Eduardo López-corella - Academia.edu (original) (raw)
Papers by Eduardo López-corella
Acta Pediátrica de México, Dec 6, 2023
Cerramos un año, estamos abriendo el siguiente. Es el momento de evaluar aciertos y desaciertos, ... more Cerramos un año, estamos abriendo el siguiente. Es el momento de evaluar aciertos y desaciertos, desfacer entuertos y preparar el salto siguiente, siempre para adelante. Y los aciertos allí están. Llevamos más de cuarenta años publicando, un largo aliento sin interrupción. De hablarle y escuchar a la comunidad de pediatras, de decirles lo que hacemos y platicarles lo que se hace en otras partes. De juntar opiniones expertas de las soluciones de los problemas cotidianos del pediatra. De hacerle llegar noticias y comentarios de lo que sucede en la vanguardia de la investigación pediátrica.
Acta Pediatr Mex, Sep 1, 1990
Acta Pediátrica de México, 2006
a vacuna de BCG (Bacillus Calmette-Guérin derivada de M. bovis) ha sido utilizada en gran escala ... more a vacuna de BCG (Bacillus Calmette-Guérin derivada de M. bovis) ha sido utilizada en gran escala desde 1921 para la prevención de tuberculosis, fundamentalmente para evitar las formas más graves de la enfermedad. En la actualidad forma parte del programa rutinario de vacunación en países donde la tuberculosis es endémica. La Organización Mundial de la Salud (OMS) recomienda la vacunación selectiva en grupos de riesgo 1,2 dentro del programa ampliado de vacunación
![Research paper thumbnail of [Primary amebic meningoencephalitis caused by Naegleria fowleri in an adolescent from Huetamo, Michoacan, Mexico]](https://attachments.academia-assets.com/111448626/thumbnails/1.jpg)
](PubMed, Sep 1, 1989
A 13 year old boy died after a three day illness with severe headache, explosive vomiting, fever ... more A 13 year old boy died after a three day illness with severe headache, explosive vomiting, fever and progressive loss of consciousness. The autopsy revealed purulent and necrotizing meningoencephalitis mainly involving the basal regions and posterior fossa and on microscopic examination numerous trophozoites of Naegleria were seen in the meninges and necrotic brain tissue. The trophozoites were identified as Naegleria fowleri by immunoperoxidase staining. This case as well as others previously reported in Mexico and the documented presence of Naegleria species from several sources indicate that primary amebic meningoencephalitis should be considered in the differential diagnosis of cases with neurological symptoms of sudden onset.
American journal of medical genetics, Oct 1, 1992
Sling left pulmonary artery (SLPA) is often associated with tracheobronchial abnormalities, inclu... more Sling left pulmonary artery (SLPA) is often associated with tracheobronchial abnormalities, including bridging bronchus (BB). We report on 3 patients with SLPA: One patient had a narrow trachea, absent right upper lobe and right main bronchus, and BB. The second patient had a long and narrow trachea, with normal segmentation of bronchial tree, abnormal cerebral gyri, and minor facial abnormalities. The third patient, with a normal trachea and main bronchi with BB, had imperforate anus, hemivertebrae, a n d atrial septa1 defect WATER association). Patients with SLPA, those with BB, or those with both SLPA and BB as well as multiple congenital anomalies represent a spectrum of anomalies. o 1992 Wiley-Liss, Inc.
