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Papers by Elaine Eisenbeisz

Research paper thumbnail of Color stability of denture resins after staining and exposure to cleansing agents

Journal of Prosthetic Dentistry, Nov 1, 2015

Denture base resins must match the color and appearance of the oral tissues to provide satisfying... more Denture base resins must match the color and appearance of the oral tissues to provide satisfying esthetic results. Longterm color stability in denture resins starts with the resin maintaining its color and translucency during processing. 1 Overheating or insufficient pressure during polymerization can cause porosity, excessive residual monomers, 2-6 unfavorable surface characteristics, 7,8 and microporosity of the resins. 2,9 These factors contribute to discoloration during water sorption, 10 dissolution of ingredients, and degradation of intrinsic pigments. For example, porosity in hard denture bases has been associated with color changes during the consumption of extrinsic factors such as coffee, colas, and wine. 3,11-15 The acidity of consumed drinks has also been associated with discoloration of denture base resins. 8,16,17 Routine denture cleaning regimens with commercial denture cleansers are designed to control the accumulation of plaque, calculus, and extrinsic discoloration. Regimens include brushing the denture with a mild soap and/or soaking in commercial denture cleansers. Main denture cleanser types are alkaline peroxides or those containing ethylenediaminetetraacetic acid (EDTA) and enzymes. 18,19 Peroxide cleaners, which are the most commonly used denture cleansers, create an alkaline hydrogen peroxide (H 2 O 2) solution. These cleansers also contain detergents which release oxygen into the solution to reduce surface tension and sodium perborate or percarbonate. The oxygen bubbles are thought to provide a mechanical cleansing action.

Research paper thumbnail of 559 Biomarker correlates of clinical response with FLT3L/nivo backbone treatment in the multi-cohort phase 1 PORTER platform trial in metastatic castration-resistant prostate cancer patients

Regular and Young Investigator Award Abstracts, Nov 1, 2022

Research paper thumbnail of 555 Clinical and pharmacodynamic biomarker results from PORTER, a multi-cohort phase 1 platform trial of combination immunotherapy for metastatic castration-resistant prostate cancer patients

Regular and Young Investigator Award Abstracts, Nov 1, 2022

Research paper thumbnail of Comparison of Transcutaneous and Serum Bilirubin Measurements in Neonates 30 to 34 JOURNAL/ancr/04.03/00149525-201804000-00012/12FSM1/v/2023-07-21T043933Z/r/image-gif Weeks' Gestation Before, During, and After Phototherapy

Advances in Neonatal Care, 2018

Background: The use of noninvasive, transcutaneous bilirubin monitoring (TcB) as a jaundice scree... more Background: The use of noninvasive, transcutaneous bilirubin monitoring (TcB) as a jaundice screen in full-term infants is well established; however, there is a paucity of research evaluating the use of TcB in premature infants. Purpose: To compare agreement and consistency of transcutaneous and serum bilirubin measurements in a multiracial premature infant population ranging from 30 to 34 JOURNAL/ancr/04.03/00149525-201804000-00012/12FSM1/v/2023-07-21T043933Z/r/image-gif weeks' gestation before, during, and after phototherapy. Methods: Forty-five neonates, 30 to 34 JOURNAL/ancr/04.03/00149525-201804000-00012/12FSM1/v/2023-07-21T043933Z/r/image-gif weeks' gestation, were enrolled in this prospective, correlational study over a 12-month period. One set of paired transcutaneous and serum bilirubin measurements, per neonate, was obtained before phototherapy, during therapy, and after phototherapy. Exclusion criteria included neonates with positive direct coombs test or evidence...

