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Papers by E. Perissinotto

Research paper thumbnail of The prevalence of chondrocalcinosis in elderly people and its association with osteoarthritis and osteoporosis: The Prova study from northeastern Italy (Venetian)

Research paper thumbnail of Cancer incidence among male military and civil pilots and flight attendants: an analysis on published data

Toxicology and Industrial Health, 2005

Flight personnel are exposed to cosmic ionizing radiation, chemicals (fuel, jet engine exhausts, ... more Flight personnel are exposed to cosmic ionizing radiation, chemicals (fuel, jet engine exhausts, cabin air pollutants), electromagnetic fields from cockpit instruments, and disrupted sleep patterns. Only recently has cancer risk among these workers been investigated. With the aim of increasing the precision of risk estimates of cancer incidence, follow-up studies reporting a standardized incidence ratio for cancer among male flight attendants, civil and military pilots were obtained from online databases and analysed. A meta-analysis was performed by applying a random effect model, obtaining a meta-standardized incidence ratio (SIR), and 95% confidence interval (CI). In male cabin attendants, and civil and military pilots, meta-SIRs were 3.42 (CI = 1.94-6.06), 2.18 (1.69-2.80), 1.43 (1.09-1.87) for melanoma; and 7.46 (3.52-15.89), 1.88 (1.23-2.88), 1.80 (1.25-2.58) for other skin cancer, respectively. These tumors share as risk factors, ionizing radiation, recreational sun exposure and socioeconomic status. The meta-SIRs are not adjusted for confounding; the magnitude of risk for melanoma decreased when we corrected for socioeconomic status. In civil pilots, meta-SIR was 1.47 (1.06-2.05) for prostate cancer. Age (civil pilots are older than military pilots and cabin attendants) and disrupted sleep pattern (entailing hyposecretion of melatonin, which has been reported to suppress proliferative effects of androgen on prostate cancer cells) might be involved. In male cabin attendants, meta-SIR was 21.5 (2.25-205.8) for Kaposi's sarcoma and 2.49 (1.03-6.03) for non-Hodgkin's lymphoma. AIDS, which was the most frequent single cause of death in this occupational category, likely explains the excess of the latter two tumors.

Research paper thumbnail of Parkinson's disease and parkinsonism in a longitudinal study: Two-fold higher incidence in men

Neurology, 2000

al. Stimulation of highaffinity adenosine A 2 receptors decreases the affinity of dopamine D 2 re... more al. Stimulation of highaffinity adenosine A 2 receptors decreases the affinity of dopamine D 2 receptors in rat striatal membranes. Proc Natl Acad Sci USA 1991;88:7238 -7241. 37. Ledent C, Vaugeois J-M, Schiffmann SN, et al. Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A sub 2a receptor. Nature 1997;388:674 -678. 38. Hellenbrand W, Boeing H, Robra B-P, et al. Diet and Parkinson's disease II: a possible role for the past intake of specific nutrients: results from a self-administered food-frequency questionnaire in a case-control study. Neurology 1996;47:644 -650. 39. Sackett DL. Bias in analytic research. J Chronic Dis 1979;32: 51-63. 40. Morens DM, Grandinetti A, Davis JW, et al. Evidence against the operation of selective mortality in explaining the association between cigarette smoking and reduced occurrence of idiopathic Parkinson disease. Am J Epidemiol 1996;144:400 -404. 41. Ellenberg JH. Differential postmorbidity mortality in observational studies of risk factors for neurologic disorders.

Research paper thumbnail of Cancer Incidence among Female Flight Attendants: A Meta-Analysis of Published Data

Journal of Women's Health, 2006

Background: Flight attendants are exposed to cosmic ionizing radiation and other potential cancer... more Background: Flight attendants are exposed to cosmic ionizing radiation and other potential cancer risk factors, but only recently have epidemiological studies been performed to assess the risk of cancer among these workers. The aim of the present work was to evaluate the incidence of various types of cancer among female cabin attendants by combining cancer incidence estimates reported in published studies.