Fetal and Pediatric Pathology, 1996
Fetal and Pediatric Pathology, Feb 1, 1996
Acta Pediátrica de México, 2010
Journal of Pediatric Hematology Oncology, 1987
The histological diagnosis of non-Hodgkin's lymphoma (Burkitt's lymphoma excluded) in 147... more The histological diagnosis of non-Hodgkin's lymphoma (Burkitt's lymphoma excluded) in 147 children was reviewed. The most common site of presentation was in the abdomen (32.6%). The most frequent site of metastatic disease at diagnosis was the bone marrow (27.2%). The most common histology was diffuse undifferentiated non-Burkitt type (37.4%). According to the Murphy staging system, 40.1% were stage III and 27.2% were stage IV. In a nonrandomized prospective study, 121 patients were submitted to a treatment regimen (protocol 8001) and compared with 26 historical controls treated with the COP regimen, consisting of cyclophosphamide, vincristine and prednisone. Of those patients treated with protocol 8001, nine had intestinal perforation at the site of primary disease. All patients in this group were malnourished at the time of perforation. The overall rate of initial complete remission in those patients treated with protocol 8001 was 90.7%. The duration of remission was from 16 to 108 months, with a median of 39 months. The actuarial rate of disease-free survival was 69% at 2 years and 63% at 6 years, compared with 36% at 6 years of the control group (COP) (p < 0.01). None of the patients have relapsed after 4 years.
Elsevier Masson, Nov 9, 2011
New England Journal of Medicine, 1996
Pediatric Dermatology, 1988
: We cared for 124 pediatric patients With a histologic diagnosis of Langerhans' cell histioc... more : We cared for 124 pediatric patients With a histologic diagnosis of Langerhans' cell histiocytosis (histiocytosis X) over a period of 14 years. Clinical, laboratory. and radiographic findings were analyzed. The most frequent manifestations were bone lesions, lymph node involvement, and skin infiltralion. Liver disease was noted in 50% of patients and lung disease in 23% he‐matologic changes were also frequent‐ Dysfunction and involvement of these three organ systems, plus age of onset, distinguished the group of patients with the highest mortality. All palienis with generalized disease or organ dysfunclion were Lrealed with systemie chemotherapy. The actuarial survival curve at 10 Years was 63%
Journal of Pediatric Hematology/Oncology, 1987
The histological diagnosis of non-Hodgkin's lymphoma (Burkitt's lymphoma excluded) in 147... more The histological diagnosis of non-Hodgkin's lymphoma (Burkitt's lymphoma excluded) in 147 children was reviewed. The most common site of presentation was in the abdomen (32.6%). The most frequent site of metastatic disease at diagnosis was the bone marrow (27.2%). The most common histology was diffuse undifferentiated non-Burkitt type (37.4%). According to the Murphy staging system, 40.1% were stage III and 27.2% were stage IV. In a nonrandomized prospective study, 121 patients were submitted to a treatment regimen (protocol 8001) and compared with 26 historical controls treated with the COP regimen, consisting of cyclophosphamide, vincristine and prednisone. Of those patients treated with protocol 8001, nine had intestinal perforation at the site of primary disease. All patients in this group were malnourished at the time of perforation. The overall rate of initial complete remission in those patients treated with protocol 8001 was 90.7%. The duration of remission was from 16 to 108 months, with a median of 39 months. The actuarial rate of disease-free survival was 69% at 2 years and 63% at 6 years, compared with 36% at 6 years of the control group (COP) (p < 0.01). None of the patients have relapsed after 4 years.
Acta Pediátrica de México, 2014
Male patient age 6 years 9 months, native of the State of Mexico, without relevant antecedents. P... more Male patient age 6 years 9 months, native of the State of Mexico, without relevant antecedents. Parents age 32 years, with highschool level education, merchants; subject has a brother age 10 years and a sister age 4 years. His government vaccination plan is complete. Two months ago he presented onset of fever, epistaxis, and splenomegaly. At Hospital Materno Infantil de Toluca the blood biometry reported: hemoglobin 8.8 g/dL, hematocrit 24%, leukocytes 230,500/mm3, neutrophils 21%, bands 34%, lymphocytes 9%, monocytes 7%, blasts 14%, basophils 11%, eosinophils 4%. An analysis found: serum creatinine and liver function tests normal.