Research paper thumbnail of Color stability of denture resins after staining and exposure to cleansing agents

The Journal of Prosthetic Dentistry, 2015

Denture base resins must match the color and appearance of the oral tissues to provide satisfying... more Denture base resins must match the color and appearance of the oral tissues to provide satisfying esthetic results. Longterm color stability in denture resins starts with the resin maintaining its color and translucency during processing. 1 Overheating or insufficient pressure during polymerization can cause porosity, excessive residual monomers, 2-6 unfavorable surface characteristics, 7,8 and microporosity of the resins. 2,9 These factors contribute to discoloration during water sorption, 10 dissolution of ingredients, and degradation of intrinsic pigments. For example, porosity in hard denture bases has been associated with color changes during the consumption of extrinsic factors such as coffee, colas, and wine. 3,11-15 The acidity of consumed drinks has also been associated with discoloration of denture base resins. 8,16,17 Routine denture cleaning regimens with commercial denture cleansers are designed to control the accumulation of plaque, calculus, and extrinsic discoloration. Regimens include brushing the denture with a mild soap and/or soaking in commercial denture cleansers. Main denture cleanser types are alkaline peroxides or those containing ethylenediaminetetraacetic acid (EDTA) and enzymes. 18,19 Peroxide cleaners, which are the most commonly used denture cleansers, create an alkaline hydrogen peroxide (H 2 O 2) solution. These cleansers also contain detergents which release oxygen into the solution to reduce surface tension and sodium perborate or percarbonate. The oxygen bubbles are thought to provide a mechanical cleansing action.

Research paper thumbnail of Hypofractionated versus standard fractionation radiotherapy in early glottic cancer: A retrospective review

Asia-Pacific Journal of Clinical Oncology, 2008

ABSTRACT Aim: This retrospective review was conducted to compare outcomes using different fractio... more ABSTRACT Aim: This retrospective review was conducted to compare outcomes using different fractionation schedules for early stage glottic cancer treated with radiotherapy between 1991 and 2003.Methods: The records of 87 patients with either T1 or T2 squamous cell carcinomas of the glottic larynx were analysed, dividing the patients into those treated with a hypofractionated schedule, mostly 51 Gy/16# (<53 Gy) and standard fractionation, minimum 60 Gy/30# in 2 Gy fractions. The median follow up was 4 years and 7 months.Results: Local control at 5 years was 81% with standard fractionation vs 93% in the hypofractionated group (P = 0.1). Laryngectomy free survival at 5 years was 78% with standard fractionation versus 95% in the hypofractionated arm (P = 0.017). Overall survival at 5 years was 65%with standard fractionation versus 74% in the hypofractionated arm (P = 0.55).Conclusion: In early stage glottic cancer, a hypofractionated course of radiotherapy has been shown to be a safe and possibly more effective treatment compared with standard fractionation.

Research paper thumbnail of Hypofractionated Versus Standard Fractionated Proton-beam Therapy for Low-risk Prostate Cancer

American Journal of Clinical Oncology, Feb 1, 2018

To identify differences in terms of quality of life, the American Urological Association Symptom ... more To identify differences in terms of quality of life, the American Urological Association Symptom Index (AUA), or adverse events (AEs) among patients with prostate cancer treated with either standard fractionation or hypofractionation proton-beam therapy. Materials and Methods: Patients were prospectively randomized to receive 38 Gy relative biological effectiveness (RBE) in 5 treatments (n = 49) or 79.2 Gy RBE in 44 treatments (n = 33). All patients had lowrisk prostate cancer and were treated with proton therapy using fiducial markers and daily image guidance. Results: Median follow-up for both groups was 18 months; 33 patients had follow-up of 2 years or longer. Baseline median (range) AUA was 4.7 (0 to 13) for the 38 Gy RBE arm and 4.8 (0 to 17) for the 79.2 Gy RBE arm. We observed no difference between the groups regarding the Expanded Prostate Index Composite urinary, bowel, or sexual function scores at 3, 6, 12, 18, or 24 months after treatment. The only significant difference was the AUA score at 12 months (8 for the 38 Gy RBE arm vs. 5 for the 79.2 Gy RBE arm; P = 0.04); AUA scores otherwise were similar between groups. No grade 3 or higher AEs occurred in either arm. Conclusions: Patients treated with proton therapy in this randomized trial tolerated treatment well, with excellent quality-of-life scores, persistent low AUA, and no grade 3 or higher AEs on either arm. We showed no apparent clinical difference in outcomes with hypofractionated proton-beam therapy compared with standard fractionation on the basis of this interim analysis.

