Elena Poriazova - Academia.edu (original) (raw)

Papers by Elena Poriazova

PubMed, 2001

We present case 96 (the first one in Bulgaria) of primary localized amyloidosis of the urinary bl... more We present case 96 (the first one in Bulgaria) of primary localized amyloidosis of the urinary bladder in a 72-year-old woman with episodes of painless hematuria. The amyloid tumor is situated on the anterior wall of the bladder--a yellowish prominence 15 mm in diameter with superficial erosion that is surrounded by a reddish ring and bullous edema of the mucosa. Rough and regularly pink perivascular deposits, thickened vessel walls and focal lymphoplasmocyte infiltrates are present in the submucosa. After preliminary treatment with KHMnO4, AL-amyloid is detected in polarized light by Congorot staining and in ultraviolet light using thioflavin. Immunoglobulins and C3 deposits are not found. On electron microscopy deposits of amyloid fibrils are seen in abundance close to collagen bundles. Diseases that may be associated with systemic amyloidosis have been clinically excluded. Nodular amyloidosis resulting from a local immune dyscrasia is accepted in the case. The patient is in good health 11 months after the first biopsy. A literature review on this rare form of localized amyloidosis has been made. Generally, the disease has a favorable prognosis and non-active behavior is recommended. Intravesical instillations of dimethyl sulfoxide, sectional resection or plastic surgery that preserve the urinary tract are used in the rare case of progressive course.

Australian and New Zealand Journal of Obstetrics and Gynaecology, 2009

A case of an attempted suicide with atypical antipsychotic (clozapine) in late pregnancy is repor... more A case of an attempted suicide with atypical antipsychotic (clozapine) in late pregnancy is reported. Toxic effects of clozapine in the mother as well as in the fetus and newborn were observed. It should be remembered as a rare cause of unexplained loss of consciousness in pregnant women, a cause of abnormalities on fetal cardiotocogram as well as a cause of delayed peristalsis in a newborn baby.

Folia medica, 2021

Tumours arising from the spinal nerve roots are more common in men between the third and fourth d... more Tumours arising from the spinal nerve roots are more common in men between the third and fourth decades of life, located mainly in the intradural space of the lumbar region. The clinical symptoms of spinal schwannomas and neurofibromas are similar and depend on the location of the tumour and its relationship to the spinal cord and nerve roots. The pain (radiculalgia and/or vertebralgia) is the earliest symptom, followed by sensory deficit, while motor deficits and sphincter disorders are late symptoms. Magnetic resonance imaging is the diagnostic tool of choice and should be performed when the disease is suspected, as early and accurate diagnosis is essential for treatment outcome. The treatment of these lesions is surgical aiming at total tumour resection that promotes neurological recovery and prevents from recurrences. Subtotal removal also provides favourable outcome but at higher recurrence rates. The aim of this literature review was to study some important characteristics of ...

European Radiology, 2003

Amyloidosis is a disorder of protein metabolism characterized by extracellular deposition of abno... more Amyloidosis is a disorder of protein metabolism characterized by extracellular deposition of abnormal protein fibrils. It may either be localized to any organ or systematically distributed throughout the body. The biochemical nature of proteins varies but the physical and tinctorial properties are shared by all the amyloidogenic proteins. In the West, it is mainly composed of amyloid light (AL) type immunoglobulin (Ig) light chains. Amyloidosis of the genitourinary tract is rare except for the kidney and isolated primary amyloidosis of the urinary bladder is even rarer. It mainly presents as intermittent painless gross hematuria. It mimics transitional cell carcinoma on imaging and endoscopic examination. We herein present a case of fifty six-years-old male with history of painless hematuria for three months. Cystoscopy revealed a 1 cm hyperemic area on the posterior wall of urinary bladder. The biopsy showed features of amyloidosis and amyloid A (AA) immunostaining was negative. Extensive workup was done to exclude other sites of involvement and a final diagnosis of primary localized amyloidosis of the urinary bladder was made. The patient is on regular follow-up.