Gaceta Mexicana de Oncología, Sep 1, 2012
PubMed, Mar 1, 1995
Children with congenital hypothyroidism are prone to die unexpectedly. In order to test this hypo... more Children with congenital hypothyroidism are prone to die unexpectedly. In order to test this hypothesis, the primary and contributing causes of death were studied in a case series of sixteen consecutive children coming to autopsy. Four patients with absent thyroid died undiagnosed and untreated. The remaining twelve cases had documented hypothyroidism with low T3 and T4 levels. Diagnosis was established after the age of two months. Nine of the sixteen cases died unexpectedly, three while in the hospital and six at home. Autopsy findings suggested bronchoaspiration in five and heart failure in four. The remaining seven cases died under predictable circumstances with serious infections. Children with congenital hypothyroidism with delayed treatment may die unexpectedly as a result of the organic dysfunction caused by their primary disease.
American Journal of Clinical Pathology, Dec 1, 2003
Guarner et al / ADENOVIRUS IN INTESTINAL INTUSSUSCEPTION archival samples. Its application to a l... more Guarner et al / ADENOVIRUS IN INTESTINAL INTUSSUSCEPTION archival samples. Its application to a larger pediatric population that includes patients from different countries might confirm the present evidence that adenovirus, especially species C, might be a frequent cause of intussusception in Mexican children and possibly other countries such as the United States.
Journal of Medical Virology, Nov 1, 2001
Rabies virus is a highly neuronotropic virus that causes encephalomyelitis. Rabies virus infectio... more Rabies virus is a highly neuronotropic virus that causes encephalomyelitis. Rabies virus infection was studied in neurons in the brain of an 8‐year‐old girl that died of rabies in Mexico. The extent of the neuronal infection was evaluated quantitatively in neuronal cell types of the brain using histologic staining for Negri bodies and immunoperoxidase staining for rabies virus antigen in the same neurons. Quantitative image analysis was used to compare the amount of infection in five different neuronal cell types, which was expressed as a percentage of neuronal area. Purkinje cells and periaqueductal gray neurons showed the largest percentage area for both Negri bodies and signal for rabies virus antigen. In general, there was a good linear relationship between the area of Negri bodies and the area of signal for rabies virus antigen. Many neurons with rabies virus antigen did not have Negri bodies, however, and some neurons with large antigen signals, especially Purkinje cells and periaqueductal gray neurons, lacked Negri bodies. Formation of Negri bodies is likely influenced by factors that vary in different neuronal cell types. J. Med. Virol. 65:614–618, 2001. © 2001 Wiley‐Liss, Inc.
Acta Pediátrica de México, Dec 6, 2023
Cerramos un año, estamos abriendo el siguiente. Es el momento de evaluar aciertos y desaciertos, ... more Cerramos un año, estamos abriendo el siguiente. Es el momento de evaluar aciertos y desaciertos, desfacer entuertos y preparar el salto siguiente, siempre para adelante. Y los aciertos allí están. Llevamos más de cuarenta años publicando, un largo aliento sin interrupción. De hablarle y escuchar a la comunidad de pediatras, de decirles lo que hacemos y platicarles lo que se hace en otras partes. De juntar opiniones expertas de las soluciones de los problemas cotidianos del pediatra. De hacerle llegar noticias y comentarios de lo que sucede en la vanguardia de la investigación pediátrica.
Acta Pediatr Mex, Sep 1, 1990
Acta Pediátrica de México, 2006
a vacuna de BCG (Bacillus Calmette-Guérin derivada de M. bovis) ha sido utilizada en gran escala ... more a vacuna de BCG (Bacillus Calmette-Guérin derivada de M. bovis) ha sido utilizada en gran escala desde 1921 para la prevención de tuberculosis, fundamentalmente para evitar las formas más graves de la enfermedad. En la actualidad forma parte del programa rutinario de vacunación en países donde la tuberculosis es endémica. La Organización Mundial de la Salud (OMS) recomienda la vacunación selectiva en grupos de riesgo 1,2 dentro del programa ampliado de vacunación
PubMed, Sep 1, 1989
A 13 year old boy died after a three day illness with severe headache, explosive vomiting, fever ... more A 13 year old boy died after a three day illness with severe headache, explosive vomiting, fever and progressive loss of consciousness. The autopsy revealed purulent and necrotizing meningoencephalitis mainly involving the basal regions and posterior fossa and on microscopic examination numerous trophozoites of Naegleria were seen in the meninges and necrotic brain tissue. The trophozoites were identified as Naegleria fowleri by immunoperoxidase staining. This case as well as others previously reported in Mexico and the documented presence of Naegleria species from several sources indicate that primary amebic meningoencephalitis should be considered in the differential diagnosis of cases with neurological symptoms of sudden onset.