Research paper thumbnail of Color stability of denture resins after staining and exposure to cleansing agents

Journal of Prosthetic Dentistry, Nov 1, 2015

Denture base resins must match the color and appearance of the oral tissues to provide satisfying... more Denture base resins must match the color and appearance of the oral tissues to provide satisfying esthetic results. Longterm color stability in denture resins starts with the resin maintaining its color and translucency during processing. 1 Overheating or insufficient pressure during polymerization can cause porosity, excessive residual monomers, 2-6 unfavorable surface characteristics, 7,8 and microporosity of the resins. 2,9 These factors contribute to discoloration during water sorption, 10 dissolution of ingredients, and degradation of intrinsic pigments. For example, porosity in hard denture bases has been associated with color changes during the consumption of extrinsic factors such as coffee, colas, and wine. 3,11-15 The acidity of consumed drinks has also been associated with discoloration of denture base resins. 8,16,17 Routine denture cleaning regimens with commercial denture cleansers are designed to control the accumulation of plaque, calculus, and extrinsic discoloration. Regimens include brushing the denture with a mild soap and/or soaking in commercial denture cleansers. Main denture cleanser types are alkaline peroxides or those containing ethylenediaminetetraacetic acid (EDTA) and enzymes. 18,19 Peroxide cleaners, which are the most commonly used denture cleansers, create an alkaline hydrogen peroxide (H 2 O 2) solution. These cleansers also contain detergents which release oxygen into the solution to reduce surface tension and sodium perborate or percarbonate. The oxygen bubbles are thought to provide a mechanical cleansing action.

Research paper thumbnail of 559 Biomarker correlates of clinical response with FLT3L/nivo backbone treatment in the multi-cohort phase 1 PORTER platform trial in metastatic castration-resistant prostate cancer patients

Regular and Young Investigator Award Abstracts, Nov 1, 2022

Research paper thumbnail of 555 Clinical and pharmacodynamic biomarker results from PORTER, a multi-cohort phase 1 platform trial of combination immunotherapy for metastatic castration-resistant prostate cancer patients

Regular and Young Investigator Award Abstracts, Nov 1, 2022

Research paper thumbnail of Comparison of Transcutaneous and Serum Bilirubin Measurements in Neonates 30 to 34 JOURNAL/ancr/04.03/00149525-201804000-00012/12FSM1/v/2023-07-21T043933Z/r/image-gif Weeks' Gestation Before, During, and After Phototherapy

Advances in Neonatal Care, 2018

Background: The use of noninvasive, transcutaneous bilirubin monitoring (TcB) as a jaundice scree... more Background: The use of noninvasive, transcutaneous bilirubin monitoring (TcB) as a jaundice screen in full-term infants is well established; however, there is a paucity of research evaluating the use of TcB in premature infants. Purpose: To compare agreement and consistency of transcutaneous and serum bilirubin measurements in a multiracial premature infant population ranging from 30 to 34 JOURNAL/ancr/04.03/00149525-201804000-00012/12FSM1/v/2023-07-21T043933Z/r/image-gif weeks' gestation before, during, and after phototherapy. Methods: Forty-five neonates, 30 to 34 JOURNAL/ancr/04.03/00149525-201804000-00012/12FSM1/v/2023-07-21T043933Z/r/image-gif weeks' gestation, were enrolled in this prospective, correlational study over a 12-month period. One set of paired transcutaneous and serum bilirubin measurements, per neonate, was obtained before phototherapy, during therapy, and after phototherapy. Exclusion criteria included neonates with positive direct coombs test or evidence...