Folia Medica, 2006

Echinococcosis is a frequent helminthiasis in Bulgaria. Hydatid cysts commonly affect the liver a... more Echinococcosis is a frequent helminthiasis in Bulgaria. Hydatid cysts commonly affect the liver and the lung. Echinococcosis rarely involves bones (0.5 to 2.5%) and vertebral column is affected in 50% of the cases. We report a case of a 67-year-old female with echinococcosis of the pelvic bone clinically manifested by pain and swelling of the right iliac region and complicated by abscess of the surrounding soft tissue. The patient underwent surgery at the Department of Orthopedics and Traumatology, University hospital "St. George", Medical University, Plovdiv. Diagnosis was based on imaging findings, serologic and histological methods. Biopsy material was investigated by standard histological methods hematoxilin-eosin (H-E),PAS and hydrargyrum impregnation after Gommori, which presented both chitin and germinative membranes of the hydatid cyst. The patient underwent complete resection of the bone lesion along with the surrounding soft tissue. Purulent collection of 1200 ml...

Primary pulmonary liposarcoma is extremely rare. There are only 12 cases reported in the literatu... more Primary pulmonary liposarcoma is extremely rare. There are only 12 cases reported in the literature. We presented a case of low-grade primary pulmonary myxoid liposarcoma, which was diagnosed and underwent surgery in our clinic. The diagnosis was established after imaging investigations (X-ray and CT), histologic and immunohistochemical examinations. The patient was followed up one year after the operation.

INTRODUCTION Echinococcosis is a frequent helminthiasis in Bulgaria. Hydatid cysts commonly affec... more INTRODUCTION Echinococcosis is a frequent helminthiasis in Bulgaria. Hydatid cysts commonly affect the liver and the lung. Echinococcosis rarely involves bones (0.5 to 2.5%) and vertebral column is affected in 50% of the cases. PATIENTS AND METHODS We report a case of a 67-year-old female with echinococcosis of the pelvic bone clinically manifested by pain and swelling of the right iliac region and complicated by abscess of the surrounding soft tissue. The patient underwent surgery at the Department of Orthopedics and Traumatology, University hospital "St. George", Medical University, Plovdiv. Diagnosis was based on imaging findings, serologic and histological methods. Biopsy material was investigated by standard histological methods hematoxilin-eosin (H-E),PAS and hydrargyrum impregnation after Gommori, which presented both chitin and germinative membranes of the hydatid cyst. RESULTS The patient underwent complete resection of the bone lesion along with the surrounding s...

Summary: Malignant fibrous histiocytoma (MFH)represents the diagnosis that is still commonly used... more Summary: Malignant fibrous histiocytoma (MFH)represents the diagnosis that is still commonly used byboth patients and physicians although in 2002., theWorld Health Organization (WHO) declassified MFHas a formal diagnostic entity, renaming it as an undiffe-rentiated pleomorphic sarcoma not specifying it furt-her. MFH is extremely rare in the oral cavity. The aimof this article was to describe a newly diagnosed caseof primary MFH in a 78-year-old male presented after4-months history of rapidly increasing swelling of lo-wer lip. Histopathology of the lesion showed highlymalignant cell infiltration with epithelioid/spindle celltype morphology. Immunohistochemical study waspositive forvimentin (++),S-100 protein (++)and neg-ative for desmin and cytokeratin. The authors discus-sed the possibilities of immunohistochemical studyand necessity of individual treatment plan in patientswith MFH, comparing their point of view with otherstudies. Key words: malignant fibrous histiocytoma, un-differ...

The Internet Journal of Hematology, 2009

Tumor-like extramedullary hematopoiesis with liver localization in beta-thalassemia is an extreme... more Tumor-like extramedullary hematopoiesis with liver localization in beta-thalassemia is an extremely rare clinical phenomenon and a prerequisite for serious deferential diagnostic problems. We present a case of homozygous beta-thalassemia in a 23year-old woman.The patient was examined by abdominal ultrasonography and CT scan because of biliary crisis and found to have microconcrements in the gallbladder and a tumor-like formation (34 x 30 mm) in the 7th liver segment. Conventional cholecystectomy was performed. The histological examination showed it focal extramedullary hematopoiesis with an underlying diagnosis of Cooley’s anemia. Differential diagnostic difficulties and necessary diagnostic steps are discussed. Fine needle biopsy and/or immunohistochemical examination are the best methods for the precise diagnosis of extramedullary hematopoiesis.

