Eduardo Alegría - Academia.edu (original) (raw)

Papers by Eduardo Alegría

Research paper thumbnail of Trends in Risk Factors and Treatments in Patients With Stable Ischemic Heart Disease Seen at Cardiology Clinics Between 2006 and 2014

Revista Española de Cardiología (English Edition), 2016

Research paper thumbnail of El grosor íntima-media carotídeo requiere un estudio prospectivo de morbimortalidad en España definitivo

Revista Española de Cardiología, 2013

Importancia de la definició n y la té cnica en el diagnó stico de puentes intramiocá rdicos por a... more Importancia de la definició n y la té cnica en el diagnó stico de puentes intramiocá rdicos por angiografía coronaria no invasiva. Respuesta

Research paper thumbnail of Dislipemia en población diabética tratada con estatinas. Resultados del estudio DYSIS en España

Medicina Clínica, 2013

Type 2 diabetes mellitus (DM2) is characterized by carrying a high cardiovascular risk. This situ... more Type 2 diabetes mellitus (DM2) is characterized by carrying a high cardiovascular risk. This situation underscores the importance of intensively treating the risk factors present in diabetic patients, notably dyslipemia. The treatment with cholesterol-lowering drugs may be especially effective to reduce the cardiovascular risk in diabetic patients. Therefore, LDL-cholesterol is a priority target in the lipid management of these patients. This study analyzes the alterations in the lipid profile of diabetic patients receiving treatment with statins, which therefore may contribute to persistent cardiovascular risk in such individuals. The DYSIS (Dyslipidemia International Study) is an international, observational trial analyzing the lipid profile of patients treated with statins and followed-up on in outpatient clinics by primary care physicians and specialists. This study is referred to the data on the diabetic patients. Of the total patients enrolled in the DYSIS, the present study included 3703 patients, 39% being diabetics. A total of 59.2% of diabetics showed LDL-C out of goal; triglyceride elevation was observed in 43.6% and 36.4% showed low HDL-C. In diabetics patients with coronary heart disease, 31% had uncontrolled levels of all three lipid parameters. The prevalence of out of goal LDL-C in diabetic patients with metabolic syndrome was close to 60%; 39.8% had low levels of HDL-C and 46,6% high levels of triglycerides. In addition, 57% of diabetic patients with obesity showed LDL-C out of control, despite statins treatment. Cardiovascular diseases remain the main cause of morbidity-mortality in patients with DM2. The results of the present study show that in diabetic patients the degree of control is very limited with regard to LDL-cholesterol. More than half of diabetic patients treated with statins had LDL-cholesterol out of goal. The level of dyslipidemia control was low, despite statins treatment. Therefore, the detection of atherogenic dyslipidemia may point to the advisability of using combination therapy for dyslipidemia in diabetic patients.

Research paper thumbnail of Factores de riesgo cardiovascular y estilo de vida asociados a la aparición prematura de infarto agudo de miocardio

Revista Española de Cardiología, 2011

Research paper thumbnail of Update in Cardiology: Vascular Risk and Cardiac Rehabilitation

Revista Española de Cardiología (English Edition), 2014

Research paper thumbnail of Cardiovascular Risk Factors and the Metabolic Syndrome in Pediatric Nonalcoholic Fatty Liver Disease

Circulation, 2008

Background— Nonalcoholic fatty liver disease (NAFLD), the most common cause of liver disease in c... more Background— Nonalcoholic fatty liver disease (NAFLD), the most common cause of liver disease in children, is associated with obesity and insulin resistance. However, the relationship between NAFLD and cardiovascular risk factors in children is not fully understood. The objective of this study was to determine the association between NAFLD and the presence of metabolic syndrome in overweight and obese children. Methods and Results— This case-control study of 150 overweight children with biopsy-proven NAFLD and 150 overweight children without NAFLD compared rates of metabolic syndrome using Adult Treatment Panel III criteria. Cases and controls were well matched in age, sex, and severity of obesity. Children with NAFLD had significantly higher fasting glucose, insulin, total cholesterol, low-density lipoprotein cholesterol, triglycerides, systolic blood pressure, and diastolic blood pressure than overweight and obese children without NAFLD. Subjects with NAFLD also had significantly l...

