Ebad Asadi - Academia.edu (original) (raw)
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Islamic Azad University, Science and Research Branch
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Papers by Ebad Asadi
Korean Journal of Chemical Engineering, 2014
We prepared high selective imprinted nanoparticle polymers by a miniemulsion polymerization tech... more We prepared high selective imprinted nanoparticle polymers by a miniemulsion polymerization technique, using risperidone as the template, MAA as the functional monomers, and TRIM as the cross-linker in acetonitrile as solvent. The morphology of the nanoparticles determined by scanning electron microscopy (SEM) images and drug release, binding properties and dynamic light scattering (DLS) of molecularly imprinted polymers (MIPs) were studied. Controlled release of risperidone from nanoparticles was investigated through in 1% wt sodium dodecyl sulfate aqueous solution and by measuring the absorbance by HPLC-UV. The results showed that the imprinted nanoparticles exhibited a higher binding level and slower release rate than non-imprinted nanoparticles, which contributed to interaction of risperidone with imprinted cavities within nanoparticles. Furthermore, the results from HPLC showed good precision (5% for 50.0 g L 1) and recoveries (between 86-91) using MIP from human plasma samples.
Beilstein Journal of Nanotechnology, 2013
Four novel organotin(IV) complexes containing phosphoric triamide ligands were synthesized and ch... more Four novel organotin(IV) complexes containing phosphoric triamide ligands were synthesized and characterized by multinuclear (1H, 31P, 13C) NMR, infrared, ultraviolet and fluorescence spectroscopy as well as elemental analysis. The 1H NMR spectra of complexes 1–4 proved that the Sn atoms adopt octahedral configurations. The nanoparticles of the complexes were also prepared by ultrasonication, and their SEM micrographs indicated identical spherical morphologies with particles sizes about 20–25 nm. The fluorescence spectra exhibited blue shifts for the maximum wavelength of emission upon complexation.
Carbon nanotube-natural biopolymer nanovectors have important potential applications in delivery ... more Carbon nanotube-natural biopolymer nanovectors have important potential applications in delivery system for drugs and biomolecules. In this work, the use of multi-wall CNTs as nanoreserviors for drug loading and controlled release is demonstrated .We synthesized CNT-based Drug delivery systems; MWCNT-CS nanoparticles based on an ionotropic gelation method as a sustained-release systems for the delivery of Tenofovir (hydrophilic anti-retroviral drug). Molecularly imprinted polymer used as shell for encapsulating the synthesized polymer to reduce the toxicity of CNT and improved theit application in Drug Delivery System. The prepared nanoparticles were characterized by FTIR spectroscopy. TGA was applied to study the thermal stabilities, and SEM to investigate the morphology.
RSC Adv., 2014
The aim of this study was to prepare efficient imprinted polymer nanoparticles from an olanzapine... more The aim of this study was to prepare efficient imprinted polymer nanoparticles from an olanzapine template for the controlled release of olanzapine as a therapeutic drug for CNS diseases.
Anal. Methods, 2015
A highly selective voltammetric sensor for the determination of meloxicam using a MIP@MWCNT–CPE i... more A highly selective voltammetric sensor for the determination of meloxicam using a MIP@MWCNT–CPE is introduced.
RSC Adv., 2014
During the last years, artificial nanostructured materials attracted increasing scientific intere... more During the last years, artificial nanostructured materials attracted increasing scientific interest due to some remarkable properties such as high surface-to-volume ratio, low cost and straightforward preparation and handling. Among others, such materials show high potential for highly selective recognition in different fields of Analytical Chemistry, such as chemical sensor design. Carrying forward the approach of molecular imprinting from bulk/thin film to nanoparticles is one possible way to actually achieve that goal. Recent years have hence seen substantial increase in the number of MIP nanoparticle publications. This review gives a detailed overview of established precipitation and microemulsion methods for synthesising molecularly imprinted polymer (MIP) nanoparticles (NPs) as well as giving an outlook on improving those by “living” polymerisation techniques to achieve controlled geometry and thickness as well as post-synthesis functionalisation. Besides these techniques, nov...
