Edamisan Temiye - Academia.edu (original) (raw)

Papers by Edamisan Temiye

Archives of Ibadan Medicine, Jun 27, 2005

PubMed, Jun 15, 2016

Background: HIV infection/AIDS being a multi-systemic disease affects the skin at various stages ... more Background: HIV infection/AIDS being a multi-systemic disease affects the skin at various stages in course of the illness. A knowledge of the common skin diseases associated with HIV infection can lead to early detection, appropriate staging and commencement of appropriate care in the infected patients. Objective: The study was to document the prevalence and pattern of skin diseases in children with HIV infection seen at the Paediatric department of a tertiary centre in Nigeria. Methods: HIV positive children attending the PEPFAR HIV clinic of Lagos University Teaching Hospital, Nigeria were examined for the presence of skin lesions. Anthropometric measurements were also obtained. Blood samples Were taken for CD4+ cell count, viral load and full blood count. Results: Two hundred and fourteen (214) patients were studied, consisting of 107 HIV infected children and 107 uninfected children as controls. Skin lesions were observed in 89 (83%) of the HIV infected patients, while only 72 uninfected controls had skin lesions. (p = 0.035). The predominant skin disease in the HIV infected children was Pruritic papular eruption (PPE) with a frequency of 25.9%, followed by fungal infections (24.6%). Herpes zoster was found only in HIV infected children (p = 0.041). There was a strong correlation between the degree of immunosuppression (as reflected by the value of age dependent CD4+ cell count/CD4+ percentage). and the prevalence of skin disease in the HIV infected patients. The presence of pruritic papular eruptions and Herpes zoster was associated with advanced immunosuppression. Conclusion: Skin diseases are common in HIV infection in our environment. Early detection of HIV infection can be made in the presence of skin diseases like Pruritic papular eruption and Herpes zoster.

Journal of clinical sciences, 2005

Objective: The study was carried out to review the clinical stage at which cases of Wilms' tu... more Objective: The study was carried out to review the clinical stage at which cases of Wilms' tumour in children were admitted in Lagos University Teaching Hospital, Lagos, Nigeria, the pathology of the disease, the management employed, the outcome and the effectiveness of the out-patient clinic follow up. Method: The case-notes of all patients managed for Wilms' tumour in the department of Paediatrics, Lagos University Teaching Hospital were reviewed over a period of five years, 1999 to 2003, in a retrospective study. Results: A total of 35 cases were admitted during the study period; comprising 20 males and 15 females. Nineteen of them had nephrectomy, chemotherapy and radiotherapy. Sixteen of these 19 patients were in stages III to V. One patient died three days after nephrectomy. Two out of the patients who had no surgery had chemotherapy and radiotherapy but died before surgery could be performed. The remaining 14 patients had some courses of chemotherapy and radiotherapy but were later discharged against medical advice; also 87.5% of all the cases discharged were lost to follow up. Conclusion: Majority of cases of Wilms' tumour managed in Lagos University Teaching Hospital presented late. There was a high rate of discharge against medical advice. Also there was a high rate of default at the follow-up clinic.

Iraqi journal of hematology, 2019

BACKGROUND: Sickle cell anemia is the most common inheritable hemoglobin disorder in the world wi... more BACKGROUND: Sickle cell anemia is the most common inheritable hemoglobin disorder in the world with very high prevalence, morbidity, and mortality in Sub-Saharan Africa. Acute chest syndrome (ACS) is one of the most common causes of mortality among individuals with the condition. The management of this condition involves watchful waiting which may be deleterious in resource-constrained settings. The use of exchange blood transfusion (EBT) has been reported to be beneficial. The use of this great intervention is even further hampered in most of the developing world. The aim of this study was to review the outcome data of children managed with an algorithm adopted in 2015 at a University Teaching Hospital in a resource-constrained setting.

Nigerian Journal of Paediatrics, 2020

Background: Newborns of mothers with hypertensive disorders in pregnancy have an increased risk o... more Background: Newborns of mothers with hypertensive disorders in pregnancy have an increased risk of preterm delivery, low birth weight, perinatalasphyxia and haematological derangements such as polycythaemia, thrombocytopenia and neutropenia. These morbidities are associated with uteroplacental insufficiency. The haematological derangements however have not been studied in detail in African neonates. Objective: To determine the clinical and haematological features of newborns of hypertensive mothers Methods: Cross-sectional study involving 250 newborns; 125 newborns each of hypertensive mothers (cases), and normotensive mothers (controls). The babies were examined following delivery, their clinical data were recorded, and umbilical cord blood samples were analysed for haematological indices. Results: Preterm deliveries were significantly higher amongst infants of hypertensive mothers (31.2%)compared with controls (12.0%);p = 0.000. Similarly, the birth weight, length and head circu...