Bone surgical interventions are performed using two major techniques: an osteoplasty and osteotom... more Bone surgical interventions are performed using two major techniques: an osteoplasty and osteotomy. They are carried out by a great number of tools (osteotomes) which cause certain changes in bone morphology, i.e. cell vitality and physiology.1-14 The applicability of different osteotomes in bone surgery depends on the severity of tissues damage and the healing process afterwards.1 Therefore, the features of bone repair have been object of a many histomorphological research trials performed on laboratory animals.1–3 The analyses of the results published showed tissue recovery following ultrasound and laser osteotomy to be superior to the procedures performed by conventional rotary tools.1,4,5 However, the conclusions from these researches are not automatically relevant to humans. Therefore, the aim of this study was to evaluate the histological changes in the border area following in vivo human bone cutting by an ultrasonic device and an Er:YAG laser during extractions of impacted m...

Journal of IMAB - Annual Proceeding (Scientific Papers)

Only a few cases of intramedullary meningiomas in the cervical and thoracic region have been repo... more Only a few cases of intramedullary meningiomas in the cervical and thoracic region have been reported in the literature. We present a rare case of intramedullary meningioma in the lower thoracic region. A 68-year-old woman with complaints of back pain, gait disturbance, and paresthesias in both lower extremities for 4 months was admitted to our institution. Initially, she presented with weakness in her legs that gradually deteriorated over time. The patient had been operated on for breast cancer 2 years prior to the onset of current complaints. The neurological examination revealed spastic inferior paraparesis (McCormick grade IV), hypoesthesia below Th10 dermatome, bowel and bladder disturbances. Magnetic resonance imaging of the thoracic spine demonstrated intramedullary tumor that was hypointense on T1 and T2-weighted images but showed homogenous enhancement after gadolinium administration. After gross total resection, the histopathological examination confirmed the diagnosis of ...

Folia medica, Sep 1, 2017

Spinal neurofibroma is one of the rarest of the neoplasms involving the spinal cord or roots and ... more Spinal neurofibroma is one of the rarest of the neoplasms involving the spinal cord or roots and occurs much less often than neurinoma, meningioma or glioma. The sixth pediatric case of solitary intramedullary tumor was described in 2013, according to B. Eljebbouri et al. We present a rare, difficult to diagnose and may-be the seventh pediatric case of solitary neurofibroma of the cauda equine in an 11-month-old infant. The patient underwent a laminectomy of T12, L1, L2 and L3, extirpation of intradural, intramedullary and extramedullary spinal cord tumor. The patient is fully recovered for 5 years of monitoring. Although rare, spinal neurofibromas in children should be diagnostically considered and radically treated for a favorable outcome.

Journal of IMAB - Annual Proceeding (Scientific Papers)

The osteoma is a benign osteogenic neoplasm. It consists of well-differentiated compact or cancel... more The osteoma is a benign osteogenic neoplasm. It consists of well-differentiated compact or cancellous bone. The prevalence of osteomas in the normal population is about 4 %. Osteomas may be classified as peripheral, central or extraskeletal. Peripheral osteomas occur not commonly in jawbones. It affects more frequently mandible than maxilla, and the most common sites are the angle and lower border of the body. The aim of this article is to present a rare case of peripheral osteoma, arising from a mental spine. 77 years old women, was reffered in our department with complaints of hard, nonpainful spike under her tongue, which hinder stability of her dentures during the eating and speaking. A traditional radiography was made. A surgical removal of formation was performed. The diagnose was established after the pathohistological examination was made. No complications were noted during the observed 6 months post surgery period.

Folia Medica, 2016

BACKGROUND: Surgical treatment of odontogenic jaw cysts may include one of the following four bas... more BACKGROUND: Surgical treatment of odontogenic jaw cysts may include one of the following four basic methods: enucleation, marsupialization, staged combination of marsupialization and enucleation, or enucleation with curettage. Enucleation/cystectomy, alone or combined with other procedures, is the preferred choice of treatment. OBJECTIVE: The aim of the case report was to present the outcome of an ultrasound-assistant periapical cystectomy in a frontal upper tooth with indications for extraction. RESULTS: Postoperative recovery was uneventful. The functional result was satisfactory. On the follow-up X-rays a reduction of the intraosseous defect by a new bone formation could be observed. CONCLUSION: We found ultrasonic surgery to be a promising approach for safe and effective odontogenic jaw cyst removal reducing the risk of its recurrence.