Research paper thumbnail of Body Mass Index as a Predictor of All-Cause Mortality in Nursing Home Residents During a 5-Year Follow-up

Journal of the American Medical Directors Association, 2013

Body mass index (BMI) is considered a short-term mortality predictor, but a consensus has not bee... more Body mass index (BMI) is considered a short-term mortality predictor, but a consensus has not been reached on its role and that of other nutritional parameters in predicting long-term mortality in nursing home residents. To correlate BMI, Mini Nutritional Assessment scores, and serum albumin levels with the 5-year mortality rate in institutionalized elderly subjects. A total of 181 nursing home residents aged ≥ 70 years were included in a 5-year longitudinal study. Data were collected on all participants' nutritional, health, cognitive, and functional status by means of a comprehensive geriatric assessment. Data on the participants' vital status were obtained 5 years after beginning the study, and a survival analysis was conducted using Kaplan-Meier curves and multivariate Cox proportional hazards models. The 5-year mortality rate was 63%. The deceased subjects (n = 115) had a lower BMI (24.7 ± 4.6 vs 26.6 ± 5.0 kg/m(2); P = .03) and Mini Nutritional Assessment score (18.6 ± 3.7 vs 20.1 ± 3.6; P = .02) than those still alive. Serum albumin levels did not differ between the two groups. Among the three indicators of nutritional status considered in this study, only BMI ≥ 30 kg/m(2) was significantly associated with a lower mortality risk at 5 years (hazard ratio = 0.432; 95% CI 0.20-0.70; P = .04), the risk for death being greater the lower the BMI class (log-rank test: P < .001). Our findings suggest that BMI is the best of the three parameters considered as a nutritional predictor of nursing home residents' mortality in the longer term, and indicate that a lower mortality risk coincides with a higher BMI.

Research paper thumbnail of 465 CAN WE SAFELY USE DONOR LIVERS WITH STEATOSIS IN HCV-POSITIVE RECIPIENTS?

Journal of Hepatology, 2009

Pegboard), executive function (Hooper) and memory (Auditory Verbal Learning). Results: 1. Short-t... more Pegboard), executive function (Hooper) and memory (Auditory Verbal Learning). Results: 1. Short-term post-LTx: The VV (cm3) increased by 8%. Fourteen patients exhibited FWML that decreased the volume by 20%, which can be explained by reversible brain edema in this areas. Neuropsychological tests improved indicating reversal of minimal hepatic encephalopathy. 2. Long-term post-LTx: The VV increased by 60% and the volume of FWML increased by 25%. Neuropsychological tests remained stable, except for memory that showed deterioration. Changes in VV or FWML were not associated with prior HE. Among patients with larger changes in FWML (>15%) pharmacological treatment for arterial hypertension was more common (88% vs. 33%, p = 0.05) and creatinine tended to be higher (1.37±0.21 vs. 1.19±0.15 mg/dl, p = 0.06). Conclusion: Following LTx patients develop a decrease in brain volume despite a successful outcome of liver function. The initial decrease probably reflects disappearance of brain edema related to HE. The decrease at long-term is part of a degenerative process in part caused by small-vessel cerebrovascular disease. Adequate control of vascular risk factors appears critical to prevent neurological deterioration following LTx.

Research paper thumbnail of P.161 SELF-REPORTED ADHERENCE TO MEDICAL REGIMEN BEFORE AND AFTER LIVER TRANSPLANTATION (LT)

Digestive and Liver Disease, 2010

Research paper thumbnail of Telomere shortening in mucosa surrounding the tumor: Biosensor of field cancerization and prognostic marker of mucosal failure in head and neck squamous cell carcinoma

Oral Oncology, 2015

Field cancerization Head and neck cancer Human papilloma virus Local relapse Molecular biology Su... more Field cancerization Head and neck cancer Human papilloma virus Local relapse Molecular biology Survival Telomerase reverse transcriptase Telomeres TERT s u m m a r y Objectives: The aim of the present study was to investigate the pattern of telomere length and telomerase expression in cancer tissues and the surrounding mucosa (SM), as markers of field cancerization and clinical outcome in patients successfully treated for with head and neck squamous cell carcinoma (HNSCC). Materials and methods: This investigation was a prospective cohort study. Telomere length and levels of telomerase reverse transcriptase (TERT) transcripts were quantified by real-time PCR in cancer tissues and SM from 139 and 90 patients with HNSCC, respectively. Results: No correlation was found between age and telomere length in SM. Patients with short telomeres in SM had a higher risk of mucosal failure (adjusted HR = 4.29). Patients with high TERT levels in cancer tissues had a higher risk of regional failure (HR = 2.88), distant failure (HR = 7.27), worse disease-specific survival (HR for related death = 2.62) but not mucosal failure. High-risk patients having both short telomeres in SM and high levels of TERT in cancer showed a significantly lower overall survival (HR = 2.46). Conclusions: Overall these findings suggest that telomere shortening in SM is a marker of field cancerization and may precede reactivation of TERT. Short telomeres in SM are strongly prognostic of mucosal failure, whereas TERT levels in cancer tissues increase with the aggressiveness of the disease and are prognostic of tumor spread.