Research paper thumbnail of Color stability of denture resins after staining and exposure to cleansing agents

The Journal of Prosthetic Dentistry, 2015

Denture base resins must match the color and appearance of the oral tissues to provide satisfying... more Denture base resins must match the color and appearance of the oral tissues to provide satisfying esthetic results. Longterm color stability in denture resins starts with the resin maintaining its color and translucency during processing. 1 Overheating or insufficient pressure during polymerization can cause porosity, excessive residual monomers, 2-6 unfavorable surface characteristics, 7,8 and microporosity of the resins. 2,9 These factors contribute to discoloration during water sorption, 10 dissolution of ingredients, and degradation of intrinsic pigments. For example, porosity in hard denture bases has been associated with color changes during the consumption of extrinsic factors such as coffee, colas, and wine. 3,11-15 The acidity of consumed drinks has also been associated with discoloration of denture base resins. 8,16,17 Routine denture cleaning regimens with commercial denture cleansers are designed to control the accumulation of plaque, calculus, and extrinsic discoloration. Regimens include brushing the denture with a mild soap and/or soaking in commercial denture cleansers. Main denture cleanser types are alkaline peroxides or those containing ethylenediaminetetraacetic acid (EDTA) and enzymes. 18,19 Peroxide cleaners, which are the most commonly used denture cleansers, create an alkaline hydrogen peroxide (H 2 O 2) solution. These cleansers also contain detergents which release oxygen into the solution to reduce surface tension and sodium perborate or percarbonate. The oxygen bubbles are thought to provide a mechanical cleansing action.

Research paper thumbnail of Hypofractionated versus standard fractionation radiotherapy in early glottic cancer: A retrospective review

Asia-Pacific Journal of Clinical Oncology, 2008

ABSTRACT Aim: This retrospective review was conducted to compare outcomes using different fractio... more ABSTRACT Aim: This retrospective review was conducted to compare outcomes using different fractionation schedules for early stage glottic cancer treated with radiotherapy between 1991 and 2003.Methods: The records of 87 patients with either T1 or T2 squamous cell carcinomas of the glottic larynx were analysed, dividing the patients into those treated with a hypofractionated schedule, mostly 51 Gy/16# (<53 Gy) and standard fractionation, minimum 60 Gy/30# in 2 Gy fractions. The median follow up was 4 years and 7 months.Results: Local control at 5 years was 81% with standard fractionation vs 93% in the hypofractionated group (P = 0.1). Laryngectomy free survival at 5 years was 78% with standard fractionation versus 95% in the hypofractionated arm (P = 0.017). Overall survival at 5 years was 65%with standard fractionation versus 74% in the hypofractionated arm (P = 0.55).Conclusion: In early stage glottic cancer, a hypofractionated course of radiotherapy has been shown to be a safe and possibly more effective treatment compared with standard fractionation.

Research paper thumbnail of Hypofractionated Versus Standard Fractionated Proton-beam Therapy for Low-risk Prostate Cancer

American Journal of Clinical Oncology, Feb 1, 2018

To identify differences in terms of quality of life, the American Urological Association Symptom ... more To identify differences in terms of quality of life, the American Urological Association Symptom Index (AUA), or adverse events (AEs) among patients with prostate cancer treated with either standard fractionation or hypofractionation proton-beam therapy. Materials and Methods: Patients were prospectively randomized to receive 38 Gy relative biological effectiveness (RBE) in 5 treatments (n = 49) or 79.2 Gy RBE in 44 treatments (n = 33). All patients had lowrisk prostate cancer and were treated with proton therapy using fiducial markers and daily image guidance. Results: Median follow-up for both groups was 18 months; 33 patients had follow-up of 2 years or longer. Baseline median (range) AUA was 4.7 (0 to 13) for the 38 Gy RBE arm and 4.8 (0 to 17) for the 79.2 Gy RBE arm. We observed no difference between the groups regarding the Expanded Prostate Index Composite urinary, bowel, or sexual function scores at 3, 6, 12, 18, or 24 months after treatment. The only significant difference was the AUA score at 12 months (8 for the 38 Gy RBE arm vs. 5 for the 79.2 Gy RBE arm; P = 0.04); AUA scores otherwise were similar between groups. No grade 3 or higher AEs occurred in either arm. Conclusions: Patients treated with proton therapy in this randomized trial tolerated treatment well, with excellent quality-of-life scores, persistent low AUA, and no grade 3 or higher AEs on either arm. We showed no apparent clinical difference in outcomes with hypofractionated proton-beam therapy compared with standard fractionation on the basis of this interim analysis.