Research paper thumbnail of Trends in Risk Factors and Treatments in Patients With Stable Ischemic Heart Disease Seen at Cardiology Clinics Between 2006 and 2014

Revista Española de Cardiología (English Edition), 2016

Research paper thumbnail of El grosor íntima-media carotídeo requiere un estudio prospectivo de morbimortalidad en España definitivo

Revista Española de Cardiología, 2013

Importancia de la definició n y la té cnica en el diagnó stico de puentes intramiocá rdicos por a... more Importancia de la definició n y la té cnica en el diagnó stico de puentes intramiocá rdicos por angiografía coronaria no invasiva. Respuesta

Research paper thumbnail of Dislipemia en población diabética tratada con estatinas. Resultados del estudio DYSIS en España

Medicina Clínica, 2013

Type 2 diabetes mellitus (DM2) is characterized by carrying a high cardiovascular risk. This situ... more Type 2 diabetes mellitus (DM2) is characterized by carrying a high cardiovascular risk. This situation underscores the importance of intensively treating the risk factors present in diabetic patients, notably dyslipemia. The treatment with cholesterol-lowering drugs may be especially effective to reduce the cardiovascular risk in diabetic patients. Therefore, LDL-cholesterol is a priority target in the lipid management of these patients. This study analyzes the alterations in the lipid profile of diabetic patients receiving treatment with statins, which therefore may contribute to persistent cardiovascular risk in such individuals. The DYSIS (Dyslipidemia International Study) is an international, observational trial analyzing the lipid profile of patients treated with statins and followed-up on in outpatient clinics by primary care physicians and specialists. This study is referred to the data on the diabetic patients. Of the total patients enrolled in the DYSIS, the present study included 3703 patients, 39% being diabetics. A total of 59.2% of diabetics showed LDL-C out of goal; triglyceride elevation was observed in 43.6% and 36.4% showed low HDL-C. In diabetics patients with coronary heart disease, 31% had uncontrolled levels of all three lipid parameters. The prevalence of out of goal LDL-C in diabetic patients with metabolic syndrome was close to 60%; 39.8% had low levels of HDL-C and 46,6% high levels of triglycerides. In addition, 57% of diabetic patients with obesity showed LDL-C out of control, despite statins treatment. Cardiovascular diseases remain the main cause of morbidity-mortality in patients with DM2. The results of the present study show that in diabetic patients the degree of control is very limited with regard to LDL-cholesterol. More than half of diabetic patients treated with statins had LDL-cholesterol out of goal. The level of dyslipidemia control was low, despite statins treatment. Therefore, the detection of atherogenic dyslipidemia may point to the advisability of using combination therapy for dyslipidemia in diabetic patients.

Research paper thumbnail of Factores de riesgo cardiovascular y estilo de vida asociados a la aparición prematura de infarto agudo de miocardio

Revista Española de Cardiología, 2011

Research paper thumbnail of Update in Cardiology: Vascular Risk and Cardiac Rehabilitation

Revista Española de Cardiología (English Edition), 2014

Research paper thumbnail of Cardiovascular Risk Factors and the Metabolic Syndrome in Pediatric Nonalcoholic Fatty Liver Disease

Circulation, 2008

Background— Nonalcoholic fatty liver disease (NAFLD), the most common cause of liver disease in c... more Background— Nonalcoholic fatty liver disease (NAFLD), the most common cause of liver disease in children, is associated with obesity and insulin resistance. However, the relationship between NAFLD and cardiovascular risk factors in children is not fully understood. The objective of this study was to determine the association between NAFLD and the presence of metabolic syndrome in overweight and obese children. Methods and Results— This case-control study of 150 overweight children with biopsy-proven NAFLD and 150 overweight children without NAFLD compared rates of metabolic syndrome using Adult Treatment Panel III criteria. Cases and controls were well matched in age, sex, and severity of obesity. Children with NAFLD had significantly higher fasting glucose, insulin, total cholesterol, low-density lipoprotein cholesterol, triglycerides, systolic blood pressure, and diastolic blood pressure than overweight and obese children without NAFLD. Subjects with NAFLD also had significantly l...