American journal of medical genetics, Oct 1, 1992
Sling left pulmonary artery (SLPA) is often associated with tracheobronchial abnormalities, inclu... more Sling left pulmonary artery (SLPA) is often associated with tracheobronchial abnormalities, including bridging bronchus (BB). We report on 3 patients with SLPA: One patient had a narrow trachea, absent right upper lobe and right main bronchus, and BB. The second patient had a long and narrow trachea, with normal segmentation of bronchial tree, abnormal cerebral gyri, and minor facial abnormalities. The third patient, with a normal trachea and main bronchi with BB, had imperforate anus, hemivertebrae, a n d atrial septa1 defect WATER association). Patients with SLPA, those with BB, or those with both SLPA and BB as well as multiple congenital anomalies represent a spectrum of anomalies. o 1992 Wiley-Liss, Inc.
Fetal and Pediatric Pathology, 1996
Fetal and Pediatric Pathology, Feb 1, 1996
Acta Pediátrica de México, 2010
Journal of Pediatric Hematology Oncology, 1987
The histological diagnosis of non-Hodgkin's lymphoma (Burkitt's lymphoma excluded) in 147... more The histological diagnosis of non-Hodgkin's lymphoma (Burkitt's lymphoma excluded) in 147 children was reviewed. The most common site of presentation was in the abdomen (32.6%). The most frequent site of metastatic disease at diagnosis was the bone marrow (27.2%). The most common histology was diffuse undifferentiated non-Burkitt type (37.4%). According to the Murphy staging system, 40.1% were stage III and 27.2% were stage IV. In a nonrandomized prospective study, 121 patients were submitted to a treatment regimen (protocol 8001) and compared with 26 historical controls treated with the COP regimen, consisting of cyclophosphamide, vincristine and prednisone. Of those patients treated with protocol 8001, nine had intestinal perforation at the site of primary disease. All patients in this group were malnourished at the time of perforation. The overall rate of initial complete remission in those patients treated with protocol 8001 was 90.7%. The duration of remission was from 16 to 108 months, with a median of 39 months. The actuarial rate of disease-free survival was 69% at 2 years and 63% at 6 years, compared with 36% at 6 years of the control group (COP) (p < 0.01). None of the patients have relapsed after 4 years.
Elsevier Masson, Nov 9, 2011
New England Journal of Medicine, 1996
Pediatric Dermatology, 1988
: We cared for 124 pediatric patients With a histologic diagnosis of Langerhans' cell histioc... more : We cared for 124 pediatric patients With a histologic diagnosis of Langerhans' cell histiocytosis (histiocytosis X) over a period of 14 years. Clinical, laboratory. and radiographic findings were analyzed. The most frequent manifestations were bone lesions, lymph node involvement, and skin infiltralion. Liver disease was noted in 50% of patients and lung disease in 23% he‐matologic changes were also frequent‐ Dysfunction and involvement of these three organ systems, plus age of onset, distinguished the group of patients with the highest mortality. All palienis with generalized disease or organ dysfunclion were Lrealed with systemie chemotherapy. The actuarial survival curve at 10 Years was 63%
Journal of Pediatric Hematology/Oncology, 1987
The histological diagnosis of non-Hodgkin's lymphoma (Burkitt's lymphoma excluded) in 147... more The histological diagnosis of non-Hodgkin's lymphoma (Burkitt's lymphoma excluded) in 147 children was reviewed. The most common site of presentation was in the abdomen (32.6%). The most frequent site of metastatic disease at diagnosis was the bone marrow (27.2%). The most common histology was diffuse undifferentiated non-Burkitt type (37.4%). According to the Murphy staging system, 40.1% were stage III and 27.2% were stage IV. In a nonrandomized prospective study, 121 patients were submitted to a treatment regimen (protocol 8001) and compared with 26 historical controls treated with the COP regimen, consisting of cyclophosphamide, vincristine and prednisone. Of those patients treated with protocol 8001, nine had intestinal perforation at the site of primary disease. All patients in this group were malnourished at the time of perforation. The overall rate of initial complete remission in those patients treated with protocol 8001 was 90.7%. The duration of remission was from 16 to 108 months, with a median of 39 months. The actuarial rate of disease-free survival was 69% at 2 years and 63% at 6 years, compared with 36% at 6 years of the control group (COP) (p < 0.01). None of the patients have relapsed after 4 years.
