Everett Spees - Academia.edu (original) (raw)

Papers by Everett Spees

Research paper thumbnail of Reactivation of Ocular Malignant Melanoma After Renal Transplantation

Research paper thumbnail of Microvascular architecture of anthropoid primate intestine

Circulatory shock, 1978

Microvascular architecture of the small intestine of New World monkey, ape, and man was examined ... more Microvascular architecture of the small intestine of New World monkey, ape, and man was examined with the silicone rubber injection technique and the results compared to previous observations in dogs and Old World monkeys. In man, chimpanzee, and New World monkey the small intestine villus contains a single centrally located vein draining a subepithelial capillary plexus converging at the apex of the villus. These villi also contain a single eccentrically located artery rising to the midlevel of the villus, where it branches into subepithelial capillaries over the rest of its length. This vascular architecture most closely resembles that observed in the gut of Old World monkeys in which the villus artery is absent altogether. This observation contrasts the microvascular architecture of canine intestinal villi in which marginal arteries surround a centrally located vein. These patterns of microvascular anatomy are analyzed in terms of the role of the gut in the pathogenesis of experi...

Research paper thumbnail of Improved cardiac transplant survival with thyroxine treatment of hemodynamically unstable donors: 95.2% graft survival at 6 and 30 months

Transplantation proceedings, 1993

Research paper thumbnail of Prospective study utilizing a quantitative polymerase chain reaction for detection of cytomegalovirus DNA in the blood of renal transplant patients

Transplantation proceedings, 1993

Research paper thumbnail of Decreased numbers of cadaveric donors with traumatic injuries equals increasing donor age: a 6-year analysis

Transplantation proceedings, 1993

Research paper thumbnail of Skin autografts to cover exposed renal allografts

Surgery, 1981

Exteriorized renal allografts that protrude abnormally after dehiscence of transplant wounds pose... more Exteriorized renal allografts that protrude abnormally after dehiscence of transplant wounds pose a rare but formidable surgical problem. If good renal allograft function is present and wound sepsis is controlled, the renal allograft need not be removed even if the wound cannot be approximated. The exposed kidney behaves like other body soft tissues, and resurfacing the renal cortex with skin autografts can be performed successfully. We present four cases demonstrating that split-thickness autografts can be successfully utilized to cover an exposed renal allograft with salvage of allograft function. The incidence of this situation was 0.62% in a series of 641 consecutive renal transplants. We also observed, incidentally, that there was no apparent linkage between the HL-A complex and the tendency for keloid formation.

Research paper thumbnail of Transplantation of proliferated human pre-islet cells into diabetic patients with renal transplants

Transplantation proceedings, 1989

... Voss F, Brewin A, Dawidson I, Lafferty K, Spees E, Collins G, Bry W. Hana Biologics, Inc., Al... more ... Voss F, Brewin A, Dawidson I, Lafferty K, Spees E, Collins G, Bry W. Hana Biologics, Inc., Alameda, California 94501. ... Islets of Langerhans Transplantation*; Kidney Transplantation*; Magnetic Resonance Imaging; Male; Mice; Mice, Nude; Middle Aged; Quality Control; ...

Research paper thumbnail of The successful use of marginal cadaveric donor kidneys

Transplantation proceedings, 1990

Research paper thumbnail of Successful kidney transplantation with a positive IgM crossmatch

Transplantation proceedings, 1990

Research paper thumbnail of Efficacy of simultaneous cadaveric pancreas and liver recovery

Transplantation proceedings, 1990

Research paper thumbnail of Successful use of cadaver kidneys from diabetic donors for transplantation

Transplantation proceedings, 1990

Research paper thumbnail of Are pediatric donors well utilized?

