Ebonie Sampson - Academia.edu (original) (raw)
Papers by Ebonie Sampson
Breast Cancer Research and Treatment, 2009
Background There has been growing interest in providing clinical trial participants with study re... more Background There has been growing interest in providing clinical trial participants with study results yet only limited information exists regarding the process and impact of sharing results. We sought to evaluate patient perceptions of how results had been shared from a large randomized cooperative group trial, and the impact of learning results. Patients and methods A subset of women who
Clinical breast …, 2008
Breast cancer is one of the most commonly diagnosed malignancies in women of childbearing age. An... more Breast cancer is one of the most commonly diagnosed malignancies in women of childbearing age. Annually in the United States alone, > 23,000 women diagnosed with breast cancer are aged < 45 years, comprising approximately 10% of all women diagnosed with breast cancer. 1,2 For women interested in having a child after breast cancer, the impact on fertility of their breast cancer diagnosis and treatment might be of great concern. 2 Adjuvant chemotherapy for breast cancer might render a premenopausal woman amenorrheic, temporarily or permanently. Even women who continue to have regular menstrual cycles after chemotherapy might be less fertile than women who have not received chemotherapy, or they might go through menopause earlier than they might have otherwise. 4-6 Although endocrine therapies such as tamoxifen do not generally cause permanent infertility, they entail years of treatment during which time a pregnancy is not recommended, thereby increasing the future risk of agerelated infertility. Breast cancer is the leading cause of cancer-related deaths in women aged 25-40 years, and women in this age group have a higher risk of dying of their disease than do their older counterparts. 2 It is also well recognized that amenorrhea, in the absence of other endocrine therapy, might improve prognosis among young women with a history of Fertility and Menopausal Outcomes in Young Breast Cancer Survivors Background: Following treatment for breast cancer, many young women are interested in having a child. There are few data available regarding actual fertility and menopausal outcomes in young breast cancer survivors. We evaluated these outcomes among young breast cancer survivors in collaboration with the Young Survival Coalition, an international advocacy group for young women with breast cancer. Patients and Methods: All registered Young Survival Coalition survivor members were sent a link to the survey about fertility issues for women with early-stage breast cancer via e-mail; 440 women who completed the survey were eligible for this analysis. Survey respondents were a median of 2.8 years from diagnosis. Mean age at breast cancer diagnosis was 32.6 years. Results: Of the 440 women in this cohort, 247 women (56%) recalled that they had desired a future pregnancy at diagnosis, and 43 women (10%) took steps to preserve fertility. A total of 384 women (87%) received chemotherapy. A total of 295 women (67%) reported that they remained premenopausal, and an additional 33 women (8%) were receiving ovarian suppression therapy at the time of the survey. Since diagnosis, 70 women (16%) had been pregnant ≥ 1 time; 40 women (9%) had ≥ 1 live birth. Out of the 247 women who reported wanting a future pregnancy at diagnosis, 59 (24%) had become pregnant. Of the 60 women who reported having tried to become pregnant since diagnosis, 34 (57%) were successful. Conclusion: Most young women remain premenopausal after breast cancer treatment, including chemotherapy. A relatively small percentage of women in this series had become pregnant; however, the median time since diagnosis was relatively short.
Breast Cancer Research and Treatment, 2009
Background There has been growing interest in providing clinical trial participants with study re... more Background There has been growing interest in providing clinical trial participants with study results yet only limited information exists regarding the process and impact of sharing results. We sought to evaluate patient perceptions of how results had been shared from a large randomized cooperative group trial, and the impact of learning results. Patients and methods A subset of women who
Clinical breast …, 2008
Breast cancer is one of the most commonly diagnosed malignancies in women of childbearing age. An... more Breast cancer is one of the most commonly diagnosed malignancies in women of childbearing age. Annually in the United States alone, > 23,000 women diagnosed with breast cancer are aged < 45 years, comprising approximately 10% of all women diagnosed with breast cancer. 1,2 For women interested in having a child after breast cancer, the impact on fertility of their breast cancer diagnosis and treatment might be of great concern. 2 Adjuvant chemotherapy for breast cancer might render a premenopausal woman amenorrheic, temporarily or permanently. Even women who continue to have regular menstrual cycles after chemotherapy might be less fertile than women who have not received chemotherapy, or they might go through menopause earlier than they might have otherwise. 4-6 Although endocrine therapies such as tamoxifen do not generally cause permanent infertility, they entail years of treatment during which time a pregnancy is not recommended, thereby increasing the future risk of agerelated infertility. Breast cancer is the leading cause of cancer-related deaths in women aged 25-40 years, and women in this age group have a higher risk of dying of their disease than do their older counterparts. 2 It is also well recognized that amenorrhea, in the absence of other endocrine therapy, might improve prognosis among young women with a history of Fertility and Menopausal Outcomes in Young Breast Cancer Survivors Background: Following treatment for breast cancer, many young women are interested in having a child. There are few data available regarding actual fertility and menopausal outcomes in young breast cancer survivors. We evaluated these outcomes among young breast cancer survivors in collaboration with the Young Survival Coalition, an international advocacy group for young women with breast cancer. Patients and Methods: All registered Young Survival Coalition survivor members were sent a link to the survey about fertility issues for women with early-stage breast cancer via e-mail; 440 women who completed the survey were eligible for this analysis. Survey respondents were a median of 2.8 years from diagnosis. Mean age at breast cancer diagnosis was 32.6 years. Results: Of the 440 women in this cohort, 247 women (56%) recalled that they had desired a future pregnancy at diagnosis, and 43 women (10%) took steps to preserve fertility. A total of 384 women (87%) received chemotherapy. A total of 295 women (67%) reported that they remained premenopausal, and an additional 33 women (8%) were receiving ovarian suppression therapy at the time of the survey. Since diagnosis, 70 women (16%) had been pregnant ≥ 1 time; 40 women (9%) had ≥ 1 live birth. Out of the 247 women who reported wanting a future pregnancy at diagnosis, 59 (24%) had become pregnant. Of the 60 women who reported having tried to become pregnant since diagnosis, 34 (57%) were successful. Conclusion: Most young women remain premenopausal after breast cancer treatment, including chemotherapy. A relatively small percentage of women in this series had become pregnant; however, the median time since diagnosis was relatively short.