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Papers by Eiichiro Nagata

Research paper thumbnail of Elevation of inositol pyrophosphate IP7 in the mammalian spinal cord of amyotrophic lateral sclerosis

Frontiers in Neurology, Jan 10, 2024

Research paper thumbnail of Onset Mechanisms and Prognosis of Neurally Mediated Syncope

Research paper thumbnail of Detection of APP gene recombinant in human blood plasma

Research Square (Research Square), Jun 9, 2023

Research paper thumbnail of Regeneration-associated cell transplantation contributes to tissue recovery in mice with acute ischemic stroke

Research paper thumbnail of Hydrophilic interaction liquid chromatography–tandem mass spectrometry for the quantitative analysis of mammalian-derived inositol poly/pyrophosphates

Journal of Chromatography A, Oct 1, 2018

Research paper thumbnail of Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP<sub>7</sub> metabolism in enteric nervous system

bioRxiv (Cold Spring Harbor Laboratory), Sep 19, 2022

Research paper thumbnail of Identification of biomarkers associated with migraine

Rinshō shinkeigaku, 2012

Research paper thumbnail of Effectiveness of Nonvitamin K Antagonist Oral Anticoagulants and Warfarin for Preventing Further Cerebral Microbleeds in Acute Ischemic Stroke Patients with Nonvalvular Atrial Fibrillation and At Least One Microbleed: CMB-NOW Multisite Pilot Trial

Journal of stroke and cerebrovascular diseases, Jul 1, 2019

Research paper thumbnail of Novel <i>SPG11</i> Mutations in a Patient with Symptoms Mimicking Multiple Sclerosis

Internal Medicine, Nov 1, 2018

Research paper thumbnail of AKR1A1 Variant Associated With Schizophrenia Causes Exon Skipping, Leading to Loss of Enzymatic Activity

Frontiers in Genetics, Dec 6, 2021

Research paper thumbnail of Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP7 metabolism in enteric nervous system

Inositol pyrophosphates (PP-IPs) regulate diverse physiological processes; to better understand t... more Inositol pyrophosphates (PP-IPs) regulate diverse physiological processes; to better understand their functional roles, assessing their tissue-specific distribution is important. Here, we profiled PP-IP levels in mammalian organs using a novel HILIC-MS/MS protocol and discovered that the gastrointestinal tract (GIT) contained the highest levels of IP7 and its precursor IP6. Although their absolute levels in the GIT is diet-dependent, elevated IP7 metabolism still exists under dietary regimes devoid of exogenous IP7. Of the major GIT cells, enteric neurons selectively express the IP7-synthesizing enzyme IP6K2. IP6K2-knockout mice exhibited significantly impaired IP7 metabolism in the various organs including the proximal GIT. Additionally, HILIC-MS/MS analysis displayed that genetic ablation of IP6K2 significantly impaired IP7 metabolism in the gut and duodenal muscularis externa containing myenteric plexus. Whole transcriptome analysis of duodenal muscularis externa further suggeste...

Research paper thumbnail of Effect of early enteral nutrition on critical care outcomes in patients with acute ischemic stroke

Journal of International Medical Research, 2021

Objective Stroke-associated pneumonia (SAP) is a comorbidity of ischemic stroke related to clinic... more Objective Stroke-associated pneumonia (SAP) is a comorbidity of ischemic stroke related to clinical outcomes. Early enteral nutrition (EEN; within 48 hours) reduces the incidence of infection and length of intensive care unit (ICU)/hospital stay. The relationship between EEN and critical care outcomes, including SAP, in patients with ischemic stroke has been insufficiently studied. Methods We recruited 499 patients in this retrospective observational study. We evaluated SAP incidence within 14 days from admission. Patients were divided into an EEN group and a late EN group (LEN; start later than EEN). We compared groups regarding background and length of ICU/hospital stay. Results EN was started within 48 hours in 236 patients. SAP was diagnosed in 94 patients (18.8%), with most in the LEN group (28.1% vs. 8.5%). Median [interquartile range] lengths of hospitalization (22 [12–30] days vs. 35 [20–45] days) and ICU stay (4 [2–5] days vs. 6 [3–8] days) were longer in the LEN group. EEN...

