Ekrem Kutluay - Academia.edu (original) (raw)

Papers by Ekrem Kutluay

Invasive Studies of the Human Epileptic Brain

Intracranial exploration of the sensorimotor cortex exemplifies the balance of preserving functio... more Intracranial exploration of the sensorimotor cortex exemplifies the balance of preserving function while optimizing the surgical quest for seizure freedom. While surgical intervention in the sensorimotor region is certainly a ‘high-stakes’ undertaking, positive results can be obtained for carefully selected patients. In this chapter, the clinical features of sensorimotor epilepsy are reviewed and the anatomy of this critical functional region is described. The intrinsic rhythms that are commonly seen on intracranial sensorimotor recordings are also discussed. A description of sensorimotor mapping techniques and findings is followed by a discussion of special surgical considerations for patients with sensorimotor cortex epilepsy.

Journal of Clinical Neurophysiology, 2016

Objective: This purpose of this study was to evaluate the usefulness of a prototype battery-power... more Objective: This purpose of this study was to evaluate the usefulness of a prototype battery-powered dry electrode system (DES) EEG recording headset in Veteran patients by comparing it with standard EEG. Methods: Twenty-one Veterans had both a standard electrode system recording and DES recording in nine different patient states at the same encounter. Setup time, patient comfort, and subject preference were measured. Three experts performed technical quality rating of each EEG recording in a blinded fashion using the web-based EEGnet system. Power spectra were compared between DES and standard electrode system recordings. Results: The average time for DES setup was 5.7 minutes versus 21.1 minutes for standard electrode system. Subjects reported that the DES was more comfortable during setup. Most subjects (15 of 21) preferred the DES. On a five-point scale (1—best quality to 5—worst quality), the technical quality of the standard electrode system recordings was significantly better ...

Journal of Neuroscience Methods, 2013

h i g h l i g h t s We describe our new web-based software for collecting expert opinion on parox... more h i g h l i g h t s We describe our new web-based software for collecting expert opinion on paroxysmal activity in routine scalp EEG. We report that inter-rater correlation among our groups of 11 board-certified EEG scorers was only moderate. Our machine learning analysis suggests that our EEG database needs to be larger than its current size to adequately represent the variability of waveform morphologies in EEG. Our artificial neural network machine learning classifiers performed better than our Bayesian classifiers and the wavelet features were the most useful.

Alzheimer Disease & Associated Disorders, 2013

Clinical Eeg and Neuroscience, Dec 14, 2022

Journal of the Neurological Sciences

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society, Jan 27, 2018

The goal of the study was to measure the performance of academic and private practice (PP) neurol... more The goal of the study was to measure the performance of academic and private practice (PP) neurologists in detecting interictal epileptiform discharges in routine scalp EEG recordings. Thirty-five EEG scorers (EEGers) participated (19 academic and 16 PP) and marked the location of ETs in 200 30-second EEG segments using a web-based EEG annotation system. All participants provided board certification status, years of Epilepsy Fellowship Training (EFT), and years in practice. The Persyst P13 automated IED detection algorithm was also run on the EEG segments for comparison. Academic EEGers had an average of 1.66 years of EFT versus 0.50 years of EFT for PP EEGers (P < 0.0001) and had higher rates of board certification. Inter-rater agreement for the 35 EEGers was fair. There was higher performance for EEGers in academics, with at least 1.5 years of EFT, and with American Board of Clinical Neurophysiology and American Board of Psychiatry and Neurology-E specialty board certification....

The Neurodiagnostic journal, 2017

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society, 2017

The goal of the project is to determine characteristics of academic neurophysiologist EEG interpr... more The goal of the project is to determine characteristics of academic neurophysiologist EEG interpreters (EEGers), which predict good interrater agreement (IRA) and to determine the number of EEGers needed to develop an ideal standardized testing and training data set for epileptiform transient (ET) detection algorithms. A three-phase scoring method was used. In phase 1, 19 EEGers marked the location of ETs in two hundred 30-second segments of EEG from 200 different patients. In phase 2, EEG events marked by at least 2 EEGers were annotated by 18 EEGers on a 5-point scale to indicate whether they were ETs. In phase 3, a third opinion was obtained from EEGers on any inconsistencies between phase 1 and phase 2 scoring. The IRA for the 18 EEGers was only fair. A select group of the EEGers had good IRA and the other EEGers had low IRA. Board certification by the American Board of Clinical Neurophysiology was associated with better IRA performance but other board certifications, years of f...

Co-morbidities and Quality of Life, 2015

Clinical Neurophysiology, 2015

Expert opinion on pharmacotherapy, 2002

Oxcarbazepine is one of the recently introduced anti-epileptic drugs (AEDs) in the US. This drug ... more Oxcarbazepine is one of the recently introduced anti-epileptic drugs (AEDs) in the US. This drug has demonstrated efficacy as adjunctive therapy in adults and children, and as monotherapy in adults for the treatment of seizures of partial onset. There is also convincing evidence of its efficacy in patients with newly diagnosed and refractory trigeminal neuralgia. In addition, the initial efficacy results of oxcarbazepine in other neuropathic pain conditions and in bipolar disorders are encouraging. In this review, recommendations on the optimal clinical use of oxcarbazepine are given based on its pharmacokinetic profile, efficacy and tolerability in those various conditions.

Tüberküloz ve toraks, 2011

Use of a questionnaire that predicts the diagnosis and influence of sleep related breathing disor... more Use of a questionnaire that predicts the diagnosis and influence of sleep related breathing disorder (SRBD) may be a cost-effective method to aid in both diagnostic algorithm and therapy. Therefore, the aim of this study was to adapt Pediatric Sleep Questionnaire (PSQ) into Turkish and to test the validity and reliability of the Turkish questionnaire. Total of 111 children (59 male, 52 female) aged 2 to 17 years who had symptoms suggestive of SRBD were enrolled consecutively. Demographic characteristics such as age and gender of all children enrolled in the study were recorded. All parents were questioned about symptom severity, frequency and duration. Lastly, PSQ was administered to all parents. Mean age of the children enrolled in the study was 8.1 ± 3.4 years. Total PSQ score ranged between 0 and 0.95 and mean score was 0.35 ± 0.22. Comparison of total PSQ scores between children reporting different symptom frequencies demonstrated that PSQ score increased as the symptom frequenc...

Puzzling Cases of Epilepsy, 2008

$Research paper thumbnail of Conversion to monotherapy: Clinical trials in patients with refractory partial seizures$

Neurology, 2003

The efficacy, tolerability, and safety of a potential antiepileptic drug (AED) are initially eval... more The efficacy, tolerability, and safety of a potential antiepileptic drug (AED) are initially evaluated in clinical trials employing add-on designs. When positive, those trials allow us only to conclude that the study drug is efficacious when administered as adjunctive therapy. However, to demonstrate efficacy and safety as monotherapy, the drug must be evaluated using a monotherapy trial design. Such a design needs to take into account important methodologic issues that can affect clinical relevance and/or raise ethical concerns. This review critically assesses two monotherapy trial designs: outpatient conversion to monotherapy and presurgical conversion to monotherapy in patients with medically refractory seizures of partial onset. The efficacy and safety data derived from published studies of AED monotherapy in patients with partial-onset seizures that utilize these trial designs are evaluated and the advantages and disadvantages of each trial design are discussed.

Journal of Neurology, 1996

Expert Opinion on Pharmacotherapy, 2002