ESTEBAN PINEDA - Academia.edu (original) (raw)
Papers by ESTEBAN PINEDA
Journal of Child Neurology, 2002
Symptoms of attention-deficit hyperactivity disorder (ADHD) include motor hyperactivity, behavior... more Symptoms of attention-deficit hyperactivity disorder (ADHD) include motor hyperactivity, behavioral impulsivity, cognitive inattention, and emotional instability.
Human Genetics, 2005
Rett syndrome (RTT), the second most common cause of mental retardation in females, has been asso... more Rett syndrome (RTT), the second most common cause of mental retardation in females, has been associated with mutations in MeCP2, the archetypical member of the methyl-CpG binding domain (MBD) family of proteins. MeCP2 additionally possesses a transcriptional repression domain (TRD). We have compared the gene expression profiles of RTT- and normal female-derived lymphoblastoid cells by using cDNA microarrays. Clustering analysis allowed the classification of RTT patients according to the localization of the MeCP2 mutation (MBD or TRD) and those with clinically diagnosed RTT but without detectable MeCP2 mutations. Numerous genes were observed to be overexpressed in RTT patients compared with control samples, including excellent candidate genes for neurodevelopmental disease. Chromatin immunoprecipitation analysis confirmed that binding of MeCP2 to corresponding promoter CpG islands was lost in RTT-derived cells harboring a mutation in the region of the MECP2 gene encoding the MBD. Bisulfite genomic sequencing demonstrated that the majority of MeCP2 binding occurred in DNA sequences with methylation-associated silencing. Most importantly, the finding that these genes are also methylated and bound by MeCP2 in neuron-related cells suggests a role in this neurodevelopmental disease. Our results provide new data of the underlying mechanisms of RTT and unveil novel targets of MeCP2-mediated gene repression.
New England Journal of Medicine, 1960
Since the 1950's Latin America and the Caribbean have lost relative income share on a consistent ... more Since the 1950's Latin America and the Caribbean have lost relative income share on a consistent basis in relation to the World and the developed countries on average. This paper presents a regional comparative statistical and econometric analysis for 1950-2007 for seven regions in the world, showing that for Latin America and the Caribbean convergence results mainly from weak expansions. Contractions have, as expected, a negative effect on the performance of Latin America and the Caribbean in historical perspective. At the same time in comparison to other regions, Latin America and the Caribbean recover quickly. Contrarily during expansions Latin America and the Caribbean tend to perform below the World and developing World regional average. Latin America and the Caribbean countries are, from a regional comparative perspective, 'good' at withstanding the negative effects of contractions and 'bad' at taking advantage of expansions to achieve convergence with the developed world. The paper argues that instead of viewing expansions through the lens of 'crisis management,' expansions should be seen and understood as an opportunity to grow and expand and promote greater levels of well-being, employment and equity in the region.
¿cóMO AlGO TAN pEqUEñO TERMINó SIENDO AlGO TAN GRANDE? cRISIS fINANcIERA, MEcANISMOS DE cONTAGIO ... more ¿cóMO AlGO TAN pEqUEñO TERMINó SIENDO AlGO TAN GRANDE? cRISIS fINANcIERA, MEcANISMOS DE cONTAGIO y EfEcTOS En AméRIcA lATInA • DAnIEl TITElmAn, ESTEbAn péREz-cAlDEnTEy y RAmón pInEDA 8 CEPAL 98 LIBRO.indb 8
New England Journal of Medicine, 1958
... 18. Banks, Benjamin M., Pineda, Esteban P., Goldbarg, Julius A., Rutenburg, Alexander M., . (... more ... 18. Banks, Benjamin M., Pineda, Esteban P., Goldbarg, Julius A., Rutenburg, Alexander M., . (1960) Clinical Value of Serum Leucine Aminopeptidase ... 21. Hoffman, Elmer, Nachlas, Marvin M., Gaby, Samuel D., Abrams, Samuel J., Seligman, Arnold M., . (1960) Limitations in the ...
Lab View ® permite la creación de paneles frontales en pantalla, con instrumentos virtuales espec... more Lab View ® permite la creación de paneles frontales en pantalla, con instrumentos virtuales específicos que se operan a través del mouse o el teclado y la versatibilidad de utilizar la pantalla de una computadora como escenario del software para controlar un sistema de medición de la movilidad virtual. El sistema permite evaluar el movimiento dentario en sentido anteroposterior, utilizando sensores tipo L.V.D.T. (Linear Viriable Directional Transformer). Es útil para medición sobre modelos de laboratorio, así como en seres vivos. Esta aplicación habilita el control de la medición, su registro, archivo e impresión; además de la calibración y revisión de los sensores de desplazamiento y fuerza utilizados.