Research paper thumbnail of Author Correction: Insufficient production of IL-10 from M2 macrophages impairs in vitro endothelial progenitor cell differentiation in patients with Moyamoya disease

Scientific Reports, 2020

An amendment to this paper has been published and can be accessed via a link at the top of the pa... more An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Research paper thumbnail of Recent advances in the elucidation of migraine pathophysiology

Research paper thumbnail of Study of adenylate cyclase activity in NMS patients based on heterotype of α2B-AR gene

Autonomic Neuroscience, 2018

Research paper thumbnail of Clinical practice guideline for chronic headache 2013

Neurology and Clinical Neuroscience, 2019

International Headache Society published the International Classification of Headache Disorders 2... more International Headache Society published the International Classification of Headache Disorders 2nd Edition (ICHD‐II) in 2004. In response to this development, the “Clinical Practice Guideline for Chronic Headache” was compiled in Japan by the Study Group for Chronic Headache Clinical Practice Guideline Development. In 2006, the book entitled “The Clinical Practice Guideline for Chronic Headache (edited by Japanese Headache Society)” was published as the first edition. As triptans have become widely used, clinical practice for chronic headache has also been changed in Japan and there was a need to revise the first edition. Essentially based on the first edition, the new guideline has added the latest information and presented the concept of international standards of chronic headache care. This guideline included eight chapters and appendix: I. headache: general considerations, II. migraine, III. tension‐type headache, IV. trigeminal autonomic cephalalgias, V. other primary headache...

Research paper thumbnail of A case of recurrent Mikulicz’s disease with mononeuritis multiplex

Central European Journal of Immunology, 2018

Research paper thumbnail of Novel SPG11 Mutations in a Patient with Symptoms Mimicking Multiple Sclerosis

Internal medicine (Tokyo, Japan), Jan 6, 2018

We describe the cases of two sisters with spastic paraplegia 11 (SPG11). The younger sister devel... more We describe the cases of two sisters with spastic paraplegia 11 (SPG11). The younger sister developed relapsing lesions in the brain white matter with enhancement during the acute phase that mimicked multiple sclerosis (MS). The elevation of myelin basic protein in the CSF suggested demyelination, but a normal IgG index, the absence of oligoclonal bands, and the ineffectiveness of steroid treatment indicate that an autoimmune mechanism may not have been involved. In these affected sisters, we identified novel compound heterozygous mutations in the SPG11 gene. Our cases indicate the possible existence of a broader phenotypic spectrum of SPG11 mutations.

Research paper thumbnail of Contrast-enhanced ultrasonography is useful for evaluating the intraplaque neovascularization in aortic complex plaque of ischemic stroke patients

Medical Ultrasonography, 2016

Research paper thumbnail of Adult-onset Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke (MELAS)-like Encephalopathy Diagnosed Based on the Complete Sequencing of Mitochondrial DNA Extracted from Biopsied Muscle without any Myopathic Changes

Research paper thumbnail of Elevation of inositol pyrophosphate IP7 in the mammalian spinal cord of amyotrophic lateral sclerosis

Frontiers in Neurology, Jan 10, 2024

Research paper thumbnail of Onset Mechanisms and Prognosis of Neurally Mediated Syncope

Research paper thumbnail of Detection of APP gene recombinant in human blood plasma

Research Square (Research Square), Jun 9, 2023

Research paper thumbnail of Regeneration-associated cell transplantation contributes to tissue recovery in mice with acute ischemic stroke

Research paper thumbnail of Hydrophilic interaction liquid chromatography–tandem mass spectrometry for the quantitative analysis of mammalian-derived inositol poly/pyrophosphates

Journal of Chromatography A, Oct 1, 2018

Research paper thumbnail of Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP<sub>7</sub> metabolism in enteric nervous system

bioRxiv (Cold Spring Harbor Laboratory), Sep 19, 2022

Research paper thumbnail of Identification of biomarkers associated with migraine

Rinshō shinkeigaku, 2012

Research paper thumbnail of Effectiveness of Nonvitamin K Antagonist Oral Anticoagulants and Warfarin for Preventing Further Cerebral Microbleeds in Acute Ischemic Stroke Patients with Nonvalvular Atrial Fibrillation and At Least One Microbleed: CMB-NOW Multisite Pilot Trial

Journal of stroke and cerebrovascular diseases, Jul 1, 2019

Research paper thumbnail of Novel <i>SPG11</i> Mutations in a Patient with Symptoms Mimicking Multiple Sclerosis

Internal Medicine, Nov 1, 2018

Research paper thumbnail of AKR1A1 Variant Associated With Schizophrenia Causes Exon Skipping, Leading to Loss of Enzymatic Activity

Frontiers in Genetics, Dec 6, 2021

Research paper thumbnail of Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP7 metabolism in enteric nervous system

Inositol pyrophosphates (PP-IPs) regulate diverse physiological processes; to better understand t... more Inositol pyrophosphates (PP-IPs) regulate diverse physiological processes; to better understand their functional roles, assessing their tissue-specific distribution is important. Here, we profiled PP-IP levels in mammalian organs using a novel HILIC-MS/MS protocol and discovered that the gastrointestinal tract (GIT) contained the highest levels of IP7 and its precursor IP6. Although their absolute levels in the GIT is diet-dependent, elevated IP7 metabolism still exists under dietary regimes devoid of exogenous IP7. Of the major GIT cells, enteric neurons selectively express the IP7-synthesizing enzyme IP6K2. IP6K2-knockout mice exhibited significantly impaired IP7 metabolism in the various organs including the proximal GIT. Additionally, HILIC-MS/MS analysis displayed that genetic ablation of IP6K2 significantly impaired IP7 metabolism in the gut and duodenal muscularis externa containing myenteric plexus. Whole transcriptome analysis of duodenal muscularis externa further suggeste...

