the aminoglycoside antibiotic, which has a broad spectrum activities against gram positive and gram negative bacteria, but most effective in the treatment of gram negative bacteria. Gentamicin can withstand ABSTRACT This study investigated the effect of dichloromethane extract of Solanum dasyphyllum on gentamicin-induced nephrotoxicity in mice. Thirty mice were randomly divided into six groups (Groups 1-6, 5 each). Nephrotoxicity was induced using 100 mg/kg gentamicin administered intraperitoneally with concomitant administration of different doses of dichloromethane Solanum dasyphyllum extract (SdDMF) (100, 200, and 400mg/kg respectively) orally for 8 days. After the treatment, blood samples were obtained, allowed to clot, and centrifuged to obtain the serum which was used to determine urea, creatinine, and blood urea nitrogen (BUN). Kidney tissue malondialdehyde (MDA) and glutathione (GSH) concentrations; and catalase (CAT) activities were also determined. Result revealed a decrease in tissue MDA, serum creatinine, urea, and BUN in the extract-treated groups. Also, increased tissue CAT activities and GSH concentrations were observed in the extract-treated groups. In conclusion, this study showed that SdDMF can be reno-protective and effectively inhibit gentamicin-induced nephrotoxicity.

Research paper thumbnail of Citrus aurantifolia (Chrism.) Swingle Peel Extract attenuate nephrotoxicity induced by doxorubicin

Pharmacological research. Modern Chinese medicine, Mar 1, 2024

Research paper thumbnail of Evaluation of phytochemical constituents, total phenolic contents and in vitro antioxidant activities of Mucuna pruriens fractions leaves

Journal of Phytomedicine and Therapeutics

Mucuna pruriens is a tropical annual climbing legume plant used in traditional medicine systems t... more Mucuna pruriens is a tropical annual climbing legume plant used in traditional medicine systems to treat diabetes, arthritis, dysentery, hematinics, inflammation, and cardiovascular conditions. The present study investigates the phytochemical constituents, phenolic contents and in vitro, antioxidant potentials of M. pruriens leaf fractions using spectrophotometric methods. Phytochemical screening of hexane, chloroform, ethyl acetate, and methanol fractions of M. pruriens was determined using standard methods. The antioxidant activities of the fractions were assessed against total phenolic contents, total antioxidant contents, ferric ion reducing antioxidant power assay, and 1,1-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity using standard protocols. Phytochemical screening showed that only the ethyl acetate fraction of M. pruriens leaves contain all the phytochemical constituents tested for, saponins, tannins, flavonoids, cardiac glycosides, anthraquinones, terpenoids, steroid...

Research paper thumbnail of Toxicological evaluation of hydroethanol leaf extract of Pupalia lappacea (Linn.) Juss. (Amaranthaceae) in rodents

Drug Metabolism and Personalized Therapy

Objectives Several studies have established the ethnobotanical benefits of Pupalia lappacea (PL) ... more Objectives Several studies have established the ethnobotanical benefits of Pupalia lappacea (PL) in laboratory animals without extensive toxicological evaluation of its safety profiles. Thus, an extensive toxicological investigation of sub-chronic oral administration of the hydroethanol leaf extract of P. lappacea in rodents was carried out in this study. Methods Different groups of rats were treated orally with the extract (10, 50 and 250 mg/kg) daily for 90 consecutive days. The control group received distilled water (10 mL/kg). After 90 days, some rats were left for additional 30 days without treatment for reversibility study. Blood and organs samples were collected for different evaluations at the end of study periods. Results The extract decreased the bodyweights, feeding and water intakes in female rats. PL increased the weights of the liver and kidney in male rats. PL increased the red blood cell (RBC), packed cell volume (PCV), hemoglobin (Hb), triglycerides (TRIG), choleste...

Research paper thumbnail of Hypolipidaemic Potentials of Vernonia amygdalina (Bitter Leaf) in male albino rats fed high-sucrose diet

Background: Increasing prevalence of obesity, overweight and metabolic syndrome secondary to exce... more Background: Increasing prevalence of obesity, overweight and metabolic syndrome secondary to excessive consumption of a high-sucrose and high-fat diet is a major global health problem. Objective: This study was meant to determine the h ypolipidaemic potentials of phytochemicals present in Vernonia amygdalina (Bitter leaf) in obese rats . Method: Thirty-two (6 weeks old, weighing 150-160g) male Wistar rats, were randomly selected and grouped into four: with eight rats in each group. The rats in the control group were fed normal rat chow and water while the three experimental groups were fed the various compounded diets and water ad libitum . At the end of 12th week, the animals fasted overnight, and Oral Glucose Tolerance Test (OGTT) was performed in some while others were anaesthetized using diethyl ether. Fasting plasma, liver tissue lipid and lipoprotein levels were determined, and LDL-C was calculated. Result: Rapid weight gain (89.9%) was recorded in rats fed High Sucrose Diet [...