Anales Del Sistema Sanitario De Navarra, 2007
... Correspondencia: José Javier Pineda Arribas Servicio de Endocrinología Hospital de Navarra C/... more ... Correspondencia: José Javier Pineda Arribas Servicio de Endocrinología Hospital de Navarra C/ Irunlarrea, 3 31008 Pamplona Tfno. 848 422038 E-mail: endopineda@hotmail.com ... 7. ALLAN WC, HADDOW JE, PALOMAKI GE, WILLIAMS JR, MITCHELL ML, HERMOS RJ et al. ...
Astrophysical Journal, 2009
We present mid-infrared (MIR) observations, made with the TIMMI2 camera on the ESO 3.6 m telescop... more We present mid-infrared (MIR) observations, made with the TIMMI2 camera on the ESO 3.6 m telescope, toward 14 young massive star-forming regions. All regions were imaged in the N band, and nine in the Q band, with an angular resolution of ~ 1 arcsec. Typically, the regions exhibit a single or two compact sources (with sizes in the range 0.008-0.18 pc) plus extended diffuse emission. The Spitzer-Galactic Legacy Infrared Mid-Plane Survey Extraordinaire images of these regions show much more extended emission than that seen by TIMMI2, and this is attributed to polycyclic aromatic hydrocarbon (PAH) bands. For the MIR sources associated with radio continuum radiation (Paper I) there is a close morphological correspondence between the two emissions, suggesting that the ionized gas (radio source) and hot dust (MIR source) coexist inside the H II region. We found five MIR compact sources which are not associated with radio continuum emission, and are thus prime candidates for hosting young massive protostars. In particular, objects IRAS 14593-5852 II (only detected at 17.7 microns) and 17008-4040 I are likely to be genuine O-type protostellar objects. We also present TIMMI2 N-band spectra of eight sources, all of which are dominated by a prominent silicate absorption feature (~ 9.7 microns). From these data we estimate column densities in the range (7-17)x10^22 cm^-2, in good agreement with those derived from the 1.2 mm data (Paper II). Seven sources show bright [Ne II] line emission, as expected from ionized gas regions. Only IRAS 123830-6128 shows detectable PAH emission at 8.6 and 11.3 microns.
Journal of Child Neurology, 2002
Symptoms of attention-deficit hyperactivity disorder (ADHD) include motor hyperactivity, behavior... more Symptoms of attention-deficit hyperactivity disorder (ADHD) include motor hyperactivity, behavioral impulsivity, cognitive inattention, and emotional instability.
Human Genetics, 2005
Rett syndrome (RTT), the second most common cause of mental retardation in females, has been asso... more Rett syndrome (RTT), the second most common cause of mental retardation in females, has been associated with mutations in MeCP2, the archetypical member of the methyl-CpG binding domain (MBD) family of proteins. MeCP2 additionally possesses a transcriptional repression domain (TRD). We have compared the gene expression profiles of RTT- and normal female-derived lymphoblastoid cells by using cDNA microarrays. Clustering analysis allowed the classification of RTT patients according to the localization of the MeCP2 mutation (MBD or TRD) and those with clinically diagnosed RTT but without detectable MeCP2 mutations. Numerous genes were observed to be overexpressed in RTT patients compared with control samples, including excellent candidate genes for neurodevelopmental disease. Chromatin immunoprecipitation analysis confirmed that binding of MeCP2 to corresponding promoter CpG islands was lost in RTT-derived cells harboring a mutation in the region of the MECP2 gene encoding the MBD. Bisulfite genomic sequencing demonstrated that the majority of MeCP2 binding occurred in DNA sequences with methylation-associated silencing. Most importantly, the finding that these genes are also methylated and bound by MeCP2 in neuron-related cells suggests a role in this neurodevelopmental disease. Our results provide new data of the underlying mechanisms of RTT and unveil novel targets of MeCP2-mediated gene repression.
New England Journal of Medicine, 1960
Since the 1950's Latin America and the Caribbean have lost relative income share on a consistent ... more Since the 1950's Latin America and the Caribbean have lost relative income share on a consistent basis in relation to the World and the developed countries on average. This paper presents a regional comparative statistical and econometric analysis for 1950-2007 for seven regions in the world, showing that for Latin America and the Caribbean convergence results mainly from weak expansions. Contractions have, as expected, a negative effect on the performance of Latin America and the Caribbean in historical perspective. At the same time in comparison to other regions, Latin America and the Caribbean recover quickly. Contrarily during expansions Latin America and the Caribbean tend to perform below the World and developing World regional average. Latin America and the Caribbean countries are, from a regional comparative perspective, 'good' at withstanding the negative effects of contractions and 'bad' at taking advantage of expansions to achieve convergence with the developed world. The paper argues that instead of viewing expansions through the lens of 'crisis management,' expansions should be seen and understood as an opportunity to grow and expand and promote greater levels of well-being, employment and equity in the region.