Acta Clinica Croatica, Jun 28, 2011

A severe complication of the administration of bisphosphonate-containing medications is known as ... more A severe complication of the administration of bisphosphonate-containing medications is known as bisphosphonate-associated osteonecrosis of the jaws (BONJ). A case series of three patients affected by BONJ is presented. These patients currently represent the only described cases of BONJ in Bulgaria. Exposed necrotic bone of the mandible was observed in two patients and the maxilla was affected in the third case. Two of the patients had been treated with zoledronate for metastatic prostate cancer and one patient for metastatic endometrioid cancer. All three patients underwent surgical treatment. One of the patients received conservative surgical debridement, i.e. removal of necrotic bone only, and primary wound closure. Conservative surgical debridement and application of local medications without wound closure were used in the other two patients. All three patients received systemic antibiotic treatment. No evidence of disease progression was observed during the follow-up period of 3 to 12 months. The surgical approach utilized in the present study is discussed in the light of the etiopathogenesis, prevention and treatment of BONJ.

Acta Clinica Croatica, Jun 1, 2011

A severe complication of the administration of bisphosphonate-containing medications is known as ... more A severe complication of the administration of bisphosphonate-containing medications is known as bisphosphonate-associated osteonecrosis of the jaws (BONJ). A case series of three patients affected by BONJ is presented. These patients currently represent the only described cases of BONJ in Bulgaria. Exposed necrotic bone of the mandible was observed in two patients and the maxilla was affected in the third case. Two of the patients had been treated with zoledronate for metastatic prostate cancer and one patient for metastatic endometrioid cancer. All three patients underwent surgical treatment. One of the patients received conservative surgical debridement, i.e. removal of necrotic bone only, and primary wound closure. Conservative surgical debridement and application of local medications without wound closure were used in the other two patients. All three patients received systemic antibiotic treatment. No evidence of disease progression was observed during the follow-up period of 3 to 12 months. The surgical approach utilized in the present study is discussed in the light of the etiopathogenesis, prevention and treatment of BONJ.

PubMed, 2001

We present case 96 (the first one in Bulgaria) of primary localized amyloidosis of the urinary bl... more We present case 96 (the first one in Bulgaria) of primary localized amyloidosis of the urinary bladder in a 72-year-old woman with episodes of painless hematuria. The amyloid tumor is situated on the anterior wall of the bladder--a yellowish prominence 15 mm in diameter with superficial erosion that is surrounded by a reddish ring and bullous edema of the mucosa. Rough and regularly pink perivascular deposits, thickened vessel walls and focal lymphoplasmocyte infiltrates are present in the submucosa. After preliminary treatment with KHMnO4, AL-amyloid is detected in polarized light by Congorot staining and in ultraviolet light using thioflavin. Immunoglobulins and C3 deposits are not found. On electron microscopy deposits of amyloid fibrils are seen in abundance close to collagen bundles. Diseases that may be associated with systemic amyloidosis have been clinically excluded. Nodular amyloidosis resulting from a local immune dyscrasia is accepted in the case. The patient is in good health 11 months after the first biopsy. A literature review on this rare form of localized amyloidosis has been made. Generally, the disease has a favorable prognosis and non-active behavior is recommended. Intravesical instillations of dimethyl sulfoxide, sectional resection or plastic surgery that preserve the urinary tract are used in the rare case of progressive course.

Australian and New Zealand Journal of Obstetrics and Gynaecology, 2009

A case of an attempted suicide with atypical antipsychotic (clozapine) in late pregnancy is repor... more A case of an attempted suicide with atypical antipsychotic (clozapine) in late pregnancy is reported. Toxic effects of clozapine in the mother as well as in the fetus and newborn were observed. It should be remembered as a rare cause of unexplained loss of consciousness in pregnant women, a cause of abnormalities on fetal cardiotocogram as well as a cause of delayed peristalsis in a newborn baby.