Research paper thumbnail of The prevalence of chondrocalcinosis in elderly people and its association with osteoarthritis and osteoporosis: The Prova study from northeastern Italy (Venetian)

Research paper thumbnail of Cancer incidence among male military and civil pilots and flight attendants: an analysis on published data

Toxicology and Industrial Health, 2005

Flight personnel are exposed to cosmic ionizing radiation, chemicals (fuel, jet engine exhausts, ... more Flight personnel are exposed to cosmic ionizing radiation, chemicals (fuel, jet engine exhausts, cabin air pollutants), electromagnetic fields from cockpit instruments, and disrupted sleep patterns. Only recently has cancer risk among these workers been investigated. With the aim of increasing the precision of risk estimates of cancer incidence, follow-up studies reporting a standardized incidence ratio for cancer among male flight attendants, civil and military pilots were obtained from online databases and analysed. A meta-analysis was performed by applying a random effect model, obtaining a meta-standardized incidence ratio (SIR), and 95% confidence interval (CI). In male cabin attendants, and civil and military pilots, meta-SIRs were 3.42 (CI = 1.94-6.06), 2.18 (1.69-2.80), 1.43 (1.09-1.87) for melanoma; and 7.46 (3.52-15.89), 1.88 (1.23-2.88), 1.80 (1.25-2.58) for other skin cancer, respectively. These tumors share as risk factors, ionizing radiation, recreational sun exposure and socioeconomic status. The meta-SIRs are not adjusted for confounding; the magnitude of risk for melanoma decreased when we corrected for socioeconomic status. In civil pilots, meta-SIR was 1.47 (1.06-2.05) for prostate cancer. Age (civil pilots are older than military pilots and cabin attendants) and disrupted sleep pattern (entailing hyposecretion of melatonin, which has been reported to suppress proliferative effects of androgen on prostate cancer cells) might be involved. In male cabin attendants, meta-SIR was 21.5 (2.25-205.8) for Kaposi's sarcoma and 2.49 (1.03-6.03) for non-Hodgkin's lymphoma. AIDS, which was the most frequent single cause of death in this occupational category, likely explains the excess of the latter two tumors.

Research paper thumbnail of Parkinson's disease and parkinsonism in a longitudinal study: Two-fold higher incidence in men

Neurology, 2000

al. Stimulation of highaffinity adenosine A 2 receptors decreases the affinity of dopamine D 2 re... more al. Stimulation of highaffinity adenosine A 2 receptors decreases the affinity of dopamine D 2 receptors in rat striatal membranes. Proc Natl Acad Sci USA 1991;88:7238 -7241. 37. Ledent C, Vaugeois J-M, Schiffmann SN, et al. Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A sub 2a receptor. Nature 1997;388:674 -678. 38. Hellenbrand W, Boeing H, Robra B-P, et al. Diet and Parkinson's disease II: a possible role for the past intake of specific nutrients: results from a self-administered food-frequency questionnaire in a case-control study. Neurology 1996;47:644 -650. 39. Sackett DL. Bias in analytic research. J Chronic Dis 1979;32: 51-63. 40. Morens DM, Grandinetti A, Davis JW, et al. Evidence against the operation of selective mortality in explaining the association between cigarette smoking and reduced occurrence of idiopathic Parkinson disease. Am J Epidemiol 1996;144:400 -404. 41. Ellenberg JH. Differential postmorbidity mortality in observational studies of risk factors for neurologic disorders.

Research paper thumbnail of Cancer Incidence among Female Flight Attendants: A Meta-Analysis of Published Data

Journal of Women's Health, 2006

Background: Flight attendants are exposed to cosmic ionizing radiation and other potential cancer... more Background: Flight attendants are exposed to cosmic ionizing radiation and other potential cancer risk factors, but only recently have epidemiological studies been performed to assess the risk of cancer among these workers. The aim of the present work was to evaluate the incidence of various types of cancer among female cabin attendants by combining cancer incidence estimates reported in published studies.

