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Papers by Elaine L. Bearer

Future Virology, Sep 1, 2012

HSV, a neurotropic virus, travels within neuronal processes by fast axonal transport. During neur... more HSV, a neurotropic virus, travels within neuronal processes by fast axonal transport. During neuronal infection HSV travels retrograde from the sensory nerve terminus to the neuronal cell body, where it replicates or enters latency. During replication HSV travels anterograde from the cell body to the nerve terminus. Postmortem studies find a high frequency of HSV DNA in the trigeminal ganglia as well as the brain. Studies correlating HSV with Alzheimer's disease (AD) have been controversial. Here we review clinical evidence supporting such a link. Furthermore, the author describes experimental data showing physical interactions between nascent HSV particles and host transport machinery implicated in AD. The author concludes that the complexity of this relationship has been insufficiently explored, although the relative ease and nontoxicity of a potential anti-HSV treatment for AD demands further study.

Mitophagy was impaired after rotenone exposure, as TOM-20 levels increased 40% indicating mitocho... more Mitophagy was impaired after rotenone exposure, as TOM-20 levels increased 40% indicating mitochondria accumulation, whereas physical training during early neurodegeneration prevented that increase. PINK1 levels showed a tendency of decrease in substantia nigra of aged rats exposed to rotenone, which was not present in exercised rats. Physical activity also prevented H2O2 increase during early neurodegeneration, although the mechanism involved remains to be elucidated, since the antioxidant enzymes evaluated did not changed. TrkB levels and its anterograde trafficking in substantia nigra seem not to be influenced by moderate treadmill running during early neurodegeneration. In conclusion, moderate physical training could prevent early neurodegeneration in substantia nigra through the improvement of autophagy and mitophagy.

The Biological Bulletin, Oct 1, 1996

... microtubule decorated with associated pro-teins [-5 X lO-23 Nm'] (9) the average number ... more ... microtubule decorated with associated pro-teins [-5 X lO-23 Nm'] (9) the average number of microtu-bules of a newt lung kinetochore [-201 ... Method for Visualizing Filaments in Axoplasm by Electron Microscopy EL Bearer (Brown University)', J. Liu'32, A. Hsu',~, and TS Reese'-3 ...

Supplementary Methods, Figure Legends 1-3 from Multiparameter Computational Modeling of Tumor Inv... more Supplementary Methods, Figure Legends 1-3 from Multiparameter Computational Modeling of Tumor Invasion

Supplementary Figure 2 from Multiparameter Computational Modeling of Tumor Invasion

Supplementary Figure 3 from Multiparameter Computational Modeling of Tumor Invasion

Supplementary Figure 1 from Multiparameter Computational Modeling of Tumor Invasion

Psychology Press, Apr 4, 2014

Proceedings of the International Society for Magnetic Resonance in Medicine ... Scientific Meeting and Exhibition. International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition, 2018

Posttraumatic stress disorder (PTSD) occurs in some people after exposure to life-threatening fea... more Posttraumatic stress disorder (PTSD) occurs in some people after exposure to life-threatening fear, and impacts up to 8% of the general population, including veterans and victims of domestic violence. One of the central questions involved in PTSD research is how a traumatic event fundamentally alters neural circuits. Early life stress (ELS) and serotonergic dis-regulation are associated with PTSD, and fear activates serotonergic and noradrenergic systems, and the HPA axis. Mouse lines knocked-out for the serotonin transporter gene (SERT-KO) have increased fear responses to predator stress (PS), with prolongation of the fear response1. Using manganese-enhanced MRI (MEMRI) tract-tracing, we reported that SERT-KO mice have abnormal circuitry in the prelimbic system2. To determine if this circuit is affected by fear, SERT-KO and WT mice were exposed to PS and the effects on neural activity and circuitry assayed by MEMRI before and after stress. Predator stress is a known naturalistic pr...

Journal of Neuropathology & Experimental Neurology, 2021

Despite extensive research and aggressive therapies, glioblastoma (GBM) remains a central nervous... more Despite extensive research and aggressive therapies, glioblastoma (GBM) remains a central nervous system malignancy with poor prognosis. The varied histopathology of GBM suggests a landscape of differing microenvironments and clonal expansions, which may influence metabolism, driving tumor progression. Indeed, GBM metabolic plasticity in response to differing nutrient supply within these microenvironments has emerged as a key driver of aggressiveness. Additionally, emergent biophysical and biochemical interactions in the tumor microenvironment (TME) are offering new perspectives on GBM metabolism. Perivascular and hypoxic niches exert crucial roles in tumor maintenance and progression, facilitating metabolic relationships between stromal and tumor cells. Alterations in extracellular matrix and its biophysical characteristics, such as rigidity and topography, regulate GBM metabolism through mechanotransductive mechanisms. This review highlights insights gained from deployment of bioe...