Transplantation proceedings, 1990

Research paper thumbnail of Evolution of the Colorado Organ Recovery Systems

Transplantation proceedings, 1990

Research paper thumbnail of Limited survival of human preislet cells transplanted into diabetic renal transplant recipients after 15 months

Transplantation proceedings, 1990

Research paper thumbnail of Identification of Donor Factors Predisposing to High Discard Rates of Cadaver Kidneys and Increased Graft Loss Within One Year Posttransplantation—Seopf 1977–1982

Research paper thumbnail of Successful use of polycystic cadaver donor kidneys

Transplantation proceedings, 1990

Research paper thumbnail of Method of Preservation is Not a Determinant of Graft Outcome in Kidneys Transplanted by Southeastern Organ Procurement Foundation Institutions

Research paper thumbnail of Comparative Effects of Pregnancy, Transfusion, and Prior Graft Rejection on Sensitization and Renal Transplant Results

Research paper thumbnail of The Effect of Hla-A, -B Matching on Cadaver Renal Allograft Rejection Comparing Public and Private Specificities

Transplantation, 1984

Data collected prospectively on 3811 cadaver renal transplants performed between June 1977 and Ju... more Data collected prospectively on 3811 cadaver renal transplants performed between June 1977 and July 1982 by the 42 member institutions of the South-Eastern Organ Procurement Foundation (SEOPF) were analyzed to determine whether donor-recipient compatibility based on public rather than private HLA-A,-B specificities influenced the beneficial effect of HLA matching on outcome. HLA compatibility was calculated considering match and mismatch based on common private or various public (crossreactive group, [CREG]) specificities. Donor-recipient compatibility using certain CREG assignments provided an equivalent means of stratifying graft outcome by the degree of HLA-A,-B match or mismatch, and other CREGs assignments did not. Multivariate Cox regression analysis of donor-recipient compatibility based on certain public antigens showed as high an association (P less than 10(-5) between good matching and decreased graft rejection as did matching for private antigens alone. Patient stratification by HLA match provided a stronger association with graft outcome than by HLA mismatch, irrespective of whether private or public antigens were considered. The likelihood of finding a better match was significantly increased using CREG assignments, and patients with at least one matched private antigen had equivalent or better graft survival when additional public antigens were matched. These findings indicate that with conventional immunosuppressive therapy: (1) matching of private or public HLA-A,-B antigens plays a highly significant role in decreasing renal allograft rejection; (2) matching based on certain public antigens can provide the same or a better association with outcome as private antigens; and (3) the association (crossreactivity) of various HLA specificities can be defined on a functional basis in terms of graft survival.

Research paper thumbnail of Increasing Consent by Providing Accurate Information

Research paper thumbnail of Reactivation of Ocular Malignant Melanoma After Renal Transplantation

Research paper thumbnail of Microvascular architecture of anthropoid primate intestine

Circulatory shock, 1978

Microvascular architecture of the small intestine of New World monkey, ape, and man was examined ... more Microvascular architecture of the small intestine of New World monkey, ape, and man was examined with the silicone rubber injection technique and the results compared to previous observations in dogs and Old World monkeys. In man, chimpanzee, and New World monkey the small intestine villus contains a single centrally located vein draining a subepithelial capillary plexus converging at the apex of the villus. These villi also contain a single eccentrically located artery rising to the midlevel of the villus, where it branches into subepithelial capillaries over the rest of its length. This vascular architecture most closely resembles that observed in the gut of Old World monkeys in which the villus artery is absent altogether. This observation contrasts the microvascular architecture of canine intestinal villi in which marginal arteries surround a centrally located vein. These patterns of microvascular anatomy are analyzed in terms of the role of the gut in the pathogenesis of experi...

Research paper thumbnail of Improved cardiac transplant survival with thyroxine treatment of hemodynamically unstable donors: 95.2% graft survival at 6 and 30 months

Transplantation proceedings, 1993

Research paper thumbnail of Prospective study utilizing a quantitative polymerase chain reaction for detection of cytomegalovirus DNA in the blood of renal transplant patients

Transplantation proceedings, 1993

Research paper thumbnail of Decreased numbers of cadaveric donors with traumatic injuries equals increasing donor age: a 6-year analysis

Transplantation proceedings, 1993

Research paper thumbnail of Skin autografts to cover exposed renal allografts

Surgery, 1981

Exteriorized renal allografts that protrude abnormally after dehiscence of transplant wounds pose... more Exteriorized renal allografts that protrude abnormally after dehiscence of transplant wounds pose a rare but formidable surgical problem. If good renal allograft function is present and wound sepsis is controlled, the renal allograft need not be removed even if the wound cannot be approximated. The exposed kidney behaves like other body soft tissues, and resurfacing the renal cortex with skin autografts can be performed successfully. We present four cases demonstrating that split-thickness autografts can be successfully utilized to cover an exposed renal allograft with salvage of allograft function. The incidence of this situation was 0.62% in a series of 641 consecutive renal transplants. We also observed, incidentally, that there was no apparent linkage between the HL-A complex and the tendency for keloid formation.