Folia medica, 2021

Tumours arising from the spinal nerve roots are more common in men between the third and fourth d... more Tumours arising from the spinal nerve roots are more common in men between the third and fourth decades of life, located mainly in the intradural space of the lumbar region. The clinical symptoms of spinal schwannomas and neurofibromas are similar and depend on the location of the tumour and its relationship to the spinal cord and nerve roots. The pain (radiculalgia and/or vertebralgia) is the earliest symptom, followed by sensory deficit, while motor deficits and sphincter disorders are late symptoms. Magnetic resonance imaging is the diagnostic tool of choice and should be performed when the disease is suspected, as early and accurate diagnosis is essential for treatment outcome. The treatment of these lesions is surgical aiming at total tumour resection that promotes neurological recovery and prevents from recurrences. Subtotal removal also provides favourable outcome but at higher recurrence rates. The aim of this literature review was to study some important characteristics of ...

European Radiology, 2003

Amyloidosis is a disorder of protein metabolism characterized by extracellular deposition of abno... more Amyloidosis is a disorder of protein metabolism characterized by extracellular deposition of abnormal protein fibrils. It may either be localized to any organ or systematically distributed throughout the body. The biochemical nature of proteins varies but the physical and tinctorial properties are shared by all the amyloidogenic proteins. In the West, it is mainly composed of amyloid light (AL) type immunoglobulin (Ig) light chains. Amyloidosis of the genitourinary tract is rare except for the kidney and isolated primary amyloidosis of the urinary bladder is even rarer. It mainly presents as intermittent painless gross hematuria. It mimics transitional cell carcinoma on imaging and endoscopic examination. We herein present a case of fifty six-years-old male with history of painless hematuria for three months. Cystoscopy revealed a 1 cm hyperemic area on the posterior wall of urinary bladder. The biopsy showed features of amyloidosis and amyloid A (AA) immunostaining was negative. Extensive workup was done to exclude other sites of involvement and a final diagnosis of primary localized amyloidosis of the urinary bladder was made. The patient is on regular follow-up.

Folia Medica, 2006

Echinococcosis is a frequent helminthiasis in Bulgaria. Hydatid cysts commonly affect the liver a... more Echinococcosis is a frequent helminthiasis in Bulgaria. Hydatid cysts commonly affect the liver and the lung. Echinococcosis rarely involves bones (0.5 to 2.5%) and vertebral column is affected in 50% of the cases. We report a case of a 67-year-old female with echinococcosis of the pelvic bone clinically manifested by pain and swelling of the right iliac region and complicated by abscess of the surrounding soft tissue. The patient underwent surgery at the Department of Orthopedics and Traumatology, University hospital "St. George", Medical University, Plovdiv. Diagnosis was based on imaging findings, serologic and histological methods. Biopsy material was investigated by standard histological methods hematoxilin-eosin (H-E),PAS and hydrargyrum impregnation after Gommori, which presented both chitin and germinative membranes of the hydatid cyst. The patient underwent complete resection of the bone lesion along with the surrounding soft tissue. Purulent collection of 1200 ml...

Primary pulmonary liposarcoma is extremely rare. There are only 12 cases reported in the literatu... more Primary pulmonary liposarcoma is extremely rare. There are only 12 cases reported in the literature. We presented a case of low-grade primary pulmonary myxoid liposarcoma, which was diagnosed and underwent surgery in our clinic. The diagnosis was established after imaging investigations (X-ray and CT), histologic and immunohistochemical examinations. The patient was followed up one year after the operation.

INTRODUCTION Echinococcosis is a frequent helminthiasis in Bulgaria. Hydatid cysts commonly affec... more INTRODUCTION Echinococcosis is a frequent helminthiasis in Bulgaria. Hydatid cysts commonly affect the liver and the lung. Echinococcosis rarely involves bones (0.5 to 2.5%) and vertebral column is affected in 50% of the cases. PATIENTS AND METHODS We report a case of a 67-year-old female with echinococcosis of the pelvic bone clinically manifested by pain and swelling of the right iliac region and complicated by abscess of the surrounding soft tissue. The patient underwent surgery at the Department of Orthopedics and Traumatology, University hospital "St. George", Medical University, Plovdiv. Diagnosis was based on imaging findings, serologic and histological methods. Biopsy material was investigated by standard histological methods hematoxilin-eosin (H-E),PAS and hydrargyrum impregnation after Gommori, which presented both chitin and germinative membranes of the hydatid cyst. RESULTS The patient underwent complete resection of the bone lesion along with the surrounding s...