Introduction: Sickle cell disease is the most common inherited haemoglobin disorder with the high... more Introduction: Sickle cell disease is the most common inherited haemoglobin disorder with the highest prevalence in Sub-saharan Africa. The clinical course of the disease has improved with newborn screening, penicillin prophylaxis and hydroxycarbamide use amongst other interventions. Despite the data on the benefit of hydroxycarbamide use, the uptake of hydroxycarbamide in poor resource  settings is still very low. Materials and Methods: This was a retrospective study at the Lagos University Teaching Hospital from January to December 2017 among children with sickle cell anemia on hydroxycarbamide. Ethical Approval was obtained from the Health, Research and Ethicscommittee of the Hospital. Statistical analysis was with SPSS version 20. Results: Atotal of 1039 children were seen in the period under review with 13.5% of them on hydroxycarbamide. The commonest  indication for hydroxycarbamide was high risk for stroke while lumbar infarction was the least common indication. Adverse effects were seen in 2.1% of the recipients and all these patients had derangements of liver function. None of the recipients had hematologic adverse effects. Conclusion: The use of hydroxycarbamide is relatively safe among children living in resource constrained settings but long term follow-up among a larger cohort is desired. Key words: Hydroxycarbamide, indications, sickle cell diseas

West African journal of medicine, 2014

BACKGROUND Oral manifestations are common in HIV positive children and have been reported as poss... more BACKGROUND Oral manifestations are common in HIV positive children and have been reported as possible predictors of HIV disease progression. This study assessed the prevalence of oral manifestations of HIV/AIDS and its association with immune suppression in a group of HIV positive Nigerian children. STUDY DESIGN One hundred and twelve HIV positive children were examined for oral manifestations of HIV. The manifestations were compared with CDC Immune suppression categories using age specific CD4 lymphocyte counts. RESULTS A total of 85 (76%) children had oral lesions. Oral candidiasis (65.2%) and parotid gland swelling (33%) were the most common lesions. Presence of oral lesions was significantly associated with declining immune status, p<0.05. CONCLUSION The presence of oral lesions was significantly associated with lower immune status.

Noninvasive assessment of splenic volume is used in the clinical management of patients with sick... more Noninvasive assessment of splenic volume is used in the clinical management of patients with sickle cell diseases.. The importance of multidimensional ultrasound in the study of the pathologic conditions of the spleen has been attributed to its simplicity of use and absence of stress to the patient. It is readily available, cheap, reliable and providing reproducible results. There is no hazard of ionizing radiation or serious side effect This study involved 200 children with sickle cell anaemia in steady state attending the paediatric sickle cell clinic of the Lagos University Teaching Hospital and 200 normal children. All patients were scanned at the Radiology department of LUTH by transabdominal ultrasonography (TAUS) using Aloka prosound 3500 plus) ultrasound scanner with a curvilinear 3.5Mhz transducer. Calculations of the splenic volume were based on measurement of splenic length (L) width (W) and thickness (T) utilizing the standard ellipsoidal formula (LxWxT). Splenomegaly wa...

Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, 2020

Hydroxyurea is an approved therapy in the management of children suffering from sickle cell disea... more Hydroxyurea is an approved therapy in the management of children suffering from sickle cell disease (SCD). In adults co-administration of hydroxyurea and L-Arginine in adult sufferers of SCD had shown some benefits. This study examined the effect of co-administration of hydroxyurea (15-35mg/kg/day) and L-Arginine (500 mg/day) for 6 weeks on blood pressure, haematological parameters, liver and antioxidant enzymes levels. The levels of these parameters when the subjects were on hydroxyurea alone were taken as control values. Results showed that the combined therapy (HU + L-Arginine) decreased SBP, DBP, MAP and PP (p <0.01 in each case) but increased %HbF, Hb and PCV (p< o.001 in each case). It elevated CAT, SOD, GPX (p < 0.001 in each case) but depressed MDA, AST, ALT and ALP (p < 0.001 in each case). The study shows that L-Arginine used as an adjunct to hydroxyurea therapy may be beneficial to children suffering from sickle cell anaemia.