Korean Journal of Chemical Engineering, 2014
We prepared high selective imprinted nanoparticle polymers by a miniemulsion polymerization tech... more We prepared high selective imprinted nanoparticle polymers by a miniemulsion polymerization technique, using risperidone as the template, MAA as the functional monomers, and TRIM as the cross-linker in acetonitrile as solvent. The morphology of the nanoparticles determined by scanning electron microscopy (SEM) images and drug release, binding properties and dynamic light scattering (DLS) of molecularly imprinted polymers (MIPs) were studied. Controlled release of risperidone from nanoparticles was investigated through in 1% wt sodium dodecyl sulfate aqueous solution and by measuring the absorbance by HPLC-UV. The results showed that the imprinted nanoparticles exhibited a higher binding level and slower release rate than non-imprinted nanoparticles, which contributed to interaction of risperidone with imprinted cavities within nanoparticles. Furthermore, the results from HPLC showed good precision (5% for 50.0 g L 1) and recoveries (between 86-91) using MIP from human plasma samples.
Beilstein Journal of Nanotechnology, 2013
Four novel organotin(IV) complexes containing phosphoric triamide ligands were synthesized and ch... more Four novel organotin(IV) complexes containing phosphoric triamide ligands were synthesized and characterized by multinuclear (1H, 31P, 13C) NMR, infrared, ultraviolet and fluorescence spectroscopy as well as elemental analysis. The 1H NMR spectra of complexes 1–4 proved that the Sn atoms adopt octahedral configurations. The nanoparticles of the complexes were also prepared by ultrasonication, and their SEM micrographs indicated identical spherical morphologies with particles sizes about 20–25 nm. The fluorescence spectra exhibited blue shifts for the maximum wavelength of emission upon complexation.
Carbon nanotube-natural biopolymer nanovectors have important potential applications in delivery ... more Carbon nanotube-natural biopolymer nanovectors have important potential applications in delivery system for drugs and biomolecules. In this work, the use of multi-wall CNTs as nanoreserviors for drug loading and controlled release is demonstrated .We synthesized CNT-based Drug delivery systems; MWCNT-CS nanoparticles based on an ionotropic gelation method as a sustained-release systems for the delivery of Tenofovir (hydrophilic anti-retroviral drug). Molecularly imprinted polymer used as shell for encapsulating the synthesized polymer to reduce the toxicity of CNT and improved theit application in Drug Delivery System. The prepared nanoparticles were characterized by FTIR spectroscopy. TGA was applied to study the thermal stabilities, and SEM to investigate the morphology.
RSC Adv., 2014
The aim of this study was to prepare efficient imprinted polymer nanoparticles from an olanzapine... more The aim of this study was to prepare efficient imprinted polymer nanoparticles from an olanzapine template for the controlled release of olanzapine as a therapeutic drug for CNS diseases.
Anal. Methods, 2015
A highly selective voltammetric sensor for the determination of meloxicam using a MIP@MWCNT–CPE i... more A highly selective voltammetric sensor for the determination of meloxicam using a MIP@MWCNT–CPE is introduced.
RSC Adv., 2014
During the last years, artificial nanostructured materials attracted increasing scientific intere... more During the last years, artificial nanostructured materials attracted increasing scientific interest due to some remarkable properties such as high surface-to-volume ratio, low cost and straightforward preparation and handling. Among others, such materials show high potential for highly selective recognition in different fields of Analytical Chemistry, such as chemical sensor design. Carrying forward the approach of molecular imprinting from bulk/thin film to nanoparticles is one possible way to actually achieve that goal. Recent years have hence seen substantial increase in the number of MIP nanoparticle publications. This review gives a detailed overview of established precipitation and microemulsion methods for synthesising molecularly imprinted polymer (MIP) nanoparticles (NPs) as well as giving an outlook on improving those by “living” polymerisation techniques to achieve controlled geometry and thickness as well as post-synthesis functionalisation. Besides these techniques, nov...