Summary: Malignant fibrous histiocytoma (MFH)represents the diagnosis that is still commonly used... more Summary: Malignant fibrous histiocytoma (MFH)represents the diagnosis that is still commonly used byboth patients and physicians although in 2002., theWorld Health Organization (WHO) declassified MFHas a formal diagnostic entity, renaming it as an undiffe-rentiated pleomorphic sarcoma not specifying it furt-her. MFH is extremely rare in the oral cavity. The aimof this article was to describe a newly diagnosed caseof primary MFH in a 78-year-old male presented after4-months history of rapidly increasing swelling of lo-wer lip. Histopathology of the lesion showed highlymalignant cell infiltration with epithelioid/spindle celltype morphology. Immunohistochemical study waspositive forvimentin (++),S-100 protein (++)and neg-ative for desmin and cytokeratin. The authors discus-sed the possibilities of immunohistochemical studyand necessity of individual treatment plan in patientswith MFH, comparing their point of view with otherstudies. Key words: malignant fibrous histiocytoma, un-differ...

The Internet Journal of Hematology, 2009

Tumor-like extramedullary hematopoiesis with liver localization in beta-thalassemia is an extreme... more Tumor-like extramedullary hematopoiesis with liver localization in beta-thalassemia is an extremely rare clinical phenomenon and a prerequisite for serious deferential diagnostic problems. We present a case of homozygous beta-thalassemia in a 23year-old woman.The patient was examined by abdominal ultrasonography and CT scan because of biliary crisis and found to have microconcrements in the gallbladder and a tumor-like formation (34 x 30 mm) in the 7th liver segment. Conventional cholecystectomy was performed. The histological examination showed it focal extramedullary hematopoiesis with an underlying diagnosis of Cooley’s anemia. Differential diagnostic difficulties and necessary diagnostic steps are discussed. Fine needle biopsy and/or immunohistochemical examination are the best methods for the precise diagnosis of extramedullary hematopoiesis.

Bone surgical interventions are performed using two major techniques: an osteoplasty and osteotom... more Bone surgical interventions are performed using two major techniques: an osteoplasty and osteotomy. They are carried out by a great number of tools (osteotomes) which cause certain changes in bone morphology, i.e. cell vitality and physiology.1-14 The applicability of different osteotomes in bone surgery depends on the severity of tissues damage and the healing process afterwards.1 Therefore, the features of bone repair have been object of a many histomorphological research trials performed on laboratory animals.1–3 The analyses of the results published showed tissue recovery following ultrasound and laser osteotomy to be superior to the procedures performed by conventional rotary tools.1,4,5 However, the conclusions from these researches are not automatically relevant to humans. Therefore, the aim of this study was to evaluate the histological changes in the border area following in vivo human bone cutting by an ultrasonic device and an Er:YAG laser during extractions of impacted m...

Journal of IMAB - Annual Proceeding (Scientific Papers)

Only a few cases of intramedullary meningiomas in the cervical and thoracic region have been repo... more Only a few cases of intramedullary meningiomas in the cervical and thoracic region have been reported in the literature. We present a rare case of intramedullary meningioma in the lower thoracic region. A 68-year-old woman with complaints of back pain, gait disturbance, and paresthesias in both lower extremities for 4 months was admitted to our institution. Initially, she presented with weakness in her legs that gradually deteriorated over time. The patient had been operated on for breast cancer 2 years prior to the onset of current complaints. The neurological examination revealed spastic inferior paraparesis (McCormick grade IV), hypoesthesia below Th10 dermatome, bowel and bladder disturbances. Magnetic resonance imaging of the thoracic spine demonstrated intramedullary tumor that was hypointense on T1 and T2-weighted images but showed homogenous enhancement after gadolinium administration. After gross total resection, the histopathological examination confirmed the diagnosis of ...