Nigerian Journal of Medical Rehabilitation, 2012

Background: Exercise therapy in the form of passive mobilisation and functional training is the m... more Background: Exercise therapy in the form of passive mobilisation and functional training is the most common physiotherapy modality used in improving motor function and modulating spasticity in children with CP. However, modulating spasticity in CP patients remains a huge clinical challenge to physiotherapists and caregivers. The Healthtron device (HD) is an attenuated high voltage electrotherapy gadget claimed to have the ability of modulating spasticity and improving function in children with CP. Objective: To investigate the therapeutic efficacy of the HD in improving motor function and modulating spasticity in children with CP. Methods: A randomised controlled study in which 24 children with CP of age 1.3 10.0 years having gross motor function classification score (GMFCS) III to V were put in either a Healthtron device (HD) or control (CON) group. The HD group had conventional physiotherapy and the HD treatment while the CON group had conventional physiotherapy alone. Participants in both groups had a total of 12 treatment sessions of 3 times a week for 4 weeks. Outcomes were assessed pre and post-intervention using the gross motor function measure-66 (GMFM-66) and modified asworth scale (MAS) to determine any therapeutic effects of the HD on participants. Results: Significant improvement was noted in the GMFM-66 and the MAS in the HD and CON groups (p<0.05), except in the MAS measurement for the CON group (p=0.083). A significantly superior improvement was found in the HD group over the CON group for both outcome measures especially in the modulation of spasticity (p<0.001). Conclusion: Attenuated high voltage current generated from the HD combined with conventional physiotherapy resulted in a significant improvement in gross motor function and reduction in spasticity in children with CP. The HD may serve as an adjunct electrotherapy device with other physiotherapy modalities in improving function and modulating spasticity in children with CP. We recommend that laboratory studies be carried out to fully understand the physiological and biochemical effects of the HD on the human body.

PLOS ONE, 2017

Background Pulmonary hypertension (PHT) is a significant cause of mortality in patients with sick... more Background Pulmonary hypertension (PHT) is a significant cause of mortality in patients with sickle cell disease (SCD). Few studies on PHT in SCD have been carried out in children. This study aimed to estimate the prevalence of PHT in children with sickle cell anaemia (SCA) and determine its clinical and laboratory correlates. Methods In this cross sectional study, evaluation involved obtaining bio-data, history and physical examination findings in 175 SCA subjects with haemoglobin genotype SS aged 5 to 18 years and 175 age and sex matched controls with haemoglobin genotype AA. PHT was determined using peak Tricuspid Regurgitant Velocity (TRV) obtained from echocardiography as a marker. Complete blood count (CBC), lactate dehydrogenase (LDH) assay, reticulocyte count, foetal haemoglobin (HbF) estimation as well as Human Immunodeficiency Virus (HIV) I and II, Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) screening were done for patients with SCA. Results The mean peak TRV of subjects with SCA and controls was 2.2 ± 0.4 m/s and 1.9 ± 0.3 m/s respectively and prevalence of PHT among children with SCA and controls was 22.9% and 2.3% respectively. PHT in SCA correlated negatively with body mass index, haematocrit and haemoglobin. Conclusion This study affirms that PHT prevalence is high in children with SCA in Nigeria. Cardiovascular examination for signs of PHT is recommended for children with SCA and if required, further echocardiographic assessment from as early as five years.

Nigerian Medical Journal, 2013

surgery while electrolytes, urea and creatinine assess the renal function and hence the body's ab... more surgery while electrolytes, urea and creatinine assess the renal function and hence the body's ability to excrete anaesthetic drugs. The haemoglobin electrophoresis is performed to rule out sickle cell anaemia, which is endemic in sub-Saharan Africa. The heterozygous carrier state (sickle cell trait) is as high as 25% in the population while the homozygous disease state (sickle cell anaemia) ranges between 1% and 3%. 3-5 However, based on the low prevalence of homozygous disease state and in view of the high cost of performing haemoglobin electrophoresis analysis, which ranges between 10and10 and 10and15 depending on the laboratory, the investigation is considered not cost effective. This is especially pertinent in sub-Saharan Africa where more than half of the population live below the poverty line. The aims of this study were to determine the prevalence of sickle cell anaemia in patients for herniotomy in our centre and determine if the practice of routine screening for sickle cell anaemia is justified. The packed cell volume (or haemoglobin) is used to determine the oxygen carrying capacity of the blood during

African Journal of Clinical and Experimental Microbiology

Background: Antimicrobial resistance (AMR) has become a public health emergency with increasing r... more Background: Antimicrobial resistance (AMR) has become a public health emergency with increasing rates and spread globally. Antimicrobial stewardship (AMS) has been advocated to reduce the burden of antimicrobial resistance, promote rational and appropriate use of antibiotics and improve clinical outcomes. Education and training are one of the AMS interventions to improve antimicrobial use. We present the roll out of a successful AMS programme with education and training using the Global-PPS as data collection tool to measure AMS interventions and impact.Methodology: This was a cross sectional study on the implementation of an AMS programme at the Lagos University Teaching Hospital. Global PPS was conducted in 2015 to collect baseline data which was used to identify targets for quality improvement in AMS and was repeated in 2017 and 2018 to measure impact of AMS interventions. AMS interventions included education, feedback of Global-PPS result and writing of the hospitalwide antibiot...