Research paper thumbnail of Transplantation of proliferated human pre-islet cells into diabetic patients with renal transplants

Transplantation proceedings, 1989

... Voss F, Brewin A, Dawidson I, Lafferty K, Spees E, Collins G, Bry W. Hana Biologics, Inc., Al... more ... Voss F, Brewin A, Dawidson I, Lafferty K, Spees E, Collins G, Bry W. Hana Biologics, Inc., Alameda, California 94501. ... Islets of Langerhans Transplantation*; Kidney Transplantation*; Magnetic Resonance Imaging; Male; Mice; Mice, Nude; Middle Aged; Quality Control; ...

Research paper thumbnail of The successful use of marginal cadaveric donor kidneys

Transplantation proceedings, 1990

Research paper thumbnail of Successful kidney transplantation with a positive IgM crossmatch

Transplantation proceedings, 1990

Research paper thumbnail of Efficacy of simultaneous cadaveric pancreas and liver recovery

Transplantation proceedings, 1990

Research paper thumbnail of Successful use of cadaver kidneys from diabetic donors for transplantation

Transplantation proceedings, 1990

Research paper thumbnail of Are pediatric donors well utilized?

Transplantation proceedings, 1990

Research paper thumbnail of Evolution of the Colorado Organ Recovery Systems

Transplantation proceedings, 1990

Research paper thumbnail of Limited survival of human preislet cells transplanted into diabetic renal transplant recipients after 15 months

Transplantation proceedings, 1990

Research paper thumbnail of Identification of Donor Factors Predisposing to High Discard Rates of Cadaver Kidneys and Increased Graft Loss Within One Year Posttransplantation—Seopf 1977–1982

Research paper thumbnail of Successful use of polycystic cadaver donor kidneys

Transplantation proceedings, 1990

Research paper thumbnail of Method of Preservation is Not a Determinant of Graft Outcome in Kidneys Transplanted by Southeastern Organ Procurement Foundation Institutions

Research paper thumbnail of Comparative Effects of Pregnancy, Transfusion, and Prior Graft Rejection on Sensitization and Renal Transplant Results

Research paper thumbnail of The Effect of Hla-A, -B Matching on Cadaver Renal Allograft Rejection Comparing Public and Private Specificities

Transplantation, 1984

Data collected prospectively on 3811 cadaver renal transplants performed between June 1977 and Ju... more Data collected prospectively on 3811 cadaver renal transplants performed between June 1977 and July 1982 by the 42 member institutions of the South-Eastern Organ Procurement Foundation (SEOPF) were analyzed to determine whether donor-recipient compatibility based on public rather than private HLA-A,-B specificities influenced the beneficial effect of HLA matching on outcome. HLA compatibility was calculated considering match and mismatch based on common private or various public (crossreactive group, [CREG]) specificities. Donor-recipient compatibility using certain CREG assignments provided an equivalent means of stratifying graft outcome by the degree of HLA-A,-B match or mismatch, and other CREGs assignments did not. Multivariate Cox regression analysis of donor-recipient compatibility based on certain public antigens showed as high an association (P less than 10(-5) between good matching and decreased graft rejection as did matching for private antigens alone. Patient stratification by HLA match provided a stronger association with graft outcome than by HLA mismatch, irrespective of whether private or public antigens were considered. The likelihood of finding a better match was significantly increased using CREG assignments, and patients with at least one matched private antigen had equivalent or better graft survival when additional public antigens were matched. These findings indicate that with conventional immunosuppressive therapy: (1) matching of private or public HLA-A,-B antigens plays a highly significant role in decreasing renal allograft rejection; (2) matching based on certain public antigens can provide the same or a better association with outcome as private antigens; and (3) the association (crossreactivity) of various HLA specificities can be defined on a functional basis in terms of graft survival.

Research paper thumbnail of Increasing Consent by Providing Accurate Information