Folia medica, Sep 1, 2017

Spinal neurofibroma is one of the rarest of the neoplasms involving the spinal cord or roots and ... more Spinal neurofibroma is one of the rarest of the neoplasms involving the spinal cord or roots and occurs much less often than neurinoma, meningioma or glioma. The sixth pediatric case of solitary intramedullary tumor was described in 2013, according to B. Eljebbouri et al. We present a rare, difficult to diagnose and may-be the seventh pediatric case of solitary neurofibroma of the cauda equine in an 11-month-old infant. The patient underwent a laminectomy of T12, L1, L2 and L3, extirpation of intradural, intramedullary and extramedullary spinal cord tumor. The patient is fully recovered for 5 years of monitoring. Although rare, spinal neurofibromas in children should be diagnostically considered and radically treated for a favorable outcome.

Journal of IMAB - Annual Proceeding (Scientific Papers)

The osteoma is a benign osteogenic neoplasm. It consists of well-differentiated compact or cancel... more The osteoma is a benign osteogenic neoplasm. It consists of well-differentiated compact or cancellous bone. The prevalence of osteomas in the normal population is about 4 %. Osteomas may be classified as peripheral, central or extraskeletal. Peripheral osteomas occur not commonly in jawbones. It affects more frequently mandible than maxilla, and the most common sites are the angle and lower border of the body. The aim of this article is to present a rare case of peripheral osteoma, arising from a mental spine. 77 years old women, was reffered in our department with complaints of hard, nonpainful spike under her tongue, which hinder stability of her dentures during the eating and speaking. A traditional radiography was made. A surgical removal of formation was performed. The diagnose was established after the pathohistological examination was made. No complications were noted during the observed 6 months post surgery period.

Folia Medica, 2016

BACKGROUND: Surgical treatment of odontogenic jaw cysts may include one of the following four bas... more BACKGROUND: Surgical treatment of odontogenic jaw cysts may include one of the following four basic methods: enucleation, marsupialization, staged combination of marsupialization and enucleation, or enucleation with curettage. Enucleation/cystectomy, alone or combined with other procedures, is the preferred choice of treatment. OBJECTIVE: The aim of the case report was to present the outcome of an ultrasound-assistant periapical cystectomy in a frontal upper tooth with indications for extraction. RESULTS: Postoperative recovery was uneventful. The functional result was satisfactory. On the follow-up X-rays a reduction of the intraosseous defect by a new bone formation could be observed. CONCLUSION: We found ultrasonic surgery to be a promising approach for safe and effective odontogenic jaw cyst removal reducing the risk of its recurrence.

Acta Clinica Croatica, Jun 28, 2011

A severe complication of the administration of bisphosphonate-containing medications is known as ... more A severe complication of the administration of bisphosphonate-containing medications is known as bisphosphonate-associated osteonecrosis of the jaws (BONJ). A case series of three patients affected by BONJ is presented. These patients currently represent the only described cases of BONJ in Bulgaria. Exposed necrotic bone of the mandible was observed in two patients and the maxilla was affected in the third case. Two of the patients had been treated with zoledronate for metastatic prostate cancer and one patient for metastatic endometrioid cancer. All three patients underwent surgical treatment. One of the patients received conservative surgical debridement, i.e. removal of necrotic bone only, and primary wound closure. Conservative surgical debridement and application of local medications without wound closure were used in the other two patients. All three patients received systemic antibiotic treatment. No evidence of disease progression was observed during the follow-up period of 3 to 12 months. The surgical approach utilized in the present study is discussed in the light of the etiopathogenesis, prevention and treatment of BONJ.

Acta Clinica Croatica, Jun 1, 2011

A severe complication of the administration of bisphosphonate-containing medications is known as ... more A severe complication of the administration of bisphosphonate-containing medications is known as bisphosphonate-associated osteonecrosis of the jaws (BONJ). A case series of three patients affected by BONJ is presented. These patients currently represent the only described cases of BONJ in Bulgaria. Exposed necrotic bone of the mandible was observed in two patients and the maxilla was affected in the third case. Two of the patients had been treated with zoledronate for metastatic prostate cancer and one patient for metastatic endometrioid cancer. All three patients underwent surgical treatment. One of the patients received conservative surgical debridement, i.e. removal of necrotic bone only, and primary wound closure. Conservative surgical debridement and application of local medications without wound closure were used in the other two patients. All three patients received systemic antibiotic treatment. No evidence of disease progression was observed during the follow-up period of 3 to 12 months. The surgical approach utilized in the present study is discussed in the light of the etiopathogenesis, prevention and treatment of BONJ.