Acta Pediátrica de México, 2014
Male patient age 6 years 9 months, native of the State of Mexico, without relevant antecedents. P... more Male patient age 6 years 9 months, native of the State of Mexico, without relevant antecedents. Parents age 32 years, with highschool level education, merchants; subject has a brother age 10 years and a sister age 4 years. His government vaccination plan is complete. Two months ago he presented onset of fever, epistaxis, and splenomegaly. At Hospital Materno Infantil de Toluca the blood biometry reported: hemoglobin 8.8 g/dL, hematocrit 24%, leukocytes 230,500/mm3, neutrophils 21%, bands 34%, lymphocytes 9%, monocytes 7%, blasts 14%, basophils 11%, eosinophils 4%. An analysis found: serum creatinine and liver function tests normal.
Gaceta Mexicana de Oncología, Sep 1, 2012
PubMed, Mar 1, 1995
Children with congenital hypothyroidism are prone to die unexpectedly. In order to test this hypo... more Children with congenital hypothyroidism are prone to die unexpectedly. In order to test this hypothesis, the primary and contributing causes of death were studied in a case series of sixteen consecutive children coming to autopsy. Four patients with absent thyroid died undiagnosed and untreated. The remaining twelve cases had documented hypothyroidism with low T3 and T4 levels. Diagnosis was established after the age of two months. Nine of the sixteen cases died unexpectedly, three while in the hospital and six at home. Autopsy findings suggested bronchoaspiration in five and heart failure in four. The remaining seven cases died under predictable circumstances with serious infections. Children with congenital hypothyroidism with delayed treatment may die unexpectedly as a result of the organic dysfunction caused by their primary disease.
American Journal of Clinical Pathology, Dec 1, 2003
Guarner et al / ADENOVIRUS IN INTESTINAL INTUSSUSCEPTION archival samples. Its application to a l... more Guarner et al / ADENOVIRUS IN INTESTINAL INTUSSUSCEPTION archival samples. Its application to a larger pediatric population that includes patients from different countries might confirm the present evidence that adenovirus, especially species C, might be a frequent cause of intussusception in Mexican children and possibly other countries such as the United States.
Journal of Medical Virology, Nov 1, 2001
Rabies virus is a highly neuronotropic virus that causes encephalomyelitis. Rabies virus infectio... more Rabies virus is a highly neuronotropic virus that causes encephalomyelitis. Rabies virus infection was studied in neurons in the brain of an 8‐year‐old girl that died of rabies in Mexico. The extent of the neuronal infection was evaluated quantitatively in neuronal cell types of the brain using histologic staining for Negri bodies and immunoperoxidase staining for rabies virus antigen in the same neurons. Quantitative image analysis was used to compare the amount of infection in five different neuronal cell types, which was expressed as a percentage of neuronal area. Purkinje cells and periaqueductal gray neurons showed the largest percentage area for both Negri bodies and signal for rabies virus antigen. In general, there was a good linear relationship between the area of Negri bodies and the area of signal for rabies virus antigen. Many neurons with rabies virus antigen did not have Negri bodies, however, and some neurons with large antigen signals, especially Purkinje cells and periaqueductal gray neurons, lacked Negri bodies. Formation of Negri bodies is likely influenced by factors that vary in different neuronal cell types. J. Med. Virol. 65:614–618, 2001. © 2001 Wiley‐Liss, Inc.