Research paper thumbnail of Body Mass Index as a Predictor of All-Cause Mortality in Nursing Home Residents During a 5-Year Follow-up

Journal of the American Medical Directors Association, 2013

Body mass index (BMI) is considered a short-term mortality predictor, but a consensus has not bee... more Body mass index (BMI) is considered a short-term mortality predictor, but a consensus has not been reached on its role and that of other nutritional parameters in predicting long-term mortality in nursing home residents. To correlate BMI, Mini Nutritional Assessment scores, and serum albumin levels with the 5-year mortality rate in institutionalized elderly subjects. A total of 181 nursing home residents aged ≥ 70 years were included in a 5-year longitudinal study. Data were collected on all participants' nutritional, health, cognitive, and functional status by means of a comprehensive geriatric assessment. Data on the participants' vital status were obtained 5 years after beginning the study, and a survival analysis was conducted using Kaplan-Meier curves and multivariate Cox proportional hazards models. The 5-year mortality rate was 63%. The deceased subjects (n = 115) had a lower BMI (24.7 ± 4.6 vs 26.6 ± 5.0 kg/m(2); P = .03) and Mini Nutritional Assessment score (18.6 ± 3.7 vs 20.1 ± 3.6; P = .02) than those still alive. Serum albumin levels did not differ between the two groups. Among the three indicators of nutritional status considered in this study, only BMI ≥ 30 kg/m(2) was significantly associated with a lower mortality risk at 5 years (hazard ratio = 0.432; 95% CI 0.20-0.70; P = .04), the risk for death being greater the lower the BMI class (log-rank test: P < .001). Our findings suggest that BMI is the best of the three parameters considered as a nutritional predictor of nursing home residents' mortality in the longer term, and indicate that a lower mortality risk coincides with a higher BMI.

Research paper thumbnail of 465 CAN WE SAFELY USE DONOR LIVERS WITH STEATOSIS IN HCV-POSITIVE RECIPIENTS?

Journal of Hepatology, 2009

Pegboard), executive function (Hooper) and memory (Auditory Verbal Learning). Results: 1. Short-t... more Pegboard), executive function (Hooper) and memory (Auditory Verbal Learning). Results: 1. Short-term post-LTx: The VV (cm3) increased by 8%. Fourteen patients exhibited FWML that decreased the volume by 20%, which can be explained by reversible brain edema in this areas. Neuropsychological tests improved indicating reversal of minimal hepatic encephalopathy. 2. Long-term post-LTx: The VV increased by 60% and the volume of FWML increased by 25%. Neuropsychological tests remained stable, except for memory that showed deterioration. Changes in VV or FWML were not associated with prior HE. Among patients with larger changes in FWML (>15%) pharmacological treatment for arterial hypertension was more common (88% vs. 33%, p = 0.05) and creatinine tended to be higher (1.37±0.21 vs. 1.19±0.15 mg/dl, p = 0.06). Conclusion: Following LTx patients develop a decrease in brain volume despite a successful outcome of liver function. The initial decrease probably reflects disappearance of brain edema related to HE. The decrease at long-term is part of a degenerative process in part caused by small-vessel cerebrovascular disease. Adequate control of vascular risk factors appears critical to prevent neurological deterioration following LTx.

Research paper thumbnail of P.161 SELF-REPORTED ADHERENCE TO MEDICAL REGIMEN BEFORE AND AFTER LIVER TRANSPLANTATION (LT)

Digestive and Liver Disease, 2010

Research paper thumbnail of Telomere shortening in mucosa surrounding the tumor: Biosensor of field cancerization and prognostic marker of mucosal failure in head and neck squamous cell carcinoma

Oral Oncology, 2015

Field cancerization Head and neck cancer Human papilloma virus Local relapse Molecular biology Su... more Field cancerization Head and neck cancer Human papilloma virus Local relapse Molecular biology Survival Telomerase reverse transcriptase Telomeres TERT s u m m a r y Objectives: The aim of the present study was to investigate the pattern of telomere length and telomerase expression in cancer tissues and the surrounding mucosa (SM), as markers of field cancerization and clinical outcome in patients successfully treated for with head and neck squamous cell carcinoma (HNSCC). Materials and methods: This investigation was a prospective cohort study. Telomere length and levels of telomerase reverse transcriptase (TERT) transcripts were quantified by real-time PCR in cancer tissues and SM from 139 and 90 patients with HNSCC, respectively. Results: No correlation was found between age and telomere length in SM. Patients with short telomeres in SM had a higher risk of mucosal failure (adjusted HR = 4.29). Patients with high TERT levels in cancer tissues had a higher risk of regional failure (HR = 2.88), distant failure (HR = 7.27), worse disease-specific survival (HR for related death = 2.62) but not mucosal failure. High-risk patients having both short telomeres in SM and high levels of TERT in cancer showed a significantly lower overall survival (HR = 2.46). Conclusions: Overall these findings suggest that telomere shortening in SM is a marker of field cancerization and may precede reactivation of TERT. Short telomeres in SM are strongly prognostic of mucosal failure, whereas TERT levels in cancer tissues increase with the aggressiveness of the disease and are prognostic of tumor spread.