Background Antibiotic resistance has been widely described in children by various pathogens to mu... more Background Antibiotic resistance has been widely described in children by various pathogens to multiple antibiotics, these have become a global health crisis and an emergency. Factors associated with antibiotic use are both community and hospital based as studies have reported increased use of antibiotics by parents and caregivers as well as health care providers This study aimed to describe prevalence rates of antibiotic prescribing and evaluate antibiotic prescribing practices as well as targets for improving the quality of antimicrobial prescribing in children over time. Method Point prevalence survey of antimicrobial use was performed yearly for 4 years to monitor trends in antimicrobial prescribing., Data from all patients admitted before 8 am on the day of the PPS were included. A web-based application designed by the University of Antwerp was used for data-entry, validation and analysis (http://www.global-pps.com). Results A total of 260 children including 90 (34.6%) neonates...

African Journal of Paediatric Surgery, 2022

Background: Over the last two decades, there has been significant improvement in the outcomes of ... more Background: Over the last two decades, there has been significant improvement in the outcomes of children with Wilms' tumour (WT) in high income countries (HICs) with approximately 85% survival rate globally. This is partly attributable to a multi-disciplinary team approach to care and the evolution of more robust treatment measures. A previous review in our centre prior to multi-disciplinary team shows a survival rate of 31.48%, However, the survival rates from low- and middle-income countries are still low when compared to HICs due to delays in access to care at all levels, poor to non-existent health insurance coverage, limited workforce resources, weak health-care systems and infrastructure. The aim of this study is to determine the impact of a multi-disciplinary team approach on the treatment outcomes of children with WT. Methodology: This is a 5-year retrospective review of all patients managed with WT at the Lagos University Teaching Hospital, Lagos, Nigeria. Information was extracted from the patients' case notes, operation notes and ward admission records. The data were analysed with SPSS 25, and P < 0.05 was considered to be statistically significant. Results: Forty patients were included in the study; male to female ratio was 1.6:1. The disease occurred in the right kidney in 23 patients (57.5%) and on the left in 17 patients (42.5%). The average duration of symptoms before presentation was 3.6 months (range 1–7 months), majority of patients presented with abdominal masses and were assessed as per unit protocol with abdominal Computerized tomography scan, chest X-ray and abdominal ultrasound scan to assign the patient International Society of Paediatric oncology regimen. The predominant stage at surgery was Stage III 26 (65%), while Stage IV was 9 (22.5%). Morbidity after chemotherapy was 10 (25%). Twenty-five patients (63%) completed chemotherapy while 15 patients (37%) started chemotherapy but defaulted midway. The 5-year survival rate was 75%. Increasing age and male sex were associated with reduced odds of mortality; however, this was not statistically significant. Increased duration of treatment, being treated with chemotherapy alone, as well as advanced tumour stage and histology were associated with increased odds of mortality, however, this was not statistically significant. Conclusion: The development of an institutional WT treatment pathway involving a multidisciplinary team has resulted in improved outcomes. There is need for increased community awareness to improve the time to presentation.

Current Pediatric Research, 2013

This study aimed to document the cardiovascular features of children with sickle cell anaemia (SC... more This study aimed to document the cardiovascular features of children with sickle cell anaemia (SCA), in steady state at the Lagos University Teaching Hospital (LUTH) using clinical evaluation. A prospective and cross-sectional study involving 100 children with SCA and 100 age and sex matched controls aged one to fifteen years. Their cardiovascular statuses were evaluated by clinical examination. About 80% of the subject were diagnosed after one years of age, twenty two [36.7%] of the 60 sixty subjects had received at least one blood transfusion. The commonest signs in subjects were hepatomegaly, pallor and laterally displaced apex beat. They had significantly lower systolic blood pressure and diastolic blood pressure but higher respiratory rates and pulse rates compared to controls. (p< 0.01). Sickle cell anaemia is diagnosed late among Nigerian children. Blood transfusion is common among children with SCA, Increased Respiratory rate and heart rate but lower systolic and diastoli...

Nigerian quarterly journal of hospital medicine, 2015

BACKGROUND HIV affects more than 2.3 million children worldwide and 90% live in Africa. Malnutrit... more BACKGROUND HIV affects more than 2.3 million children worldwide and 90% live in Africa. Malnutrition is also a major problem in Africa with 25% of children under the age of five being malnourished. OBJECTIVE The study is to determine the nutritional status of HIV infected children using weight-for-age, height-for-age and weight-for-height. METHODS This was a cross sectional descriptive study where the severity of malnutrition based on weight for age, height for age and weight for weight for height of HIV infected children were compared with controls. RESULTS The study showed that both HIV infected children and controls were both wasted stunted and underweight, however the severity was more marked in the HIV infected children. The prevalence of wasting was 17.5% in the HIV group compared to 6.6% of the controls, while 17.1% and 7.5% in the HIV infected and controls respectively were stunted. The HIV infected children were more underweight 18.5% compared to the non-infected 8%. CONCLU...