Research paper thumbnail of Effect of early enteral nutrition on critical care outcomes in patients with acute ischemic stroke

Journal of International Medical Research, 2021

Objective Stroke-associated pneumonia (SAP) is a comorbidity of ischemic stroke related to clinic... more Objective Stroke-associated pneumonia (SAP) is a comorbidity of ischemic stroke related to clinical outcomes. Early enteral nutrition (EEN; within 48 hours) reduces the incidence of infection and length of intensive care unit (ICU)/hospital stay. The relationship between EEN and critical care outcomes, including SAP, in patients with ischemic stroke has been insufficiently studied. Methods We recruited 499 patients in this retrospective observational study. We evaluated SAP incidence within 14 days from admission. Patients were divided into an EEN group and a late EN group (LEN; start later than EEN). We compared groups regarding background and length of ICU/hospital stay. Results EN was started within 48 hours in 236 patients. SAP was diagnosed in 94 patients (18.8%), with most in the LEN group (28.1% vs. 8.5%). Median [interquartile range] lengths of hospitalization (22 [12–30] days vs. 35 [20–45] days) and ICU stay (4 [2–5] days vs. 6 [3–8] days) were longer in the LEN group. EEN...

Research paper thumbnail of Author Correction: Insufficient production of IL-10 from M2 macrophages impairs in vitro endothelial progenitor cell differentiation in patients with Moyamoya disease

Scientific Reports, 2020

An amendment to this paper has been published and can be accessed via a link at the top of the pa... more An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Research paper thumbnail of Recent advances in the elucidation of migraine pathophysiology

Research paper thumbnail of Study of adenylate cyclase activity in NMS patients based on heterotype of α2B-AR gene

Autonomic Neuroscience, 2018

Research paper thumbnail of Clinical practice guideline for chronic headache 2013

Neurology and Clinical Neuroscience, 2019

International Headache Society published the International Classification of Headache Disorders 2... more International Headache Society published the International Classification of Headache Disorders 2nd Edition (ICHD‐II) in 2004. In response to this development, the “Clinical Practice Guideline for Chronic Headache” was compiled in Japan by the Study Group for Chronic Headache Clinical Practice Guideline Development. In 2006, the book entitled “The Clinical Practice Guideline for Chronic Headache (edited by Japanese Headache Society)” was published as the first edition. As triptans have become widely used, clinical practice for chronic headache has also been changed in Japan and there was a need to revise the first edition. Essentially based on the first edition, the new guideline has added the latest information and presented the concept of international standards of chronic headache care. This guideline included eight chapters and appendix: I. headache: general considerations, II. migraine, III. tension‐type headache, IV. trigeminal autonomic cephalalgias, V. other primary headache...

Research paper thumbnail of A case of recurrent Mikulicz’s disease with mononeuritis multiplex

Central European Journal of Immunology, 2018

Research paper thumbnail of Novel SPG11 Mutations in a Patient with Symptoms Mimicking Multiple Sclerosis

Internal medicine (Tokyo, Japan), Jan 6, 2018

We describe the cases of two sisters with spastic paraplegia 11 (SPG11). The younger sister devel... more We describe the cases of two sisters with spastic paraplegia 11 (SPG11). The younger sister developed relapsing lesions in the brain white matter with enhancement during the acute phase that mimicked multiple sclerosis (MS). The elevation of myelin basic protein in the CSF suggested demyelination, but a normal IgG index, the absence of oligoclonal bands, and the ineffectiveness of steroid treatment indicate that an autoimmune mechanism may not have been involved. In these affected sisters, we identified novel compound heterozygous mutations in the SPG11 gene. Our cases indicate the possible existence of a broader phenotypic spectrum of SPG11 mutations.

Research paper thumbnail of Contrast-enhanced ultrasonography is useful for evaluating the intraplaque neovascularization in aortic complex plaque of ischemic stroke patients

Medical Ultrasonography, 2016

Research paper thumbnail of Adult-onset Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke (MELAS)-like Encephalopathy Diagnosed Based on the Complete Sequencing of Mitochondrial DNA Extracted from Biopsied Muscle without any Myopathic Changes