¿cóMO AlGO TAN pEqUEñO TERMINó SIENDO AlGO TAN GRANDE? cRISIS fINANcIERA, MEcANISMOS DE cONTAGIO ... more ¿cóMO AlGO TAN pEqUEñO TERMINó SIENDO AlGO TAN GRANDE? cRISIS fINANcIERA, MEcANISMOS DE cONTAGIO y EfEcTOS En AméRIcA lATInA • DAnIEl TITElmAn, ESTEbAn péREz-cAlDEnTEy y RAmón pInEDA 8 CEPAL 98 LIBRO.indb 8
New England Journal of Medicine, 1958
... 18. Banks, Benjamin M., Pineda, Esteban P., Goldbarg, Julius A., Rutenburg, Alexander M., . (... more ... 18. Banks, Benjamin M., Pineda, Esteban P., Goldbarg, Julius A., Rutenburg, Alexander M., . (1960) Clinical Value of Serum Leucine Aminopeptidase ... 21. Hoffman, Elmer, Nachlas, Marvin M., Gaby, Samuel D., Abrams, Samuel J., Seligman, Arnold M., . (1960) Limitations in the ...
Lab View ® permite la creación de paneles frontales en pantalla, con instrumentos virtuales espec... more Lab View ® permite la creación de paneles frontales en pantalla, con instrumentos virtuales específicos que se operan a través del mouse o el teclado y la versatibilidad de utilizar la pantalla de una computadora como escenario del software para controlar un sistema de medición de la movilidad virtual. El sistema permite evaluar el movimiento dentario en sentido anteroposterior, utilizando sensores tipo L.V.D.T. (Linear Viriable Directional Transformer). Es útil para medición sobre modelos de laboratorio, así como en seres vivos. Esta aplicación habilita el control de la medición, su registro, archivo e impresión; además de la calibración y revisión de los sensores de desplazamiento y fuerza utilizados.
Anales Del Sistema Sanitario De Navarra, 2007
... Correspondencia: José Javier Pineda Arribas Servicio de Endocrinología Hospital de Navarra C/... more ... Correspondencia: José Javier Pineda Arribas Servicio de Endocrinología Hospital de Navarra C/ Irunlarrea, 3 31008 Pamplona Tfno. 848 422038 E-mail: endopineda@hotmail.com ... 7. ALLAN WC, HADDOW JE, PALOMAKI GE, WILLIAMS JR, MITCHELL ML, HERMOS RJ et al. ...
Astrophysical Journal, 2009
We present mid-infrared (MIR) observations, made with the TIMMI2 camera on the ESO 3.6 m telescop... more We present mid-infrared (MIR) observations, made with the TIMMI2 camera on the ESO 3.6 m telescope, toward 14 young massive star-forming regions. All regions were imaged in the N band, and nine in the Q band, with an angular resolution of ~ 1 arcsec. Typically, the regions exhibit a single or two compact sources (with sizes in the range 0.008-0.18 pc) plus extended diffuse emission. The Spitzer-Galactic Legacy Infrared Mid-Plane Survey Extraordinaire images of these regions show much more extended emission than that seen by TIMMI2, and this is attributed to polycyclic aromatic hydrocarbon (PAH) bands. For the MIR sources associated with radio continuum radiation (Paper I) there is a close morphological correspondence between the two emissions, suggesting that the ionized gas (radio source) and hot dust (MIR source) coexist inside the H II region. We found five MIR compact sources which are not associated with radio continuum emission, and are thus prime candidates for hosting young massive protostars. In particular, objects IRAS 14593-5852 II (only detected at 17.7 microns) and 17008-4040 I are likely to be genuine O-type protostellar objects. We also present TIMMI2 N-band spectra of eight sources, all of which are dominated by a prominent silicate absorption feature (~ 9.7 microns). From these data we estimate column densities in the range (7-17)x10^22 cm^-2, in good agreement with those derived from the 1.2 mm data (Paper II). Seven sources show bright [Ne II] line emission, as expected from ionized gas regions. Only IRAS 123830-6128 shows detectable PAH emission at 8.6 and 11.3 microns.