E. Lachambre - Academia.edu (original) (raw)

Papers by E. Lachambre

Archives de Pédiatrie, 2015

Archives de Pédiatrie, 2014

Journal of Pediatric Gastroenterology and Nutrition, 2004

Archives de Pédiatrie, 2012

Lactose has beneficial nutritional effects in infancy, particularly on calcium retention and on B... more Lactose has beneficial nutritional effects in infancy, particularly on calcium retention and on Bifidobacterium colon microflora development. The objective of this controlled, prospective, randomized double-blind study was to assess the adequacy and safety of an infant formula containing only lactose as carbohydrate, as compared to a usual formula. Healthy non-breast-fed infants aged under 7 days were randomized to be fed exclusively with a conventional formula containing lactose (9.6 g/100 kcal) and maltodextrin (1.6 g/100 kcal) or the isocaloric-isoprotein study formula containing 100% lactose (11.2 g/100 kcal) for 120 days. Primary outcome was daily weight gain at D0 and D120. Weight, length, body mass index, formula consumption, tolerance, and safety were assessed monthly. The non-inferiority of the study formula was rejected if the difference in weight gain was higher than 2.5 g/day in the control group. One hundred and seventy-eight infants were enrolled. Mean daily weight gain in the study group differed by 0.71 g/day (95% CI: -2.23; 0.82) indicating the non-inferiority of the study formula. Growth was normal and similar in the two groups, but formula intake was decreased in the study group, leading to a decrease in energy and protein intakes. Tolerance was good and adverse events did not differ between the two groups. The 100% lactose study infant formula was safe and non-inferior to a conventional formula in ensuring normal growth during the first 4 months of life.

Archives de Pédiatrie, 2008

Objectif -20 à 50 % des nourrissons présentent des régurgitations ; à l'âge d'un an 5 % en souffr... more Objectif -20 à 50 % des nourrissons présentent des régurgitations ; à l'âge d'un an 5 % en souffrent encore, celles-ci peuvent alors être évocatrices de RGO (Refl ux Gastro-Oesophagien). Nous avions observé dans un travail précédent qu'une préparation infantile contenant 2g d'amidon pour 100mL chez des nourrissons de moins de 3 mois présentant des régurgitations permettait une diminution rapide de la fréquence des régurgitations et une persistance de l'effet dans le temps. L'objectif de cette étude observationnelle était de suivre ces mêmes nourrissons, ayant bénéfi cié d'une prise en charge diététique pour régurgitations durant 1 mois, jusqu'à l'âge d'un an et d'évaluer la persistance des régurgitations et leur étiologie. Patients et Méthodes -Les nourrissons avaient au préalable été inclus dans une étude ouverte et multicentrique. Ces enfants devaient avoir moins de 3 mois au moment de l'inclusion et présenter des régurgitations. Ils ont reçu un lait infantile épaissi à l'amidon (2g/100mL) et contenant des lipides structurés durant 30 jours consécutifs, à l'issue desquels la fréquence des régurgitations avaient diminué de plus de 50 %. L'évolution des régurgitations a ensuite été évaluée dans le cadre d'une visite à l'âge d'un an. Résultats -52 nourrissons ont été revus à l'âge de 12,09 (+/-0.51) mois. Ils étaient tous diversifi és depuis l'âge de 5.51 (+/-0.69) mois et la moitié de la population avait déjà effectué ses premiers pas. 8 nourrissons ont pris un traitement médicamenteux anti-refl ux pour RGO suite à la première étude, mais sans qu'aucune exploration n'ait été réalisée. Seuls 4 nourrissons (soit 8 %) régurgitaient encore à l'âge d'un an, dont deux présentaient un score de « Vandenplas » d'une valeur de 2 (sur une échelle de 0 à 6, le score 0 correspondant à « pas de régurgitation » et le score 6 à « régurgitation complète à la fi n de chaque repas ») et deux d'une valeur de 1. Conclusion -Cette première étude observationnelle a permis de confi rmer la possible persistance chez certains nourrissons jusqu'à l'âge d'un an de régurgitations, sans diagnostic de RGO. Ce travail invite à recommander la réalisation d'études avec un suivi prolongé afi n de mieux évaluer l'effet de la prise en charge diététique et médicamenteuse et l'épidémiologie en termes d'exploration.

Archives de Pédiatrie, 2009

Objectives. The purpose of this open multicenter study was to evaluate the value of a new starch-... more Objectives. The purpose of this open multicenter study was to evaluate the value of a new starch-thickened formula in infants with regurgitations in ambulatory pediatric practice. Population and methods. The study population comprised fullterm infants with an age at inclusion of 1-90 days, who were bottlefed and presented regurgitations. The formula tested was an infant formula-thickened with starch (2 g/100 mL). The primary endpoint was the frequency of bottles regurgitated, expressed in percentage of meals per day after 15 days of feeding with the preparation studied. Secondary endpoints were the assessment of regurgitations using the Vandenplas' score, as well as the daily increase in weight, height, and cranial circumference, overall and gastrointestinal tolerance, and formula acceptability. Results. Sixty-four infants presenting regurgitation were included. The frequency of bottles regurgitated estimated at 80.3% at inclusion significantly decreased at D3, D15, and D30 to 40.1, 40.2 and 37.2% (P < 0.0001), respectively. Thirty percent of infants did not present regurgitations at all at D30. Similarly, a significant decrease in the Vandenplas' score was observed from 1.9 at D0 to 0.9 at D30 (P < 0.0001). Infant growth was similar to the French and European growth curves. Conclusion. The results showed rapid and lasting improvement in decreasing the frequency of feeding-bottles regurgitated by 50% from the first 3 days of using this new starch-thickened formula (2 g/100 mL). These satisfying results encourage the use of the tested formula in cases of infant regurgitation, in line with the Résumé

Archives de Pédiatrie, 2006

ABSTRACT Besides assuring growth and development in early infancy, human breast milk plays a key ... more ABSTRACT Besides assuring growth and development in early infancy, human breast milk plays a key role in preventing infections, in particular by favouring the growth of bifidobacteria. The development of infant formulas containing probiotic agents consequently represents a significant advance in the provision of an optimal alternative to breast feeding when this is not feasible. A further concern is to avoid an excessively high protein content relative to breast milk, potentially favouring obesity in later life. The objective of this open Multicenter comparative study was to demonstrate that a new infant formula, characterized by a reduced protein content and the presence of a probiotic agent, was as effective as conventional formulas in assuring growth during the first months of life. The study population comprised full-term healthy infants with an age at inclusion of 1-28 days, whose mothers no longer wished to continue breast feeding or were unable to breast feed. The test formula (GE), enriched with Bifidobacterium lactis, had a protein content of 1.5 g/100 ml. The primary end point was daily weight gain from day 0 to day 90. Secondary end points were daily increase in height and cranial circumference, overall and gastrointestinal tolerance and formula acceptability. A total of 203 infants were included in the analysis, 117 receiving GE and 86 the formula habitually prescribed by the paediatrician. Daily gains in weight, height and cranial circumference did not differ significantly between the groups. The rates of overall and gastrointestinal adverse events were comparable in the two groups and the acceptability of GE was consistently good, similar to that of the standard formulas. The results of this study demonstrated that the new probiotic infant formula GE has equivalent efficacy to conventional formulas in achieving growth in early infancy, and is well tolerated.

Pediatric Research, 2011

Background: Significant reduction of necrotizing enterocolitis (NEC) and mortality rate has been ... more Background: Significant reduction of necrotizing enterocolitis (NEC) and mortality rate has been recently reported in preterm infants supplemented with oral probiotics.